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抗白粉病基因 Pm40 在我国“后 Pm21 时代”小麦育种中的重要作用 Perspective

唐圣雯,胡玉亭,钟胜福,罗培高

《工程（英文）》 2018年第4卷第4期页码 500-506 doi: 10.1016/j.eng.2018.06.004

摘要： 20 世纪80 年代，通过簇毛麦（Heuchera villosa）的6VS 染色体与小麦6AL 染色体易位将抗白粉病基因Pm21 转移到普通小麦中。最近，在一些地方发现了对Pm21 有毒的Bgt，虽然这些菌株的病理学特性还有待研究，但这一现象提醒小麦育种者应注意应用Pm21 的风险。通过细胞学研究，并未在Pm40 的载体品种中发现大片段外缘染色体。过去几年的研究发现，Pm40 的载体品种具有优良的农艺性状。因此，我们相信在未来的育种工程中，Pm40 将会在Pm21 的抗性被克服之后起巨大的作用。另外，Pm21 和Pm40 都来源于外缘物种，这暗示着外源基因的抗性可能比小麦本身的基因更为持久和有效。

关键词：小麦白粉病 Pm21 Pm40 外源基因内源抗性

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一种融合多特征聚类与神经网络的PM_2.5小时浓度预测新模型及其在中国城市的应用 Article

刘辉, 龙治豪, 段铸, 施惠鹏

《工程（英文）》 2020年第6卷第8期页码 944-956 doi: 10.1016/j.eng.2020.05.009

摘要：

PM_2.5浓度预测对空气污染物早期预警具有重要意义。本文提出一种改进的PM_2.5浓度多步预测模型，即多特征聚类分解(MCD)-回声状态网络(ESN)-粒子群优化(PSO)混合模型。该模型包括分解预测部分和优化预测部分。在MCD方法中，采用RSAR算法选择重要的空气污染物变量，使用KC算法对所得变量进行聚类，利用EWT算法将PM_2.5浓度序列的聚类结果分解为多个子层。利用我国4个不同城市的真实PM_2.5浓度数据，验证了所提出模型的有效性。实验结果表明，所提出预测模型适用于PM_2.5浓度的多步高精度预测，具有比基准模型更优的预测性能。

关键词： PM_2.52.5浓度预测 PM_2.52.5浓度聚类经验小波分解多步预测

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Diverse bacterial populations of PM in urban and suburb Shanghai, China

《环境科学与工程前沿（英文）》 2021年第15卷第3期 doi: 10.1007/s11783-020-1329-7

摘要：

• Urban aerosols harbour diverse bacterial communities in Shanghai.

关键词： PM_2.5 Bacteria 16S rRNA SEM analysis Shanghai City

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

《医学前沿（英文）》 2023年第17卷第2期页码 240-262 doi: 10.1007/s11684-022-0936-z

摘要： Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

关键词： glioma progression molecular classification EM/PM subtyping intratumor heterogeneity

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Temporal variation of PM-associated health effects in Shijiazhuang, Hebei

《环境科学与工程前沿（英文）》 2021年第15卷第5期 doi: 10.1007/s11783-020-1376-0

摘要：

•Annual mean PM_2.5 in Shijiazhuang were 87, 95, and 82 µg/m³ in 2015–2017.

关键词： PM_2.5 Health effects Integrated exposure-response model Shijiazhuang

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面向21世纪的中国林业遥感

赵宪文

《中国工程科学》 1999年第1卷第3期页码 16-21

摘要：对21世纪中国林业遥感前景进行了展望。作者认为下一个世纪中国林业遥感发展的主要方向是：包容各种新技术，形成新的技术体系，并与国际接轨；利用遥感的优势，研究森林的宏观状况与作用；与森林经营进一步结合。

关键词：林业遥感持续发展 21世纪

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Local and regional contributions to PM in the Beijing 2022 Winter Olympics infrastructure areas during

《环境科学与工程前沿（英文）》 2021年第15卷第6期 doi: 10.1007/s11783-021-1434-2

摘要：

• Regional transportation contributed more than local emissions during haze episodes.

关键词： 2022 Winter Olympics PM_2.5 Source apportionment

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

《医学前沿（英文）》 2013年第7卷第1期页码 25-30 doi: 10.1007/s11684-013-0244-8

摘要：

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.

