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The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

《医学前沿（英文）》 2007年 第1卷 第4期   页码 423-428 doi: 10.1007/s11684-007-0083-6

摘要： This paper reported the epidemiology of the colistin-only-sensitive (COS-AB) in a tertiary teaching hospital in China. We analyzed the clinical data of 136 COS-AB isolates from June 2004 to May 2005 and collected 66 . isolates in which 33 strains were COS-AB, and the rest were non-COS-AB. Random amplified polymorphic DNA (RAPD) analysis (primer ERIC2 and 272) showed that all COS-AB were identical, while pulsed-field gel electrophotesis (PFGE) analysis showed two separate genotypes of these COS-AB which were distinctly different from that of non-COS-AB. The COS-AB from burn wards showed the identical PFGE pattern which was distinguished from the genotype of COS-AB in other departments, mainly surgical systems. The cross-infection was severe and strict methods of disinfection and sterilization should be implemented. Meanwhile, the epidemiology of COS-AB in environment and patients should be closely monitored. The PFGE analysis is a reliable method of . typing.

关键词： identical     different     teaching hospital     genotype     colistin-only-sensitive    

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Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

《化学科学与工程前沿（英文）》 2022年 第16卷 第1期   页码 128-135 doi: 10.1007/s11705-021-2080-8

摘要： The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.

关键词： fluorescence     probes     iron     screening     library    

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基于代价敏感学习的实体-关系联合知识嵌入 Article

Sheng-kang YU, Xue-yi ZHAO, Xi LI, Zhong-fei ZHANG

《信息与电子工程前沿（英文）》 2017年 第18卷 第11期   页码 1867-1873 doi: 10.1631/FITEE.1601255

摘要： 我们将实体嵌入问题看作同时完成两个不同但相关的嵌入任务（实体嵌入和关系嵌入）的联合优化问题，并在联合嵌入框架下求解该问题。在该嵌入框架下，我们设计了联合评分函数，用以对实体和关系间的相关性实例进行量化评价，并将评分函数融入最大间隔学习方法中，使用知识库中的上下文信息学习实体与关系的嵌入向量。通过求解联合优化问题，我们的设计有效地表达了嵌入空间的固有拓扑结构。实验结果证实了我们的嵌入框架在表达不同关系的语义相关性和进行知识推理中的关系预测时的有效性。

关键词： 知识嵌入；联合嵌入；代价敏感学习    

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Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia

John C. Radcliffe, Declan Page, Bruce Naumann, Peter Dillon

《环境科学与工程前沿（英文）》 2017年 第11卷 第4期 doi: 10.1007/s11783-017-0937-3

摘要： Australia has developed extensive policies and guidelines for the management of its water. The City of Salisbury, located within metropolitan Adelaide, South Australia, developed rapidly through urbanisation from the 1970s. Water sensitive urban design principles were adopted to maximise the use of the increased run-off generated by urbanisation and ameliorate flood risk. Managed aquifer recharge was introduced for storing remediated low-salinity stormwater by aquifer storage and recovery (ASR) in a brackish aquifer for subsequent irrigation. This paper outlines how a municipal government has progressively adopted principles of Water Sensitive Urban Design during its development within a framework of evolving national water policies. Salisbury’s success with stormwater harvesting led to the formation of a pioneering water business that includes linking projects from nine sites to provide a non-potable supply of 5 × 10 m ·year . These installations hosted a number of applied research projects addressing well configuration, water quality, reliability and economics and facilitated the evaluation of its system as a potential potable water source. The evaluation showed that while untreated stormwater contained contaminants, subsurface storage and end-use controls were sufficient to make recovered water safe for public open space irrigation, and with chlorination, acceptable for third pipe supplies. Drinking water quality could be achieved by adding microfiltration, disinfection with UV and chlorination. The costs that would need to be expended to achieve drinking water safety standards were found to be considerably less than the cost of establishing dual pipe distribution systems. The full cost of supply was determined to be AUD$1.57 m for non-potable water for public open space irrigation, much cheaper than mains water, AUD$3.45 m at that time. Producing and storing potable water was found to cost AUD$1.96 to $2.24 m .

