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期刊论文 19

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2023 2

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2021 1

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2015 3

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纳米技术 3

肺癌 2

中性粒细胞 1

主体行为 1

产业化 1

仪器生产 1

复合树脂 1

扫描探针显微镜 1

抗菌 1

机械性能 1

电子显微镜 1

纳米医学 1

纳米技术；可逆逻辑；能量耗散；量子点元胞自动机（QCA）；可逆门；米勒算法 1

纳米测量 1

纳米科技 1

聚合收缩 1

聚焦离子束-电子束装置 1

肿瘤微环境 1

诊断，治疗 1

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Special issue: Nanotechnology in energy

Changying ZHAO, Zhuomin ZHANG, Xing ZHANG

《能源前沿（英文）》 2018年第12卷第1期页码 1-4 doi: 10.1007/s11708-018-0544-4

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Modern developments related to nanotechnology and nanoengineering of concrete

Konstantin SOBOLEV

《结构与土木工程前沿（英文）》 2016年第10卷第2期页码 131-141 doi: 10.1007/s11709-016-0343-0

摘要： This paper reports on modern developments related to nanotechnology of cement and concrete. Recent advances in instrumentation and design of advanced nano-composite materials is discussed. New technological directions and historical milestones in nanoengineering and nanomodi?cation of cement-based materials are presented. It is concluded that there is a strong potential of nanotechnology to improve the performance of cement-based materials.

关键词： nanotechnology cement concrete nanoparticle nano-composite nanomodification carbon nanotubes C-S-H gel photocatalyst

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纳米技术产业化过程中的主体行为

汲志华,张矢的,洪振挺

《中国工程科学》 2010年第12卷第3期页码 73-76

摘要：

纳米技术的发展使越来越多的国家和企业界认识到纳米技术具有促进创新和经济发展，增强产业竞争力的巨大潜力，它将引发21世纪新一轮的产业革命。如何加速我国纳米技术产业化进程，将是一个新的研究课题。在此过程中，将伴随着政府、科研机构和企业这三个主体行为的完善和规范。

关键词：纳米技术产业化主体行为

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Barriers to advancing nanotechnology to better improve and translate nanomedicines

Yuwei WANG,David W. Grainger

《化学科学与工程前沿（英文）》 2014年第8卷第3期页码 265-275 doi: 10.1007/s11705-014-1442-x

摘要： Engineered nanomaterials and nanotechnologies promise many benefits to enhance both and performance. This is now manifest in the increasing number of reported biomedical products under development and testing that contain nanotechnologies as their distinguishing performance—enhancing components. In many cases, nano-sized materials are selected to provide a specific functional aspect that contributes to improved medical performance, either or . Nanoparticles are most commonly exploited in diverse roles in topical lotions and creams, solubilization aids, for and diagnostic and targeting agents in nanomedicines and theranostics. Despite fundamental scientific excitement and many claims to nanotechnology-based improvements in new biomedical applications, several fundamental and long-standing challenges remain to be addressed using nanomedicines to make clinically important progress. This review addresses several issues that must be fairly and objectively reported and then overcome to provide truly credible performance for nanomedicines.

关键词： nanotechnology nanomedicine drug delivery therapeutic target delivery

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Bismuth oxide-related photocatalysts in green nanotechnology: A critical analysis

Andrea P. Reverberi, P.S. Varbanov, M. Vocciante, B. Fabiano

《化学科学与工程前沿（英文）》 2018年第12卷第4期页码 878-892 doi: 10.1007/s11705-018-1744-5

摘要： A survey addressing the uses of bismuth oxide in photocatalysis is presented. The richness of literature on such a specific topic proves the growing importance of this compound as a valid tool in pollution abatement and environmental decontamination. Many research groups have focused their activity on how to improve the photocatalytic properties of this semiconductor and several solutions have been adopted in the synthesis method, often based on wet-chemical processes. The impressive development of nanoscience helped in understanding and identifying process variables and operative conditions aiming at optimizing the yield of this promising photocatalytic material in the utilization of solar energy.

