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期刊论文 19

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HY-2A卫星 1

中国铁路企业 1

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国际竞争力 1

在轨工作 1

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多圈层相互作用过程 1

妇女病 1

子宫颈癌 1

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惯性神经网络；反周期解；全局指数稳定；脉冲；时变延迟；双向联想记忆 1

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Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

《医学前沿（英文）》 2021年 第15卷 第6期   页码 903-912 doi: 10.1007/s11684-021-0871-4

摘要： A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ≥15.0 µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY (≥15.0 µmol/L). Finally, 110 551 residents ≥40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9 µmol/L (interquartile range 7.9–15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338–2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.

关键词： homocysteine     hyperhomocysteinemia     H-type hypertension     Chinese    

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Joint slip investigation based on finite element modelling verified by experimental results on wind turbine

Saleh YAGHOOBI, Ahmad SHOOSHTARI

《结构与土木工程前沿（英文）》 2018年 第12卷 第3期   页码 341-351 doi: 10.1007/s11709-017-0393-y

摘要：

Slippage corresponds to the relative displacement of a bolted joint subjected to shear loads since the construction clearance between the bolt shank and the bolthole at assembly can cause joint slip. Deflections of towers with joint slippage effects is up to 1.9 times greater than the displacements obtained by linear analytical methods. In this study, 8 different types of joints are modelled and studied in the finite element program, and the results are verified by the experimental results which have been done in the laboratory. Moreover, several types of joints have been modelled and studied and load-deformation curves have also been presented. Finally, joint slip data for different types of angles, bolt diameter and bolt arrangements are generated. Thereupon, damping ratios (z) for different types of connections are reported. The study can be useful to help in designing of wind turbine towers with a higher level of accuracy and safety.

关键词： Joint slip     cyclic loading     Finite element modelling     Experimental joint behavior     damping ratios (   

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重大装备研发成果转化为生产力的理论与实践

张晓鲁

《中国工程科学》 2011年 第13卷 第8期   页码 50-54

摘要：

从发电企业的科技研发与工程应用特点着手，阐述了重大装备研发成果转化为生产力的理论分析和组织方法。作者面对广泛存在的科技研发到成果应用旷日持久、难以推进的普遍问题，推行“用户主导，产学研联合”，“以示范工程的商业化实施为导向、以工程项目管理的责任体系为前提、集中全国的优势力量联合攻关，形成企业负责，研究机构支撑”的重大装备研发管理思路，探索了“研发与推广同步”的成果推广模式。用2个案例阐述了这种科研管理方法取得的成效，其中“超超临界燃煤发电技术”在电力发展中得到广泛应用，成为我国新建大型燃煤电厂的首选技术；“火电机组空冷系统研发与工程示范”项目解决了我国北方地区发电厂的节水问题。笔者还剖析了在科研成果所属权和成果认定过程中存在的问题，并提出了相应建议。

关键词： 研发     重大装备     产学研联合     成果转化     管理    

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Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 470-474 doi: 10.1007/s11684-009-0077-7

摘要： The aim of this paper was to observe the clinical effect of gentamycin combined with sodium bicarbonate for the prevention of irinotecan-induced diarrhea. A total of 98 patients with stage IV cancers were recruited and divided into a prevention group (52 patients) and a control group (46 patients). All patients received the chemotherapy including irinotecan. The prevention group received gentamycin and sodium bicarbonate before the use of irinotecan for 4 days; the control group did not receive any prevention. The use of gentamycin and sodium bicarbonate resulted in significantly higher stool pH ( < 0.001), while the incidence of diarrhea by irinotecan was reduced (prevention group 13.70% control group 34.83%; < 0.001). Gentamycin combined with sodium bicarbonate appears to be useful in preventing the diarrhea induced by irinotecan and reducing the dosage of loperamide and fluid replacement.

