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Early-onset diabetes: an epidemic in China
Jiemin Pan, Weiping Jia
《医学前沿(英文)》 2018年 第12卷 第6期 页码 624-633 doi: 10.1007/s11684-018-0669-1
Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.
《医学前沿(英文)》 2023年 第17卷 第1期 页码 156-164 doi: 10.1007/s11684-022-0932-3
关键词: dietary zinc intake new-onset hypertension general population CHNS
YAN Jiangtao, SHAO Jiaomei, WANG Daowen, YUE Zhengliang, HUI Rutai
《医学前沿(英文)》 2008年 第2卷 第4期 页码 352-355 doi: 10.1007/s11684-008-0067-1
Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 333-339 doi: 10.1007/s11684-017-0564-1
Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosuppressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell–matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.
关键词: nephrotic syndrome focal segmental glomerulosclerosis genetic
Jiangtao YAN, Rutai HUI, Daowen WANG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 30-35 doi: 10.1007/s11684-009-0005-x
Shilin DENG MD ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 323-329 doi: 10.1007/s11684-009-0061-2
关键词: early postmenopausal women bone mineral density exercise effects
RESEARCH AND APPLICATION OF CROP PEST MONITORING AND EARLY WARNING TECHNOLOGY IN CHINA
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 页码 19-36 doi: 10.15302/J-FASE-2021411
The importance of food security, especially in combating the problem of acute hunger, has been underscored as a key component of sustainable development. Considering the major challenge of rapidly increasing demands for both food security and safety, the management and control of major pests is urged to secure supplies of major agricultural products. However, owing to global climate change, biological invasion (e.g., fall armyworm), decreasing agricultural biodiversity, and other factors, a wide range of crop pest outbreaks are becoming more frequent and serious, making China, one of the world’s largest country in terms of agricultural production, one of the primary victims of crop yield loss and the largest pesticide consumer in the world. Nevertheless, the use of science and technology in monitoring and early warning of major crop pests provides better pest management and acts as a fundamental part of an integrated plant protection strategy to achieve the goal of sustainable development of agriculture. This review summarizes the most fundamental information on pest monitoring and early warning in China by documenting the developmental history of research and application, Chinese laws and regulations related to plant protection, and the National Monitoring and Early Warning System, with the purpose of presenting the Chinese model as an example of how to promote regional management of crop pests, especially of cross border pests such as fall armyworm and locust, by international cooperation across pest-related countries.
Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion
Geqing XIA, Chaoying WU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 216-219 doi: 10.1007/s11684-009-0028-3
关键词: mifepristone inducible nitric oxide synthase early pregnancy placental immunity
P50 auditory sensory gating in first onset schizophrenics and normal healthy adults
WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin
《医学前沿(英文)》 2007年 第1卷 第4期 页码 429-432 doi: 10.1007/s11684-007-0084-5
Role of chemerin/CMKLR1 in the maintenance of early pregnancy
Xuezhou Yang, Junning Yao, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Xiaozhen Quan, Yanli Lan, Hui Xing
《医学前沿(英文)》 2018年 第12卷 第5期 页码 525-532 doi: 10.1007/s11684-017-0577-9
Chemerin is a cytokine that attracts much attention in the reproductive process. This study aimed to explore the effects of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) on the maintenance of early pregnancy. The expression levels of chemerin and CMKLR1 in the decidua tissues of 20 early normal pregnant women and 20 early spontaneous abortion women were examined by Western blot and real-time polymerase chain reaction analyses. CMKLR1 receptor antagonist (α-NETA) was then intrauterinely injected into normal pregnant mice model to assess its effect on the outcome of pregnancy and the phosphorylation rate of ERK1/2 in decidua tissues. We found that the expression level of chemerin in women who had experienced early spontaneous abortion was lower than in those who had experienced normal early pregnancy (P<0.01); conversely, CMKLR1 expression was higher in the former than in the latter (P<0.01). In a pregnant-mouse model, the embryo resorption rate of α-NETA group was higher than that in the negative control group (61.5% vs. 10.8%) (P<0.001). Compared with the control group, ERK1/2 phosphorylation in decidua tissues decreased in the α-NETA-treated group (P<0.01). These results suggested that the inhibition of the chemerin/CMKLR1 signaling pathway can lead to the abortion of mouse embryos, and that chemerin/CMKLR1 may play an important role in the maintenance of early pregnancy possibly by regulating ERK1/2 phosphorylation.
