Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 4

年份

2023 1

2019 1

2013 1

2010 1

关键词

气态递质 1

硫化氢 1

肥胖症 1

胰岛素 1

脂肪形成 1

脂肪细胞 1

脂质 1

葡萄糖 1

展开︾

检索范围：

排序：展示方式：

Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

《医学前沿（英文）》 2019年第13卷第3期页码 314-329 doi: 10.1007/s11684-018-0625-0

摘要： The biological relevance of cytokines is known for more than 20 years. Evidence suggests that adipogenesis is one of the biological events involved in the regulation of cytokines, and pro-inflammatory cytokines (e.g., TNF and IL-1 ) inhibit adipogenesis through various pathways. This inhibitory effect can constrain the hyperplastic expandability of adipose tissues. Meanwhile, chronic low-grade inflammation is commonly observed in obese populations. In some individuals, the impaired ability of adipose tissues to recruit new adipocytes to adipose depots during overnutrition results in adipocyte hypertrophy, ectopic lipid accumulation, and insulin resistance. Intervention studies showed that pro-inflammatory cytokine antagonists improve metabolism in patients with metabolic syndrome. This review focuses on the cytokines currently known to regulate adipogenesis under physiological and pathophysiological circumstances. Recent studies on how inhibited adipogenesis leads to metabolic disorders were summarized. Although the interplay of cytokines and lipid metabolism is yet incompletely understood, cytokines represent a class of potential therapeutic targets in the treatment of metabolic disorders.

关键词： cytokines inflammation adipogenesis type 2 diabetes mellitus metabolic disorder

HTML PDF 收藏

The role of microRNAs in adipocyte differentiation

null

《医学前沿（英文）》 2013年第7卷第2期页码 223-230 doi: 10.1007/s11684-013-0252-8

摘要：

Adipocytes differentiate from mesenchymal stem cells (MSCs) in a process known as adipogenesis. The programme of adipogenesis is regulated by the sequential activation of transcription factors and several signaling pathways. There is growing evidence indicating that a class of small non-coding single-stranded RNAs known as “microRNAs (miRNAs)” also are involved in this process. In this review, we summarize the biology and functional mechanisms of miRNAs in adipocyte differentiation. In addition, we further discuss the miRNAs profiling, the miRNAs function and miRNAs target prediction in the adipogenesis.

关键词： microRNA adipocyte differentiation adipogenesis

HTML PDF 收藏

Ablation of steroid receptor coactivator-3 in mice impairs adipogenesis and enhances energy expenditure

Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,

《医学前沿（英文）》 2010年第4卷第2期页码 229-234 doi: 10.1007/s11684-010-0028-3

摘要： Obesity is a medical condition in which excess body fat has accumulated to an extent and may have an adverse effect on health, leading to reduced life expectancy, impaired energy homeostasis and increased health problems. The p160 steroid receptor coactivator (SRC) gene family members have been suggested to be involved in energy homeostasis, but the impact of SRC-3 ablation on white and brown adipose tissue needs to be elucidated. In the current study, we collected data and carried out morphological studies on the effect of SRC-3 deficiency on white adipose tissue (WAT) and brown adipose tissue (BAT). Primary cells were cultured to investigate the differentiation ability of both adipocytes. Western blot was applied to detect the expression of master genes governing adipogenesis and thermogenesis. We observed that SRC-3 mice were lean, with reduced WAT and decreased serum leptin levels, mainly due to the smaller white adipocyte size caused by impaired adipogenesis, presented by decreased peroxisome proliferator activated receptor (PPAR) expression. In the BAT, the lipid droplets decreased significantly in SRC-3 mice as demonstrated by histological analysis and electron microscopic observation, which could be explained by enhanced thermogenesis. The expression of thermogenic marker gene PPAR coactivator 1α and uncoupling protein-1 increased in BAT of SRC-3 mice, which proved our observations. Collectively, these results demonstrate that SRC-3 plays a key role in adipogenesis and energy expenditure.

关键词： steroid receptor coactivator-3 white adipose tissue brown adipose tissue obesity adipocytes energy expenditure

HTML PDF 收藏

硫化氢促进脂肪细胞分化、增生和肥大 Article

Richa Verma, 傅明, 杨广东, 吴凌云, 王睿

《工程（英文）》 2023年第20卷第1期页码 36-48 doi: 10.1016/j.eng.2022.09.010

摘要：

硫化氢（H₂S）在脂肪细胞和脂肪组织中内源性产生并刺激脂肪形成。然而，H₂S 对肥胖症发展的综合致病作用及其潜在机制尚不清楚。本研究发现降低的内源性H₂S水平降低了小鼠脂肪细胞中的脂质积累。在脂肪形成诱导6 d 后，外源性H₂S 处理显著增加了原代小鼠前脂肪细胞的脂肪生成。在脂肪生成的早
期阶段，H₂S增加细胞增殖并为细胞增生做好准备。H₂S处理10 d 后，前脂肪细胞的细胞表面积和直径明显增大，表明细胞肥大。虽然H₂S 刺激脂质积累和脂肪生成，但H₂S 对脂肪分解没有影响。随着营养过载和高葡萄糖/胰岛素孵化，H₂S 进一步刺激葡萄糖消耗并恶化脂肪细胞肥大。H₂S 上调增生基因[CCAAT/增强子结合蛋白（C/EBPβ）、细胞分裂周期25（Cdc25）、微染色体维持3（Mcm3）和细胞分裂周期（Cdc45）]和细胞周期蛋白依赖性激酶2 蛋白（Cdk2），调节细胞增殖。H₂S 还上调了胰岛素受体β（Irβ）激活的丝裂原活化蛋白激酶（MAPK）和蛋白激酶B（Akt）通路，从而导致脂肪生成。总之，H₂S 增加脂肪细胞分化、肥大和增生，提示它在肥胖症中起致病作用。