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Precision glass molding: Toward an optimal fabrication of optical lenses

Liangchi ZHANG,Weidong LIU

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 1, Pages 3-17 doi: 10.1007/s11465-017-0408-3

Abstract: Precision glass molding (PGM) has thus been developed to realize an efficient manufacture of such opticalThis review will discuss some of the central issues in PGM processes and provide a method based on a manufacturing

Keywords： precision glass molding optical lens constitutive modeling optimization manufacturing chain Industry

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Development Strategy for Precision Manufacturing of Composite Components Facing 2035

Shan Zhongde, SongWenzhe, Fan Congze,Wang Jun

Strategic Study of CAE 2023, Volume 25, Issue 1, Pages 113-120 doi: 10.15302/J-SSCAE-2023.07.002

Abstract: In this study, the current status and trends of precision manufacturing of composite componentsare analyzed, and the key technologies and equipment for precision manufacturing of composite components, including high-precision numerical control winding, automatic placement, preform forming, additivemanufacturing, and high-performance carbon fiber production, are summarized.After specifying the key problems limiting the development of composite manufacturing technologies

Keywords： composite precision manufacturing advanced equipment structure-function integration

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Ultra-Precision Machining Technology and Equipment for High-End Optical Elements

Jiang Zhuangde, Li Changsheng , Sun Lin, Duan Duanzhi, Kang Chengwei ,Chen Shanshan, Lin Qijing, Yang Shuming

Strategic Study of CAE 2023, Volume 25, Issue 1, Pages 131-141 doi: 10.15302/J-SSCAE-2023.07.003

Abstract: Researching the ultra-precision machining technology and equipment for high-end optical elementsis crucial for strengthening China's manufacturing industry and satisfying the requirementsbasic components, and measurement methods and equipment used in ultra-precision optical machining Five development trends are summarized including extremalization of precision and size, integration ofThrough extensive survey and discussions, a technology roadmap for ultra-precision manufacturing of high-end

Keywords： optical element precision manufacturing ultra-precision machine tool ultra-precision machining optical

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A Large Range Flexure-Based Servo System Supporting Precision Additive Manufacturing

Zhen Zhang, Peng Yan, Guangbo Hao

Engineering 2017, Volume 3, Issue 5, Pages 708-715 doi: 10.1016/J.ENG.2017.05.020

Abstract:

This paper presents the design, development, and control of a large range beam flexure-based nano servo system for the micro-stereolithography (MSL) process. As a key enabler of high accuracy in this process, a compact desktop-size beam flexure-based nanopositioner was designed with millimeter range and nanometric motion quality. This beam flexure-based motion system is highly suitable for harsh operation conditions, as no assembly or maintenance is required during the operation. From a mechanism design viewpoint, a mirror-symmetric arrangement and appropriate redundant constraints are crucial to reduce undesired parasitic motion. Detailed finite element analysis (FEA) was conducted and showed satisfactory mechanical features. With the identified dynamic models of the nanopositioner, real-time control strategies were designed and implemented into the monolithically fabricated prototype system, demonstrating the enhanced tracking capability of the MSL process. The servo system has both a millimeter operating range and a root mean square (RMS) tracking error of about 80 nm for a circular trajectory.

Keywords： Precision additive manufacturing.Micro-stereolithography.Nanopositioning.Beam flexure

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Manufacturing error analysis of compliant 3-DOF microrobot

CHAO Dai-hong, LIU Rong, WU Yue-min, SHI Long, ZONG Guang-hua

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 3, Pages 299-304 doi: 10.1007/s11465-006-0030-2

Abstract: the fields of micro/nanopositioning application, error analysis is an effective way to enhance the precisionManufacturing imperfections, which are inevitable, are the most important factors influencing the accuracyTherefore, various manufacturing imperfections were studied by taking a planar 3 degrees of freedom (By formulating static stiffness of the robot, mapping between manufacturing imperfections and end-effectordifferences of configurable parameters to guarantee precision in the positioning of the end-effector

Keywords： centerline stiffness effective manipulator precision

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Do not let precision medicine be kidnapped

Zhiping Yang

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 512-513 doi: 10.1007/s11684-015-0425-8

Abstract:

Obama’s precision medicine initiative made the medical community boil over after the initiativePrecision medicine has been advocated by the majority of scientists and doctors.This article does not oppose precision medicine.However, the incentive of vigorously promoting precision medicine at present is a concern.

Keywords： precision medicine personalized medicine genomics

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Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 2, Pages 158-180 doi: 10.1007/s11465-017-0455-9

Abstract:

Ultra-precision machining technologies are the essential methods, to obtain the highest form accuracyThe conception, applications and history of ultra-precision machining are introduced in this article,and the developments of ultra-precision machining technologies, especially ultra-precision grinding,ultra-precision cutting and polishing are also reviewed.

Keywords： ultra-precision grinding ultra-precision cutting ultra-precision polishing research status in China development

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Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3, Pages 348-353 doi: 10.1007/s11465-008-0065-7

Abstract: This paper presents the principle of self-generation of machining precision by explaining its basic conceptThe self-generation of machining precision for solid balls with super precision is emphatically explainedNecessary conditions for achieving self-generation of machining precision are given.Establishment of the system for machining solid balls with super precision is discussed.Self-generation of machining precision for solid balls with super precision on the basis of the capability

Keywords： self-generation necessary self-regulation capability viewpoint Necessary

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Human pangenome: far-reaching implications in precision medicine

Frontiers of Medicine doi: 10.1007/s11684-023-1039-1

Abstract: Human pangenome: far-reaching implications in precision medicine

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Highlights in precision agriculture

Chunjiang ZHAO, Minzan LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4, Pages 391-392 doi: 10.15302/J-FASE-2018246

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High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4, Pages 393-405 doi: 10.15302/J-FASE-2018226

Abstract:

The central concept of precision agriculture is to manage within-field soil and crop growth variabilityRemote sensing has been an integral part of precision agriculture since the farming technology startedagricultural applications over large geographic areas since the 1970s, but they have limited use for precisionaerial coverage, make high resolution satellite sensors attractive for many applications, including precisionThe applications of these sensors for precision agriculture are reviewed and application examples based

Keywords： high resolution satellite sensor multispectral imagery precision agriculture spatial resolution temporal

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract:

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

Keywords： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Given the rapid development in precision medicine, tremendous efforts have been devoted to discoveringcell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precisionThe future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed

Keywords： ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis

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Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract:

Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosisThey could also provide the ideal scheme to personalize treatment in precision medicine.

Keywords： liquid biopsy circulating tumor cells cell-free ctDNA exosomes precision medicine