关键词： Managed Aquifer Recharge (MAR)     Stormwater harvesting     Water recycling drinking water     Low impact development     Water sensitive urban design    

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盾构隧道长距离独头掘进的控制测量技术

许维青,韩福忠

《中国工程科学》 2010年 第12卷 第12期   页码 56-58

摘要：

北京地下直径线盾构独头掘进距离达5.2 km，因此隧道贯通精度控制难度大。通过测量精度分析，单纯通过导线测量已不能满足设计规定的贯通限差要求，施工中通过导线直接传递定向、洞内加测陀螺边、地上地下控制网紧密联系等辅助方法，提高了贯通横向误差的精度，达到了预期效果。

关键词： 盾构     长距离     独头掘进     控制测量    

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Prediction of cyclic large plasticity for prestrained structural steel using only tensile coupon tests

Liang-Jiu JIA, Tsuyoshi KOYAMA, Hitoshi KUWAMURA

《结构与土木工程前沿（英文）》 2013年 第7卷 第4期   页码 466-476 doi: 10.1007/s11709-013-0219-5

摘要： Cold-formed steel members, which experience complicated prestrain histories, are frequently applied in structural engineering. This paper aims to predict cyclic plasticity of structural steels with tensile and compressive prestrain. Monotonic and cyclic tests on hourglass specimens with tensile and compressive prestrain are conducted, and compared with numerical simulations using the Chaboche model. Two approaches are taken in the simulation. The first requires only the monotonic tensile test data from the prestrained steels, and the second requires both the monotonic tensile test data from the virgin steel and the prestrain histories. The first approach slightly overestimates the compressive stress for specimens with tensile prestrain, while the second approach is able to accurately predict the cyclic plasticity in specimens with tensile and compressive prestrain.

关键词： cyclic plasticity     prestrain     Chaboche model     mild steel    

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single-stranded DNA-reduced graphene oxide nanocomposites based electrochemical biosensor for highly sensitive

《化学科学与工程前沿（英文）》 2021年 第15卷 第6期   页码 1572-1582 doi: 10.1007/s11705-021-2112-4

摘要： High density and uniform distribution of the gold nanoparticles functionalized single-stranded DNA modified reduced graphene oxide nanocomposites were obtained by non-covalent interaction. The positive gold nanoparticles prepared by phase inversion method exhibited good dimensional homogeneity and dispersibility, which could readily combine with single-stranded DNA modified reduced graphene oxide nanocomposites by electrostatic interactions. The modification of single-stranded DNA endowed the reduced graphene oxide with favorable biocompatibility and provided the preferable surface with negative charge for further assembling of gold nanoparticles to obtain gold nanoparticles/single-stranded DNA modified reduced graphene oxide nanocomposites with better conductivity, larger specific surface area, biocompatibility and electrocatalytic characteristics. The as-prepared nanocomposites were applied as substrates for the construction of cholesterol oxidase modified electrode and well realized the direct electron transfer between the enzyme and electrode. The modified gold nanoparticles could further catalyze the products of cholesterol oxidation catalyzed by cholesterol oxidase, which was beneficial to the enzyme-catalyzed reaction. The as-fabricated bioelectrode exhibited excellent electrocatalytic performance for the cholesterol with a linear range of 7.5‒280.5 μmol·L‒1, a low detection limit of 2.1 μmol·L‒1, good stability and reproducibility. Moreover, the electrochemical biosensor showed good selectivity and acceptable accuracy for the detection of cholesterol in human serum samples.

关键词： reduced graphene oxide     gold nanoparticles     electrochemical biosensor     cholesterol oxidase     cholesterol    

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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

