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Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 289-297 doi: 10.1007/s11684-018-0667-3

Abstract: Malignant cell transformation could be considered as a series of cell reprogramming events driven by oncogenic transcription factors and upstream signalling pathways. Chromatin plasticity and dynamics are critical determinants in the control of cell reprograming. An increase in chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumour cell heterogeneity, which is indispensable for the selection of aggressive properties, including the ability of cells to disseminate and acquire resistance to treatments. Histone supply and dosage, as well as histone variants, are the best-known regulators of chromatin dynamics. By facilitating cell reprogramming, histone under-dosage and histone variants should also be crucial in cell transformation and tumour metastasis. Here we summarize and discuss our knowledge of the role of histone supply and histone variants in chromatin dynamics and their ability to enhance oncogenic cell reprogramming and tumour heterogeneity.

Keywords： cancer-testis     TH2B     TH2A     H1T     H1.0     H1F0     linker histones    

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Separation and extraction of bridge dynamic strain data

Baijian WU, Zhaoxia LI, Ying WANG, T. H. T. CHAN,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4,   Pages 395-400 doi: 10.1007/s11709-009-0049-7

Abstract: Through comparing the measured data of dynamic strains due to loading and temperature by the stain gauge and temperature sensor at the same location, the information in the strain data was divided into three parts in the frequency domain by using the defined index named power spectral density (PSD)-ratio index. The three parts are dominated respectively by temperature varying, stresses, and noises and thus can be distinguished from the determined the separatrix frequencies. Also, a simple algorithm was developed to separate the three types of information and to extract the strain caused mainly by structural stresses. As an application of the proposed method, the effect of strain deformation and noises on the fatigue assessment was investigated based on the separated data. The results show that, the determined values of separatrix frequencies are valuable for the monitoring data from other bridges. The algorithm is a multiresolution and hierarchical method, which has been validated as a simple and effective method for data analyses, and is suitable for the compression and preprocessing of the great amount monitoring data and easy to be integrated into the structural health monitoring (SHM) soft system. The strain due to temperature varying attributes a little to the errors of fatigue assessment; however, the noises or random disturbance existed in the monitoring data have much responsibility for the errors, and the main reason is that the random disturbance shifts the real strain/stress amplitude picked up by real structural stress or strain.

Keywords： dynamic     valuable     separatrix     strain/stress amplitude     frequency    

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Fabrication, modification and environmental applications of TiO

ROHANI, T. ISIMJAN, A. MOHAMED, H. KAZEMIAN, M. SALEM, T. WANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 1,   Pages 112-122 doi: 10.1007/s11705-011-1144-6

Abstract: Among the semiconductors, titanium dioxide has been identified as an effective photocatalyst due to its abundance, low cost, stability, and superior electronic energy band structure. Highly ordered nanotube arrays of titania were produced by anodization and mild sonication. The band gap energy of the titania nanotube arrays was reduced to 2.6 eV by co-doping with Fe, C, N atoms using an electrolyte solution containing K Fe(CN) . The photoconversion of phenol in a batch photoreactor increased to more than 18% based on the initial concentration of phenol by using a composite nanomaterial consisting of titania nanotube arrays and Pt/ZIF-8 nanoparticles. A layer-by-layer assembly technique for the deposition of titania nanoparticles was developed to fabricate air filters for the degradation of trace amounts of toluene in the air and preparation of superhyrophobic surfaces for oil-water separation and anti-corrosion surfaces.

Keywords： TiO2 nanotube arrays and nanoparticles     anodization     bandgap modification     layer-by-layer deposition     oil-water separation    

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 123-138 doi: 10.1007/s11705-022-2194-7

Abstract: The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues.NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers.quinone oxidoreductase 1 to diagnose tumours.quinone oxidoreductase 1-activating drug β-lapachone.quinone oxidoreductase 1.

