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期刊论文 43

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Pm21 1

Pm40 1

CMAQ模型 1

Halbach阵列 1

PM2.5 1

PM2.5脱除 1

PM_2.5 1

PM_2.52.5浓度聚类 1

PM_2.52.5浓度预测 1

低碳发展 1

信息速度 1

内源抗性 1

区域传输 1

外源基因 1

多步预测 1

多轴差分吸收光谱仪 1

大气年龄 1

大气污染治理 1

大气污染；PM2.5；臭氧；气候变化；空气质量改善 1

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抗白粉病基因 Pm40 在我国“后 Pm21 时代”小麦育种中的重要作用 Perspective

唐圣雯,胡玉亭,钟胜福,罗培高

《工程（英文）》 2018年第4卷第4期页码 500-506 doi: 10.1016/j.eng.2018.06.004

摘要：最近，在一些地方发现了对Pm21 有毒的Bgt，虽然这些菌株的病理学特性还有待研究，但这一现象提醒小麦育种者应注意应用Pm21 的风险。来源于普通小麦与中间偃麦草（Thinopyrum intermedium）杂种后代的抗白粉病基因Pm40，被定位在小麦7BS 染色体上，对Bgt 具有广谱和持久的抗性通过细胞学研究，并未在Pm40 的载体品种中发现大片段外缘染色体。过去几年的研究发现，Pm40 的载体品种具有优良的农艺性状。因此，我们相信在未来的育种工程中，Pm40 将会在Pm21 的抗性被克服之后起巨大的作用。另外，Pm21 和Pm40 都来源于外缘物种，这暗示着外源基因的抗性可能比小麦本身的基因更为持久和有效。

关键词：小麦白粉病 Pm21 Pm40 外源基因内源抗性

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

《医学前沿（英文）》 doi: 10.1007/s11684-023-0996-8

摘要： OX40 is a costimulatory receptor that is expressed primarily on activated CD4⁺, CD8⁺, and regulatory T cells. The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activation and also promotes dendritic cells to mature to enhance their cytokine production. Therefore, the use of agonistic anti-OX40 antibodies for cancer immunotherapy has gained great interest. However, most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy. Here, we discovered that BGB-A445, a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation, induced optimal T cell activation without impairing dendritic cell function. In addition, BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity. In the MC38 syngeneic model established in humanized OX40 knock-in mice, BGB-A445 demonstrated robust and dose-dependent antitumor efficacy, whereas the ligand-competitive anti-OX40 antibody showed antitumor efficacy characterized by a hook effect. Furthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody. Taken together, our findings show that BGB-A445, which does not block OX40–OX40L interaction in contrast to clinical-stage anti-OX40 antibodies, shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation.

关键词： BGB-A445 OX40 agonistic antibody OX40L noncompetitive

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一种融合多特征聚类与神经网络的PM_2.5小时浓度预测新模型及其在中国城市的应用 Article

刘辉, 龙治豪, 段铸, 施惠鹏

《工程（英文）》 2020年第6卷第8期页码 944-956 doi: 10.1016/j.eng.2020.05.009

摘要：

PM_2.5浓度预测对空气污染物早期预警具有重要意义。本文提出一种改进的PM_2.5浓度多步预测模型，即多特征聚类分解(MCD)-回声状态网络(ESN)-粒子群优化(PSO)混合模型。该模型包括分解预测部分和优化预测部分。在MCD方法中，采用RSAR算法选择重要的空气污染物变量，使用KC算法对所得变量进行聚类，利用EWT算法将PM_2.5浓度序列的聚类结果分解为多个子层。利用我国4个不同城市的真实PM_2.5浓度数据，验证了所提出模型的有效性。实验结果表明，所提出预测模型适用于PM_2.5浓度的多步高精度预测，具有比基准模型更优的预测性能。

关键词： PM_2.52.5浓度预测 PM_2.52.5浓度聚类经验小波分解多步预测

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Diverse bacterial populations of PM in urban and suburb Shanghai, China

《环境科学与工程前沿（英文）》 2021年第15卷第3期 doi: 10.1007/s11783-020-1329-7

摘要：

• Urban aerosols harbour diverse bacterial communities in Shanghai.

关键词： PM_2.5 Bacteria 16S rRNA SEM analysis Shanghai City

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

《医学前沿（英文）》 2023年第17卷第2期页码 240-262 doi: 10.1007/s11684-022-0936-z

摘要： Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

关键词： glioma progression molecular classification EM/PM subtyping intratumor heterogeneity

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Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

《环境科学与工程前沿（英文）》 2021年第15卷第5期 doi: 10.1007/s11783-020-1376-0

摘要：

•Annual mean PM_2.5 in Shijiazhuang were 87, 95, and 82 µg/m³ in 2015–2017.

关键词： PM_2.5 Health effects Integrated exposure-response model Shijiazhuang

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Local and regional contributions to PM in the Beijing 2022 Winter Olympics infrastructure areas during

《环境科学与工程前沿（英文）》 2021年第15卷第6期 doi: 10.1007/s11783-021-1434-2

摘要：

• Regional transportation contributed more than local emissions during haze episodes.

