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Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

GU Jin, YAO Yunfeng, LI Jiyou, LU Aiping, WANG Hongyi

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 333-337 doi: 10.1007/s11684-007-0064-9

Abstract: Here, we report on the case of a 63-year-old man who presented with an upper-third rectal adenocarcinoma

Keywords： CK7+/CK20+     resection     different     therapeutic strategy     upper-third    

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 383-388 doi: 10.1007/s11684-016-0488-1

Abstract: AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positiveThe mechanisms of resistance to third-generation inhibitors reported to date include the EGFR

Keywords： EGFR     tyrosine kinase inhibitor     AZD9291     EAI045    

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 701-713 doi: 10.1007/s11684-022-0951-0

Abstract: clinical challenge in lung cancer treatment is management of the inevitable acquired resistance to third-generationIt has been clearly shown that effective induction of apoptosis is a key mechanism for third generationapoptosis using various means promises an effective strategy for the management of acquired resistance to third

Keywords： acquired resistance     EGFR inhibitor     apoptosis     lung cancer    

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Approaching the upper boundary of driver-response relationships: identifying factors using a novel framework

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 6, doi: 10.1007/s11783-023-1676-2

Abstract:

● A novel framework integrating quantile regression with machine learning is proposed.

Keywords： Driver-response     Upper boundary of relationship     Interpretable machine learning     Quantile regression    

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Optimum design and preliminary experiments of a novel parallel end traction apparatus for upper-limb

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 4,   Pages 726-746 doi: 10.1007/s11465-021-0651-5

Abstract: Robot-assisted technology has been increasingly employed in the therapy of post stroke patients to deliver high-quality treatment and alleviate therapists’ burden. This paper introduces a novel parallel end traction apparatus (PETA) to supplement equipment selection. Considering the appearance and performance of the PETA, two types of special five-bar linkage mechanisms are selected as the potential configurations of the actuation execution unit because of their compact arrangement and parallel structure. Kinematic analysis of each mechanism, i.e., position solutions and Jacobian matrix, is carried out. Subsequently, a comparative study between the two mechanisms is conducted. In the established source of nondimensional parameter synthesis, the singularity, maximum continuous workspace, and performance variation trends are analyzed. Based on the evaluation results, the final scheme with determined configuration and corresponding near-optimized nondimensional parameters is obtained. Then, a prototype is constructed. By adding a lockable translational degree of freedom in the vertical direction, the PETA can provide 2D planar exercise and 3D spatial exercise. Finally, a control system is developed for passive exercise mode based on the derived inverse position solution, and preliminary experiments are performed to verify the applicability of the PETA.

Keywords： parallel mechanism     upper-limb rehabilitation     singularity and workspace analyses     performance evaluation    

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Regeneration of vernacular architecture: new rammed earth houses on the upper reaches of the Yangtze

Jiaping LIU, Rongrong HU, Liu YANG, Runshan WANG,

Frontiers in Energy 2010, Volume 4, Issue 1,   Pages 93-99 doi: 10.1007/s11708-010-0002-4

Abstract: briefly describes a project about creating a new prototype of earth house for the migrants along the upper

Keywords： earth house     low-energy housing     upper reaches of the Yangtze River     passive solar technique    

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Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 4,   Pages 409-418 doi: 10.1007/s11465-011-0245-8

Abstract:

The response of an infinite Timoshenko beam subjected to a harmonic moving load based on the third-order

Keywords： timoshenko composite beam     pasternak viscoelastic foundation     third-order shear deformation theory (TSDT    

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Design and preliminary evaluation of an exoskeleton for upper limb resistance training

Tzong-Ming WU, Dar-Zen CHEN

Frontiers of Mechanical Engineering 2012, Volume 7, Issue 2,   Pages 188-198 doi: 10.1007/s11465-012-0327-2

Abstract: A compact design of upper limb exoskeleton mechanism for home-based resistance training using a spring-loadedupper limb exoskeleton with a three degree-of-freedom shoulder joint and a one degree-of-freedom elbowjoint allows a patient or a healthy individual to move the upper limb with multiple joints in differentthe spring length to train additional muscle groups and reduce the number of potential injuries to upperverify our prototype of the exoskeleton and determine the optimal configuration of the spring-loaded upper

Keywords： exoskeleton     free-weight exercise     upper limb     motion analysis    

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 93-101 doi: 10.1007/s11684-021-0914-x

Abstract: Here we report a pilot open-label trial of a third dose of BBIBP-CorV, an inactivated SARS-CoV-2 vaccineimmunity-associated cytokines and chemokines were also detected in the majority of participants after the thirdTogether, these results indicate that a third immunization schedule with either homologous or heterologous

Keywords： COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

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EEG controlled neuromuscular electrical stimulation of the upper limb for stroke patients