《医学前沿（英文）》 2023年 第17卷 第1期   页码 75-84 doi: 10.1007/s11684-022-0950-1

摘要： This retrospective single-center registry study included all consecutive patients who underwent percutaneous coronary intervention (PCI) for a de novo left main coronary artery lesion using drug coated-balloon (DCB)-only strategy between August 2011 and December 2018. To best of our knowledge, no previous studies of DCB-only strategy of treating de novo left main coronary artery disease, exist. The primary endpoint was major adverse cardiovascular events (MACEs) including cardiac death, non-fatal myocardial infarction, and target lesion revascularization (TLR). The cohort was divided into two groups depending on weather the lesion preparation was done according to the international consensus group guidelines. Sixty-six patients (mean age 75±8.6, 72% male), 52% of whom had acute coronary syndrome, underwent left main PCI with the DCB-only strategy. No procedural mortality and no acute closures of the treated left main occurred. At 12 months, MACE and TLR occurred in 24% and 6% of the whole cohort, respectively. If the lesion preparation was done according to the guidelines, the MACE and TLR rates were 21.2% and 1.9%. Left main PCI with the DCB only-strategy is safe leading to acceptable MACE and low TLR rates at one year, if the lesion preparation is done according to the guidelines.

关键词： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary intervention    

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仅用结构响应数据识别系统模态参数的方法研究

霍兵勇,易伟建

《中国工程科学》 2015年 第17卷 第1期   页码 151-160

摘要：

随着实验模态分析方法的广泛应用和不断发展，在工程应用中，研究者希望能减少限制条件，增加分析的可靠性。本文发展一种识别系统模态参数的新方法，本方法无需知道系统的输入信息且不用建立系统模型，仅通过对测试记录的响应信号进行频谱分析即可识别系统的模态参数，依据系统中各响应点的信号，先采用离散反卷积方法从各响应点信号中分离出谐波参数作为初步的识别结果，在此基础之上，结合频域空间曲线拟合的方法修正识别结果中受频谱混叠影响而偏差较大的谐波参数，再联合这些已提取的谐波参数得到系统的模态参数。通过对实际结构测试数据的分析，证明本方法只用输出数据识别的模态参数与模态分析软件用传递函数识别的结果一致。

关键词： 仅有输出响应；系统模态参数识别；空间曲线拟合；频谱混叠    

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青藏高原“敏感区”对我国灾害天气气候的影响及其监测

徐祥德

《中国工程科学》 2009年 第11卷 第10期   页码 96-107

摘要：

根据中国区域大范围洪涝、暴雨、暴雪天气预报上游关键区，以及气候变化敏感区多圈层信息平台等重大需求。从“世界屋脊”青藏高原为灾害性天气上游关键区与气候信号敏感区的观点出发，提出高原及周边观测工程建网新思路与应用新技术方案，设计、构建了新一代气象综合观测预警长期监测系统，实现科学试验－工程建设－工程应用开发途径，发展高原及周边敏感区灾害天气上游早期预警系统监测平台，为灾害性天气预报与区域气候变化提供多功能业务服务应用平台；采用高原东缘南－北轴向观测数据信息（GPS监测站与AWS站）应用于改进WRF（weather research and forecasts）模式三维变分方案，实现了模式优化站网信息的同化技术，可提升中国区域暴雨、南方雪灾模式预报能力。针对夏季暴雨、南方暴雪，检验、证明了高原观测工程布网“早期预警”的显著效果。

关键词： 青藏高原     上游关键敏感区     灾害天气     早期预警    

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Cystine-assisted accumulation of gold nanoparticles on ZnO to construct a sensitive surface-enhanced

《化学科学与工程前沿（英文）》 2023年 第17卷 第1期   页码 15-23 doi: 10.1007/s11705-022-2177-8

摘要： Recently, various semiconductor/metal composites have been developed to fabricate surface-enhanced Raman spectroscopy substrates. However, low metal loading on semiconductors is still a challenge. In this study, cystine was introduced to increase the accumulation of gold nanoparticles on zinc oxide, owing to the biomineralization property of cystine. Morphological analysis revealed that the obtained ZnO/Au/cystine composite not only had a higher metal loading but also formed a porous structure, which is beneficial for Raman performance. Compared with ZnO/Au, the ZnO/Au/cystine substrate displayed a 40-fold enhancement in the Raman signal and a lower limit of detection (10–11 mol·L−1) in the detection of rhodamine 6G. Moreover, the substrate has favorable homogeneity and stability. Finally, ZnO/Au/cystine displayed excellent performance toward crystal violet and methylene blue in a test based on river water samples. This study provided a promising method to fabricate sensitive semiconductor/noble metal-based surface-enhanced Raman spectroscopy substrates for Raman detection.

