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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: investigate the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3-L1-L1 cells.Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionThe glucose uptake decreased with the increase in gene expression in 3T3-L1 cells, which was independent, GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissue engineering applications

Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 3,   Pages 339-347 doi: 10.1007/s11705-012-1209-1

Abstract: preparation of Dex-HA cryogel scaffold with satisfied properties was 5% (w/w) at the HA-MA concentration of 1%The culture of 3T3-L1 preadipocyte within the scaffold was investigated and observed by SEM.

Keywords： cryogel scaffold     tissue engineering     dextran     hyaluronate     3T3-L1 preadipocyte    

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randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 259-263 doi: 10.1007/s11684-008-0049-3

Abstract: intravesical bacillus Calmette-Guerin (BCG) could reduce recurrence after transurethral resection of tumor 1grade 3 (T1G3) superficial bladder cancer.resection plus another treatment on the treatment results in patients with superficial bladder cancer of T1G3resection of bladder tumor (TURBT) is an effective conservative treatment for preventing recurrence of T1G3
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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract:

T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advancedOne negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3).We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity incell culture and in murine xenograft model, which is comparable to standard CAR-T cells.

Keywords： CAR-T     CRISPR-Cas9     LAG-3    

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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: metabolism, survival, and immune response by forming two important complexes, namely, mTOR complex 1(mTORC1) and complex 2 (mTORC2). mTOR signaling is often dysregulated in cancers and has been consideredBeyond early findings on induced activation of PI3K/Akt, MEK/ERK, and Mnk/eIF4E survival signaling pathwayscompromise the efficacy of rapalog-based cancer therapy, recent findings on the essential role of GSK3in mediating cancer cell response to mTOR inhibitors and mTORC1 inhibition-induced upregulation of PD-L1

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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An extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) for free vibration analysis

NGUYEN-THOI,L. Le-ANH,V. Ho-HUU,H. Dang-TRUNG,T. NGUYEN-THOI

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 341-358 doi: 10.1007/s11709-015-0302-1

Abstract: A cell-based smoothed discrete shear gap method (CS-FEM-DSG3) was recently proposed and proven to beIn addition, due to using only three-node triangular elements generated automatically, the CS-FEM-DSG3The paper hence tries to extend the CS-FEM-DSG3 for free vibration analysis of cracked Reissner-Mindlinshells by integrating the original CS-FEM-DSG3 with discontinuous and crack−tip singular enrichmentmethod (XFEM) to give a so-called extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3)

Keywords： Reissner-Mindlin shell     free vibration analysis     cell-based smoothed discrete shear gap method (CS-FEM-DSG3)     extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3)     smoothed finite element methods    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression andhypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolaseHere, we identified a novel mutation (NM_001301860: p.1835A>T/p.D612V) of Lipin3 in a large family withthe overexpression and abnormal distribution of Lipin1 in cytosol and nucleoplasm.The increased expression of Lipin1 in cytosol may contribute to TG anabolism, and the decreased Lipin1in nucleoplasm can reduce PGC1α, further leading to mitochondrial dysfunction and reduced TG catabolism

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: The patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cis with a poly-T of 5T (T5) sequence, 3 bp upstream in intron 9.plasmid containing c.1210-3C together with T7 sequence produced a normal transcript and partial exon10-skipping-transcript, whereas mutant plasmid containing c.1210-3G in cis with T5 sequence causedOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Ka-band broadband filtering packaging antenna based on through-glass vias (TGVs) Research Article

Zhen FANG, Jihua ZHANG, Libin GAO, Hongwei CHEN, Wenlei LI, Tianpeng LIANG, Xudong CAI, Xingzhou CAI, Weicong JIA, Huan GUO, Yong LI,zhenfang@std.uestc.edu.cn,jhzhang@uestc.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 6,   Pages 916-926 doi: 10.1631/FITEE.2200573

Abstract: .), TGVs are more suitable for miniaturization (millimeter-wave three-dimensional (3D) packaging devicesGlass substrate can realize 3D high-density interconnection through bonding technology, while the coefficient

Keywords： Filtering packaging antenna (FPA)     Through-glass vias (TGVs)     3D packaging devices     Laser bonding    

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APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: MdSIZ1 is a SUMO (small ubiquitin-like modifier) E3 ligase that promotes SUMO binding to substrate proteinsHere, we demonstrate that MdSIZ1 in apple has a negative relationship with drought tolerance MdSIZ1 RNAi transgenic apple trees had a higher survival rate after drought stress.In addition, MdSIZ1 RNAi transgenic plants had a higher net photosynthetic rate duringTaken together, these results indicate that apple MdSIZ1 negatively regulates drought stress by enhancing

Keywords： apple / drought tolerance / gene expression / MdSIZ1    

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Wideband circular-polarized transmitarray for generating a high-purity vortex beam Correspondence

Liangjie QIU, Xiuping LI, Zihang QI, Wenyu ZHAO, Yuhan HUANG,xpli@bupt.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 6,   Pages 927-934 doi: 10.1631/FITEE.2200539

Abstract: structure and double-resonance characteristics ensure the stable phase shift of the element within the 1-Owing to the honeycomb arrangement of elements, the mode purity of l​​=​​−1 is >0.93 in a wide band fromThe measured peak gain is 22.3 dBic, and the 3-dB axial ratio bandwidth is 27.6%.

Keywords： 轨道角动量；涡旋波束；透射阵；宽带；高纯度    

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Self-motions of 3-RPS manipulators

Josef SCHADLBAUER, Manfred L. HUSTY, Stéphane CARO, Philippe WENGERY

Frontiers of Mechanical Engineering 2013, Volume 8, Issue 1,   Pages 62-69 doi: 10.1007/s11465-013-0366-3

Abstract:

Recently a complete kinematic description of the 3-RPS parallel manipulator was obtained using algebraic

Keywords： 3-RPS-manipulator     singularity     self-motion    

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APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 662-662 doi: 10.15302/J-FASE-2021408

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Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients throughimmunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis ofKnockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcomaIn vitro and in vivo studies also demonstrated that inhibiting by 3-MA inhibited cell growthdemonstrated that autophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

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Title Author Date Type Operation

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissue engineering applications

Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN

Journal Article

randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3

PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa

Journal Article

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

An extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) for free vibration analysis

NGUYEN-THOI,L. Le-ANH,V. Ho-HUU,H. Dang-TRUNG,T. NGUYEN-THOI

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression andhypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Conference Videos

Ka-band broadband filtering packaging antenna based on through-glass vias (TGVs)

Zhen FANG, Jihua ZHANG, Libin GAO, Hongwei CHEN, Wenlei LI, Tianpeng LIANG, Xudong CAI, Xingzhou CAI, Weicong JIA, Huan GUO, Yong LI,zhenfang@std.uestc.edu.cn,jhzhang@uestc.edu.cn

Journal Article

APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Journal Article

Wideband circular-polarized transmitarray for generating a high-purity vortex beam

Liangjie QIU, Xiuping LI, Zihang QI, Wenyu ZHAO, Yuhan HUANG,xpli@bupt.edu.cn

Journal Article

Self-motions of 3-RPS manipulators

Josef SCHADLBAUER, Manfred L. HUSTY, Stéphane CARO, Philippe WENGERY

Journal Article

APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article