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Strategic Study of CAE >> 2015, Volume 17, Issue 6

Pituitary-ovarian hormone and follicular development of various combined oral contraceptives regimens

Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China

Received: 2015-06-16 Available online: 2015-07-06 13:41:48.000

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Abstract

The combined oral contraceptives (COCs) are combinations of exogenous estrogen and progestin. The primary mode of action for COCs is thought to be suppression of the pituitary-ovarian axis by higher than physiological levels of estrogen and progestin, secondarily leading to suppression of endogenous gonadotropin and gonadal hormone secretion and ovarian function. During the hormone-free interval (HFI), COCs users experience activation of their pituitary–ovarian axis. The level of hormones and follicular development are associated with the doses of estrogen, progestin formulations and the changes of HFI.

Keywords

COCs ; HFI ; hormone ; follicle

References

[ 1 ] 黄紫蓉. 现代口服避孕药的发展与研制特点[J]. 实用妇产科杂 志,2009,25(2):67. link1

[ 2 ] 朱 焰,谢淑武,曹 霖. 新型孕激素及抗孕激素国外研发进 展[J]. 中国新药杂志,2011,20(19):23. link1

[ 3 ] Deb S,Campbell B K,Pincott-Allen C,et al. Quantifying effect of combined oral contraceptive pill on functional ovarian reserve as measured by serum anti-Müllerian hormone and small antral follicle count using three- dimensional ultrasound[J]. Ultrasound in Obstetrics & Gynecology,2012,39(5):574-580. link1

[ 4 ] Holt V L,Cushing- Haugen K L,Daling J R. Oral contraceptives,tubal sterilization,and functional ovarian cyst risk[J]. Obstetrics and Gynecology,2003,102(2):252-258. link1

[ 5 ] Spona J,Elstein M,Feichtinger W,et al. Shorter pill-free interval in combined oral contraceptives decreases follicular development[J]. Contraception,1996,54(2):71-77. link1

[ 6 ] Anzai Y,Heger-Manhn D,Schellschmidt I,et al.Suppression of ovarian activity with a low-dose 21/7-day regimen oral contraceptive containing ethinylestradiol 20 mcg/drospirenone 3 mg in Japanese and Caucasian women[J]. Contraception,2012,86(1): 28-34. link1

[ 7 ] Schlaff W D,Lynch A M ,Hughes H D,et al. Manipulation of the pill- free interval in oral contraceptive pill users:The effect on follicular suppression[J]. American Journal of Obstetrics and Gynecology,2004,190(4):943-951. link1

[ 8 ] van Heusden A M,Fauser B C. Activity of the pituitary-ovarian axis in the pill- free interval during use of low- dose combined oral contraceptives[J]. Contraception,1999,59(4):237-243. link1

[ 9 ] Vandever M A,Kuehl T J,Sulak P J,et al. Evaluation of pituitary-ovarian axis suppression with three oral contraceptive regimens[J]. Contraception,2008,77(3):162-170. link1

[10] Schallmayer S,Hughes B M. Impact of oral contraceptiron and neuroticism on cardiovascular stress reactivity across the menstrual cycle[J].Psychology Health & Medicine,2010,15(1): 105-115. link1

[11] Gallo M F,Nanda K,Grimes D A,et al. Twenty micrograms vs >20 microg estrogen oral contraceptives for contraception: Systematic review of randomized controlled trials[J]. Contraception,2005,71(3):162-169. link1

[12] Baerwald A R,Pierson R A. Ovarian follicular development during the use of oral contraception:A review[J] .Journal of Obstetrics and Gynaecology Canada,2004,26(1):19-24. link1

[13] Brenner P F,Mishell D R Jr,Stanczyk F Z,et al. Serum levels of d- norgestrel,luteinizing hormone,follicle- stimulating hormone,estradiol and progesterone in women during and following ingestion of combination oral contraceptives containing DLnorgestrel[J]. American Journal of Obstetrics and Gynecology, 1977,129(2):133-140. link1

[14] Killick S R,Fitzgerald C,Davis A. Ovarian activity in women taking an oral contraceptive containing 20 microg ethinyl estradiol and 150 microg desogestrel:Effects of low estrogen doses during the hormone free interval[J]. American Journal of Obstetrics and Gynecology,1998,179(1):S18-S24. link1

