2008, Volume 10, Issue 5
Strategic Study of CAE >> 2008, Volume 10, Issue 5
The brain areas and the neural mechanism involved in the Chinese paired-word associated learning and memory in healthy volunteers——a brain functional magnetic resonance imaging study
1. Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China;
2. Laboratory of Photonic Traditional Chinese Medicine, South China Normal University, Guangzhou 510631, China;
3. Dept Neurology, Nanfan Hospital, Southern Medical University,Guangzhou 510515, China
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Abstract
This paper is to investigate the activated brain areas and the neuronal mechanism of Chinese paired-word associated learning and memory in healthy volunteers by functional magnetic resonance imaging (fMRI) technique. 16 right-handed normal volunteers participated in a test of paired-word associated learning and memory, while the fMRI data were recorded. Control tasks were performed for the block-design. SPM 99 was used to analyze the data and to get the activated brain regions. 14 volunteers passed the paired-word associated learning and memory task. Both cortex and subcortical structures were activated. The brain cortex areas include the bilateral frontal lobes, the bilateral parietal lobes, the bilateral occipital lobes, the bilateral cingulate gyrus and the bilateral parahippocampal gyrus with extremely left hemisphere predominance and the left temporal lobe were activated by both coding and retrieval stages of the paired-word associated learning and memory task. The subcortical structures including the striatum and its marginal division (MrD) were activated with left predominance, the caudate and the thalamus were also activated during the tasks. However, the left occipital lobe and the middle and inferior frontal gyrus of the left frontal lobe were more activative than others in scope and brightness during the coding stage of the paired-word associated learning and memory task, while the left parietal lobe and dorsolateral part of the middle frontal gyrus were more activative than others in scope and brightness during the retrieval stage of the paired-word associated learning and memory task. The left middle and inferior frontal gyrus of the frontal lobe, the left lateral parts of the occipital lobe, the left superior lobule and supramarginal gyrus and the angular gyrus of the parietal lobe might play more important roles in the paired-word associated learning and memory task than the rest of the cortex. The MrD of the striatum was mainly involved in coding stages of the paired-word associated learning and memory task. The results of this study revealed that the subcortical structures mainly the striatum as well as the cortex were involved in the associated learning and memory of language in human brain. The transform of activated brain areas from the coding stage to the retrieval stage of the Chinese paired-word learning and memory was described and its neural mechanism was discussed.
Keywords
functional magnetic resonance imaging (fMRI) of human brain ; paired-word ; language ; associated learning and memory ; cortex and subcortical structures
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References
[ 1 ] “临床记忆量表”编制协作组.“临床记忆量表”的编制[J].心理学报,1986,1:100-108 link1
[ 2 ] 皮连生,王小明,王映学.现代认知学习心理学[M].北京:警官教育出版社,1998.111-113
[ 3 ] Chee M W, Caplan D.Face encoding and psychometric testing in healthy dextrals with right hemisphere language [ J] .Neurology, 2002 , 59 ( 12 ) : 1928 -1934 link1
[ 4 ] Shaywitz B A, Shaywitz S E, Pugh K R, et al.Sex differences in the functional organization of the brain for language [ J] .Nature, 1995 , 373 ( 6515 ) : 607 -609 link1
[ 5 ] Petersen S E, Fox P T, Snyder A Z,et al.Activation of extrastri- ate and frontal cortical areas by visual words and word -like stimu- li[ J] .Science, 1990 , 249 ( 4972 ) : 1041 -1044 link1
[ 6 ] Tan L H, Liu H L, Perfeffi C A, et al.The neural system under- lying Chinese logograph reading [ J] .Neuroimage, 2001 , 13 ( 5 ) : 836 -846 link1
[ 7 ] Nakai T, Matsuo K, Kato C, et al.A functional magnetic reso- nance imaging study of listening comprehension of languages in hu- man at 3 tesla -comprehension level and activation of the language areas [ J] .Neurosci Lett, 1999 , 263 ( 1 ) : 33 -36 link1
[ 8 ] Rakic P S.Architecture of the prefrontal cortex and the central ex- ecutive [ J] .Ann N Y Acad Sci, 1995 , 769 : 71 -83 link1
[ 9 ] Tan L H, Spinks J A, Feng C M, et al.Neural system of second language reading are shaped by native language [ J] .Human Brain Mapp, 2003 , 18 ( 3 ) : 158 -166 link1
[10] Tan L H, Spinks J A, Gao J H, et al.Brain activation in the processing of Chinese characters and words: A functional MRI study [ J] .Human Brain Map, 2000 , 10 : 16 -27 link1