关键词： irinotecan     diarrhea     gentamycin     sodium bicarbonate     prevention    

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improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results

《医学前沿（英文）》   页码 878-888 doi: 10.1007/s11684-023-0993-y

摘要： Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from prospective skin cancer centers and the German national skin cancer registry (ADOReg) of the German Dermatologic Cooperative Oncology Group (DeCOG). Two cohorts were compared: patients with LDT (cohort A, n = 78) versus those without LDT (cohort B, n = 104). Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (OS). The median OS was significantly longer in cohort A than in cohort B (20.1 vs. 13.8 months; P = 0.0016) and a trend towards improved PFS was observed for cohort A (3.0 vs. 2.5 months; P = 0.054). The objective response rate to any ICB (16.7% vs. 3.8%, P = 0.0073) and combined ICB (14.1% vs. 4.5%, P = 0.017) was more favorable in cohort A. Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM.

关键词： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

《医学前沿（英文）》 2010年 第4卷 第1期   页码 67-70 doi: 10.1007/s11684-010-0023-8

摘要： A community-based multi-center randomized controlled trial was conducted to evaluate the effectiveness of blood pressure control for hypertension patients in communities in urban Shanghai by integrated intervention. At present, patients (=1395) from four communities have completed follow-up for one year, including the intervention group (=921) and usual care group (=474). The intervention programs included disease management by a care manager. Blood pressure of each patient was measured regularly. Compared with the control group, the net change of mean systolic blood pressure (SBP) was −6.75 (95% CI: −7.79 to −5.71, <0.001) mmHg, mean diastolic blood pressure (DBP) was −4.29 (95% CI: −5.08 to −3.49, <0.001) mmHg, and mean pulse pressure (PP) was −2.46 (95% CI: −3.50 to −1.43, <0.001) mmHg in the intervention group. The net change extent was larger in patients with regular pharmacological treatment than in those with irregular pharmacological treatment or non-pharmacological treatment. The measures of integrated intervention for hypertension patients in communities can lower significantly not only SBP and DBP, but also PP. It is suggested that measures of integrated intervention can decrease the risk of cardiovascular diseases in hypertension patients.

关键词： hypertension     community     pharmacological adherence     control of blood pressure    

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Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

《医学前沿（英文）》 2021年 第15卷 第1期   页码 101-107 doi: 10.1007/s11684-020-0752-2

摘要： Primary hypothyroidism commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone (TSH) levels. We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma (HL) in a prospective cohort study. From 1998 to 2001, a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL, scheduled for craniospinal irradiation and mediastinum/neck radiotherapy, respectively, underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of craniospinal iiradiation. From 14 days before and up to the end of radiotherapy, patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3 μIU/mL. During follow-up, blood tests and ultrasound were repeated; primary hypothyroidism was considered an increased TSH level greater than normal range. Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels ˂ 0.3 μIU/mL and well matched for other variables. Twenty years on, hypothyroidism-free survival rates differed significantly, being 60%±15% and 15.6%±8.2% in TSH-suppressed vs. not-TSH suppressed patients, respectively ( =0.001). These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae, but it should be confirmed in a larger cohort.

关键词： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

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产业化困境要靠制度建设来解脱

郭励弘

《中国工程科学》 2002年 第4卷 第1期   页码 23-25

摘要：

论述了我国在短缺经济基本结束之后，当前在各个领域所面临的最大短缺是制度的短缺；为了推动 高新技术成果的产业化，增强我国的经济竞争力，应强化经济体制改革也即制度建设的力度。

关键词： 高新技术     产业化     经济体制改革    

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An experimental study on the flexural behavior of heavily steel reinforced beams with high-strength concrete

Yasser SHARIFI, Ali Akbar MAGHSOUDI

《结构与土木工程前沿（英文）》 2014年 第8卷 第1期   页码 46-56 doi: 10.1007/s11709-014-0237-y

摘要： In recent years, an emerging technology termed high-strength concrete (HSC) has become popular in construction industry. Present study describes an experimental research on the behavior of high-strength concrete beams in ultimate and service state. Six simply supported beams were tested, by applying comprising two symmetric concentrated loads. Tests are reported in this study on the flexural behavior of high-strength reinforced concrete (HSRC) beams made with coarse and fine aggregate together with Microsilica. Test parameter considered includes effect of being compressive reinforcement. Based on the obtained results, the behavior of such members is more deeply reviewed. Also a comparison between theoretical and experimental results is reported here. The beams were made from concrete having compressive strength of 66.81–77.72 N/mm and percentage reinforcement ratio ( / ) in the range of 0.56% – 1.20%. The ultimate moment for the tested beams was found to be in a good agreement with that of the predicted ultimate moment based on ACI 318-11, ACI 363 and CSA-04 provisions. The predicted deflection based classical formulation based on code provisions for serviceability requirements is found to underestimate the maximum deflection of HSC reinforced beams at service load.

