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Removal of 17β-estradiol in laccase catalyzed treatment processes

XIA Qing,KONG Deyang,LIU Guoqiang,HUANG Qingguo,ALALEWI Aamr,LU Junhe

《环境科学与工程前沿（英文）》 2014年第8卷第3期页码 372-378 doi: 10.1007/s11783-013-0567-3

摘要： The removal of 17β-estradiol (E2) in laccase catalyzed oxidative coupling processes was systematically studied in this work. We focused on the influence of pH and natural organic matter (NOM) on the performance of the enzymatic treatment processes. It was found that the optimal pH for E2 removal was between 4 and 6. The removal of E2 was slightly inhibited in the presence of NOM. Enzymatic transformation of E2 was second-order in kinetics with first-order to both the concentrations of the enzyme and contaminant. Mass spectrum (MS) analysis suggested that coupling products were formed through radical-radical coupling mechanism. The results of this study demonstrated that laccase catalyzed oxidative coupling process could potentially serve as a treatment strategy to control steroid estrogens.

关键词： 17β-estradiol laccase oxidative coupling processes kinetics mechanisms

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Effect of biochar amendment on soil’s retention capacity for estrogenic hormones from poultry manure treatment

Sukhjot MANN, Zhiming QI, Shiv O. PRASHER, Lanhai LI, Dongwei GUI, Qianjing JIANG

《农业科学与工程前沿（英文）》 2017年第4卷第2期页码 208-219 doi: 10.15302/J-FASE-2017138

摘要： Most animals, including humans, produce natural sex hormones such as estrogens: 17β-estradiol (E2) and estrone (E1). These compounds are able to disrupt the reproductive systems of living organisms at trace concentrations (ng·L ). This experiment tests the hypothesis that 1% slow pyrolysis biochar-amended sandy soil could retain significant amount of estrogens (E1, E2) from poultry manure in its second year of application. The experiment was conducted over 46 days and consisted of a series of lysimeters containing sandy soil with biochar-amended topsoil. The application rate of poultry manure was kept at 2.47 kg·m . The biochar held a significant concentration of hormone during the first year of its application. However, in the following year (current study), there was no significant retention of hormones in the biochar-amended soil. During the first year after application, the biochar was fresh, so its pores were available for hydrophobic interactions and held significant concentration of hormones. As time passed there were several biotic and abiotic changes on the surface of the biochar so that after some physical fragmentation, pores on the surface were no longer available for hydrophobic interactions. The biochar started releasing dissolved organic carbon, which facilitated greater mobility of hormones from poultry manure down the soil profile.

关键词： adsorption degradation dissolved organic carbon 17β-estradiol (E2) estrone (E1)

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Th17 Cells in autoimmune diseases

null

《医学前沿（英文）》 2015年第9卷第1期页码 10-19 doi: 10.1007/s11684-015-0388-9

摘要：

Th17 cells are a new subset of CD4⁺ T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sj?gren’s syndrome, inflammatory bowel disease, and multiple sclerosis.

关键词： IL-17 Th17 cells RORγt autoimmune diseases posttranslational modification inhibitors

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Relationship between Th17 cells and allograft rejection

Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,

《医学前沿（英文）》 2009年第3卷第4期页码 491-494 doi: 10.1007/s11684-009-0066-x

摘要： Thl7 cells, a special kind of auxiliary type T cells, can secrete IL-17A, IL-17F, IL-21, IL-22, etc., as a newly discovered T-cell subset in recent years. As a different subset from the Thl and Th2 cells, Th17 cells play an important role in the development of a variety of autoimmune diseases. A current study shows that the IL-6 inflammatory response of the organization in combination with the occurrence of TGF-β can induce the differentiation of Thl7 cells. IL-23 can promote the production of IL17, as well as participate in amplification and maintenance of the survival of IL-l7 generating cells. In this process, STAT3 and ROR-γt are key transcription factors for the growing of Thl7 cells. As our knowledge on Th17 family members is rapidly growing and changing, it will be important to specify their involvement in the induction and regulation of allograft rejection in animal models as well as in clinical settings. Herein, we review the key features of Th17 cells and discuss their potential relevance to transplantation immunity.

