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Genome-wide analysis reveals selection for Chinese Rongchang pigs

Lei CHEN, Shilin TIAN, Long JIN, Zongyi GUO, Dan ZHU, Lan JING, Tiandong CHE, Qianzi TANG, Siqing CHEN, Liang ZHANG, Tinghuan ZHANG, Zuohua LIU, Jinyong WANG, Mingzhou LI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 319-326 doi: 10.15302/J-FASE-2017161

Abstract: Livestock have undergone domestication and consequently strong selective pressure on genes or genomic regions that control desirable traits. To identify selection signatures in the genome of Chinese Rongchang pigs, we generated a total of about 170 Gb of DNA sequence data with about 6.4-fold coverage for each of six female individuals. By combining these data with the publically available genome data of 10 Asian wild boars, we identified 449 protein-coding genes with selection signatures in Rongchang pigs, which are mainly involved in growth and hormone binding, nervous system development, and drug metabolism. The accelerated evolution of these genes may contribute to the dramatic phenotypic differences between Rongchang pigs and Chinese wild boars. This study illustrated how domestication and subsequent artificial selection have shaped patterns of genetic variation in Rongchang pigs and provides valuable genetic resources that can enhance the use of pigs in agricultural production and biomedical studies.

Keywords： domestication     genome     pig     re-sequencing     selection    

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Presence and Antimicrobial Susceptibility of RE-cmeABC-Positive Campylobacter Isolated Article

Dejun Liu, Weiwen Liu, Xing Li, Hong Yao, Zhangqi Shen, Yang Wang, Jianzhong Shen

Engineering 2020, Volume 6, Issue 1,   Pages 34-39 doi: 10.1016/j.eng.2019.10.013

Abstract: RE-CmeABC is a newly identified resistance-enhancing multidrug efflux pump of C.In this study, we analyzed the presence and antimicrobial susceptibility of RE-cmeABC-positiveCampylobacter isolates (931 C. coli and 157 C. jejuni) were recovered from the REWe detected 122 (11.2%) RE-cmeABC-positive isolates of chicken origin, including 111 (70.7%)The level of resistance was significantly different in 111 RE-cmeABC-positive C. jejuni<

Keywords： RE-cmeABC     Campylobacter     Ciprofloxacin     Florfenicol    

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Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging and re-emerging

Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 449-461 doi: 10.1007/s11684-017-0589-5

Abstract:

In recent years, unexpected outbreaks of infectious diseases caused by emerging and re-emerging virusesreplication and translation, thereby demonstrating potent therapeutic effect against various emerging and re-emerging

Keywords： emerging and re-emerging viruses     small-molecule inhibitor     coronavirus     Ebola virus     Zika virus     life cycle    

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Exome sequencing greatly expedites the progressive research of Mendelian diseases

Xuejun Zhang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 42-57 doi: 10.1007/s11684-014-0303-9

Abstract:

The advent of whole-exome sequencing (WES) has facilitated the discovery of rare structure and functionalCombining exome sequencing with linkage studies is one of the most efficient strategies in searchingWe illustrate the workflow of exome capture and sequencing to highlight the advantages of WES.

Keywords： genetics     whole-exome sequencing     Mendelian disease     disease gene    

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Responses to emerging and re-emerging infectious diseases: One world, One health

Jianqing Xu, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 1-2 doi: 10.1007/s11684-018-0619-y

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Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 240-250 doi: 10.1007/s11684-021-0909-7

Abstract: , we profiled 3′-terminal 2′-O-methyl plant miRNAs in the livers of rice-fed mice by oxidative deep sequencing

Keywords： small RNAs     2′-O-methylation     sequencing     RT-qPCR    

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TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 322-330 doi: 10.1007/s11684-015-0408-9

Abstract:

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular

Keywords： TCGA     whole-transcriptome sequencing     HCC     liver cancer    

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Re-electrification in China Under the Carbon Neutrality Goal

Shu Yinbiao , Xie Dian , Zhao Liang , Gao Yajing , Zhao Yong , Zhou Chaoyang

Strategic Study of CAE 2022, Volume 24, Issue 3,   Pages 195-204 doi: 10.15302/J-SSCAE-2022.03.020

Abstract: Implementing re-electrification to realize clean substitution at the energy production side and electricIn this article, we analyze the concept of re-electrification and propose to help China achieve low-carbondevelopment with re-electrification considering the basic national conditions and resource endowmentThe development prospect of re-electrification is also proposed.The research results show that re-electrification will significantly promote carbon neutrality.

Keywords： re-electrification     carbon neutrality     energy transition     electric energy substitution    

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Influence of increasing numbers of RE-inverters on the power quality in the distribution grids: A PQ

Przemyslaw JANIK, Grzegorz KOSOBUDZKI, Harald SCHWARZ

Frontiers in Energy 2017, Volume 11, Issue 2,   Pages 155-167 doi: 10.1007/s11708-017-0469-3

Abstract: This paper presents the selected power quality (PQ) indicia of a wind generator and a photovoltaic installation considered to be the representative of medium voltage and low voltage distribution grids. The analysis of measured values suggests that the decrease in PQ is a case of specific combination of distributed generation, grid parameters and load behaviour. Modern generators have a limited impact on PQ. On the other hand, fluctuations in power generation are regarded as an emerging PQ indicator. The growing number of distributed renewable installations causes stochastic, variable, and hardly predictable power flows in the distribution grid. The nature of fluctuations in wind and solar generation is different. In both cases, new indexes for the quantification of fluctuations are needed and are yet not standardised. Proper assessment of these fluctuations enables definition of useful fluctuation limits and rules for optimal storage system integration.

