2011, Volume 13, Issue 10
Strategic Study of CAE >> 2011, Volume 13, Issue 10
An investigation of local high spatial resolution adaptive PET system
1. Wuhan National Laboratory for Optoelectronics(Preparatory) , Wuhan 430074, China;
2. School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China;
3. School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
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Abstract
A critical challenge in positron emission tomography (PET) is to develop affordable systems having high spatial resolution. We imagine a PET system, for imaging a region of interest (ROI) with ultra high performances and other regions with normal performances by use of inhomogeneous performances PET detectors. We propose such a prototype, consisting of a few ultra high intrinsic spatial resolution PET detectors and quite a few normal ones. In this paper, we investigate the effect of the location and the number of high resolution detectors. The high resolution detectors are grouped in a continuous partial ring. The initial results show that such a prototype is capable to bring the advantages of significantly improving the spatial resolution in a ROI. For a specified area, the improvement is influenced by the location and fraction of high resolution detectors in a ring. The encouraging results also indicate the possibilities to regulate detectors to achieve high spatial resolution according to the application, which is possibly formulated.
Keywords
positron emission tomography ; adaptive PET system ; region of interest ; local spatial resolution ; inhomogeneous performance PET detector
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References
[ 1 ] Phelps M E.PET: The merging of biology and imaging into molec- ular imaging[ J] .Journal of Nuclear Medicine, 2000 , 41 : 661 - 681. link1
[ 2 ] Nichol C, Kim E E.Molecular imaging and gene therapy [ J ] . Journal of Nuclear Medicine, 2001 , 42 : 1368 -1373. link1
[ 3 ] Ursula Nestle, Wolfgang Weber, Michael Hentschel, et al.Bio- logical imaging in radiation therapy: Role of positron emission tomography[ J] .Physics in Medicine and Biology, 2009 , 54 : 1 - 25. link1
[ 4 ] Lancelot S, Zimmer L.Small-animal positron emission tomography as a tool for neuropharmacology [ J ] .Trends in Pharmacological Sciences, 2010 , 31 ( 9 ) : 411 -417. link1
[ 5 ] Jennings J R, Christie I C, Muldoon M F, et al.Brain function, cognition, and the blood pressure response to pharmacological treatment [ J ] .Psychosomatic Medicine, 2010 , 72 ( 7 ) : 702 - 711. link1
[ 6 ] Jennifer R Stickel, Simon R Cherry.High-resolution PET detector design: Modeling components of intrinsic spatial resolution [ J ] . Physics in Medicine and Biology, 2005 , 50 : 179 -195. link1
[ 7 ] John A Kennedy, Ora Israel, Alex Frenkel, et al.Super-resolu- tion in PET imaging[ J] .IEEE Transactions on Medical Imaging, 2006 , 25 ( 2 ) : 137 -147. link1
[ 8 ] Suleman Surti, Ryan Scheuermann, Matthew E Werner, et al. Improved spatial resolution in PET scanners using sampling tech- niques [ J ] .IEEE Transactions on Nuclear Science, 2009 , 56 ( 3 ) : 596 -601. link1
[ 9 ] Seiichi Yamamoto, Masao Imaizumi, Tadashi Watabe, et al.De- velopment of a Si-PM-based high-resolution PET system for small animals[ J] .Physics in Medicine and Biology, 2009 , 55 : 5817 - 5831. link1
[10] Vandenbrouche A, Foudray A M , Olcott P D, et al.Perform- ance characterization of a new high resolution PET scintillation detector[ J] .Physics in Medicine and Biology, 2010 , 55 ( 19 ) : 5895 -5911. link1
[11] de Jong H W, van Velden F H, Kloet R W, et al.Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner[ J] .Physics in Medicine and Biology, 2007 , 52 ( 5 ) : 1505 -1526. link1
[12] Cristian C Constantinescu, Jogeshwar Mukherjee.Performance evaluation of an inveon PET preclinical scanner [ J] .Physics in Medicine and Biology, 2009 , 54 : 2885 -2899. link1
[13] Parham Geramifar, Mohammad Reza Ay, Mojtaba Shamsaie Za- farghandi, et al.Performance comparison of four commercial GE discovery PET /CT scanners: a Monte Carlo study using GATE [ J] .Journal of Nuclear Medicine, 2009 , 17 ( 2 ) : 26 -33. link1
[14] Wu Heyu, Debashish Pal, Joseph A, et al.A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution [ J] .Journal of Nuclear Medi- cine, 2007 , 49 : 79 -87. link1
[15] Tai Yuan-Chuan, Wu Heyu, Debashish Pal, et al.Virtual-pin- hole PET [ J] .Journal of Nuclear Medicine, 2008 , 49 ( 3 ) : 471 -479. link1
[16] Tai Yuan-Chuan, Laforest R, Ruangma A.Design study of a detector insert for high resolution clinical PET imaging[ C] //IEEE 2003 Nuclear Science Symposium Conference, 2003 : 1714 - 1717.
[17] Janecek M, Wu Heyu, Tai Yuan-Chuan.A simulation study of the design of a prototype insert for whole-body PET scanners [ J] .IEEE Transactions on Nuclear Medicine, 2006 , 53 : 1143 -1149. link1
[18] Wu Heyu, Tae Yong Song, Debashish Pal, et al.A high resolu- tion PET insert system for clinical PET /CT scanners[ C] //IEEE 2008 Nuclear Science Symposium Conference, 2008 : 5442 - 5444.
[19] Zhou Jian, Qi Jinyi.Theoretical analysis and simulation study of a high-resolution zoom-in PET system [ J] .Physics in Medicine and Biology, 2009 , 54 :5193 -5208. link1
[20] Zhou Jian, Qi Jinyi.Adaptive imaging for lesion detection using a zoom-in PET system [ J] .IEEE Transactions on Medical Ima- ging, 2011 , 30 ( 1 ) :119 -130. link1
[21] Xie Qingguo, Kao Chien-Min, Xia Rongsheng, et al.A simple all-digital PET system[ C] //Proceedings of SPIE.2007 , 6510 : 41.
[22] Xie Qingguo, Kao Chien-Min, Zekai Hsiau, et al.A new ap- proach for pulse processing in positron emission tomography[ J] . IEEE Transactions on Nuclear Science, 2005 , 52 ( 4 ) : 988 - 995. link1
[23] Xie Qingguo, Kao Chien-Min, Wang Xi, et al.Potentials of dig- itally sampling scintillation pulses in timing determination in PET [ J] .IEEE Transactions on Nuclear Science, 2009 , 56 ( 5 ) : 2607 -2613.
[24] Moses W W, Derenzo S E.Empirical observation of resolution degradation in positron emission tomographs utilizing block detec- tors [ J] .Journal of Nuclear Medicine, 1993 , 34 : 101. link1
[25] Siddon R L.Fast calculation of the exact radiological path for a three-dimensional CT array [ J ] . Medical Physics, 1985 , 12 ( 2 ) : 252 -255. link1
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