Keywords： NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

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Modeling of alkali-silica reaction in concrete: a review

PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 1,   Pages 1-18 doi: 10.1007/s11709-012-0141-2

Abstract: This paper presents a comprehensive review of modeling of alkali-silica reaction (ASR) in concrete. Such modeling is essential for investigating the chemical expansion mechanism and the subsequent influence on the mechanical aspects of the material. The concept of ASR and the mechanism of expansion are first outlined, and the state-of-the-art of modeling for ASR, the focus of the paper, is then presented in detail. The modeling includes theoretical approaches, meso- and macroscopic models for ASR analysis. The theoretical approaches dealt with the chemical reaction mechanism and were used for predicting pessimum size of aggregate. Mesoscopic models have attempted to explain the mechanism of mechanical deterioration of ASR-affected concrete at material scale. The macroscopic models, chemo-mechanical coupling models, have been generally developed by combining the chemical reaction kinetics with linear or nonlinear mechanical constitutive, and were applied to reproduce and predict the long-term behavior of structures suffering from ASR. Finally, a conclusion and discussion of the modeling are given.

Keywords： alkali-silica reaction (ASR)     modeling     concrete     mesoscopic     macroscopic    

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Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 11-24 doi: 10.15302/J-FASE-2016092

Abstract: The H9N2 and H5N1 avian influenza viruses (AIVs) have been circulating in poultry in China and becomeof influenza viruses, such as the well-known viruses of the highly pathogenic avian influenza (HPAI) H5N2and the 2013 novel H7N7, H7N9 and H10N8 subtypes, thereby threatening both the poultry industry and

Keywords： avian influenza virus     H9N2     H5N1     novel viruses     public health    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is one of the most dangerous hematological malignancies,More than 60% of T-ALL patients carry NOTCH1 gene mutations, leading to abnormal expression ofWe found that chidamide, an HDAC inhibitor, exerts an antitumor effect on T-ALL cell lines and primarycells including an anti-NOTCH1 activity.form of NOTCH1 (NICD1) as well as MYC, partly through their ubiquitination and degradation by the proteasome

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Performance study on T-stub connected semi-rigid joint between rectangular tubular columns and H-shaped

Guochang LI, Hongping YU, Chen FANG

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 3,   Pages 296-303 doi: 10.1007/s11709-013-0217-7

Abstract: This paper investigates the performance of T-stub connected semi-rigid joint of rectangular tubular columnsand H-shaped steel beams.Meanwhile, the dimensions of T-stub, column and beam are considered as analytic parameters to discussThe analysis shows that the thickness and the length of T-stub webs, the height of beam section, boltperformance of the joint largely, and the thickness of the steel tube, the thickness and length of T-stub

Keywords： rectangular tubular columns     T-stub     semi-rigid     nonlinear finite element analysis     moment-rotation curves    

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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: Moreover, vaccines designed to generate influenza-specific T-cell responses are yet to be optimized.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Enhancement of open circuit voltage in organic solar cells by doping a fluorescent red dye

Qing LI, Junsheng YU, Yue ZANG, Nana WANG, Yadong JIANG

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 179-183 doi: 10.1007/s11708-012-0177-y

Abstract: In this paper, 4-(dicyanomethylene)-2-t-butyl-6-(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB

Keywords： organic solar cells (OSCs)     open circuit voltage     fluorescent dye doping     4-(dicyanomethylene)-2-t-butyl-6-(1     1     7     7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB)    

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MoS2/ZIF-8 Hybrid Materials for Environmental Catalysis: Solar-Driven Antibiotic-Degradation Engineering Article

Wen-Qian Chen, Linyue Li, Lin Li, Wen-Hui Qiu, Liang Tang, Ling Xu, Kejun Xu, Ming-Hong Wu

Engineering 2019, Volume 5, Issue 4,   Pages 755-767 doi: 10.1016/j.eng.2019.02.003

Abstract: This work provides a novel perspective for exploring original and efficient 1T/2H-MoS2/MOF-basedThus, 1T/2H-MoS2/MOF-based photocatalysts have excellent prospects for practical antibiotic-degradation

Keywords： 1T/2H-MoS2     ZIF-8     Antibiotic degradation     Photocatalysis    

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A performance analysis of integrated solid oxide fuel cell and heat recovery steam generator for IGFC system