关键词： photocatalysis visible light bismuth compounds nanotechnology environmental remediation decontamination pollution abatement

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Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

Grant Perry, Fernando Cortezon-Tamarit, Sofia I. Pascu

《化学科学与工程前沿（英文）》 2020年第14卷第1期页码 4-18 doi: 10.1007/s11705-019-1846-8

摘要： Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer. As the development of the disease is greatly correlated to age, the identification of novel detection methods reliable, efficient, and cost effective is a matter of significant importance in the ageing population of western societies. The detection of the prostate specific antigen (PSA) in blood samples has been the preferred method for the detection and monitoring of prostate cancer over the past decades. Despite the indications against its use in massive population screening, PSA still remains the best studied biomarker for prostate cancer and the detection of its different forms and incorporation in multiplexed designs with other biomarkers still remains a highly valuable indicator in the theranostics of prostate cancer. The latest developments in the use of nanomaterials towards the construction of PSA biosensors are reviewed hereby. The incorporation of gold nanoparticles, silica nanoparticles and graphene nanostructures to biosensing devices has represented a big leap forward in terms of sensitivity, stability and miniaturization. Both electrochemical and optical detection methods will be reviewed herein for the detection of PSA.

关键词： biosensing immunosensor PSA prostate cancer fluorescence

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Biodegradable, superhydrophobic walnut wood membrane for the separation of oil/water mixtures

《化学科学与工程前沿（英文）》 2022年第16卷第9期页码 1377-1386 doi: 10.1007/s11705-022-2157-z

摘要： The preparation of environmentally friendly oil/water separation materials remains a great challenge. Freeze-drying of wood after lignin removal yields wood aerogels, which can be used as substrates to prepare fluorine-free environmentally friendly superhydrophobic materials, However, they are more suitable for absorption rather than filtration applications due to their poor strength. A study using cross-sections of pristine wood chips as substrates retains the original strength of wood, but the use of the cross-sectional of wood pieces limits their thickness, strength, and size. In this paper, a degradable fluorine-free superhydrophobic film (max. water contact angle of approximately 164.2°) with self-cleaning and abrasion resistance characteristics was prepared by a one-step method using pristine and activated walnut longitudinal section films as the substrate, with tetraethyl orthosilicate as a precursor and dodecyltriethoxysilane as a modifier. The tensile strength results show that superhydrophobic films with pristine or activated wood substrates maintained the strength of pristine wood and were 2.2 times stronger than the wood aerogel substrate. In addition, after cross-laminating the two samples, the films had the ability to separate oil and water by continuous filtration with high efficiency (98.5%) and flux (approximately 1.3 × 10³ L∙m^‒2∙h^‒1). The method has potential for the large-scale fabrication of degradable superhydrophobic filtration separation membranes.

关键词： wood nanotechnology superhydrophobic biodegradable surface modification oil/water separation

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纳米技术——一种针对促肿瘤中性粒细胞的肺癌治疗新策略 Review

张健, 蒋莎莎, 李仕林, 江继鹏, 梅婕, 陈延东, 马永富, 刘阳, 刘颖

《工程（英文）》 2023年第27卷第8期页码 106-126 doi: 10.1016/j.eng.2022.11.006

摘要：

原发性肺癌和转移性肺癌都是肺部恶性肿瘤，两者都威胁着患者的生命，但各自的发病机制不同。肿瘤的发生和发展涉及肿瘤细胞与宿主微环境之间的交流，中性粒细胞是肿瘤微环境（TME）中最丰富的免疫细胞，它们参与炎症环境的形成，并通过其抗肿瘤和促肿瘤能力影响患者的生存。中性粒细胞可根据不同的标准分为不同的类别，常见的类别包括 N1 抗肿瘤中性粒细胞和 N2 免疫抑制中性粒细胞。中性粒细胞的抗肿瘤作用是通过活性氧、肿瘤坏死因子相关的细胞凋亡诱导配体、高级糖化终产物受体-胰蛋白酶 G 等因素共同作用以及调节其他免疫细胞的活动共同介导的。中性粒细胞作为肿瘤促进因子，也可通过影响包括癌症发生、血管生成、癌细胞增殖和侵袭能力等过程，促进肺癌的发展和转移，并在其他癌症的肺转移中发挥类似作用。纳米技术的快速发展为针对中性粒细胞的癌症治疗提供了新策略。

关键词：肺癌转移中性粒细胞肿瘤微环境纳米技术

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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

