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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 248-262 doi: 10.1007/s11684-012-0206-6
The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentin approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patientsBoth human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis-ETO to induce AML in vivo.We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the
Keywords: AML1-ETO mouse model leukemia t(8 21) pathway hits mutation hematopoiesis Kasumi-1 CD34+
Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia
Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang
Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 388-397 doi: 10.1007/s11684-018-0624-1
Keywords: AML1–ETO c-KIT homoharringtonine oridonin t(8 21) AML synergistic effect
Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu
Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 593-599 doi: 10.1007/s11684-018-0635-y
Keywords: venetoclax cytarabine AML leukemia
Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang
Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 608-620 doi: 10.1007/s11684-021-0836-7
Keywords: t(8 21)(q22 q22) AML CD34+CD117dim/ CD34+CD117bri cell population
Title Author Date Type Operation
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches
Megan A. Hatlen, Lan Wang, Stephen D. Nimer
Journal Article
Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia
Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang
Journal Article
Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid leukemia: a case report
Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu
Journal Article