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Synchronous rectal adenocarcinoma and anal canal adenocarcinoma
GU Jin, YAO Yunfeng, LI Jiyou, LU Aiping, WANG Hongyi
《医学前沿(英文)》 2007年 第1卷 第3期 页码 333-337 doi: 10.1007/s11684-007-0064-9
关键词: CK7+/CK20+ resection different therapeutic strategy upper-third
Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 383-388 doi: 10.1007/s11684-016-0488-1
The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the first line of therapy for advanced non-small cell lung cancer (NSCLC). Acquired mutations in EGFR account for one of the major mechanisms of resistance to the TKIs. Three generations of EGFR TKIs have been used in clinical applications. AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positive advanced NSCLC patients. However, resistance to AZD9291 arises after 9–13 months of therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. To overcome the acquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitor that overcomes T790M- and C797S-mediated resistance. This review summarizes recent investigations on the mechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor.
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors
《医学前沿(英文)》 2022年 第16卷 第5期 页码 701-713 doi: 10.1007/s11684-022-0951-0
关键词: acquired resistance EGFR inhibitor apoptosis lung cancer
《环境科学与工程前沿(英文)》 2023年 第17卷 第6期 doi: 10.1007/s11783-023-1676-2
● A novel framework integrating quantile regression with machine learning is proposed.
关键词: Driver-response Upper boundary of relationship Interpretable machine learning Quantile regression Total phosphorus Chlorophyll a
Optimum design and preliminary experiments of a novel parallel end traction apparatus for upper-limb
《机械工程前沿(英文)》 2021年 第16卷 第4期 页码 726-746 doi: 10.1007/s11465-021-0651-5
关键词: parallel mechanism upper-limb rehabilitation singularity and workspace analyses performance evaluation optimum design
Regeneration of vernacular architecture: new rammed earth houses on the upper reaches of the Yangtze
Jiaping LIU, Rongrong HU, Liu YANG, Runshan WANG,
《能源前沿(英文)》 2010年 第4卷 第1期 页码 93-99 doi: 10.1007/s11708-010-0002-4
关键词: earth house low-energy housing upper reaches of the Yangtze River passive solar technique
Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN
《机械工程前沿(英文)》 2011年 第6卷 第4期 页码 409-418 doi: 10.1007/s11465-011-0245-8
The response of an infinite Timoshenko beam subjected to a harmonic moving load based on the third-order shear deformation theory (TSDT) is studied. The beam is made of laminated composite, and located on a Pasternak viscoelastic foundation. By using the principle of total minimum potential energy, the governing partial differential equations of motion are obtained. The solution is directed to compute the deflection and bending moment distribution along the length of the beam. Also, the effects of two types of composite materials, stiffness and shear layer viscosity coefficients of foundation, velocity and frequency of the moving load over the beam response are studied. In order to demonstrate the accuracy of the present method, the results TSDT are compared with the previously obtained results based on first-order shear deformation theory, with which good agreements are observed.
关键词: timoshenko composite beam pasternak viscoelastic foundation third-order shear deformation theory (TSDT) harmonic moving load
Design and preliminary evaluation of an exoskeleton for upper limb resistance training
Tzong-Ming WU, Dar-Zen CHEN
《机械工程前沿(英文)》 2012年 第7卷 第2期 页码 188-198 doi: 10.1007/s11465-012-0327-2
Resistance training is a popular form of exercise recommended by national health organizations, such as the American College of Sports Medicine (ACSM) and the American Heart Association (AHA). This form of training is available for most populations. A compact design of upper limb exoskeleton mechanism for home-based resistance training using a spring-loaded upper limb exoskeleton with a three degree-of-freedom shoulder joint and a one degree-of-freedom elbow joint allows a patient or a healthy individual to move the upper limb with multiple joints in different planes. It can continuously increase the resistance by adjusting the spring length to train additional muscle groups and reduce the number of potential injuries to upper limb joints caused by the mass moment of inertia of the training equipment. The aim of this research is to perform a preliminary evaluation of the designed function by adopting an appropriate motion analysis system and experimental design to verify our prototype of the exoskeleton and determine the optimal configuration of the spring-loaded upper limb exoskeleton.