[11] Poldrack R A,Wagner A D, Prull M W, et al.Functional spe- cialization semantic and phonological processing in left inferior pre- frontal cortex [ J] .Neuroimage, 1999 ,10 ( 1 ) : 15 -35 link1
[12] Shallice T, Fletcher P, Frith C D, et al.Brain regions associated with acquisition and retrieval of verbal episodic memory [ J] .Na- ture, 1994 , 368 ( 6472 ) : 633 -635 link1
[13] Kaichle M E.What words are telling us about the brain [ J] . Cold Spring Harb Symp Quant Biol, 1996 , 61 : 9 -14 link1
[14] Paulesu E, Frith C D, Frackowiak R S.The neural correlates of the verbal component of working memory[ J] .Nature, 1993 , 326 ( 6418 ) : 342 -345 link1
[15] Grasby P M, Frith C D, Friston K J, et al.Functional mapping of brain areas implicated in auditory -verbal memory function [ J] .Brain, 1993 , 116 ( 1 ) : 1 -20 link1
[16] Baddeley A.Working memory [ J] .Science 1992 , 255 ( 5044 ) : 556 -559 link1
[17] Esposito D M, Detre J A, Alsop D C.The neural basis of the central executive system of working memory [ J] .Nature, 1995 , 378 ( 6554 ) : 279 -281 link1
[18] Petrides M.Functional organization of the human frontal cortex for mnemonic processing. Evidence from neuroimaging studies [ J] .Ann N Y Acad Sci, 1995 , 769 : 85 -96 link1
[19] Wagner A D, Schacter D L, Rotte M, et al.Building memories: remembering and forgetting of verbal experiences as predicted by brain activity [ J] .Science, 1998 , 281 ( 5380 ) :1188 -1191 link1
[20] Donaldson D I, Petersen S E, Ollinger J M, et al.Dissociating state and item components of recognition memory using fMRI[ J] . Neuroimage, 2001 , 13 ( 1 ) :129 -142 link1
[21] LaBar K S,Gitelman D R, Parrish T B, et al.Neuroanatomic o- verlap of working memory and spatial attention networks: a func- tional MRI comparison within subjects [ J] .Neuroimage, 1999 , 10 ( 6 ) : 695 -704 link1
[22] Ungerleider L G.Functional brain imaging studies of corticalmechanism for memory [ J] .Science, 1995 , 270 ( 5237 ) : 769 - 775 link1
[23] 郝晶,李坤成,王岩,等.语义判断中选择与抑制机制的功能MRI研究[J].中国医学影像技术,2004,20(2):223-226 link1
[24] Milham M P, Erickson K I, Banich M T, et al.Attentional con- trol in the aging brain: insights from an fMRI study of the stroop task[ J] .Brain Cogn, 2002 , 49 ( 3 ) :277 -296 link1
[25] MacDonald A W, Cohen J D, Stenger V A, et al.Dissociating the role of the dorsolateral prefrontal and anterior cingulated cortex in cognitive control [ J].Science, 2000, 288(5472 ) :1835 -1838 link1
[26] Shu Siyun, Penny G R, Peterson G M.The marginal division: a new subdivision in the neostriatum of the rats [ J] .J Chem Neuro- anat, 1988 , 1 ( 3 ) :147 -163 link1
[27] Shu Siyun, Bao Xinming, Li shengxiu, et al.A new subdivision of mammalian neostriatum with functional implications to learning and memory [ J] .J Neurosci Res, 1999 , 58 ( 2 ) : 242 -253 link1
[28] Shu Siyun, McGinty J F, Peterson G M.High density zinc -con- taining and dynorphin B - and P -immunoreacyive terminals in the marginal division of the rat striatum [ J ] .Brain Res Bull, 1990 , 24 ( 2 ) :201 -205 link1
[29] Shu Siyun,Bao Xinmin,Wu Yongming,et al.Hippocampal long - term potentiation attenuated by lesions in the marginal division of neostriatum[ J].Neurochem Res,2003, 28(5) : 743 -747 link1
[30] Zeng Jianxin,Shu Siyun,Bao Xinmin, et al.Properties of acetyl- choline receptor ion channels in the acutely dissociated neurons of the marginal division in the rat striatum [ J ] .Neurochem Res, 1999 ,24 ( 12 ) : 1571 -1575 link1
[31] Talley E M,Rosin D L,Lee A,et al.Distribution of alpha( 2A) -adrenergic receptor -like immunoreacitivity in the rat central nervous system [ J] .J Comp Neurol, 1996 , 372 ( 1 ) :111 -134 link1
[32] Heimer L, Zahm D S, Alheid G F.Basal ganglia [ A] .Paxinos G.The rat nervous system [ M ] .New York: Academic Press, 1995.579 -628
[33] Chudler E H, Sugiyama K, Dong W K.Nociceptive responses in the neostriatum and globus pallidus of the anesthetized rat [ J] .J Neurophysiol, 1993 , 69 ( 6 ) : 1890 -1903 link1
[34] 温志波,舒斯云,包新民,等.边缘区损伤和认知功能下降关系的临床分析(附20例报告)[J].第一军医大学学报,2003,23(12):1344-1346 link1
[35] 李爱丽,王彦丽,张蚐,等.基底节附近病变与近记忆障碍[J].中风与神经疾病杂志,1994,11(1):26-27 link1
[36] Shu Siyun.Marginal Division of the neostriatum: A subcortical memory center [ J] .J Biomedical Science, 2003 ,( 10 ) : 14 -29 link1
[37] Shu Siyun, Wu Yongming, Bao Xinmin,et al.A new area in the human brain associated with learning and memory immunohisto- chemical and functional MRI analysis[ J] .Mol Psychiatry, 2002 , 7 ( 9 ) : 1018 -1022 link1
[38] 恽虹,杨振燕,赵小虎,等.汉字词语语音､语义理相关脑区的功能磁共振研究[J].中国医学影像技术,2005,21(5),699-702 link1
[39] Kraut M A, Kremen S, Segal J B, et al.Object activation from features in the semantic system [ J ] .J Cogn Neurosci, 2002 , 14 ( 1 ) : 24 -36 link1
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