《化学科学与工程前沿（英文）》 2014年第8卷第3期页码 276-279 doi: 10.1007/s11705-014-1426-x

摘要： The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze our current abilities, and design the future technologies that will propel us to achieve the next level of drug delivery technologies. History shows that the first generation (1G) of drug delivery research during 1950–1980 was quite productive, while the second generation (2G) technologies developed during 1980–2010 were not as prolific. The ultimate goal of drug delivery research is to develop clinically useful formulations to treat various diseases. Effective drug delivery systems can be developed by overcoming formulation barriers and/or biological barriers. The engineering approach has a limit in solving the problem, if biological difficulties are not clearly identified and understood. The third generation (3G) drug delivery systems will have to focus on understanding the biological barriers so that they can be overcome by engineering manipulation of the drug delivery systems. Advances in the next 30 years will be most accelerated by starting open dialogues without any preconceived ideas on drug delivery technologies. The new generation of drug delivery scientists needs to be aware of the successes and limitations of the existing technologies to design the new technologies for meaningful advances in the future.

关键词： drug delivery history formulation barriers nanotechnology clinical product

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Applications of hollow nanomaterials in environmental remediation and monitoring: A review

Yuankai ZHANG,Zhijiang HE,Hongchen WANG,Lu QI,Guohua LIU,Xiaojun ZHANG

《环境科学与工程前沿（英文）》 2015年第9卷第5期页码 770-783 doi: 10.1007/s11783-015-0811-0

摘要： Hollow nanomaterials have attracted significant attention because of their high chemical and thermal stability, high specific surface area, high porosity, low density, and good biocompatibility. These state-of-the-art nanomaterials have been shown to efficiently adsorb heavy metals, and volatile hazardous substances, photodegrade persistent organic pollutants, and other compounds, and inactivate bacteria. Such properties have enabled the use of these materials for environmental remediation, such as in water/wastewater treatment, soil remediation, air purification, and substance monitoring, etc. Hollow nanomaterials showed higher photocatalytic activity than those without hollow structure owing to their high active surface area, reduced diffusion resistance, and improved accessibility. And, the Doping method could improve the photocatalytic performance of hollow nanomaterials further under visible light. Moreover, the synthetic mechanisms and methods of these materials are important because their size and morphology help to determine their precise properties. This article reviews the environmental applications and potential risks of these materials, in addition to their syntheses. Finally, an outlook into the development of these materials is provided.

关键词： hollow nanomaterials environmental remediation nanotechnology nanostructures morphology

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Application of nanotechnologies in the energy sector: A brief and short review

Ferric CHRISTIAN, EDITH, SELLY, Dendy ADITYAWARMAN, Antonius INDARTO

《能源前沿（英文）》 2013年第7卷第1期页码 6-18 doi: 10.1007/s11708-012-0219-5

摘要： Energy is of great importance in human life because of its benefits as the main resource for human activity. According to International Energy Agency (IEA), energy demands are expected to continue increasing until 2030. Because energy demand will never decrease, it is necessary to develop modern technology, such as nano-based technology, in order to obtain a more effective and efficient process to produce more energy. The application of nano technology or nano material in the field of energy, which involves lithium-ion battery, fuel cell, light emitting diode (LED), ultra-capacitor, and solar cell (including Gr?tzel cell), is a hot topic in many scientific researches. Unfortunately, its current development is hampered by the expensive cost of production compared to conventional technologies. Therefore, priority should be given to nano technology in the energy sector order to obtain higher efficiency, lower production cost, and easier in its application.

关键词： nanotechnology energy batteries fuel cell Gr?tzel cell solar cell

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Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

《化学科学与工程前沿（英文）》 2015年第9卷第1期页码 1-14 doi: 10.1007/s11705-015-1509-3

摘要： With the development of modern technology like high throughput screening, combinatorial chemistry and computer aid drug design, the drug discovery process has been dramatically accelerated. However, new drug candidates often exhibit poor aqueous or even organic medium solubility. Additionally, many of them may have low dissolution velocity and low oral bioavailability. Nanocrystal formulation sheds new light on advanced drug development. Due to small (nano- or micro- meters) sizes, the increased surface-volume ratio leads to dramatically enhanced drug dissolution velocity and saturation solubility. The simplicity in preparation and the potential for various administration routes allow drug nanocrystals to be a novel drug delivery system for specific diseases (i.e. cancer). In addition to the comprehensive review of different technologies and methods in drug nanocrystal preparation, suspension, and stabilization, we will also compare nano- and micro-sized drug crystals in pharmaceutical applications and discuss current nanocrystal drugs on the market and their limitations.

