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吴新霞,赵根,谢先启
《中国工程科学》 2014年 第16卷 第11期 页码 72-77
本文针对城市高架桥爆破拆除的长距离、长延时,目前只能采用非电起爆网路进行起爆的现状,研究了多发并联起爆网路的接力点雷管延期特性,提出了并联后的接力点起爆时间期望值的简易计算公式。针对不同规模的非电起爆网路提出了相应的可靠度标准,研发了既可保证高架桥倾倒过程不发生侧翻又能提高接力点起爆可靠度并可无限分段的复式交叉接力起爆网路,并推导了其起爆可靠度计算公式。相关成果为高架桥拆除爆破起爆网路设计提供了科学依据。
《医学前沿(英文)》 2023年 第17卷 第3期 页码 476-492 doi: 10.1007/s11684-022-0966-6
关键词: EIF4A1 G-quadruplex hepatocellular carcinoma tRNA-derived small RNA translation initiation
Lei WANG, Jing LIU
《能源前沿(英文)》 2013年 第7卷 第3期 页码 317-332 doi: 10.1007/s11708-013-0271-9
关键词: liquid metal material genome energy material material discovery advanced material room-temperature liquid alloy thermodynamics phase diagram
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 33-40 doi: 10.1007/s11684-016-0431-5
Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.
关键词: cancer-associated fibroblast breast cancer progression prognosis
Fatigue crack initiation of magnesium alloys under elastic stress amplitudes: A review
B. J. WANG, D. K. XU, S. D. WANG, E. H. HAN
《机械工程前沿(英文)》 2019年 第14卷 第1期 页码 113-127 doi: 10.1007/s11465-018-0482-1
关键词: Mg alloys fatigue behavior microstructure crack initiation deformation mechanism
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 412-420 doi: 10.1007/s11684-015-0423-x
Genetic mutations are considered to drive the development of acute myeloid leukemia (AML). With the rapid progress in sequencing technologies, many newly reported genes that are recurrently mutated in AML have been found to govern the initiation and relapse of AML. These findings suggest the need to distinguish the driver mutations, especially the most primitive single mutation, from the subsequent passenger mutations. Recent research on DNA methyltransferase 3A (DNMT3A) mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cells (pre-LSCs) in AML patients. Although DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing the full-blown leukemia, the function of this driver mutation appear to persist from AML initiation up to relapse. Therefore, identifying and targeting preleukemic mutations, such as DNMT3A mutations, in AML is a promising strategy for treatment and reduction of relapse risk.
关键词: preleukemic stem cell acute myeloid leukemia relapse DNMT3A
Hierarchical approach for fatigue cracking performance evaluation in asphalt pavements
Ibrahim ONIFADE, Yared DINEGDAE, Björn BIRGISSON
《结构与土木工程前沿(英文)》 2017年 第11卷 第3期 页码 257-269 doi: 10.1007/s11709-017-0410-1
关键词: fatigue cracking energy based crack initiation mechanistic approach pavement analysis
WAN Zhen-ping, LIU Ya-jun, TANG Yong, YE Bang-yan
《机械工程前沿(英文)》 2006年 第1卷 第2期 页码 194-198 doi: 10.1007/s11465-005-0011-x
关键词: different 30o-120o relationship initiation cutting parameter
《医学前沿(英文)》 2022年 第16卷 第2期 页码 276-284 doi: 10.1007/s11684-021-0855-4
关键词: gestational trophoblastic neoplasia (GTN) methotrexate (MTX) dactinomycin (ACTD)
冷振东,范勇,涂书芳,周桂松,郭一鸣
《中国工程科学》 2023年 第25卷 第1期 页码 142-154 doi: 10.15302/J-SSCAE-2023.07.001
电子雷管提高了延期精度以及起爆网路设计的灵活性,可实现“生产‒ 运输‒ 储存‒ 使用”全生命周期安全管控,成为民爆行业重点发展方向。本文从产品结构、应用场景、智能化水平、爆破设计理论、拒爆失效机理等方面着手,梳理了电子雷管起爆技术的发展现状,总结了系列化和标准化、智能化、短延时设计、大规模起爆网路等技术发展趋势;结合工程应用实践,凝练了复杂环境下拒爆现象频发、爆破应用研究脱节、产品类型单一、标准体系不健全等电子雷管起爆技术与应用问题。着眼民爆行业发展需求,提出了电子雷管起爆技术的重点研究方向:电子雷管精确延时控制爆破破岩理论,信息技术与电子雷管起爆技术融合,差异化的电子雷管产品体系,电子雷管标准体系。