Hock Guan TAN, Cheng Yap SHEE, Keng He KONG, Cuntai GUAN, Wei Tech ANG

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 1,   Pages 71-81 doi: 10.1007/s11465-011-0207-1

Abstract: without the loss of generality, the controller of the NMES is developed and is based on a model of the upper

Keywords： brain computer interface     neuromuscular electrical stimulation     stroke     musculoskeletal modeling    

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CFD Simulation of thermal hydraulic characteristics in a typical upper plenum of RPV

Mingjun WANG, Lianfa WANG, Yingjie WANG, Wenxi TIAN, Jian DENG, Guanghui SU, Suizheng QIU

Frontiers in Energy 2021, Volume 15, Issue 4,   Pages 930-945 doi: 10.1007/s11708-021-0728-1

Abstract: dynamics (CFD) study was conducted on the three different types of pressurized water reactor (PWR) upperFirst, three types of upper plenum geometry information were collected, simplified, and adopted intoThen, the geometry, including the upper half core, upper plenum region, and hot legs, was built usingcore outlet and temperature distribution and transverse velocity inside the hot legs with different upperThe results suggest that TYPE 1 upper plenum internals cause the largest flowrate difference at the core

Keywords： pressurized water reactor (PWR)     upper plenum     internal structures     temperature distribution     computational    

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Upper bound solution to seismic active earth pressure of submerged backfill subjected to partial drainage

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 6,   Pages 1480-1493 doi: 10.1007/s11709-021-0776-y

Abstract: The method comprises the following steps: i) determination of the total head, ii) upper bound solutionexpansions, and the expressions of the seismic active earth thrust and pressure are derived by using the upper

Keywords： seismic active earth pressure     partial seepage flow     pore pressure     anisotropy     upper bound theorem    

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Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 3,   Pages 315-322 doi: 10.1007/s11709-011-0117-7

Abstract: In this article, the third-moment reliability index, based on the three-parameter lognormal (3P-lognormalA simple method based on the third-moment method for estimating load and resistance factors is then proposedNumerical examples are presented to demonstrate the advantages of the proposed third moment method for

Keywords： load and resistance factors     third-moment method     three-parameter lognormal (3P-lognormal) distribution    

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Seepage analysis of Upper Gotvand Dam concerning gypsum karstification (2D and 3D approaches)

Jamshid SADREKARIMI, Majid KIYANI, Behnam FAKHRI, Mohammad Javad VAHDATIRAD, Amin BARARI

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 1,   Pages 71-78 doi: 10.1007/s11709-010-0083-5

Abstract: Upper Gotvand Dam is constructed on the Karun River at the south west of Iran.case, the rate of increase of discharge flux due to dissolution of gypsum veins was obtained to be a third-order

Keywords： Upper Gotvand Dam     seepage analysis     gypsum veins     3D model     discharge flux    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: However, the combined expression of GATA3 and microsatellite instability (MSI) in upper tract urothelial

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Title Author Date Type Operation

Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

GU Jin, YAO Yunfeng, LI Jiyou, LU Aiping, WANG Hongyi

Journal Article

Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu

Journal Article

Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

Journal Article

Approaching the upper boundary of driver-response relationships: identifying factors using a novel framework

Journal Article

Optimum design and preliminary experiments of a novel parallel end traction apparatus for upper-limb

Journal Article

Regeneration of vernacular architecture: new rammed earth houses on the upper reaches of the Yangtze

Jiaping LIU, Rongrong HU, Liu YANG, Runshan WANG,

Journal Article

Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

Journal Article

Design and preliminary evaluation of an exoskeleton for upper limb resistance training

Tzong-Ming WU, Dar-Zen CHEN

Journal Article

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Journal Article

EEG controlled neuromuscular electrical stimulation of the upper limb for stroke patients

Hock Guan TAN, Cheng Yap SHEE, Keng He KONG, Cuntai GUAN, Wei Tech ANG

Journal Article

CFD Simulation of thermal hydraulic characteristics in a typical upper plenum of RPV

Mingjun WANG, Lianfa WANG, Yingjie WANG, Wenxi TIAN, Jian DENG, Guanghui SU, Suizheng QIU

Journal Article

Upper bound solution to seismic active earth pressure of submerged backfill subjected to partial drainage

Journal Article

Estimation of load and resistance factors using the third-moment method based on the 3P-lognormal distribution

Yan-Gang ZHAO, Zhao-Hui LU

Journal Article

Seepage analysis of Upper Gotvand Dam concerning gypsum karstification (2D and 3D approaches)

Jamshid SADREKARIMI, Majid KIYANI, Behnam FAKHRI, Mohammad Javad VAHDATIRAD, Amin BARARI

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article