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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract: One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3).We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in

Keywords： CAR-T CRISPR-Cas9 LAG-3

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Dynamic behavior of superheated steam and ways of control

LI Xu

Frontiers in Energy 2008, Volume 2, Issue 1, Pages 25-30 doi: 10.1007/s11708-008-0014-5

Abstract: ., the twin lead/lag loop which is facile for engineering applications, is used in superheated steam

Keywords： engineering investment Numerous simulation lead/lag temperature

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Investigation of the Influence of Pitch/Lag on Helicopter AirResonance Stability

Xue Haifeng,Xiang Jinwu,Zhang Xiaogu,Li Shuqiang

Strategic Study of CAE 2007, Volume 9, Issue 9, Pages 58-62

Abstract:

The influence of pitch/lag coupling on helicopter air resonance is investigated First, helicopter air resonance equations of motion considering pitch/lag coupling is derived, related analysis model and calculation programs are built to study the effect of pitch/lag couplingdifferent degrees of freedom, the explanations of the helicopter air resonance considering pitch/lagstructure coupling and pitch/lag coupling together.

Keywords： helicopter dynamics instability helicopter air resonance pitch/lag coupling

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The Cyclic Bispectrum and Its Application to the Analysis of the Fault Signal About Cyclostationary

Su Zhongyuan,Jia Minping,Xu Feiyun,Hu Jianzhong

Strategic Study of CAE 2006, Volume 8, Issue 9, Pages 57-60

Abstract: the cyclic cumulant of cyclostationary signal of unknown cyclic frequency is studied, the nth-order lag

Keywords： cyclic stationary cyclic bispectrum nth-order lag product

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continuous girder with variable cross-sections in considering effect of large deflection and shear lag

Yuji CHEN, Qizhi LUO,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4, Pages 352-356 doi: 10.1007/s11709-009-0057-7

Abstract: girder with variable cross-sections, using potential variation theories, considering the effect of shear lagThe results of the calculation show that different shear lag warp functions to the cantilever, top and

Keywords： thin-walled box girder with variable cross-sections potential variational theory shear lag large deflection

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Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Keywords：营养健康

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4, Pages 343-348 doi: 10.1007/s11705-007-0062-0

Abstract: An oxetane-derived monomer, 3-acryloyloxymethyl-3′-methyloxetane (AMO) was prepared from the reactionof 3-hydromethyl-3-methyloxetane with acryloyl chloride.The cationic ring-opening copolymerization of AMO with another oxetane-derived monomer, 3-(2-(2-(2-methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane (MEMO) was conducted in CHCl solution using BF3 ·OEt/1, 4-butanediol

Keywords： 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followedThe Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000antibody and rSj14-3-3 had a promising immune reactivity.The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development challenging rSj14-3-3 resistance cultural supernatant

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第四届高性能编译、计算和通信国际会议(HP3C 2020)

Conference Date: 12 Mar 2020

Conference Place: 广东广州

Administered by: HP3C 2020

FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1, Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.

Keywords： Treg Forkhead box P3 (FOXP3) Post-translational modification Autoimmune Cancer

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: However, little is known about the function of Lipin3 in triglyceride (TG) metabolism.Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytesto explore the pathophysiological roles of Lipin3 in TG metabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

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A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5, Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract: With the rapid advancement of three-dimensional (3D) printing and 3D bioprinting technologies, many researchersThis paper reviews the applications of these 3D printing and 3D bioprinting technologies for the fabricationThis review specifically discusses the state of the art along with new developments and trends in 3Dmedical phantoms, radiologically relevant medical phantoms, and physiological medical phantoms) and 3D

Keywords： 3D printing 3D bioprinting Medical phantom Regenerated tissue/organ Scaffold

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2020第四届环境与能源工程国际会议(IC3E 2020)

Conference Date: 12 Mar 2020

Conference Place: 海南海口三亚

Administered by: APISE

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: investigate the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionreal-time RT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3and glycogen synthase kinase-3b (GSK-3)., GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1 influence resistance receptor substrate-1 transport

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Combustion and emissions of RP-3 jet fuel and diesel fuel in a single-cylinder diesel engine

Frontiers in Energy 2023, Volume 17, Issue 5, Pages 664-677 doi: 10.1007/s11708-021-0787-3

Abstract: The combustion characteristics and emission behaviors of RP-3 jet fuel were studied and compared to commercialcrank angle (CA) after top dead center (ATDC)) were adjusted to evaluate the engine performances of RP-3In comparison to diesel fuel, RP-3 jet fuel shows a retarded heat release and lagged combustion phaseAs a result, RP-3 jet fuel features a longer ignition delay (ID) time, a shorter combustion durationCompared with diesel fuel, the nitrogen oxides (NO_x) emissions of RP-3 jet fuel are

Keywords： RP-3 jet fuel diesel engine combustion emissions

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Title Author Date Type Operation

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Journal Article

Dynamic behavior of superheated steam and ways of control

LI Xu

Journal Article

Investigation of the Influence of Pitch/Lag on Helicopter AirResonance Stability

Xue Haifeng,Xiang Jinwu,Zhang Xiaogu,Li Shuqiang

Journal Article

The Cyclic Bispectrum and Its Application to the Analysis of the Fault Signal About Cyclostationary

Su Zhongyuan,Jia Minping,Xu Feiyun,Hu Jianzhong

Journal Article

continuous girder with variable cross-sections in considering effect of large deflection and shear lag

Yuji CHEN, Qizhi LUO,

Journal Article

Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Conference Videos

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

第四届高性能编译、计算和通信国际会议(HP3C 2020)

12 Mar 2020

Conference Information

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and