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Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 490-498 doi: 10.1007/s11684-016-0470-y
Keywords: conjugate vaccine pneumococcal surface adhesin A Hemophilus influenzae b immunogenicity otitis media
Thiago ANTONINI ALVES,Paulo H. D. SANTOS,Murilo A. BARBUR
Frontiers of Mechanical Engineering 2015, Volume 10, Issue 3, Pages 263-276 doi: 10.1007/s11465-015-0345-y
Keywords: channel flow conjugate forced convection-conduction cooling conjugate influence coefficients discrete
Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers
Ulrich L?CHELT, Ernst WAGNER
Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3, Pages 275-286 doi: 10.1007/s11705-011-1203-z
Dieter BOHN, Robert KREWINKEL
Frontiers in Energy 2009, Volume 3, Issue 4, Pages 406-413 doi: 10.1007/s11708-009-0041-x
Keywords: conjugate calculation effectiveness of effusion cooling multi-layer systems CMSX-4 NiAl-FG75
Kinetics of enhanced adsorption by polarization for organic pollutants on activated carbon fiber
HAN Yanhe, QUAN Xie, ZHAO Huimin, CHEN Shuo, ZHAO Yazhi
Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1, Pages 83-88 doi: 10.1007/s11783-007-0016-2
Keywords: ACF activated 17-fold enhancement donor-conjugate bridge-acceptor Electrostatic interaction
Research on transmission principle and kinematics analysis for involute spherical gear
PAN Cun-yun, WEN Xi-sen, YANG Kun-yu, XU Xiao-jun, LIU Min, YAO Qi-shui
Frontiers of Mechanical Engineering 2006, Volume 1, Issue 2, Pages 183-193 doi: 10.1007/s11465-006-0010-6
Keywords: rotational transformation orientation Furthermore conjugate number
Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang
Engineering 2015, Volume 1, Issue 4, Pages 500-505 doi: 10.15302/J-ENG-2015106
The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Acr3-NLS, by conjugating hydrophobic acridines to the N-terminus of a nuclear localization sequence (NLS), a short cationic peptide. To further improve the antimicrobial activity of our agent, dimeric (Acr3-NLS)2 was simultaneously synthesized by joining two monomeric Acr3-NLS together via a disulfide linker. Our results show that Acr3-NLS and especially (Acr3-NLS)2 display significant antimicrobial activity against gram-negative and gram-positive bacteria compared to that of the NLS. Subsequently, the results derived from the study on the mechanism of action demonstrate that Acr3-NLS and (Acr3-NLS)2 can kill bacteria by membrane disruption and DNA binding. The double targets–cell membrane and intracellular DNA–will reduce the risk of bacteria developing resistance to Acr3-NLS and (Acr3-NLS)2. Overall, this study provides a novel strategy to design highly effective antimicrobial agents with a dual mode of action for infection treatment.
Keywords: acridine nuclear localization sequence conjugate antimicrobial activity mechanism of action
Modified Therapeutic Antibodies: Improving Efficacy Review
Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen
Engineering 2021, Volume 7, Issue 11, Pages 1529-1540 doi: 10.1016/j.eng.2020.06.030
The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers, inflammatory disorders, and refractory infections. As drawbacks emerge in clinical trials and practice, such as impeded binding, reduced effector functions, and frequent adverse reactions, modifications of therapeutic antibodies are unprecedently burgeoning in research and development (R&D). These modifications include: ① modified glycosylation; ② fragment of crystallizable domain (Fc) amino acid alterations; ③ cross-isotype or cross-subclass exchanges; ④ antibody–drug conjugates (ADCs); ⑤ single chain of variable region fragment (scFv) for chimeric antigen receptor T (CAR-T) cells; and ⑥ bispecific antibodies (bsAbs) in order to promote binding affinity, half-life in circulation, effectiveness toward target cells and, ultimately, to achieve overall improved efficacy. While many achievements have been made around the world in the past decades, China has been playing an active role in this realm, with its great demand for biotherapeutics with R&D potential. This review recapitulates the international progress that has been achieved with modified therapeutic antibodies, and then focuses on that of China in an independent section.
Keywords: Therapeutic antibody Modification Efficacy Antigen Antibody–drug conjugate Bispecific antibody
A high-precision terahertz retrodirective antenna array with navigation signal at a different frequency Correspondence
Zhong-bo ZHU, Wei-dong HU, Tao QIN, Sheng LI, Xiao-jun LI, Jiang-jie ZENG, Xian-qi LIN, Leo P. LIGTHART
Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 3, Pages 377-383 doi: 10.1631/FITEE.1900581
Keywords: Terahertz Retrodirective antenna array Terahertz communications Conjugate mixing
Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,
Engineering doi: 10.1016/j.eng.2023.09.012
Keywords: Poly- N -acetylglucosamine Conjugate vaccine Monoclonal antibody
Mark Pargram: Antibody Drug Conjugate Development in Cancer Drugs (2019-9-18)
12 Aug 2021
Keywords: 医学
Title Author Date Type Operation
Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate
Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu
Journal Article
An invariant descriptor for conjugate forced convection-conduction cooling of 3D protruding heaters in
Thiago ANTONINI ALVES,Paulo H. D. SANTOS,Murilo A. BARBUR
Journal Article
Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers
Ulrich L?CHELT, Ernst WAGNER
Journal Article
Numerical investigation of the effectiveness of effusion cooling for plane multi-layer systems with different base-materials
Dieter BOHN, Robert KREWINKEL
Journal Article
Kinetics of enhanced adsorption by polarization for organic pollutants on activated carbon fiber
HAN Yanhe, QUAN Xie, ZHAO Huimin, CHEN Shuo, ZHAO Yazhi
Journal Article
Research on transmission principle and kinematics analysis for involute spherical gear
PAN Cun-yun, WEN Xi-sen, YANG Kun-yu, XU Xiao-jun, LIU Min, YAO Qi-shui
Journal Article
Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide
Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang
Journal Article
Modified Therapeutic Antibodies: Improving Efficacy
Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen
Journal Article
A high-precision terahertz retrodirective antenna array with navigation signal at a different frequency
Zhong-bo ZHU, Wei-dong HU, Tao QIN, Sheng LI, Xiao-jun LI, Jiang-jie ZENG, Xian-qi LIN, Leo P. LIGTHART
Journal Article
Antibodies Targeting a Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing β-1–6-Linked Poly-N-Acetylglucosamine (PNAG)
Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,
Journal Article
Mark Pargram: Antibody Drug Conjugate Development in Cancer Drugs (2019-9-18)
12 Aug 2021
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