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Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
《农业科学与工程前沿(英文)》 2015年 第2卷 第4期 页码 335-340 doi: 10.15302/J-FASE-2015079
关键词: b-pinene nopinone synthesis 2-amino-3-cyanopyridine anticancer
Current hepatitis B treatment guidelines and future research directions
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 145-157 doi: 10.1007/s11684-014-0335-1
Hepatitis B virus (HBV) infection causes a tremendous clinical burden across the world with more than half a million people dying annually from HBV related disease. Significant advances have been made in HBV treatment in the past decade and several guidelines have been published by professional societies and expert panels. Although these recommendations have been valuable to help optimize HBV treatment, there is discordance in treatment criteria and many patients infected with HBV may fall outside of these recommendations. This paper systematically reviews the natural history of the disease and compares and contrasts the recommendations for initiation of treatment from the various societies. There is also discussion of special groups that require particular consideration and some of the open research questions and future research directions within the field.
关键词: chronic hepatitis B HBV treatment guidelines APASL guidelines EASL guidelines AASLD guidelines
《医学前沿(英文)》 2022年 第16卷 第1期 页码 111-125 doi: 10.1007/s11684-021-0854-5
关键词: COVID-19 chronic hepatitis B liver injury coagulation dysfunction
Vaccine therapies for chronic hepatitis B: can we go further?
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 17-23 doi: 10.1007/s11684-014-0313-7
Chronic hepatitis B is a major health burden worldwide. In addition to the recent progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitis B. On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis B patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based therapeutic vaccines, which have undergone clinical trials. The advantages, disadvantages, and future perspectives for these therapeutic vaccines are discussed.
关键词: chronic hepatitis B therapeutic antigen-antibody complexes DNA vaccine
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 135-144 doi: 10.1007/s11684-014-0331-5
Chronic hepatitis B is a major health problem in China. The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infection in China from highly to moderately endemic. The most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in western provinces are genotypes D and C/D hybrid. Chronic hepatitis B poses a heavy burden to the society in China. Different treatment strategies have been explored to improve patient outcomes in a cost-effective manner. However, antiviral drugs with a low genetic barrier to resistance are still extensively used because of the generally low income and limited resources in China. Individualized antiviral therapy is closely associated with translational medicine, which utilizes information from studies on genomics, immune biomarkers, and fibrosis. The results of these studies are crucial in further improving treatment outcomes.
李伟,李强,王平
《中国工程科学》 2011年 第13卷 第1期 页码 56-61
基于概率断裂力学对B级钢货车侧架的圆角细节进行了模拟耐久性试验研究,提出了一种新的通用当量初始缺陷尺寸分布的计算方法,建立了裂纹超越概率模型
Impact analysis of compressor rotor blades of an aircraft engine
Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU
《结构与土木工程前沿(英文)》 2019年 第13卷 第3期 页码 505-514 doi: 10.1007/s11709-018-0493-3
关键词: axial flow compressor rotor and stator blades aircraft engine stress and impact analysis aluminum alloys
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 250-253 doi: 10.1007/s11684-014-0333-3
The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively. The patient has suffered from hepatitis B for 30 years. His liver function deteriorated, yielding Child-Pugh grade C and reaching a model for end-stage liver disease score of 33 points within a short period; this condition was complicated with highly active variceal bleeding and coagulation system failure (PT > 100 s). The patient also presented hepatocellular carcinoma. Comprehensive treatments included effective inhibition of hepatitis B virus replication and intensive care support. Piggyback orthotopic liver transplantation was performed as the final treatment. The patient recovered uneventfully and was discharged after surgery.
关键词: acute-on-chronic liver failure submassive necrosis viral hepatitis B esophageal variceal bleeding liver transplantation
带约束条件的C-Bézier曲面最优降多阶逼近 Article
Lian ZHOU, Xin-hui LIN, Hong-yan ZHAO, Jun CHEN
《信息与电子工程前沿(英文)》 2017年 第18卷 第12期 页码 2009-2016 doi: 10.1631/FITEE.1700458
关键词: C-Bézier曲面;降阶;边界约束
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 72-80 doi: 10.15302/J-FASE-2016089
Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 271-276 doi: 10.1007/s11684-009-0054-1
Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 235-240 doi: 10.1007/s11684-010-0002-0
《机械工程前沿(英文)》 2023年 第18卷 第4期 doi: 10.1007/s11465-023-0768-9
关键词: multiresolution multimaterial topology optimization fail-safe structure B-spline
Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)
《医学前沿(英文)》 2022年 第16卷 第5期 页码 815-826 doi: 10.1007/s11684-021-0891-0
关键词: B-cell lymphoma oral drug targeted therapy immunotherapy COVID-19 pandemic
标题 作者 时间 类型 操作
Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines
Shengliang LIAO,Shibin SHANG,Minggui SHEN,Xiaoping RAO,Hongyan SI,Jie SONG,Zhanqian SONG
期刊论文
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center
期刊论文
Impact analysis of compressor rotor blades of an aircraft engine
Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU
期刊论文
Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report
null
期刊论文
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
期刊论文
Correlation between viral load and liver cirrhosis in chronic hepatitis B patients
Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,
期刊论文
Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia
Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,
期刊论文
Multiresolution and multimaterial topology optimization of fail-safe structures under B-spline spaces
期刊论文