Keywords： power quality     harmonics     sags     photovoltaic(PV) system     doubly feed induction generator (DFIG)     inverters    

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation    

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Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 48-55 doi: 10.1007/s11684-012-0182-x

Abstract:

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeThe increased efficiency and resolution of next-generation sequencing greatly facilitate the detectionComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptome sequencingThe present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides

Keywords： next-generation sequencing     cancer genome     whole genome sequencing     exome     transcriptome    

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Comparative study on microbial community in intermittently aerated sequencing batch reactors (SBR) and

Xiaolin Sheng, Rui Liu, Xiaoyan Song, Lujun Chen, Kawagishi Tomoki

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 3, doi: 10.1007/s11783-017-0929-3

Abstract: A traditional sequencing batch reactor (SBR) and two intermittently aerated sequencing batch reactors

Keywords： wastewater     Intermittent aeration     Microbial community     Partial nitrification–denitrification process     Sequencing    

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Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Qiyong Liu, Wenbo Xu, Shan Lu, Jiafu Jiang, Jieping Zhou, Zhujun Shao, Xiaobo Liu, Lei Xu, Yanwen Xiong, Han Zheng, Sun Jin, Hai Jiang, Wuchun Cao, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 3-22 doi: 10.1007/s11684-017-0605-9

Abstract: This review summarizes the current experiences and lessons from China in managing emerging and re-emerging

Keywords： infectious disease profile     emerging infectious diseases     influence factor    

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Simultaneous denitrifying phosphorus accumulation in a sequencing batch reactor

YUAN Linjiang, HAN Wei, WANG Lei, YANG Yongzhe, WANG Zhiying

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 23-27 doi: 10.1007/s11783-007-0004-6

Abstract: treatment process, denitrifying phosphorus accumulation (DNPA) and its affecting factors were studied in a sequencing

Keywords： SBR     synthetic wastewater     Induced DNPA     resource     removal ability    

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Improvement of nitrification efficiency by bioaugmentation in sequencing batch reactors at low temperature

Di CUI,Ang LI,Tian QIU,Rui CAI,Changlong PANG,Jihua WANG,Jixian YANG,Fang MA,Nanqi REN

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6,   Pages 937-944 doi: 10.1007/s11783-014-0668-7

Abstract: Bioaugmentation is an effective method of treating municipal wastewater with high ammonia concentration in sequencing

Keywords： nitrification     sequencing batch reactors (SBRs)     bioaugmentation     low temperature    

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Title Author Date Type Operation

Genome-wide analysis reveals selection for Chinese Rongchang pigs

Lei CHEN, Shilin TIAN, Long JIN, Zongyi GUO, Dan ZHU, Lan JING, Tiandong CHE, Qianzi TANG, Siqing CHEN, Liang ZHANG, Tinghuan ZHANG, Zuohua LIU, Jinyong WANG, Mingzhou LI

Journal Article

Presence and Antimicrobial Susceptibility of RE-cmeABC-Positive Campylobacter Isolated

Dejun Liu, Weiwen Liu, Xing Li, Hong Yao, Zhangqi Shen, Yang Wang, Jianzhong Shen

Journal Article

Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging and re-emerging

Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang

Journal Article

Exome sequencing greatly expedites the progressive research of Mendelian diseases

Xuejun Zhang

Journal Article

Responses to emerging and re-emerging infectious diseases: One world, One health

Jianqing Xu, Jianguo Xu

Journal Article

Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing

Journal Article

TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Journal Article

Re-electrification in China Under the Carbon Neutrality Goal

Shu Yinbiao , Xie Dian , Zhao Liang , Gao Yajing , Zhao Yong , Zhou Chaoyang

Journal Article

Influence of increasing numbers of RE-inverters on the power quality in the distribution grids: A PQ

Przemyslaw JANIK, Grzegorz KOSOBUDZKI, Harald SCHWARZ

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Journal Article

Comparative study on microbial community in intermittently aerated sequencing batch reactors (SBR) and

Xiaolin Sheng, Rui Liu, Xiaoyan Song, Lujun Chen, Kawagishi Tomoki

Journal Article

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Qiyong Liu, Wenbo Xu, Shan Lu, Jiafu Jiang, Jieping Zhou, Zhujun Shao, Xiaobo Liu, Lei Xu, Yanwen Xiong, Han Zheng, Sun Jin, Hai Jiang, Wuchun Cao, Jianguo Xu

Journal Article

Simultaneous denitrifying phosphorus accumulation in a sequencing batch reactor

YUAN Linjiang, HAN Wei, WANG Lei, YANG Yongzhe, WANG Zhiying

Journal Article

Improvement of nitrification efficiency by bioaugmentation in sequencing batch reactors at low temperature

Di CUI,Ang LI,Tian QIU,Rui CAI,Changlong PANG,Jihua WANG,Jixian YANG,Fang MA,Nanqi REN

Journal Article