Souman RUDRA, H. T. KIM, Jinwook LEE, L. ROSENDAHL,

Frontiers in Energy 2010, Volume 4, Issue 3,   Pages 402-413 doi: 10.1007/s11708-010-0122-x

Abstract: Solid oxide fuel cell (SOFC) is a promising technology for electricity generation. Sulfur-free syngas from a gas-cleaning unit serves as fuel for SOFC in integrated gasification fuel cell (IGFC) power plants. It converts the chemical energy of fuel gas directly into electric energy, thus high efficiencies can be achieved. The outputs from SOFC can be utilized by heat recovery steam generator (HRSG), which drives the steam turbine for electricity production. The SOFC stack model was developed using the process flow sheet simulator Aspen Plus, which is of the equilibrium type. Various ranges of syngas properties gathered from different literature were used for the simulation. The results indicate a trade-off efficiency and power with respect to a variety of SOFC inputs. The HRSG located after SOFC was included in the current simulation study with various operating parameters. This paper describes IGFC power plants, particularly the optimization of HRSG to improve the efficiency of the heat recovery from the SOFC exhaust gas and to maximize the power production in the steam cycle in the IGFC system. HRSG output from different pressure levels varies depending on the SOFC output. The steam turbine efficiency was calculated for measuring the total power plant output. The aim of this paper is to provide a simulation model for the optimal selection of the operative parameters of HRSG and SOFC for the IGFC system by comparing it with other models. The simulation model should be flexible enough for use in future development and capable of predicting system performance under various operating conditions.

Keywords： SOFC     HRSG     IGFC     syngas    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: -L1 cells.Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expression-L1 cells with different gene expression levels, including insulin receptor substrate-1(IRS-1), phosphatidylinositolThe glucose uptake decreased with the increase in gene expression in 3T3-L1 cells, which was independent-L1 cells.

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Engineered T Cell Therapies from a Drug Development Viewpoint Review

Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Engineering 2019, Volume 5, Issue 1,   Pages 140-149 doi: 10.1016/j.eng.2018.11.010

Abstract: For example, T cells can be genetically modified to express chimeric antigen receptors (CARs), endowingAnti-CD19 chimeric antigen receptor T cells (CART19) have demonstrated a remarkable degree of clinicalWe believe that the success of CART19 will lead to the development of other engineered T cell therapies

Keywords： Engineered T cell therapies     Chimeric antigen receptor     Drug development process     Biomarkers     CAR19    

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Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 138-142 doi: 10.1007/s11684-013-0247-5

Abstract: The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associatedIn this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patientsSurvival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-MeierWe found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have

Keywords： SIPA1     polymorphism     metastatic breast cancer     survival    

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Title Author Date Type Operation

Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Journal Article

Separation and extraction of bridge dynamic strain data

Baijian WU, Zhaoxia LI, Ying WANG, T. H. T. CHAN,

Journal Article

Fabrication, modification and environmental applications of TiO

ROHANI, T. ISIMJAN, A. MOHAMED, H. KAZEMIAN, M. SALEM, T. WANG

Journal Article

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Journal Article

Modeling of alkali-silica reaction in concrete: a review

PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

Journal Article

Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry

Jiao HU,Xiufan LIU

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Performance study on T-stub connected semi-rigid joint between rectangular tubular columns and H-shaped

Guochang LI, Hongping YU, Chen FANG

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Enhancement of open circuit voltage in organic solar cells by doping a fluorescent red dye

Qing LI, Junsheng YU, Yue ZANG, Nana WANG, Yadong JIANG

Journal Article

MoS2/ZIF-8 Hybrid Materials for Environmental Catalysis: Solar-Driven Antibiotic-Degradation Engineering

Wen-Qian Chen, Linyue Li, Lin Li, Wen-Hui Qiu, Liang Tang, Ling Xu, Kejun Xu, Ming-Hong Wu

Journal Article

A performance analysis of integrated solid oxide fuel cell and heat recovery steam generator for IGFC system

Souman RUDRA, H. T. KIM, Jinwook LEE, L. ROSENDAHL,

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Engineered T Cell Therapies from a Drug Development Viewpoint

Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Journal Article

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

Renling Pei, Ye Xu, Yan Wei, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Journal Article