[15] Bentzen J G,Forman J L,Pinborg A,et al. Ovarian reserve parameters:A comparison between users and non- users of hormonal contraception[J]. Reproductive Biomedicine Online, 2012,25(6):612-619. link1

[16] Rabe T,Nitsche D C,Runnebaum B. The effects of monophasic and triphasic oral contraceptives on ovarian function and endometrial thickness[J].The European Journal of Contraception & Reproductive Health Care,1997,2(1):39-51. link1

[17] World Health Organization. A randomized double-blind study of six combined oral contraceptive pills[J]. Contraception,1982, 25(3):231-241. link1

[18] Elomaa K,Rolland R,Brosens I,et al. Omitting the first oral contraceptive pills of the cycle does not automatically lead to ovulation[J]. American Journal of Obstetrics and Gynecology, 1998,179(1):41-46. link1

[19] Klipping C,Duijkers I,Trummer D,et al. Suppression of ovarian activity with a drospirenone-containing oral contraceptive in a 24/4 regimen[J]. Contraception,2008,78(1):16-25. link1

[20] Zapata L B,Steenland M W,Brahmi D,et al. Effect of missed combined hormonal contraceptives on contraceptive effectiveness:A systematic review[J]. Contraception,2013,87(5): 685-700. link1

[21] Elomaa K,Lähteenmäki P. Ovulatory potential of preovulatory sized follicles during oral contraceptive treatment[J]. Contraception,1999,60(5):275-279. link1

[22] Sulak P J,Scow R D,Preece C,et al. Hormone withdrawal symptoms in oral contraceptive users[J]. Obstetrics and Gynecology,2000,95(2):261-266. link1

[23] Anderson F D,Gibbons W,Portman D. Safety and efficacy of an extended- regimen oral contraceptive utilizing continuous low-dose ethinyl estradiol[J].Contraception ,2006,73(3):229- 234. link1

[24] Yonkers K,Brown C,Pearlstein T,et al. Efficacy of a new low- dose oral contraceptive with drospirenone in premenstrual dysphoric disorder[J]. American Journal of Obstetrics and Gynecology,2005,106(3):492-501. link1

[25] Coffee A L,Sulak P J,Kuehl T J. Long- term assessment of symptomatology and satisfaction of an extended oral contraceptive regimen[J].Contraception,2007,75(6):444-449. link1

[26] Sullivan H,Furniss H,Spona J,et al. Effect of 21-day and 24- day oral contraceptive regimens containing gestodene(60 μg) and ethinyl estradiol(15 μg)on ovarian activity[J].Fertility and Sterility,1999,72(1):115-120. link1

[27] Willis S A,Kuehl T J,Spiekerman A M,et al. Greater inhibition of the pituitary-ovarian axis in oral contraceptive regimens with a shortened hormone-free interval[J]. Contraception,2006, 74(2):100-103. link1

[28] Fels H,Steward R,Melamed A,et al. Comparison of serum and cervical mucus hormone levels during hormone- free interval of 24/4 vs. 21/7 combined oral contraceptives[J]. Contraception,2013,87(6):732-737. link1

[29] Rible R D,Taylor D,Wilson M L,et al. Follicular development in a 7-day versus 4-day hormone-free interval with an oral contraceptive containing 20 mcg ethinyl estradiol and 1 mg norethindrone acetate[J]. Contraception,2009,79(3):182-188. link1

[30] 陈丽刚,熊承良. 口服避孕药中孕激素的应用及进展[J]. 国外医学(计划生育/生殖健康分册),2006,25(1):44-47. link1

[31] Africander D,Verhoog N,Hapgood J P. Molecular mechanisms of steroid receptor mediated actions by synthetic progestins used in HRT and contraception[J]. Steroids,2011,76(7): 636-652. link1

[32] Barad D H,Kim A,Kubba H,et al. Does hormonal contraception prior to in vitro fertilization(IVF)negatively affect oocyte yields? - a pilot study[J]. Reproductive Biology and Endocrinology,2013,11:28-33. link1

[33] Dinger J,Minh T D,Buttmann N,et al. Effectiveness of oral contraceptive pills in a large US cohort comparing progestogen and regimen[J]. Obstetrics and Gynecology,2011,117(1):33- 40. link1

[34] Cho M,Atrio J,Lim A H,et al. Pituitary and ovarian hormone activity during the 7-day hormone-free interval of various combined oral contraceptive regimens[J]. Contraception,2014,90 (1):94-96. link1

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