关键词： 2022 Winter Olympics PM_2.5 Source apportionment

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PM2.5 over North China based on MODIS AOD and effect of meteorological elements during 2003‒2015

Youfang Chen, Yimin Zhou, Xinyi Zhao

《环境科学与工程前沿（英文）》 2020年第14卷第2期 doi: 10.1007/s11783-019-1202-8

摘要： The Taihang Mountains was the boundary between high and low pollution areas. There were one high value center for PM2.5 pollution and two low value centers. In 2004, 2009 and after 2013, PM2.5 concentration was relatively low. Over the past 40 years, PM2.5 pollution in North China has become increasingly serious and progressively exposes the densely populated areas to pollutants. However, due to limited ground data, it is challenging to estimate accurate PM2.5 exposure levels, further making it unfavorable for the prediction and prevention of PM2.5 pollutions. This paper therefore uses the mixed effect model to estimate daily PM2.5 concentrations of North China between 2003 and 2015 with ground observation data and MODIS AOD satellite data. The tempo-spatial characteristics of PM2.5 and the influence of meteorological elements on PM2.5 is discussed with EOF and canonical correlation analysis respectively. Results show that overall R2 is 0.36 and the root mean squared predicted error was 30.1 μg/m3 for the model prediction. Our time series analysis showed that, the Taihang Mountains acted as a boundary between the high and low pollution areas in North China; while the northern part of Henan Province, the southern part of Hebei Province and the western part of Shandong Province were the most polluted areas. Although, in 2004, 2009 and dates after 2013, PM2.5 concentrations were relatively low. Meteorological/topography conditions, that include high surface humidity of area in the range of 34°‒40°N and 119°‒124°E, relatively low boundary layer heights, and southerly and easterly winds from the east and north area were common factors attributed to haze in the most polluted area. Overall, the spatial distribution of increasingly concentrated PM2.5 pollution in North China are consistent with the local emission level, unfavorable meteorological conditions and topographic changes.

关键词： Aerosol optical depth PM_2.5 MODIS Mixed effect model Canonical correlation analysis

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燃煤电站烟气污染物深度脱除技术的分析

张晓鲁

《中国工程科学》 2014年第16卷第10期页码 47-51

摘要：

近年来雾霾天气的频繁出现使得细颗粒物（PM_2.5）成为了公众关注的热点，PM2.5的控制也已增加到2012 年发布的《环境空气质量标准》中，而目前我国现有的烟气污染物控制技术难以脱除PM_2.5，因此，为深度脱除PM_2.5、SO₂、SO_{3PM_2.5脱除技术、全负荷下超超临界锅炉的低NO_x排放以及SCR工作温度的适应性}

关键词：燃煤机组烟气污染物深度脱除 PM2.5脱除

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乘坐21 世纪40 年代的高铁旅行而归

Ignacio Barron

《工程（英文）》 2016年第2卷第3期页码 292-293 doi: 10.1016/J.ENG.2016.03.020

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PM concentration declining saves health expenditure in China

《环境科学与工程前沿（英文）》 2023年第17卷第7期 doi: 10.1007/s11783-023-1690-4

摘要：

● Monthly hospitalization expenses are sensitive to increases in PM_2.5 exposure.

关键词： Air pollution Health expenditure PM_2.5 concentration Economic impact Heterogeneous effect

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我国京津冀和西北五省（自治区）大气环境容量研究

郝吉明,许嘉钰,吴剑,马乔

《中国工程科学》 2017年第19卷第4期页码 13-19 doi: 10.15302/J-SSCAE-2017.04.003

摘要：利用GEOS-Chem全球大气化学传输模式模拟计算大气污染源排放所带来的环境空气中污染物的浓度，以京津冀和西北五省（自治区）的网格平均地面PM2.5年均浓度达到环境空气质量标准（GB3095—2012）为约束条件，确定出京津冀和西北五省（自治区）SO2、NOx、一次PM2.5、VOCs和NH3五种大气污染物环境容量。结果表明，2013年京津冀和西北五省（自治区）SO2、NOx、一次PM2.5、VOCs和NH3五种大气污染物的排放量均超出大气环境容量。

关键词： PM2.5 空气质量环境容量

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“通过肠道菌群增强临床功效：中药的新领域”的勘误[工程5（2019）40–49] Corrigendum

Yan-Meng Lu, Jiao-Jiao Xie, Cong-Gao Peng, Bao-Hong Wang, Kai-Cen Wang, Lan-Juan Li

《工程（英文）》 2019年第5卷第4期页码 811-812 doi: 10.1016/j.eng.2019.05.004

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大气悬浮颗粒PM₁₀对感烟火灾探测器本底效应研究

谢启源,袁宏永,蒋亚龙

《中国工程科学》 2003年第5卷第6期页码 84-87

摘要：

针对大气污染引起的悬浮颗粒,尤其是可吸入颗粒（PM₁₀）对感烟火灾探测器产生的本底效应进行了分析，并以离子型感烟探测器为例对本底值进行计算，通过比较，显示不同程度的大气颗粒物污染对感烟探测器本底影响的差异极小

关键词：悬浮颗粒火灾探测本底效应

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PM₁₀ emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

《环境科学与工程前沿（英文）》 2017年第11卷第6期 doi: 10.1007/s11783-017-0966-y

摘要： Industrial coal-fired boiler is an important air pollutant emission source in China. The chain-grate boiler is the most extensively used type of industrial coal-fired boiler. An electrical low-pressure impactor, and a Dekati Low Pressure Impactor were applied to determine mass and number size distributions of PM at the inlet and the outlet of the particulate emission control devices at six coal-fired chain-grate boilers. The mass size distribution of PM generated from coal-fired chain-grate boilers generally displays a bimodal distribution that contains a submicron mode and a coarse mode. The PM in the submicron mode for burning with raw coal contributes to 33%±10 % of PM emissions, much higher than those for pulverized boilers. And the PM in the submicron mode for burning with briquette contributes up to 86 % of PM emissions. Multiclones and scrubbers are not efficient for controlling PM emission. Their average collection efficiencies for sub-micron particle and super-micron particle are 34% and 78%, respectively. Operating conditions of industrial steam boilers have influence on PM generation. Peak of the submicron mode during normal operation period is larger than the start-up period.

关键词： coal-fired chain-grate boiler PM₁₀ size distribution particulate emission control devices size-dependent collection efficiency