关键词： TH17 cells regulation allograft rejection

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sources of dissolved organic matter from wastewater treatment plants and their mediation effect on 17α-ethinylestradiol

《环境科学与工程前沿（英文）》 2023年第17卷第6期 doi: 10.1007/s11783-023-1669-1

摘要：

● EE2 photodegradation behavior in the presence of four WWTPs’ DOM was explored.

关键词： Photosensitivity sources 17α-ethinylestradiol Photodegradation Dissolved organic matter Wastewater treatment plants

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Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th

Michela CIGOLA,Yibing FANG

《机械工程前沿（英文）》 2016年第11卷第1期页码 3-11 doi: 10.1007/s11465-015-0359-5

摘要：

This study aims to investigate the role played by Xu Guangqi (1562–1633), minister of the Ming Dynasty, in the development of European scientific and technical knowledge in China between the 16th and 17th centuries by analyzing a book of Western technology that he wrote, namely, Taixi Shuifa (On Western Hydraulics). Several Western books related to machine knowledge are searched to trace the source of the illustrations in Taixi Shuifa. We found that Archimedes’ screw and Ctesibius’ machine, which are included in Vitruvius’ De Architectura volumes, also appear in the work of Xu Guangqi.

关键词： Vitruvius’ De Architectura Xu Guangqi’s Taixi Shuifa Jesuit missionaries Italian Renaissance drawing representation

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利用cyp17a1缺失的伪雄鲤成功构建全雌鲤群体 Article

翟刚, 舒婷婷, 陈贶新, 娄气永, 贾景怡, 黄建飞, 石闯 , 金霞, 贺江燕, 姜冬火, 钱雪桥, 胡炜, 殷战

《工程（英文）》 2022年第8卷第1期页码 181-189 doi: 10.1016/j.eng.2021.03.026

摘要：本研究针对雌鲤生长快于雄鲤的两性生长异形的特性，以cyp17a1 为靶点进行了CRISPR/Cas9介导的基因编辑操作，利用cyp17a1 敲除后形成的伪雄鲤，成功构建了全雌鲤群体首先，我们发现无论遗传性别型为XX还是XY，其cyp17a1 缺失鲤个体性腺均发育为精巢，并能正常产精。其次，利用确定的雄性特异DNA分子标记，筛选到cyp17a1 ^-/- XX伪雄个体，其具有正常的精巢发育和精子发生。将全雌群体和对照组雌雄混合群体各500 尾进行同塘生长对比养殖，至8 月龄或12 月龄时随机抽样检测，发现cyp17a1杂合突变雌鲤体重比同塘性别混养对照组分别高6.60%或32.66%

关键词：鲤两性异形生长 cyp17a1 性类固醇激素全雌群体

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17–26.5 GHz 42.5 dBm宽带高效率GaN功率放大器设计 Correspondences

黎明1,2,李智群1,3,郑权2,蔺兰峰2,陶洪琪2

《信息与电子工程前沿（英文）》 2022年第23卷第2期页码 346-350 doi: 10.1631/FITEE.2000513

摘要：该功率放大器采用0.15 μm栅长GaN-HEMT工艺，其工作频段可以覆盖整个K频段，即17–26.5 GHz。该功率放大器采用三级放大拓扑结构，在连续波条件下，测试结果表明，在17–26.5 GHz频带范围内饱和输出功率超过42.5 dBm，平均PAE为30%，在19.8 GHz时PAE达到最大，为32.1%，

关键词： K波段；高效率；宽带；氮化镓（GaN）；功率放大器

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U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen

Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang

《环境科学与工程前沿（英文）》 2016年第10卷第6期 doi: 10.1007/s11783-016-0880-8

摘要： Estrogen regulates miRNA expression in a typical U-shaped dose-response pattern. E2 can regulate in the ventral prostate. Mouse ventral prostate is most sensitive to estrogen. Nonmonotonic dose-response in prostate could be a component of estrogen signature. Many studies have focused on environmental estrogen-related diseases. However, no consistent gene markers or signatures for estrogenicity have been discovered in mammals. This study investigated the estrogenic effects of 17β-estradiol on the prostate in immature male mice. Consistent U-shaped responses were seen in bodyweight, ventral prostate epithelial morphology, and miRNA expression levels. Specifically, most estradiol regulated miRNAs were downregulated at low doses of estradiol (0.2 and 2 mg·kg ), and whose expression returned to the control level at a larger dose (200 mg·kg ). The function of these regulated miRNAs is related to the prostate cancer and PI3K-Akt signaling pathways, which is consistent with the function of estradiol. Furthermore, the miRNA-processing machinery, Drosha, in the prostate was also regulated in a similar pattern, which could be a part of the U-shaped miRNA expression mechanism. All of these data indicate that the prostate is a reliable organ for evaluating estrogenic activity and that the typical nonmonotonic dose-response relationship could be used as a novel biomarker for estrogenicity.

关键词： miRNA Prostate Estradiol Nonmonotonic dose-response Estrogenicity Drosha

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Isolation and characterization of a bacterial strain that efficiently degrades sex steroid hormones

JI Shulan, LIU Zhipeng, REN Haiyan, LIU Zhipei

《环境科学与工程前沿（英文）》 2007年第1卷第3期页码 325-328 doi: 10.1007/s11783-007-0055-8

摘要： A bacterial strain, ZY3, growing on sex steroid hormones as the sole source of carbon and energy was isolated from the sewage treatment plant of a prophylactic steroids factory. ZY3 degrades the 3-methoxy-17-hydroxy-1,3,5(10),8(9)--4-estren (MHE). This strain was preliminarily identified as sp. ZY3 according to its morphology and its 16S rRNA gene sequence. During the experimental period (72 h), the optimum temperature, pH and 3-MHE concentration for the degradation of hydride by the strain ZY3 were 35vH, 10 and 10 mg/L, respectively. The degradation rate of the sex steroid hormones increased to 87% and 85% after the addition of maltose and peptone, respectively.

关键词： maltose optimum temperature prophylactic 3-methoxy-17-hydroxy-1 3 5 addition

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Kinetics of enhanced adsorption by polarization for organic pollutants on activated carbon fiber

HAN Yanhe, QUAN Xie, ZHAO Huimin, CHEN Shuo, ZHAO Yazhi

《环境科学与工程前沿（英文）》 2007年第1卷第1期页码 83-88 doi: 10.1007/s11783-007-0016-2

摘要： The adsorption kinetics for model pollutants on activated carbon fiber (ACF) by polarization was investigated in this work. Kinetics data obtained for the adsorption of these model pollutants at open-circuit, 400 mV, and -400 mV polarization were applied to the Lagergren equation, and adsorption rate constants () were determined. With the anodic polarization of 400 mV, the capacity of sodium phenoxide was increased from 0.0083 mmol/g at open-circuit to 0.18 mmol/g, and a 17-fold enhancement was achieved; however, the capacity of -nitrophenol was decreased from 2.93 mmol/g at open-circuit to 2.65 mmol/g. With the cathodal polarization of -400 mV, the capacity of aniline was improved from 3.60 mmol/g at open-circuit to 3.88 mmol/g; however, the capacity of sodium dodecylbenzene sulfonate was reduced from 2.20 mmol/g at open-circuit to 1.59 mmol/g. The enhancement for electrosorption changed with dif ferent groups substituting. Anodic polarization enhances the adsorption of benzene with the electron-donating group. But whether anodic or not, cathodal polarization had less effect on the adsorption of electron-accepting aromatic compounds, and decreased the adsorption capacity of benzene-bearing donor-conjugate bridge-acceptor, while increasing its adsorption rate. Electrostatic interaction played a very important role in the electrosorption of ion-pollutants.