关键词： high-strength concrete (HSC) members     flexural behavior     reinforced concrete     experimental results     ultimate moment    

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强度理论与实验现象

刘大斌,韩文坝,蔡冰清,韩晓东

《中国工程科学》 2007年 第9卷 第12期   页码 44-52

摘要： 用四大经典理论、莫尔强度理论和质点平衡强度理论的准则和强度条件，对单向拉压、二向拉压、纯扭转等已被认定的实验现象进行对比，对低、中碳钢重新做了纯扭转求最大屈服剪应力实验。发现质点平衡强度理论的符合率较高，13个实验中的有12个符合。尤其是拉伸—剪切使剪切破坏试验变得容易，压缩—剪切使剪切破坏试验变得困难的实验现象与质点平衡强度理论完全符合；莫尔强度理论也只有当拉伸和压缩极限强度不同时才能符合；其他强度理论都与此实验不符合。特别是当三向等应力拉伸（或压缩）时第三强度理论出现相当应力为零；三向等应力拉伸（或压

关键词： 强度理论     实验现象     屈服现象     应力状态    

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HY-2A卫星雷达高度计设计及其在轨工作结果

许可,刘和光,姜景山

《中国工程科学》 2013年 第15卷 第7期   页码 25-32

摘要：

海洋二号（HY-2A）卫星是我国第一颗海洋动力环境卫星，雷达高度计是HY-2A卫星的主载荷之一，发射入轨后仪器工作正常，并获得了大量有效的观测数据。该仪器在20 m有效波高条件下测高精度达到了4 cm，在4 m有效波高条件下测高精度达到了2 cm，其产品精度接近Jason-2卫星高度计。本文就HY-2A卫星雷达高度计系统设计和在轨初步结果进行论述。

关键词： 雷达高度计     HY-2A卫星     在轨工作    

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Effects of Boundary Condition and Helix Angle on Meshing Performance of TI Worm Gearing

SUN Yue-hai, DUAN Lu-qian, WANG Shu-ren, ZHANG Ce

《机械工程前沿（英文）》 2006年 第1卷 第1期   页码 90-95 doi: 10.1007/s11465-005-0006-7

摘要：

To exactly describe the contact state and contact area of tooth surface of toroidal involute (TI) worm gearing, the authors introduced boundary condition into contact line analysis.With helix angle chosen as parameter, the criterion for the existence of meshing boundary line on the surface of TI worm gearing is derived. Results show that there can be four situations for meshing boundary line on the tooth surface of gear, namely, inexistence of meshing boundary line, a unique line, two lines, and two coincident lines. If the helix angle is equal to or slightly smaller than the bigger angle, which makes two meshing boundary lines superpose, a preferable meshing performance is obtained. Computer simulation proves the validity of the above conclusion.

