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Journal Article 33

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

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A distinct “repair” role of regulatory T cells in fracture healing

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 516-537 doi: 10.1007/s11684-023-1024-8

Abstract: Regulatory T cells (Tregs) suppress immune responses and inflammation. Here, we described the distinct nonimmunological role of Tregs in fracture healing. The recruitment from the circulation pool, peripheral induction, and local expansion rapidly enriched Tregs in the injured bone. The Tregs in the injured bone displayed superiority in direct osteogenesis over Tregs from lymphoid organs. Punctual depletion of Tregs compromised the fracture healing process, which leads to increased bone nonunion. In addition, bone callus Tregs showed unique T-cell receptor repertoires. Amphiregulin was the most overexpressed protein in bone callus Tregs, and it can directly facilitate the proliferation and differentiation of osteogenic precursor cells by activation of phosphatidylinositol 3-kinase/protein kinase B signaling pathways. The results of loss- and gain-function studies further evidenced that amphiregulin can reverse the compromised healing caused by Treg dysfunction. Tregs also enriched in patient bone callus and amphiregulin can promote the osteogenesis of human pre-osteoblastic cells. Our findings indicate the distinct and nonredundant role of Tregs in fracture healing, which will provide a new therapeutic target and strategy in the clinical treatment of fractures.

Keywords： regulatory T cells     fracture healing     amphiregulin     non-union     osteogenesis    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract: The timing of bile duct injury repair remains controversial.A recent review conducted in France reported 39% complications and 64% failure after immediate repairin 194 patients compared with 14% complications and 8% failure after late repair in 133 patients.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommended

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development of

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 338-345 doi: 10.1007/s11709-017-0411-0

Abstract: The fast-track repair of deteriorated concrete pavement requires materials that can be placed, cured,Based on the laboratory results, the CSA cement was selected as the partial-depth rapid repair materialThe data collected during and after the repair show that the CSA cement concrete had good short-termand long-term performances and, therefore, was suitable for the rapid repair of concrete pavement.

Keywords： Sulfoaluminate (CSA) cement     Type III cement     coefficient of thermal expansion (CTE)     shrinkage     rapid repair    

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Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 2,   Pages 164-169 doi: 10.1007/s11465-008-0035-0

Abstract: adapt to complex spatial surfaces, which satisfy the requirements of a hydraulic turbine blade in-situ repair
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Research on concrete structure defect repair based on three-dimensional printing

Frontiers of Structural and Civil Engineering 2024, Volume 18, Issue 5,   Pages 731-742 doi: 10.1007/s11709-024-1088-9

Abstract: computer vision-based robotic system, which is based on three-dimensional (3D) printing technology to repairFinally, the feasibility of this concrete defect repair method is validated through simulation and experiments

Keywords： concrete     defect detection     3D printing     deep learning     point cloud data    

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Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor

Frontiers of Medicine doi: 10.1007/s11684-023-1053-3

Abstract: BEND4 involves non-homologous end joining signaling by interacting with Ku80 and promotes DNA damage repair

Keywords： BEND4     DNA methylation     synthetic lethality     NHEJ pathway    

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Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 262-272 doi: 10.1007/s11684-019-0717-5

Abstract: Repair, on the other hand, allows restoring the function of an existing but failing organ.The recognition that human lungs can both repair and regenerate is quite novel, the concept has not beenWe present evidence that the human adult lung does repair and regenerate and introduce different waysVarious types of lung stem cells are capable of proliferating and differentiating upon injury driving the repair

Keywords： FGF     human lung     repair     regeneration     stem cells    

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Effect of natural pozzolan content on the properties of engineered cementitious composites as repair

Said CHOUCHA, Amar BENYAHIA, Mohamed GHRICI, Mohamed Said MANSOUR

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 261-269 doi: 10.1007/s11709-017-0394-x

Abstract: mechanical properties and durability characteristics on Engineered Cementitious Composites (ECC) as repairThis study focused on the evaluation of the most factors influencing compatibility between the repairThis lower Young’s modulus is desirable for repair concrete, because it prevents the stresses induced

Keywords： natural pozzolan     engineered cementitious composites     mechanical strengths     elastic modulus     capillary absorption     drying shrinkage    

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Investigating peak stresses in fitting and repair patches of buried polyethylene gas pipes

Reza KHADEMI ZAHEDI, Pouyan ALIMOURI, Hooman KHADEMI ZAHEDI, Mohammad SHISHESAZ

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 1,   Pages 147-168 doi: 10.1007/s11709-019-0587-6

