Computer-aided design (CAD) techniques provide powerful tools to help engineers design products with high efficiency and quality. However, the gaps between geometry modeling, structural analysis and optimization make the design process heavily dependent on trial-and-error and human experiences. It is therefore important to explore new design strategies to achieve high-quality designs with reduced human intervention. The research on human-aided design (HAD) in this special issue provides a novel and intelligent design strategy. In HAD, computers automatically complete a whole design process to generate high-quality designs using a novel isogeometric topology optimization approach, while humans just assist to modify the design slightly to meet certain requirements when necessary. The intelligent HAD as a brand new design strategy has a great potential to replace traditional design approaches in the next industrial revolution.