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纳米技术和纳米医学——肺癌诊断和治疗的希望之路 Review
尹伟, 潘峰, 朱俊杰, 徐军武, Diego Gonzalez-Rivas, Meinoshin Okumura, 唐志勇, 杨洋
《工程(英文)》 2021年 第7卷 第11期 页码 1577-1585 doi: 10.1016/j.eng.2020.04.017
肺癌是全球最常见的癌症,五年总生存率非常低。肺癌的常规诊断和治疗策略具有内在局限性,这就推动了纳米技术和纳米医学方法的发展,以提高早期诊断率并开发更有效、更安全的肺癌治疗方案。癌症纳米医学旨在根据每个患者独特的生理和病理特征(在基因组和蛋白质组水平上)来制定药物递送、诊断和治疗方案,在该领域引起广泛关注。尽管纳米医学技术在肺癌的科学研究中获得成功应用,但由于对纳米技术与生物学之间的相互作用知之甚少,以及毒理学、药理学、免疫学和纳米颗粒的大规模制造等方面的挑战,使得纳米医学方法的临床转化仍然具有挑战性。在本文中,我们强调了用于肺癌治疗的纳米医学的发展和机遇,并展望了该领域的前景,以及讨论了其在临床转化中面临的挑战。
Translational initiatives in thrombolytic therapy
null
《医学前沿(英文)》 2017年 第11卷 第1期 页码 1-19 doi: 10.1007/s11684-017-0497-8
Once thrombi have formed as part of the pathology defining myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis or other embolic disorders, the only clinically meaningful thrombolytic agents available for reversing the thrombogenic process are various plasminogen activators. These agents are enzymes that reverse fibrin polymerization underlying the coagulation process by converting endogenous plasminogen to plasmin, which cleaves the fibrin network to form increasingly smaller protein fragments, a process known as fibrinolysis. For the most part, the major clinically used thrombolytics, tissue plasminogen activator, urokinase and streptokinase, as well as the experimentally investigated agent staphylokinase, are the products of recombinant DNA technology, which permits molecular optimization of clinical efficacy. In all cases of molecular optimization and targeting, however, the primary challenge of thrombolytic therapy remains hemorrhagic side effects, which are especially devastating when they occur intracerebrally. Currently, the best strategy to ameliorate this adverse effect is nanoparticulate encapsulation or complexation, and many strategies of this sort are being actively pursued. This review summarizes the variety of targeted and untargeted thrombolytic formulations that have been investigated in preclinical studies.
Polymeric micelle nanocarriers in cancer research
Dae Hwan Shin, Yu Tong Tam, Glen S. Kwon
《化学科学与工程前沿(英文)》 2016年 第10卷 第3期 页码 348-359 doi: 10.1007/s11705-016-1582-2
关键词: nanomedicine parenteral poly(ethylene glycol) poly(lactic acid) reformulation
Engineering platelet-mimicking drug delivery vehicles
Quanyin Hu, Hunter N. Bomba, Zhen Gu
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 624-632 doi: 10.1007/s11705-017-1614-6
关键词: drug delivery platelets nanomedicine bio-inspired biomimetic
Barriers to advancing nanotechnology to better improve and translate nanomedicines
Yuwei WANG,David W. Grainger
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 265-275 doi: 10.1007/s11705-014-1442-x
关键词: nanotechnology nanomedicine drug delivery therapeutic target delivery
Functional ferritin nanoparticles for biomedical applications
Zhantong Wang, Haiyan Gao, Yang Zhang, Gang Liu, Gang Niu, Xiaoyuan Chen
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 633-646 doi: 10.1007/s11705-017-1620-8
关键词: nanomedicine ferritin drug delivery bioassay molecular imaging
标题 作者 时间 类型 操作
Barriers to advancing nanotechnology to better improve and translate nanomedicines
Yuwei WANG,David W. Grainger
期刊论文
Functional ferritin nanoparticles for biomedical applications
Zhantong Wang, Haiyan Gao, Yang Zhang, Gang Liu, Gang Niu, Xiaoyuan Chen
期刊论文
布拉德雷·尼尔森:机器人与纳米医学:医学机器人的未来发展方向(2019年9月18日)
2021年11月15日
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