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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety

Keywords： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

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Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 426-439 doi: 10.1007/s11684-018-0663-7

Abstract:

Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist within

Keywords： tumor microenvironment     therapy response     treatment resistance    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 430-445 doi: 10.1007/s11684-023-1049-z

Abstract: Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progressioninteraction between liver CSCs and immune cells plays a crucial role in shaping an immunosuppressive microenvironmentunderlying molecular mechanisms after presenting an overview of liver CSCs characteristic and their microenvironment

Keywords： liver cancer     cancer stem cell     immune cell     immunotherapy    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50% long-term complete response in relapsed or refractory diffuse large B-cell lymphoma (DLBCL) patients. However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cell therapy failure needs further investigation. A multi-center phase I/II trial of anti-CD19 CD28z CAR-T (FKC876, ChiCTR1800019661) was conducted. Among 22 evaluable DLBCL patients, seven achieved complete remission, 10 experienced partial remissions, while four had stable disease by day 29. Single-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected from long-term complete remission and early-progressed patients, and compared at different stages of treatment. M2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumor functions of CAR-T cells, leading to CAR-T cell therapy failure and disease progression in DLBCL. Immunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansion and disease progression, which could not be altered by infiltrating CAR-T cells. Aberrant metabolism profile of M2-subtype macrophages and those of dysfunctional T cells also contributed to the immunosuppressive tumor microenvironments. Thus, our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming immune cell metabolism as effective therapeutic strategies to prevent lymphoma relapse in future designs of CAR-T cell therapy.

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Frontiers of Medicine 2024, Volume 18, Issue 1,   Pages 147-168 doi: 10.1007/s11684-023-1017-7

Abstract: The association of neurogenesis and gliogenesis with glioma remains unclear. By conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitive oligodendrocyte precursor cell (pri-OPC)-like and radial glia (RG)-like tumors and validated it in a public cohort and TCGA glioma. The RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations, and the pri-OPC-like ones were prone to carrying TP53 mutations. Tumor subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes, suggesting their distinct immune evasion programs. Furthermore, the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct manners. Some specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytes. For example, glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes, respectively. Their expression was positively correlated with those of immune checkpoint genes (e.g., LGALS3) and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat cells. This finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

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Immunometabolism: a new dimension in immunotherapy resistance

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 585-616 doi: 10.1007/s11684-023-1012-z

Abstract: Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionized the paradigm of tumor treatment, while substantial patients remain unresponsive or develop resistance to ICIs as a single agent, which is traceable to cellular metabolic dysfunction. Although dysregulated metabolism has long been adjudged as a hallmark of tumor, it is now increasingly accepted that metabolic reprogramming is not exclusive to tumor cells but is also characteristic of immunocytes. Correspondingly, people used to pay more attention to the effect of tumor cell metabolism on immunocytes, but in practice immunocytes interact intimately with their own metabolic function in a way that has never been realized before during their activation and differentiation, which opens up a whole new frontier called immunometabolism. The metabolic intervention for tumor-infiltrating immunocytes could offer fresh opportunities to break the resistance and ameliorate existing ICI immunotherapy, whose crux might be to ascertain synergistic combinations of metabolic intervention with ICIs to reap synergic benefits and facilitate an adjusted anti-tumor immune response. Herein, we elaborate potential mechanisms underlying immunotherapy resistance from a novel dimension of metabolic reprogramming in diverse tumor-infiltrating immunocytes, and related metabolic intervention in the hope of offering a reference for targeting metabolic vulnerabilities to circumvent immunotherapeutic resistance.