关键词： biomineralization     cystine     semiconductor/metal composite     SERS detection     Raman detection    

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Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

《化学科学与工程前沿（英文）》 2017年 第11卷 第4期   页码 529-536 doi: 10.1007/s11705-017-1645-z

摘要： An anticancer drug delivery system consisting of DNA nanoparticles synthesized by rolling circle amplification (RCA) was developed for prostate cancer membrane antigen (PSMA) targeted cancer therapy. The template of RCA was a DNA oligodeoxynucleotide coded with PSMA-targeted aptamer, drug-loading domain, primer binding site and pH-sensitive spacer. Anticancer drug doxorubicin, as the model drug, was loaded into the drug-loading domain (multiple GC-pair sequences) of the DNA nanoparticles by intercalation. Due to the integrated pH-sensitive spacers in the nanoparticles, in an acidic environment, the cumulative release of doxorubicin was far more than the cumulative release of the drug in the normal physiological environment. In cell uptake experiments, treated with doxorubicin loaded DNA nanoparticles, PSMA-positive C4-2 cells could take up more doxorubicin than PSMA-null PC-3 cells. The prepared DNA nanoparticles showed the potential as drug delivery system for PSMA targeting prostate cancer therapy.

关键词： aptamer     DNA nanoparticles     rolling circle amplification     doxorubicin     drug delivery     pH sensitive    

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基于子带瞬时能量谱的铝电解槽电压槽况敏感频域分段方法 Article

曾朝晖, 桂卫华, 陈晓方, 谢永芳, 张红亮, 孙玉波

《工程（英文）》 2021年 第7卷 第9期   页码 1282-1292 doi: 10.1016/j.eng.2020.11.012

摘要：

槽电压是广泛使用且可在线测量的铝电解槽信号，多种电解槽槽况分析和控制用参数由槽电压计算得到。槽电压频域分段是设计获取这些参数的数字滤波器通带的依据。在对槽电压定性分析的基础上，本文提出子带瞬时能量谱（sub-band Instantaneous energy spectrum, SIEP），并用其对多种槽况下槽电压的频域特性进行定量表示，最终给出了槽电压槽况敏感频域分段方法。该频域分段方法将槽电压有效频段划分为低频信号区[0, 0.001] Hz和低频噪声区[0.001, 0.050] Hz；将低频噪声区再细分为[0.001, 0.010] Hz的铝液异常波动频段和[0.01, 0.05] Hz 的次低频噪声频段。与基于经验模态分解的瞬时能量谱比较，SIEP能更精细地表示槽电压有效频段内任意频段的能量随时间变化规律。该槽电压频域分段方法对槽况更敏感，可更细致地获取在线槽况信息，为工业电解槽槽况监测和控制决策提供更可靠、准确的在线依据。

关键词： 子带瞬时能量谱     槽况敏感频段     频域分段     铝液异常波动     铝电解    

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基于同一健康策略探究老挝人、动物和环境中多黏菌素耐药性的传播特征 Article

周宇晴, Refath Farzana, Somsavanh Sihalath, Sayaphet Rattanavong, Manivanh Vongsouvath, Mayfong Mayxay, Kirsty Sands, Paul N. Newton, David A.B. Dance, Brekhna Hassan, Timothy R. Walsh