关键词： preferable     inexistence     Results     validity     boundary condition    

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青藏高原多圈层相互作用观测工程及其应用

马耀明

《中国工程科学》 2012年 第14卷 第9期   页码 28-34

摘要：

青藏高原作为地球的第三极，是“水—冰—气—生”多圈层体现最全，且相互作用最强烈的地区。高原强大的动力和热力作用显著地影响着东亚气候格局、亚洲季风进程和北半球大气环流。全球气候变化不仅影响到青藏高原本身的水圈与冰冻圈过程，改变青藏高原内部的生态系统与环境，影响该地区社会经济发展与人民生存条件，而且通过大气环流与水循环过程直接影响到东亚及周边国家的用水安全和自然灾害防护。正确认识青藏高原复杂地表多圈层相互作用规律的一条有效途径是在各种不同的下垫面上建立多圈层相互作用综合观测站（点）。在中国科学院和国家相关部门的支持下，过去的7年中，中国科学院青藏高原研究所与其他相关单位一道正在整个青藏高原面上逐步建立“青藏高原观测研究平台”以研究该地区复杂地表的多圈层相互作用规律。首先具体介绍中国科学院青藏高原研究所在高原上已经建立的5个综合观测研究站，然后介绍利用各个站点观测资料分析得到的多圈层相互作用（主要是地气相互作用）的研究结果，最后提出了青藏高原多圈层相互作用观测试验研究所面临的难题和可能的解决办法。

关键词： 青藏高原     多圈层相互作用过程     观测结果    

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新疆和田地区49 384例农村妇女宫颈癌检查结果分析

王莹,王小丽,米·斯日尔格楞

《中国工程科学》 2014年 第16卷 第5期   页码 96-98

摘要：

分析和田地区子宫颈癌检查项目资料，了解当地妇女宫颈癌的发病情况，针对项目工作提出改进措施，提高农村妇女健康水平。本文采用整群抽样的方法，为项目地区的适龄妇女开展子宫颈癌流行病学调查，提供临床检查服务。结果显示，和田地区妇女患病率为49.62 %，宫颈炎和阴道炎是主要的妇科疾病，宫颈癌和癌前病变患病率为0.09 %，早期诊断率为86.05 %。和田地区妇女健康状况较差，当地妇女自我保健意识不高，当地医疗保健机构宫颈癌筛查能力有待提高。

关键词： 子宫颈癌     新疆     妇女病    

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脉冲型惯性双向联想记忆神经网络新解 Research Articles

Chaouki AOUITI, Mahjouba Ben REZEG, Yang CAO

《信息与电子工程前沿（英文）》 2020年 第21卷 第2期   页码 324-339 doi: 10.1631/FITEE.1900181

摘要： 探究了具有混合时滞和脉冲效应的惯性双向联想记忆神经网络。该研究为类似系统的反周期解的存在性、唯一性和全局指数稳定性提供了新的实用条件。使用微分不等式技术证明我们的主要结果，并给出一个仿真算例证明新结果的有效性。

关键词： 惯性神经网络；反周期解；全局指数稳定；脉冲；时变延迟；双向联想记忆    

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标题 作者 时间 类型 操作

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

期刊论文

Joint slip investigation based on finite element modelling verified by experimental results on wind turbine

Saleh YAGHOOBI, Ahmad SHOOSHTARI

期刊论文

重大装备研发成果转化为生产力的理论与实践

张晓鲁

期刊论文

Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

期刊论文

improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results

期刊论文

Effectiveness of lifestyle intervention for hypertension in Shanghai communities: Results from the Shanghai

Xin-Jian LI MD, Min-Na CHENG MPH, Yu-Heng WANG MD, Sun MIAO MPH, Zong-Qi ZHANG PhD, Yi-Sheng CHEN MD, Wei LU PhD,

期刊论文

Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

期刊论文

产业化困境要靠制度建设来解脱

郭励弘

期刊论文

An experimental study on the flexural behavior of heavily steel reinforced beams with high-strength concrete

Yasser SHARIFI, Ali Akbar MAGHSOUDI

期刊论文

强度理论与实验现象

刘大斌,韩文坝,蔡冰清,韩晓东

期刊论文

HY-2A卫星雷达高度计设计及其在轨工作结果

许可,刘和光,姜景山

期刊论文

Effects of Boundary Condition and Helix Angle on Meshing Performance of TI Worm Gearing

SUN Yue-hai, DUAN Lu-qian, WANG Shu-ren, ZHANG Ce

期刊论文

青藏高原多圈层相互作用观测工程及其应用

马耀明

期刊论文

新疆和田地区49 384例农村妇女宫颈癌检查结果分析

王莹,王小丽,米·斯日尔格楞

期刊论文

脉冲型惯性双向联想记忆神经网络新解

Chaouki AOUITI, Mahjouba Ben REZEG, Yang CAO

期刊论文