Keywords： immune cell     immunometabolism     metabolic reprogramming     immunotherapy     resistance     tumor microenvironment    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: ., the composition of the microenvironment around the tumor cells, the presence of the blood-brain barrierSeveral studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.introduce the different mechanisms involved in glioma progression, including tumor heterogeneity, the tumor microenvironment

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 122-133 doi: 10.1007/s11684-012-0193-7

Abstract: As a typical virus and inflammation-associated cancer, both host immune response and tumor microenvironmentwe examine the potential of immunotherapy and strategies targeting various components of the tumor microenvironment

Keywords： hepatocellular carcinoma     molecular classification     molecular targeted therapies     tumor microenvironment    

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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: therapeutic principle, we further discussed the tumor type-specific complexity in the immunological tumor microenvironment

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 429-441 doi: 10.1007/s11684-021-0842-9

Abstract: The local microenvironment is essential to stem cell-based therapy for ischemic stroke, and spatiotemporalchanges of the microenvironment in the pathological process provide vital clues for understanding the

Keywords： ischemic stroke     microenvironment     induced pluripotent stem cells (iPSCs)     positron emission tomography    

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Biomaterial-Related Cell Microenvironment in Tissue Engineering and Regenerative Medicine Review

Jingming Gao, Xiaoye Yu, Xinlei Wang, Yingning He, Jiandong Ding

Engineering 2022, Volume 13, Issue 6,   Pages 31-45 doi: 10.1016/j.eng.2021.11.025

Abstract:

An appropriate cell microenvironment is key to tissue engineering andRevealing the factors that influence the cell microenvironment is a fundamental research topic in theThe cell microenvironment consists of not only its surrounding cells and soluble factors, but also its③material-controlled cell geometry, ④effects of material charges on cells, ⑤ matrix stiffness and biomechanical microenvironment

Keywords： Tissue engineering     Regenerative medicine     Biomaterials     Cell microenvironment     Porous scaffold     Surface    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine tumor

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: These findings suggest that expression of 4-1BBL by normal cells in the tumor microenvironment can enhance

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Microenvironmental time-activity patterns in Chongqing, China

Yu ZHAO, Shuxiao WANG, Gangcai CHEN, Fei WANG, Kristin AUNAN, Jiming HAO

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 2,   Pages 200-209 doi: 10.1007/s11783-009-0010-y

Abstract: An investigation using recall questionnaires was conducted in winter and autumn 2006 to evaluate the time-activity patterns in Chongqing, China. The average time spent in seven microenvironments (MEs) including outdoors, transit, living room, bedroom, kitchen, classroom/office, and other indoors were found to be about 3.5, 1.1, 2.5, 9.7, 1.4, 4.2, and 1.7 h per day, respectively. According to the results of a nonparametric test, the sampling period and day of week were significant for the variation of the time spent in all MEs except for transit and outdoors. The time budget was analyzed using a general linear model (GLM), which exhibited significant variability by demographic factors such as gender, age, residence, education, and household income.

Keywords： time-activity patterns     microenvironment     general linear model (GLM)     Chongqing     China    

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A Brief Summary of Current Therapeutic Strategies for Spinal Cord Injury Review

Chun Yao, Xin Tang, Yuqi Cao, Xuhua Wang, Bin Yu

Engineering 2022, Volume 13, Issue 6,   Pages 46-52 doi: 10.1016/j.eng.2021.07.018

Abstract: Here, we summarize the recent progress that has been made in SCI repair based on the lesion microenvironment

Keywords： Spinal cord injury     Microenvironment     Neural circuits     Biomaterial scaffolds    

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Title Author Date Type Operation

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Journal Article

Immunometabolism: a new dimension in immunotherapy resistance

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Journal Article

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke

Journal Article

Biomaterial-Related Cell Microenvironment in Tissue Engineering and Regenerative Medicine

Jingming Gao, Xiaoye Yu, Xinlei Wang, Yingning He, Jiandong Ding

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine tumor

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Microenvironmental time-activity patterns in Chongqing, China

Yu ZHAO, Shuxiao WANG, Gangcai CHEN, Fei WANG, Kristin AUNAN, Jiming HAO

Journal Article

A Brief Summary of Current Therapeutic Strategies for Spinal Cord Injury

Chun Yao, Xin Tang, Yuqi Cao, Xuhua Wang, Bin Yu

Journal Article