关键词： ACF activated 17-fold enhancement donor-conjugate bridge-acceptor Electrostatic interaction

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Deep reinforcement learning: a survey

Yi-yun Zhang, Da-wei Feng, Feng Huang, Dong-sheng Li, Yi-ming Zhang,wanghaonan14@nudt.edu.cn,liuning17a

《信息与电子工程前沿（英文）》 2020年第21卷第12期页码 1671-1814 doi: 10.1631/FITEE.1900533

摘要： Deep (RL) has become one of the most popular topics in artificial intelligence research. It has been widely used in various fields, such as end-to-end control, robotic control, recommendation systems, and natural language dialogue systems. In this survey, we systematically categorize the deep RL algorithms and applications, and provide a detailed review over existing deep RL algorithms by dividing them into model-based methods, model-free methods, and advanced RL methods. We thoroughly analyze the advances including exploration, inverse RL, and transfer RL. Finally, we outline the current representative applications, and analyze four open problems for future research.

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Label-free colorimetric nanosensor with improved sensitivity for Pb

Abdul Ghaffar Memon, Xiaohong Zhou, Yunpeng Xing, Ruoyu Wang, Lanhua Liu, Mohsin Khan, Miao He

《环境科学与工程前沿（英文）》 2019年第13卷第1期 doi: 10.1007/s11783-019-1094-7

摘要：

• Unmodified-AuNP based, colorimetric nanosensor was constructed for Pb²⁺ detection.

• 5-nucleotide truncation in DNAzyme made complete substrate detachment upon Pb²⁺.

• Ultrasensitive and selective detection of Lead (II) was achieved with 0.2×10^-⁹ mol/L LOD.

关键词： Colorimetric nanosensor Truncated 8–17 DNAzyme Pb²⁺ detection Unmodified AuNPs

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17th International Congress of Immunology

会议日期： 2019年10月19日

会议地点：中国/北京/朝阳

主办单位：国际免疫学联合会；中国免疫学会

HCG注射日血清雌孕激素对试管婴儿妊娠结局的影响

周丹妮,杨菁,吴庚香,李赛姣,余楠,赵萌,文妍琪

《中国工程科学》 2014年第16卷第5期页码 79-84

摘要：

探究体外受精—胚胎移植/单精子卵泡浆内注射-胚胎移植（IVF/ICSI）患者注射人绒毛膜促性腺激素（HCG）日血清雌孕激素水平对妊娠结局的影响。回顾分析武汉大学人民医院生殖医学中心2011 年9 月—2012 年9 月符合相关条件行IVF的新鲜周期患者1 270 例，按血清孕酮值将其分为两组进行比较，低孕酮组HCG日血清孕酮值<2.0 pg/mL，高孕酮组HCG日血清孕酮值≥2.0 pg/mL；再按照孕酮与雌二醇比值（P/E2）分为两组，以0.6 作为P/E2切点。比较两组间的女方年龄、不孕年限、基础卵泡刺激素（FSH）值、促性腺激素（Gn）天数、Gn用量、获卵数、MII 卵数、受精数、卵裂数、优胚数、移植数、E2值、临床妊娠率、胚胎着床率。高孕酮组Gn天数、Gn用量、获卵数、MII数、卵裂数、E2值增加，但临床妊娠率、胚胎着床率减少；高P/E2比值组女方年龄、基础FSH、Gn 天数、Gn 用量、获卵数、受精数、优胚数、P 值均增加，妊娠结局无明显差异。HCG注射日血清孕酮水平过高会降低临床妊娠率及胚胎着床率。

关键词：孕酮值 HCG日 IVF/ICSI 新鲜周期临床妊娠率