Abstract: The second objective is to study the effectiveness of polyethylene repair patches which are used to mendAdditionally, due to the application of pipe joints, and repair patches local stresses superimposed onThe pipe is assumed to be made of PE80 resin and its jointing socket, and the repair patch is PE100 material

Keywords： Ansys software     polyethylene     buried pipelines     polyethylene joints     polyethylene patches     peak von Mises stress     soil-pipe interaction     temperature variation    

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Comparing the effects of Bassini versus tension-free hernioplasty: 3 years’ follow-up

Yulong SHI, Zhongxue SU, Leping LI, Hongjun LIU, Changqing JING,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 463-468 doi: 10.1007/s11684-010-0050-5

Abstract: recurrence rate in the Bassini group was 8.9% (24/269), significantly higher than that in the tension-free repairThe average hospital stay in the Bassini group was longer than that in the tension-free repair group

Keywords： hernioplasty     Bassini repair     tension-free repair     complication    

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Farmers Reap Right to Repair Agricultural Equipment

Mitch Leslie

Engineering 2023, Volume 27, Issue 8,   Pages 8-10 doi: 10.1016/j.eng.2023.06.002

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Development Strategy of Space Robots for Autonomous Repair and Maintenance of Spacecraft

Zhao Liangliang, Li Xueai, Zhao Jingdong, Liu Hong

Strategic Study of CAE 2024, Volume 26, Issue 1,   Pages 149-159 doi: 10.15302/J-SSCAE-2024.01.014

Abstract: This study elaborates on the great values of developing space robot technology for the autonomous repairIn addition, technical challenges and problems faced by China are dissected toward the autonomous repairThe development system and breakthrough path of China’s space robot technologies for autonomous repair

Keywords： space robots     autonomous repair and maintenance of spacecraft     intelligent operation and control     space    

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Decellularized extracellular matrix mediates tissue construction and regeneration

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 56-82 doi: 10.1007/s11684-021-0900-3

Abstract: Contributing to organ formation and tissue regeneration, extracellular matrix (ECM) constituents provide tissue with three-dimensional (3D) structural integrity and cellular-function regulation. Containing the crucial traits of the cellular microenvironment, ECM substitutes mediate cell–matrix interactions to prompt stem-cell proliferation and differentiation for 3D organoid construction in vitro or tissue regeneration in vivo. However, these ECMs are often applied generically and have yet to be extensively developed for specific cell types in 3D cultures. Cultured cells also produce rich ECM, particularly stromal cells. Cellular ECM improves 3D culture development in vitro and tissue remodeling during wound healing after implantation into the host as well. Gaining better insight into ECM derived from either tissue or cells that regulate 3D tissue reconstruction or organ regeneration helps us to select, produce, and implant the most suitable ECM and thus promote 3D organoid culture and tissue remodeling for in vivo regeneration. Overall, the decellularization methodologies and tissue/cell-derived ECM as scaffolds or cellular-growth supplements used in cell propagation and differentiation for 3D tissue culture in vitro are discussed. Moreover, current preclinical applications by which ECM components modulate the wound-healing process are reviewed.

Keywords： decellularized extracellular matrix     3D culture     organoids     tissue repair    

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Title Author Date Type Operation

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

A distinct “repair” role of regulatory T cells in fracture healing

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article

Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete

Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE

Journal Article

Mobile platform for hydraulic turbine blade repair robot

GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang

Journal Article

Research on concrete structure defect repair based on three-dimensional printing

Journal Article

Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor

Journal Article

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Journal Article

Effect of natural pozzolan content on the properties of engineered cementitious composites as repair

Said CHOUCHA, Amar BENYAHIA, Mohamed GHRICI, Mohamed Said MANSOUR

Journal Article

Investigating peak stresses in fitting and repair patches of buried polyethylene gas pipes

Reza KHADEMI ZAHEDI, Pouyan ALIMOURI, Hooman KHADEMI ZAHEDI, Mohammad SHISHESAZ

Journal Article

Comparing the effects of Bassini versus tension-free hernioplasty: 3 years’ follow-up

Yulong SHI, Zhongxue SU, Leping LI, Hongjun LIU, Changqing JING,

Journal Article

Farmers Reap Right to Repair Agricultural Equipment

Mitch Leslie

Journal Article

Development Strategy of Space Robots for Autonomous Repair and Maintenance of Spacecraft

Zhao Liangliang, Li Xueai, Zhao Jingdong, Liu Hong

Journal Article

Decellularized extracellular matrix mediates tissue construction and regeneration

Journal Article