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Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang
《医学前沿(英文)》 2020年 第14卷 第5期 页码 651-663 doi: 10.1007/s11684-019-0709-5
关键词: metabolomics liquid chromatography-mass spectrometry metabolites metabolic pathways
Regulation of T cell immunity by cellular metabolism
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 463-472 doi: 10.1007/s11684-018-0668-2
T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.
关键词: T cell immunity metabolic pathways nutrient uptake metabolic checkpoints
《环境科学与工程前沿(英文)》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1433-3
• Short-term effect of the pyridine exposure on the SAD process was investigated.
关键词: Anammox Inhibition Metabolic pathway Microbial community Pyridine SAD
《化学科学与工程前沿(英文)》 2022年 第16卷 第12期 页码 1700-1712 doi: 10.1007/s11705-022-2207-6
关键词: naphtha catalytic pyrolysis reaction pathway equilibrium yield
《环境科学与工程前沿(英文)》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1527-6
• The promoting effects for VFA generation follow the order of APG>SDBS>HTAB.
关键词: Waste activated sludge (WAS) Volatile fatty acids (VFA) Surfactant types Functional microorganisms Metabolic activity upregulation
Seasonal variations of transport pathways andpotential sources of PM
Yuan Chen, Shaodong Xie, Bin Luo
《环境科学与工程前沿(英文)》 2018年 第12卷 第1期 doi: 10.1007/s11783-018-1009-z
关键词: Transport pathway Backwardtrajectory Clustering analysis Potential source Chengdu
ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE
《农业科学与工程前沿(英文)》 2022年 第9卷 第3期 页码 316-332 doi: 10.15302/J-FASE-2022441
● The Green Revolution broadened the trade-off between yield and nitrogen-use efficiency.
关键词: Nitrogen root system architecture phytohormone crosstalk nitrogen-use efficiency breeding strategy
Metabolic hypertension: concept and practice
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 201-206 doi: 10.1007/s11684-013-0264-4
Hypertension is a serious public health problem worldwide. More than 60% of the risk factors for hypertension are associated with metabolic disturbances. Metabolic abnormalities increase the risk for hypertension and cause high blood pressure. Improving metabolic disturbances is beneficial for hypertension treatment. Due to the importance of metabolic abnormalities in the pathogenesis of hypertension, we propose a concept of metabolic hypertension. In this review, we discuss and review the clinical types, pathogenesis, risk evaluation and management of metabolic hypertension. Elucidation of the mechanism of metabolic hypertension should facilitate the design of novel pharmacotherapeutics and dedicated antihypertensive manipulations.
关键词: hypertension cardiometabolic risk factors metabolic abnormalities
Energy transition toward carbon-neutrality in China: Pathways, implications and uncertainties
《工程管理前沿(英文)》 2022年 第9卷 第3期 页码 358-372 doi: 10.1007/s42524-022-0202-8
关键词: carbon neutrality energy transition uncertainty EROI LEAP
《能源前沿(英文)》 doi: 10.1007/s11708-024-0949-1
关键词: plasma catalysis nitrogen fixation ammonia synthesis hydrogen storage catalyst carbon neutralization
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
关键词: inflammation obesity cytokine energy expenditure insulin resistance
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1715-z
● N2H4 addition enhanced and recovered anammox performance under Cr(VI) stress.
关键词: Extracellular Cr(VI) reduction Electron transfer Anammox Hydrazine Cr(VI) inhibition
Assembly of biosynthetic pathways in
Lidan Ye,Xiaomei Lv,Hongwei Yu
《化学科学与工程前沿(英文)》 2017年 第11卷 第1期 页码 126-132 doi: 10.1007/s11705-016-1597-8
关键词: pathway assembly toolbox reiterative recombination S. cerevisiae biosynthesis
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 25-30 doi: 10.1007/s11684-013-0244-8
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.
关键词: FGF21 metabolism pharmacology physiology clinical relevance
Biological conversion pathways of sulfate reduction ammonium oxidation in anammox consortia
Zhen Bi, Deqing Wanyan, Xiang Li, Yong Huang
《环境科学与工程前沿(英文)》 2020年 第14卷 第3期 doi: 10.1007/s11783-019-1217-1
关键词: Anammox bacteria Autotrophic Biological conversion Sulfate reducing ammonium oxidation (SRAO)
标题 作者 时间 类型 操作
High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome
Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang
期刊论文
denitrification system with short-term pyridine exposure: Process capability, inhibition kinetics and metabolicpathways
期刊论文
Thermodynamic analysis of reaction pathways and equilibrium yields for catalytic pyrolysis of naphtha
期刊论文
New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic
期刊论文
Seasonal variations of transport pathways andpotential sources of PM
Yuan Chen, Shaodong Xie, Bin Luo
期刊论文
ROLE OF NITROGEN SENSING AND ITS INTEGRATIVE SIGNALING PATHWAYS IN SHAPING ROOT SYSTEM ARCHITECTURE
期刊论文
Plasma-assisted ammonia synthesis under mild conditions for hydrogen and electricity storage: Mechanisms, pathways
期刊论文
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
null
期刊论文
Enhancement of extracellular Cr(VI) reduction for anammox recovery using hydrazine: performance, pathways
期刊论文