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6-trichlorophenol 1

cyp17a1 1

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Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1,   Pages 77-84 doi: 10.1007/s11783-012-0466-z

Abstract: 2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka ( ) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 μg·L . This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP exposure.

Keywords： 2     4     6-trichlorophenol     genotoxicity     Japanese medaka     piscine micronucleus test in peripheral erythrocytes     gender difference    

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Successful production of an all-female common carp (Cyprinus carpio L.) population using cyp17a1 Article

Gang Zhai,Tingting Shu,Kuangxin Chen,Qiyong Lou,Jingyi Jia,Jianfei Huang,Chuang Shi,Xia Jin,Jiangyan He,Donghuo Jiang,Xueqiao Qian,Wei Hu,Zhan Yin,

Engineering 2022, Volume 8, Issue 1,   Pages 181-189 doi: 10.1016/j.eng.2021.03.026

Abstract: Here, a novel strategy for the successful production of all-female (AF) common carp (Cyprinus carpioMale and female heterozygous cyp17a1-deficient common carp were first obtained using the clusteredAll the AF offspring sample fish from the neomale-WT female mating were confirmed as having the cyp17a1A total of 1000 carp fingerlings, 500 from the WT male and female and 500 from the neomale and WT female

Keywords： Common carp     Sexual dimorphism     Growth     cyp17a1     Sex steroids     All-female population    

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Correlative investigation of copper/low-density polyethylene nanocomposite on the endometrial angiogenesis in rats

LI Jianxiong, LIU Zilong, DUAN Yonggang, YU Jing, ZHU Changhong, LI Shuang, XIE Changsheng

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 401-404 doi: 10.1007/s11684-007-0078-3

Abstract: polyethylene nanocomposite (nano-Cu/LDPE) on the endometrial angiogenesis in rats, and 100 sexual mature female

Keywords： significant difference     female     endometrial angiogenesis     nano-Cu/LDPE     CD34    

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Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle Article

Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc

Engineering 2023, Volume 26, Issue 7,   Pages 108-118 doi: 10.1016/j.eng.2022.10.020

Abstract:

Immunoglobulin G (IgG) is the most abundant plasma glycoprotein and a prominent humoral immune mediator. Glycan composition affects the affinity of IgG to ligands and consequent immune responses. The modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex hormones modulate the immune system. Although the menstrual cycle is the central sex hormone-related physiological process in most women of reproductive age, IgG N-glycosylation dynamics during the menstrual cycle have not yet been investigated. To fill this gap, we profiled the plasma IgG N-glycans of 70 healthy premenopausal women at 12 time points during their menstrual cycles (every 7 days for 3 months) using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC). We observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycle phase and sex hormone concentration in plasma. On the integrated cohort level, the modeled average menstrual cycle effect on the abundance of IgG N-glycosylation traits was low for each trait, with the highest being 1.1% for agalactosylated N-glycans. However, intrapersonal changes were relatively high in some cases; for example, the largest difference between theminimum and maximum values during themenstrual cycle was up to 21% for sialylated N-glycans. Across all measurements, the menstrual cycle phase could explain up to 0.72% of the variation in the abundance of a single IgG glycosylation trait of monogalactosylation. In contrast, up to 99% of the variation in the abundance of digalactosylation could be attributed to interpersonal differences in IgG N-glycosylation. In conclusion, the average extent of changes in the IgG N-glycopattern that occur during the menstrual cycle is small; thus, the IgG N-glycoprofiling of women in large sample-size studies can be performed regardless of menstrual cycle phase.

Keywords： N-glycosylation     Immunoglobulin G     Menstrual cycle     Female sex hormones     Estrogen     Progesterone     Testosterone    

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Title Author Date Type Operation

Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Journal Article

Successful production of an all-female common carp (Cyprinus carpio L.) population using cyp17a1

Gang Zhai,Tingting Shu,Kuangxin Chen,Qiyong Lou,Jingyi Jia,Jianfei Huang,Chuang Shi,Xia Jin,Jiangyan He,Donghuo Jiang,Xueqiao Qian,Wei Hu,Zhan Yin,

Journal Article

Correlative investigation of copper/low-density polyethylene nanocomposite on the endometrial angiogenesis in rats

LI Jianxiong, LIU Zilong, DUAN Yonggang, YU Jing, ZHU Changhong, LI Shuang, XIE Changsheng

Journal Article

Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle

Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc

Journal Article