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Journal Article 2

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2023 1

2022 1

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Circular RNA 1

Digestive system cancer 1

Mass-spectrometry-based immunopeptidomics 1

Organoid 1

Patient-derived hepatobiliary tumor organoid 1

Precision medicine 1

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Organoid Technology and Clinical Applications in Digestive System Cancer Review

Xiaofang Zhao, Youhai Jiang, Chunliang Liu, Minghui Hou, Hongyang Wang, Jing Fu

Engineering 2022, Volume 9, Issue 2,   Pages 123-130 doi: 10.1016/j.eng.2021.04.017

Abstract:

Cancers of the digestive system (DS), including esophageal, gastric, colorectal, liver, and pancreatic cancers, have a high incidence and mortality worldwide. Current cancer models cannot faithfully recapitulate the critical features of the original tumor, resulting in the failure of translation from basic research into clinical practice. More advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine development. Organoids are in vitro cultured three dimensional (3D) self-organizing organotypic structures derived from tissues and pluripotent stem cells, which faithfully mimic the histological features and preserve the genetic heterogeneity of the original tissues. Both normal and malignant organoids can now be efficiently established from the DS tissues of patients. In this review, we summarize the general methods to generate human DS organoids and their applications as a novel model in basic cancer research, preclinical medical practice, and precision medicine.

Keywords： Organoid     Digestive system cancer     Precision medicine    

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Tumor-Specific CircRNA-Derived Antigen Peptide Identification for Hepatobiliary Tumors Article

Wenwen Wang, Lili Ma, Zheng Xing, Tinggan Yuan, Jinxia Bao, Yanjing Zhu, Xiaofang Zhao, Yan Zhao, Yali Zong, Yani Zhang, Siyun Shen, Xinyao Qiu, Shuai Yang, Hongyang Wang, Dong Gao, Peng Wang, Lei Chen

Engineering 2023, Volume 22, Issue 3,   Pages 159-170 doi: 10.1016/j.eng.2022.06.008

Abstract: recognized as an HLA-ABC-presented peptide of the organoids but also drastically reduced the tumor organoid

Keywords： Tumor antigen     Patient-derived hepatobiliary tumor organoid     Circular RNA     Mass-spectrometry-based immunopeptidomics    

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Title Author Date Type Operation

Organoid Technology and Clinical Applications in Digestive System Cancer

Xiaofang Zhao, Youhai Jiang, Chunliang Liu, Minghui Hou, Hongyang Wang, Jing Fu

Journal Article

Tumor-Specific CircRNA-Derived Antigen Peptide Identification for Hepatobiliary Tumors

Wenwen Wang, Lili Ma, Zheng Xing, Tinggan Yuan, Jinxia Bao, Yanjing Zhu, Xiaofang Zhao, Yan Zhao, Yali Zong, Yani Zhang, Siyun Shen, Xinyao Qiu, Shuai Yang, Hongyang Wang, Dong Gao, Peng Wang, Lei Chen

Journal Article