关键词： drug nanocrystal nanotechnology formulation bioavailability stabilizers drug delivery

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Locally enhanced electric field treatment (LEEFT) for water disinfection

Jianfeng Zhou, Ting Wang, Cecilia Yu, Xing Xie

《环境科学与工程前沿（英文）》 2020年第14卷第5期 doi: 10.1007/s11783-020-1253-x

摘要： • Nanowire-assisted LEEFT is applied for water disinfection with low voltages. • LEEFT inactivates bacteria by disrupting cell membrane through electroporation. • Multiple electrodes and device configurations have been developed for LEEFT. • The LEEFT is low-cost, highly efficient, and produces no DBPs. • The LEEFT can potentially be applicable for water disinfection at all scales. Water disinfection is a critical step in water and wastewater treatment. The most widely used chlorination suffers from the formation of carcinogenic disinfection by-products (DBPs) while alternative methods (e.g., UV, O3, and membrane filtration) are limited by microbial regrowth, no residual disinfectant, and high operation cost. Here, a nanowire-enabled disinfection method, locally enhanced electric field treatment (LEEFT), is introduced with advantages of no chemical addition, no DBP formation, low energy consumption, and efficient microbial inactivation. Attributed to the lightning rod effect, the electric field near the tip area of the nanowires on the electrode is significantly enhanced to inactivate microbes, even though a small external voltage (usually<5 V) is applied. In this review, after emphasizing the significance of water disinfection, the theory of the LEEFT is explained. Subsequently, the recent development of the LEEFT technology on electrode materials and device configurations are summarized. The disinfection performance is analyzed, with respect to the operating parameters, universality against different microorganisms, electrode durability, and energy consumption. The studies on the inactivation mechanisms during the LEEFT are also reviewed. Lastly, the challenges and future research of LEEFT disinfection are discussed.

关键词： Water treatment Nanotechnology Pathogen inactivation Electroporation Nanowire Chemical-free

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纳米技术在牙科复合树脂改良中的应用

夏阳,谢海峰,章非敏,顾宁

《中国工程科学》 2012年第14卷第3期页码 76-82

摘要：

以牙科复合树脂现存缺点为背景，对纳米技术对复合树脂的改良情况进行了研究，着重讨论了纳米材料对复合树脂的聚合收缩、抗菌性能和机械性能改良的一系列问题。研究结果表明,使用纳米技术和材料可以很好地改进复合树脂多方面的性能，同时对复合树脂的发展方向和研究前景进行了展望。

关键词：纳米技术复合树脂抗菌聚合收缩机械性能

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纳米技术和纳米医学——肺癌诊断和治疗的希望之路 Review

尹伟, 潘峰, 朱俊杰, 徐军武, Diego Gonzalez-Rivas, Meinoshin Okumura, 唐志勇, 杨洋

《工程（英文）》 2021年第7卷第11期页码 1577-1585 doi: 10.1016/j.eng.2020.04.017

摘要：

肺癌是全球最常见的癌症，五年总生存率非常低。肺癌的常规诊断和治疗策略具有内在局限性，这就推动了纳米技术和纳米医学方法的发展，以提高早期诊断率并开发更有效、更安全的肺癌治疗方案。癌症纳米医学旨在根据每个患者独特的生理和病理特征（在基因组和蛋白质组水平上）来制定药物递送、诊断和治疗方案，在该领域引起广泛关注。尽管纳米医学技术在肺癌的科学研究中获得成功应用，但由于对纳米技术与生物学之间的相互作用知之甚少，以及毒理学、药理学、免疫学和纳米颗粒的大规模制造等方面的挑战，使得纳米医学方法的临床转化仍然具有挑战性。在本文中，我们强调了用于肺癌治疗的纳米医学的发展和机遇，并展望了该领域的前景，以及讨论了其在临床转化中面临的挑战。

关键词：纳米医学肺癌诊断，治疗