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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract:

Bile duct injury is a common complication of cholecystectomy.The timing of bile duct injury repair remains controversial.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommendedendoscopic stenting are the mainstays of treatment of bile leak because they convert acute bile duct injury

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 887-902 doi: 10.1007/s11684-021-0879-9

Abstract: Subarachnoid hemorrhage (SAH) induces white matter injury, but the involvement of MCT1 is unclear.the SAH model of adult male Sprague-Dawley rats was used to explore the role of MCT1 in white matter injury

Keywords： microRNAs     monocarboxylate transporter 1     motor training     subarachnoid hemorrhage     white matter injury    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remain

Keywords： acute kidney injury     risk factors     prognosis    

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Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 197-205 doi: 10.15302/J-FASE-2018245

Abstract: Taken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative

Keywords： cerebral ischemia     GABA     neuroprotection     leonurine     SOD    

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Progress and perspectives of neural tissue engineering

Xiaosong Gu

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 401-411 doi: 10.1007/s11684-015-0415-x

Abstract:

Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.

Keywords： nerve injury     tissue engineering     nerve grafts    

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Protective effect of N-acetylcysteine against lipopolysaccharide injury in hepatocytes of neonatal mice

WANG Lin, LIU Yalan, XU Jianbo, TIAN Yuan, WU Heshui

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 182-185 doi: 10.1007/s11684-008-0034-x

Abstract: evidence for the effective prevention and treatment of lipopolysaccharide (LPS)-induced hepatocyte injuryNAC has protective effects in hepatocytes of neonatal mice against LPS-induced injury as shown by the
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Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 433-437 doi: 10.1007/s11684-007-0085-4

Abstract: The effect of peripherally administered oxytocin (OT) on gastric ischemia-reperfusion injury (GI-RI)These results indicated that the oxytocin could significantly protect gastric mucosal against injury

Keywords： control     significant difference     surgical     statistical significance     Sprague-Dawley    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: Rdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injuryfunctions under regular culture, the mice displayed an attenuated response to CCl -induced liver injuryThis result further implicated Rdh13 as a potential drug target in preventing chemically induced liver injury

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 87-92 doi: 10.1007/s11684-007-0017-3

Abstract: The aim of this paper is to explore the effect of intestinal ischemia/reperfusion (I/R) injury on leptinAn intestinal I/R injury model of rats was made; the rats were grouped according to the time of afterCompared with the levels before the injury, serum leptin in 60 min ischemia/30 min reperfusion (I60´R30After the injury, adipose leptin mRNA expressions of I60´R30´, I60´R240´ and I60´R360´ increased, whereasLeptin and orexin-A respond to intestinal I/R injury in a time-dependent manner, with leptin responding

Keywords： significant difference     intestinal I/R     transcriptase-polymerase     metabolic     central secretory    

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 368-373 doi: 10.1007/s11684-015-0403-1

Abstract: ) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injuryHowever, its protective abilities against I/R injury in the liver are unknown.We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats.Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury.

Keywords： ischemia/reperfusion     liver     glucagon-like peptide-2     alanine aminotransferase    

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Tissue regeneration: dream, hope and challenge

Ding Xiaobing

Strategic Study of CAE 2009, Volume 11, Issue 10,   Pages 122-128

Abstract:

Tissue regeneration is the research focus in the fields of biology and medicine in 21 century. In this paper, some very important aspects dealing with the tissue repair and regeneration were reviewed, including its brief history, key scientific points and the advance in some very important fields. Also, our perspective about its development in the future was given.

Keywords： injury     tissue     repair     regeneration    

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Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 457-467 doi: 10.1007/s11684-015-0417-8

Abstract: Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury

Keywords： drug-induced liver injury     pharmacognosy     metabolomics     stilbene     Polygonum multiflorum     Chinese herbal    

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Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 307-318 doi: 10.1007/s11684-017-0547-2

Abstract: constituents, Ginkgolide B (GB), against oxygen–glucose deprivation/reoxygenation and glucose (OGD/R) injuryPretreatment with GBE or GB increased the neuron cell viability, ameliorated cell injury, and inhibitedthe cell apoptotic rate through Bax and Bcl-2 expression regulation after OGD/R injury.neuronal cell death and enhancement of the function of brain capillary endothelial monolayers after OGD/R injury

Keywords： acute ischemic stroke     Ginkgo bilobaextract     Ginkgolide B     network model     neuroprotection    

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Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 187-219 doi: 10.1007/s11684-015-0386-y

Abstract:

Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specific autoantigens. It is characterized by female predilection, elevated aminotransferase levels, autoantibodies, increased γ-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epitopes have been identified only for the less frequent type 2. Although autoimmune hepatitis occurs in childhood, this review focuses on disease in adults. In the absence of pathognomonic biomarkers, diagnosis requires consideration of clinical, biochemical, serological and histological features, which have been codified into validated diagnostic scoring systems. Since many features also occur in other chronic liver diseases, these scoring systems aid evaluation of the differential diagnosis. New practice guidelines have redefined criteria for remission to include complete biochemical and histological normalization on immunosuppressive therapy. Immunosuppression is most often successful using prednisone or prednisolone and azathioprine; however, the combination of budesonide and azathioprine for non-cirrhotic patients offers distinct advantages. Patients failing standard immunosuppression are candidates for alternative immunosuppressive regimens, yet none of the options has been studied in a randomized, controlled trial. Overlap syndromes with either primary sclerosing cholangitis or primary biliary cirrhosis occur in a minority. Liver transplantation represents a life-saving option for patients presenting with acute liver failure, severely decompensated cirrhosis or hepatocellular carcinoma. Transplant recipients are at risk for recurrent autoimmune hepatitis in the allograft, and de novo disease may occur in patients transplanted for other indications. Patients transplanted for AIH are also at risk for recurrent or de novo inflammatory bowel disease. Progress in our understanding of the immunopathogenesis should lead to identification of specific diagnostic and prognostic biomarkers and new therapeutic strategies.

Keywords： autoimmune hepatitis     autoantibodies     diagnosis     immunological diseases     drug-induced liver injury     therapy    

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Studies of the Guiyuan Fang and Autologous Bone Marrow Stem Cells Transplantation on Hepatic Injury and

Wu Limao,Li Lianda,Liu Hong,Ning Keyong,Li Yikui

Strategic Study of CAE 2004, Volume 6, Issue 7,   Pages 34-42

Abstract: Methods Acute localized liver injury model was induced in rabbits by injecting ethanol locally, and theResults In the acute liver injury experiment, the reduction of serum GST levels was remarkable in all

Keywords： bone marrow stem cells     autologous transplantation     liver injury     liver fibrosis     guiyuan fang    

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Title Author Date Type Operation

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Journal Article

Progress and perspectives of neural tissue engineering

Xiaosong Gu

Journal Article

Protective effect of N-acetylcysteine against lipopolysaccharide injury in hepatocytes of neonatal mice

WANG Lin, LIU Yalan, XU Jianbo, TIAN Yuan, WU Heshui

Journal Article

Effect of oxytocin on gastric ischemia-reperfusion injury in rats

ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article

Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Journal Article

Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Journal Article

Tissue regeneration: dream, hope and challenge

Ding Xiaobing

Journal Article

Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Journal Article

Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/reoxygenation and glucose injury

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Journal Article

Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Journal Article

Studies of the Guiyuan Fang and Autologous Bone Marrow Stem Cells Transplantation on Hepatic Injury and

Wu Limao,Li Lianda,Liu Hong,Ning Keyong,Li Yikui

Journal Article