关键词: exoskeleton free-weight exercise upper limb motion analysis
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization
《医学前沿(英文)》 2022年 第16卷 第1期 页码 93-101 doi: 10.1007/s11684-021-0914-x
关键词: COVID-19 SARS-CoV-2 vaccine immunization booster immunization
EEG controlled neuromuscular electrical stimulation of the upper limb for stroke patients
Hock Guan TAN, Cheng Yap SHEE, Keng He KONG, Cuntai GUAN, Wei Tech ANG
《机械工程前沿(英文)》 2011年 第6卷 第1期 页码 71-81 doi: 10.1007/s11465-011-0207-1
This paper describes the Brain Computer Interface (BCI) system and the experiments to allow post-acute (<3 months) stroke patients to use electroencephalogram (EEG) to trigger neuromuscular electrical stimulation (NMES)-assisted extension of the wrist/fingers, which are essential pre-requisites for useful hand function. EEG was recorded while subjects performed motor imagery of their paretic limb, and then analyzed to determine the optimal frequency range within the -rhythm, with the greatest attenuation. Aided by visual feedback, subjects then trained to regulate their -rhythm EEG to operate the BCI to trigger NMES of the wrist/finger. 6 post-acute stroke patients successfully completed the training, with 4 able to learn to control and use the BCI to initiate NMES. This result is consistent with the reported BCI literacy rate of healthy subjects. Thereafter, without the loss of generality, the controller of the NMES is developed and is based on a model of the upper limb muscle (biceps/triceps) groups to determine the intensity of NMES required to flex or extend the forearm by a specific angle. The muscle model is based on a phenomenological approach, with parameters that are easily measured and conveniently implemented.
关键词: brain computer interface neuromuscular electrical stimulation stroke musculoskeletal modeling
CFD Simulation of thermal hydraulic characteristics in a typical upper plenum of RPV
Mingjun WANG, Lianfa WANG, Yingjie WANG, Wenxi TIAN, Jian DENG, Guanghui SU, Suizheng QIU
《能源前沿(英文)》 2021年 第15卷 第4期 页码 930-945 doi: 10.1007/s11708-021-0728-1
关键词: pressurized water reactor (PWR) upper plenum internal structures temperature distribution computational fluid dynamics (CFD)
《结构与土木工程前沿(英文)》 2021年 第15卷 第6期 页码 1480-1493 doi: 10.1007/s11709-021-0776-y
关键词: seismic active earth pressure partial seepage flow pore pressure anisotropy upper bound theorem
Yan-Gang ZHAO, Zhao-Hui LU
《结构与土木工程前沿(英文)》 2011年 第5卷 第3期 页码 315-322 doi: 10.1007/s11709-011-0117-7
关键词: load and resistance factors third-moment method three-parameter lognormal (3P-lognormal) distribution target mean resistance simple formula
Seepage analysis of Upper Gotvand Dam concerning gypsum karstification (2D and 3D approaches)
Jamshid SADREKARIMI, Majid KIYANI, Behnam FAKHRI, Mohammad Javad VAHDATIRAD, Amin BARARI
《结构与土木工程前沿(英文)》 2011年 第5卷 第1期 页码 71-78 doi: 10.1007/s11709-010-0083-5
关键词: Upper Gotvand Dam seepage analysis gypsum veins 3D model discharge flux
Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma
Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He
《医学前沿(英文)》 2019年 第13卷 第6期 页码 730-740 doi: 10.1007/s11684-019-0687-7
关键词: upper tract urothelial carcinoma GATA binding protein 3 mismatch repair microsatellite instability prognosis
标题 作者 时间 类型 操作
Synchronous rectal adenocarcinoma and anal canal adenocarcinoma
GU Jin, YAO Yunfeng, LI Jiyou, LU Aiping, WANG Hongyi
期刊论文
Approaching the upper boundary of driver-response relationships: identifying factors using a novel framework
期刊论文
Optimum design and preliminary experiments of a novel parallel end traction apparatus for upper-limb
期刊论文
Regeneration of vernacular architecture: new rammed earth houses on the upper reaches of the Yangtze
Jiaping LIU, Rongrong HU, Liu YANG, Runshan WANG,
期刊论文
Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation
Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN
期刊论文
Design and preliminary evaluation of an exoskeleton for upper limb resistance training
Tzong-Ming WU, Dar-Zen CHEN
期刊论文
Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization
期刊论文
EEG controlled neuromuscular electrical stimulation of the upper limb for stroke patients
Hock Guan TAN, Cheng Yap SHEE, Keng He KONG, Cuntai GUAN, Wei Tech ANG
期刊论文
CFD Simulation of thermal hydraulic characteristics in a typical upper plenum of RPV
Mingjun WANG, Lianfa WANG, Yingjie WANG, Wenxi TIAN, Jian DENG, Guanghui SU, Suizheng QIU
期刊论文
Upper bound solution to seismic active earth pressure of submerged backfill subjected to partial drainage
期刊论文
Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution
Yan-Gang ZHAO, Zhao-Hui LU
期刊论文
Seepage analysis of Upper Gotvand Dam concerning gypsum karstification (2D and 3D approaches)
Jamshid SADREKARIMI, Majid KIYANI, Behnam FAKHRI, Mohammad Javad VAHDATIRAD, Amin BARARI
期刊论文