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Junqin PANG, Masami MATSUDA, Masashi KURODA, Daisuke INOUE, Kazunari SEI, Kei NISHIDA, Michihiko IKE
《环境科学与工程前沿(英文)》 2016年 第10卷 第4期 doi: 10.1007/s11783-016-0846-x
关键词: DNA microarray analysis Nitrogen cycling functional genes Most probable number-polymerase chain reaction (MPN-PCR) Wastewater treatment plants (WWTPs)
Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG
《农业科学与工程前沿(英文)》 2014年 第1卷 第4期 页码 299-306 doi: 10.15302/J-FASE-2014040
关键词: Silky Fowl White Leghorn melanoblast migration gene expression
微阵列数据集的特征选择技术:综合评述、分类和未来方向 Review
Kulanthaivel BALAKRISHNAN, Ramasamy DHANALAKSHMI
《信息与电子工程前沿(英文)》 2022年 第23卷 第10期 页码 1451-1478 doi: 10.1631/FITEE.2100569
为获得最佳结果,从微阵列数据集中检索相关特征已成为特征选择(FS)技术的研究热点。本综述旨在全面阐述各种最新特征选择技术,同时介绍了基于微阵列数据集的处理多类分类问题的技术以及提高学习算法性能的不同方法。我们试图理解和解决数据集不平衡问题,以证实研究人员在微阵列数据集上的工作。对文献的分析为理解和强调在通过各种特征选择技术寻找最佳特征子集时存在的众多挑战和问题铺平了道路。同时提供了一个案例说明该方法的实施过程,该方法使用3个微阵列癌症数据集评估一些包装方法和混合方法的分类精度和收敛能力,以确认最优特征子集。
关键词: 特征选择;高维;学习技术;微阵列数据集
Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer
Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 247-253 doi: 10.1007/s11684-010-0027-4
关键词: gastric carcinoma metastasis signal transduction gene chips
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 280-289 doi: 10.1007/s11684-013-0265-3
Many gene fusions have been recognized as important diagnostic and/or prognostic markers in human malignancies. In recent years, novel gene fusions have been identified in cases without prior knowledge of the genetic background. Accompanied by a powerful computational data analysis method, new genome-wide screening approaches were used to detect cryptic genomic aberrations. This review focused on advanced genome-wide screening approaches in fusion gene identification, such as microarray-based approaches, next-generation sequencing, and NanoString nCounter gene expression system. The fundamental rationale and strategy for fusion gene identification using each biotech platform are also discussed.
关键词: gene fusion cancer microarray next-generation sequencing NanoString nCounter system
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
《环境科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 99-105 doi: 10.1007/s11783-013-0490-7
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 183-190 doi: 10.1007/s11684-016-0440-4
We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets (including 488 samples) were downloaded from the Gene Expression Omnibus (GEO) website. Data were normalized using the RMA algorithm. We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering. Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment was applied to explore the possible mechanisms. Eight distinct modules were identified by the WGCNA. Pink and red modules were associated with liver function, whereas turquoise and black modules were inversely correlated with tumor staging. Poor outcomes were found in the low expression group in the turquoise module and in the high expression group in the red module. In addition, GO enrichment analysis suggested that inflammation, immune, virus-related, and interferon-mediated pathways were enriched in the turquoise module. Several potential biomarkers, such as cyclin-dependent kinase 1 (CDK1), topoisomerase 2α (TOP2A), and serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1), were also identified. In conclusion, gene signatures identified from the genome-based assays could contribute to HCC stratification. WGCNA was able to identify significant groups of genes associated with cancer prognosis.
关键词: hepatocellular carcinoma coexpression module microarray prognosis
Gene expression disparity in giant cell tumor of bone
Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 49-56 doi: 10.1007/s11684-009-0012-y
Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372
BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding
《医学前沿(英文)》 2007年 第1卷 第1期 页码 93-98 doi: 10.1007/s11684-007-0018-2
关键词: bioinformatic analysis functional KIAA0372 detection Microarray
Nucleic acid-based diagnostics for infectious diseases in public health affairs
null
《医学前沿(英文)》 2012年 第6卷 第2期 页码 173-186 doi: 10.1007/s11684-012-0195-5
Infectious diseases, mostly caused by bacteria and viruses but also a result of fungal and parasitic infection, have been one of the most important public health concerns throughout human history. The first step in combating these pathogens is to get a timely and accurate diagnosis at an affordable cost. Many kinds of diagnostics have been developed, such as pathogen culture, biochemical tests and serological tests, to help detect and fight against the causative agents of diseases. However, these diagnostic tests are generally unsatisfactory because they are not particularly sensitive and specific and are unable to deliver speedy results. Nucleic acid-based diagnostics, detecting pathogens through the identification of their genomic sequences, have shown promise to overcome the above limitations and become more widely adopted in clinical tests. Here we review some of the most popular nucleic acid-based diagnostics and focus on their adaptability and applicability to routine clinical usage. We also compare and contrast the characteristics of different types of nucleic acid-based diagnostics.
关键词: nucleic acid-based diagnostics infectious disease PCR NASBA LAMP microarray LOAC public health affairs
Xiaoyi WEI,Weiqiang ZHANG,Qian ZHANG,Pei SUN,Zhaohu LI,Mingcai ZHANG,Jianmin LI,Liusheng DUAN
《农业科学与工程前沿(英文)》 2016年 第3卷 第3期 页码 263-282 doi: 10.15302/J-FASE-2016103
标题 作者 时间 类型 操作
Characterization of the genes involved in nitrogen cycling in wastewater treatment plants using DNA microarray
Junqin PANG, Masami MATSUDA, Masashi KURODA, Daisuke INOUE, Kazunari SEI, Kei NISHIDA, Michihiko IKE
期刊论文
A microarray study of altered gene expression during melanoblasts migration in normal pigmented White
Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG
期刊论文
Data mining of microarray for differentially expressed genes in liver metastasis from gastric cancer
Ling XU MM, Feng WANG MM, Xuan-Fu XU MD, Wen-Hui MO BM, Rong WAN MD, Chuan-Yong GUO MD, Xing-Peng WANG MD,
期刊论文
Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome
null
期刊论文
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
期刊论文
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
期刊论文
Gene expression disparity in giant cell tumor of bone
Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN
期刊论文
Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372
BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding
期刊论文