关键词: chemerin CMKLR1 early abortion
Weak characteristic information extraction from early fault of wind turbine generator gearbox
Xiaoli XU, Xiuli LIU
《机械工程前沿(英文)》 2017年 第12卷 第3期 页码 357-366 doi: 10.1007/s11465-017-0423-4
Given the weak early degradation characteristic information during early fault evolution in gearbox of wind turbine generator, traditional singular value decomposition (SVD)-based denoising may result in loss of useful information. A weak characteristic information extraction based on µ-SVD and local mean decomposition (LMD) is developed to address this problem. The basic principle of the method is as follows: Determine the denoising order based on cumulative contribution rate, perform signal reconstruction, extract and subject the noisy part of signal to LMD and µ-SVD denoising, and obtain denoised signal through superposition. Experimental results show that this method can significantly weaken signal noise, effectively extract the weak characteristic information of early fault, and facilitate the early fault warning and dynamic predictive maintenance.
关键词: wind turbine generator gearbox µ-singular value decomposition local mean decomposition weak characteristic information extraction early fault warning
Biosensor-based assay of exosome biomarker for early diagnosis of cancer
《医学前沿(英文)》 2022年 第16卷 第2期 页码 157-175 doi: 10.1007/s11684-021-0884-z
The early signal substances induced by heat stress in brains of mice
WANG Chunxu, WANG Hanxing
《医学前沿(英文)》 2008年 第2卷 第4期 页码 391-395 doi: 10.1007/s11684-008-0075-1
关键词: calcitonin gene-related subsequent ischemia/reperfusion computer cerebrum CGRP excretion
Effects of DNA damage on oocyte meiotic maturation and early embryonic development
Shen YIN,Junyu MA,Wei SHEN
《农业科学与工程前沿(英文)》 2014年 第1卷 第3期 页码 185-190 doi: 10.15302/J-FASE-2014035
Factors affecting early embryonic development in cattle: relevance for bovine cloning
Yanna DANG, Kun ZHANG
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 33-41 doi: 10.15302/J-FASE-2018228
Female infertility represents a major challenge for improving the production efficiency in the dairy industry. Historically, fertility has declined whereas milk yield has increased tremendously due to intensive genetic selection. evidence reveals about 60% pregnancy loss takes place during the first month following fertilization. Meanwhile, early embryo development is significant for somatic cell nuclear transfer in cattle as a large proportion of cloned embryos fail to develop beyond peri-implantation stage. Oocyte quality is of utmost importance for the early embryo to develop to term for both fertilized and cloned embryos. Epigenetic reprogramming is a key process occurring after fertilization and critical roles of epigenetic modifiers during preimplantation development are now clear. Incomplete epigenetic reprogramming is believed to be a major limitation to cloning efficiency. Treatment of cloned embryos with epigenetic modifying drugs (e.g., Trichostatin A) could greatly improve cloning efficiency in both mice and cattle. Recently, the rapid progress in high-throughput sequencing technologies has enabled detailed deciphering of the molecular mechanisms underlying these events. The robust efficiency of genomic editing tools also presents an alternative approach to the functional annotation of genes critical to early development.
关键词: bovine cloning embryo development somatic cell nuclear transfer X-inactive specific transcript
标题 作者 时间 类型 操作
J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study
期刊论文
Predication of increased plasma homocysteine level on the prognosis of Chinese patients with first-onset
YAN Jiangtao, SHAO Jiaomei, WANG Daowen, YUE Zhengliang, HUI Rutai
期刊论文
Elevated C-reactive protein levels predict worsening prognosis in Chinese patients with first-onset stroke
Jiangtao YAN, Rutai HUI, Daowen WANG
期刊论文
Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial
Shilin DENG MD ,
期刊论文
Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion
Geqing XIA, Chaoying WU
期刊论文
P50 auditory sensory gating in first onset schizophrenics and normal healthy adults
WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin
期刊论文
Role of chemerin/CMKLR1 in the maintenance of early pregnancy
Xuezhou Yang, Junning Yao, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Xiaozhen Quan, Yanli Lan, Hui Xing
期刊论文
Weak characteristic information extraction from early fault of wind turbine generator gearbox
Xiaoli XU, Xiuli LIU
期刊论文
Effects of DNA damage on oocyte meiotic maturation and early embryonic development
Shen YIN,Junyu MA,Wei SHEN
期刊论文