关键词： FGF21 metabolism pharmacology physiology clinical relevance

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21世纪油气工业发展刍议

陈俊武

《中国工程科学》 2000年第2卷第4期页码 21-24

摘要：文章从世界能源消费不断增长的社会发展需求出发，考虑日益苛刻的环境保护政策和举世关心的可持续发展的战略方针，结合今后科学技术的进展，分别从产品需求和资源供应、产品规格和环境保护、非常规石油进入角色及天然气前景引人瞩目四个专题进行论述，对21

关键词： 21世纪石油天然气油气工业

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PM2.5 over North China based on MODIS AOD and effect of meteorological elements during 2003‒2015

Youfang Chen, Yimin Zhou, Xinyi Zhao

《环境科学与工程前沿（英文）》 2020年第14卷第2期 doi: 10.1007/s11783-019-1202-8

摘要： The Taihang Mountains was the boundary between high and low pollution areas. There were one high value center for PM2.5 pollution and two low value centers. In 2004, 2009 and after 2013, PM2.5 concentration was relatively low. Over the past 40 years, PM2.5 pollution in North China has become increasingly serious and progressively exposes the densely populated areas to pollutants. However, due to limited ground data, it is challenging to estimate accurate PM2.5 exposure levels, further making it unfavorable for the prediction and prevention of PM2.5 pollutions. This paper therefore uses the mixed effect model to estimate daily PM2.5 concentrations of North China between 2003 and 2015 with ground observation data and MODIS AOD satellite data. The tempo-spatial characteristics of PM2.5 and the influence of meteorological elements on PM2.5 is discussed with EOF and canonical correlation analysis respectively. Results show that overall R2 is 0.36 and the root mean squared predicted error was 30.1 μg/m3 for the model prediction. Our time series analysis showed that, the Taihang Mountains acted as a boundary between the high and low pollution areas in North China; while the northern part of Henan Province, the southern part of Hebei Province and the western part of Shandong Province were the most polluted areas. Although, in 2004, 2009 and dates after 2013, PM2.5 concentrations were relatively low. Meteorological/topography conditions, that include high surface humidity of area in the range of 34°‒40°N and 119°‒124°E, relatively low boundary layer heights, and southerly and easterly winds from the east and north area were common factors attributed to haze in the most polluted area. Overall, the spatial distribution of increasingly concentrated PM2.5 pollution in North China are consistent with the local emission level, unfavorable meteorological conditions and topographic changes.

关键词： Aerosol optical depth PM_2.5 MODIS Mixed effect model Canonical correlation analysis

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燃煤电站烟气污染物深度脱除技术的分析

张晓鲁

《中国工程科学》 2014年第16卷第10期页码 47-51

摘要：

近年来雾霾天气的频繁出现使得细颗粒物（PM_2.5）成为了公众关注的热点，PM2.5的控制也已增加到2012 年发布的《环境空气质量标准》中，而目前我国现有的烟气污染物控制技术难以脱除PM_2.5，因此，为深度脱除PM_2.5、SO₂、SO_{3PM_2.5脱除技术、全负荷下超超临界锅炉的低NO_x排放以及SCR工作温度的适应性}

关键词：燃煤机组烟气污染物深度脱除 PM2.5脱除

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21世纪人类生活与生存的科技

蒋正华

《中国工程科学》 2002年第4卷第4期页码 1-11

摘要：

从管理学角度回顾了过去百年的世界历史，研究新世纪可能发生的进步，并探讨更好地建立世界和平与合作，实现共同发展的方案。

关键词： 21世纪科技进步人类生活与生存

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Digital manufacturing—the development direction of the manufacturing technology in the 21st century

XIONG You-lun, YIN Zhou-ping

《机械工程前沿（英文）》 2006年第1卷第2期页码 125-130 doi: 10.1007/s11465-006-0021-3

摘要： After introducing the concepts of digital manufacturing technology, the discipline framework of digital manufacturing is presented in the paper by discussing its basic concept, theory foundation, key technology and scientific problems in detail. As the core of the advanced manufacturing technology, digital manufacturing is gradually becoming the main manufacturing technology of the twenty-first century. Firstly, the main features of digital manufacturing are indicated and its key supporting technologies are investigated by grouping them into four levels related to product development, numerical control, production management, and enterprise collaboration, respectively. Moreover, the existing problems in the research on the multi-discipline theory foundation of digital manufacturing such as manufacturing informatics, computational manufacturing, and manufacturing intelligence, are also indicated. Then, the core scientific problems of digital manufacturing are discussed in depth, which focuses on digitization of manufacturing information, modeling of manufacturing constraints, high-speed and high-precision numerical control theory, and Internet-based collaboration and integration. Lastly, the development trends and application perspectives of digital manufacturing are concluded.

关键词： development foundation multi-discipline scientific supporting