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《医学前沿(英文)》 2022年 第16卷 第4期 页码 637-650 doi: 10.1007/s11684-021-0864-3
关键词: apigenin aminoglycosides ototoxicity oxidative stress Nrf2 signaling pathway
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 46-56 doi: 10.1007/s11684-015-0375-1
Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vaso-occlusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is increasingly recognized as an important intermediate in these pathophysiological processes and is therefore an important target for therapeutic intervention. The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeutic intent. This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease. A brief overview of oxidative stress in the clinical context of SCD is accompanied by a discussion of several pathophysiological mechanisms contributing to oxidative stress. Finally, these mechanisms are then related to current management strategies in SCD that are either utilized currently or under evaluation. The article concludes with a perspective on the potential of the various therapeutic interventions to reduce oxidative stress and morbidity associated with SCD.
关键词: oxidative stress Nrf2 triterpenoids sickle cell disease vaso-occlusion CDDO-Me
植物化学物质的生物功能及其在家畜中的应用研究——以Nrf2/Keap1系统为目标
覃思, 侯德兴
《工程(英文)》 2017年 第3卷 第5期 页码 738-752 doi: 10.1016/J.ENG.2017.03.011
《化学科学与工程前沿(英文)》 2023年 第17卷 第7期 页码 976-989 doi: 10.1007/s11705-022-2237-0
关键词: grape seed lignin structure antioxidant NE-4C cells neuroprotection
GAO Shihao, SUN Chenghui, ZHAO Xinqi, GAO Changquan
《化学科学与工程前沿(英文)》 2008年 第2卷 第1期 页码 80-84 doi: 10.1007/s11705-008-0017-0
关键词: 5-Amino-1 2 4-thiadiazol-3-yl 1 2-dichloroethane important intermediate 2-benzothiazolyl thioester temperature
Xiaohong LI, Wenying LI,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 142-146 doi: 10.1007/s11705-009-0233-2
关键词: desorption different TiO-AlOmixed physisorption ethylbenzene
Al2O3 and CeO2-promoted MgO sorbents for CO2 capture at moderate
Huimei Yu, Xiaoxing Wang, Zhu Shu, Mamoru Fujii, Chunshan Song
《化学科学与工程前沿(英文)》 2018年 第12卷 第1期 页码 83-93 doi: 10.1007/s11705-017-1691-6
以净零排放为目标的封存驱动型CO2提高采收率方法 Article
刘月亮, 芮振华
《工程(英文)》 2022年 第18卷 第11期 页码 79-87 doi: 10.1016/j.eng.2022.02.010
关键词: CO2 EOR CO2净排放量 二甲醚 封存驱动型CO2 EOR CO2封存
The stabilization effect of Al2O3 on unconventional Pb/SiO2 catalyst
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1423-1429 doi: 10.1007/s11705-023-2315-y
关键词: Pb/SiO2 Al2O3 propane dehydrogenation propene stability
Biodegradation of 2-methylisoborneol by bacteria enriched from biological activated carbon
Rongfang YUAN, Beihai ZHOU, Chunhong SHI, Liying YU, Chunlei ZHANG, Junnong GU
《环境科学与工程前沿(英文)》 2012年 第6卷 第5期 页码 701-710 doi: 10.1007/s11783-011-0367-6
关键词: 2-methylisoborneol (2-MIB) biodegradation 2-methylenebornane 2-methyl-2-bornane pseudo-first-order reaction
Encapsulation of 2-amino-2-methyl-1-propanol with tetraethyl orthosilicate for CO2 capture
Sidra Rama, Yan Zhang, Fideline Tchuenbou-Magaia, Yulong Ding, Yongliang Li
《化学科学与工程前沿(英文)》 2019年 第13卷 第4期 页码 672-683 doi: 10.1007/s11705-019-1856-6
关键词: carbon capture microencapsulated sorbents emulsion technique low temperature adsorption and absorption
Cu-doped Bi/Bi2WO6 catalysts for efficient N2 fixation by photocatalysis
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1412-1422 doi: 10.1007/s11705-023-2312-1
关键词: Bi2WO6 Cu doping work function photocatalytic N2 fixation charge separation
Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition
HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo
《环境科学与工程前沿(英文)》 2008年 第2卷 第3期 页码 326-332 doi: 10.1007/s11783-008-0038-4
CO2 methanation and co-methanation of CO and CO2 over Mn-promoted Ni/Al2
Kechao Zhao,Zhenhua Li,Li Bian
《化学科学与工程前沿(英文)》 2016年 第10卷 第2期 页码 273-280 doi: 10.1007/s11705-016-1563-5
关键词: Mn promotion nickel catalysts CO2 methanation co-methanation of CO and CO2
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 343-348 doi: 10.1007/s11705-007-0062-0
关键词: 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer
标题 作者 时间 类型 操作
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair
期刊论文
Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review
null
期刊论文
obtained from grape seeds against bisphenol AF neurotoxicity via antioxidative effects mediated by the Nrf2
期刊论文
Improvement in the synthesis of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid 2-benzothiazolyl
GAO Shihao, SUN Chenghui, ZHAO Xinqi, GAO Changquan
期刊论文
Effect of TiO 2 loading on the activity of V/TiO 2 -Al 2 O 3 in the catalytic oxidehydrogenation of ethylbenzene
Xiaohong LI, Wenying LI,
期刊论文
Al2O3 and CeO2-promoted MgO sorbents for CO2 capture at moderate
Huimei Yu, Xiaoxing Wang, Zhu Shu, Mamoru Fujii, Chunshan Song
期刊论文
Biodegradation of 2-methylisoborneol by bacteria enriched from biological activated carbon
Rongfang YUAN, Beihai ZHOU, Chunhong SHI, Liying YU, Chunlei ZHANG, Junnong GU
期刊论文
Encapsulation of 2-amino-2-methyl-1-propanol with tetraethyl orthosilicate for CO2 capture
Sidra Rama, Yan Zhang, Fideline Tchuenbou-Magaia, Yulong Ding, Yongliang Li
期刊论文
Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition
HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo
期刊论文
CO2 methanation and co-methanation of CO and CO2 over Mn-promoted Ni/Al2
Kechao Zhao,Zhenhua Li,Li Bian
期刊论文