《工程（英文）》 2022年 第15卷 第8期   页码 45-56 doi: 10.1016/j.eng.2022.01.013

摘要：

This study was designed to investigate the molecular epidemiology of mobile colistin resistance (mcr) using a "One-Health" approach in Laos and to predict whether any dominant plasmid backbone and/or strain type influences the dissemination of mcr. We collected 673 samples from humans (rectal normal flora), poultry, and the environment (water, flies, birds, etc.) in Vientiane, Lao People's Democratic Republic (Laos), from May to September 2018. A total of 238 Escherichia coli (E. coli) isolated from nonduplicative samples, consisting of 98 MCR-positive E. coli (MCRPEC) ("mcr" denotes the gene encoding mobile colistin resistance, and "MCR" denotes the subsequent protein encoded by mcr) and 140 MCRnegative E. coli (MCRNEC), were characterized by phenotype and Illumina sequencing. A subset of MCRPEC was selected for MinION sequencing, conjugation assay, plasmid stability, and growth kinetics in vitro. The prevalence of MCRPEC was found to be 14.6% (98/673), with the highest prevalence in human rectal swabs (45.9% (45/98), p < 0.0001, odds ratio (OR): 0.125, 95% confidence interval (CI): 0.077–0.202). The percentages of MCRPEC from other samples were 14.3% (2/14) in dog feces, 12.0% (24/200) in flies, 11.0% (11/100) in chicken meat, 8.9% (8/90) in chicken cloacal, 8.0% (4/50) in chicken caeca, and 7.5% (4/53) in wastewater. MCRPEC was significantly more resistant to co-amoxiclav, sulfamethoxazoletrimethoprim, levofloxacin, ciprofloxacin, and gentamicin than MCRNEC (p < 0.05). Genomic analysis revealed the distribution of MCRPEC among diverse clonal types. The putative plasmid Inc types associated with mcr-1 were IncX4, IncHI2, IncP1, IncI2, and IncFIA, and those associated with mcr-3 were IncFII, IncFIA, IncFIB, IncP1, and IncR. Recovery of highly similar plasmids from both flies and other sampling sectors implied the role of flies in the dissemination of mcr-1. mcr-positive plasmids were shown to be conjugative, and a significantly high transfer rate into a hypervirulent clone ST1193 was observed. Plasmids containing mcr irrespective of Inc type were highly stable and invariably did not exert a fitness effect upon introduction into a new host. These findings signify the urgent need for a standard infection control program to radically decontaminate the source of resistance.

关键词： 多黏菌素耐药性     mcr     大肠杆菌     老挝     水平传播    

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6G广域时延敏感物联网——移动边缘计算使能的非地面网络设计 Article

刘承骁, 冯伟, 陶晓明, 葛宁

《工程（英文）》 2022年 第8卷 第1期   页码 96-107 doi: 10.1016/j.eng.2021.11.002

摘要：

在即将到来的第六代移动通信技术（6G）时代，广域时延敏感物联网（IoT）需求不断增加。由于传统蜂窝技术难以直接用于广域时延敏感IoT，因此使用非地面基础设施，包括卫星和无人机（UAV）等，基于无蜂窝网络架构构建非地面网络（NTN）亟待研究。考虑到时延敏感业务需求和IoT 设备分布不均的特点，NTN可使用移动边缘计算（MEC）来增强业务支持能力，并提供“沙漠绿洲”状（oasis-oriented）的按需覆盖。然而，在MEC使能的NTN中，通信和MEC系统相互耦合，带来通信与计算资源协同编排难题。本文提出一种面向过程的优化框架，在更大时间尺度上设计通信和MEC系统。在这个框架中，本研究采用大尺度信道状态信息（CSI）刻画复杂传播环境，构建通信与计算资源联合编排的时延最小化问题；给出该优化问题的近似问题，并将其分解为多个子问题；然后，提出迭代算法来求解这些子问题。仿真结果表明，与现有算法相比，所提出的面向过程的方案可以降低任务总时延。这为无人机载荷部署提供了依据，也显示了在广域时延敏感IoT中NTN与MEC协同设计的潜力。

关键词： 无蜂窝     移动边缘计算     非地面网络     第六代移动通信技术     广域时延敏感物联网    

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标题 作者 时间 类型 操作

The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

期刊论文

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

期刊论文

基于代价敏感学习的实体-关系联合知识嵌入

Sheng-kang YU, Xue-yi ZHAO, Xi LI, Zhong-fei ZHANG

期刊论文

Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia

John C. Radcliffe, Declan Page, Bruce Naumann, Peter Dillon

期刊论文

盾构隧道长距离独头掘进的控制测量技术

许维青,韩福忠

期刊论文

Prediction of cyclic large plasticity for prestrained structural steel using only tensile coupon tests

Liang-Jiu JIA, Tsuyoshi KOYAMA, Hitoshi KUWAMURA

期刊论文

single-stranded DNA-reduced graphene oxide nanocomposites based electrochemical biosensor for highly sensitive

期刊论文

Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

期刊论文

仅用结构响应数据识别系统模态参数的方法研究

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