Initiation of Setaria as a model plant
Xianmin DIAO,James SCHNABLE,Jeffrey L. BENNETZEN,Jiayang LI
《农业科学与工程前沿(英文)》 2014年 第1卷 第1期 页码 16-20 doi: 10.15302/J-FASE-2014011
关键词: Setaria foxtail millet C4 photosynthesis model organism
方俊波
《中国工程科学》 2014年 第16卷 第11期 页码 58-64
城市地铁区间隧道爆破施工中面临的一个重要问题就是降低爆破振动对临近地表建筑物的影 响。青岛地铁一期工程03号线03标段下穿建筑物时,为了确保距隧道拱顶5~8 m的地表建筑物安全,采 用了大中空孔直眼掏槽技术、一次起爆分部延时爆破、浅孔多眼等技术,将地表建筑物最大垂直振速控制 在国标允许范围之内,隧道通过后地表建筑物完好无损。并在施工中解决了大断面隧道爆破施工导爆管 雷管段数不能满足施工要求、分断面施工不能同时实施爆破作业,施工效率低下的问题,既保证了工程施 工安全又满足了进度要求。
李毓堂
《中国工程科学》 2002年 第4卷 第1期 页码 15-22
文章论述了钱学森提出创建知识密集型草产业的历史背景、科学内涵、理论意义、应用成果和在21世纪中国可持续发展战略中的重要作用,并根据钱老的主张,提出当前启动全国大规模草产业工程必须创新管理机制。
Cracking evolution behaviors of lightweight materials based on
Y. Luo, S. C. Wu, Y. N. Hu, Y. N. Fu
《机械工程前沿(英文)》 2018年 第13卷 第4期 页码 461-481 doi: 10.1007/s11465-018-0481-2
Damage accumulation and failure behaviors are crucial concerns during the design and service of a critical component, leading researchers and engineers to thoroughly identifying the crack evolution. Third-generation synchrotron radiation X-ray computed microtomography can be used to detect the inner damage evolution of a large-density material or component. This paper provides a brief review of studying the crack initiation and propagation inside lightweight materials with advanced synchrotron three-dimensional (3D) X-ray imaging, such as aluminum materials. Various damage modes under both static and dynamic loading are elucidated for pure aluminum, aluminum alloy matrix, aluminum alloy metal matrix composite, and aluminum alloy welded joint. For aluminum alloy matrix, metallurgical defects (porosity, void, inclusion, precipitate, etc.) or artificial defects (notch, scratch, pit, etc.) strongly affect the crack initiation and propagation. For aluminum alloy metal matrix composites, the fracture occurs either from the particle debonding or voids at the particle/matrix interface, and the void evolution is closely related with fatigued cycles. For the hybrid laser welded aluminum alloy, fatigue cracks usually initiate from gas pores located at the surface or sub-surface and gradually propagate to a quarter ellipse or a typical semi-ellipse profile.
关键词: fatigue crack initiation and growth fatigue damage mechanism damage tolerance defect characterization laser welded aluminum alloys
标题 作者 时间 类型 操作
hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation
期刊论文
Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy
Lei WANG, Jing LIU
期刊论文
Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications
null
期刊论文
Fatigue crack initiation of magnesium alloys under elastic stress amplitudes: A review
B. J. WANG, D. K. XU, S. D. WANG, E. H. HAN
期刊论文
regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation
null
期刊论文
Hierarchical approach for fatigue cracking performance evaluation in asphalt pavements
Ibrahim ONIFADE, Yared DINEGDAE, Björn BIRGISSON
期刊论文
Initiation and propagation laws of the glass cracks in specimens subjected to normal loading under the
WAN Zhen-ping, LIU Ya-jun, TANG Yong, YE Bang-yan
期刊论文
Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course
期刊论文
Initiation of Setaria as a model plant
Xianmin DIAO,James SCHNABLE,Jeffrey L. BENNETZEN,Jiayang LI
期刊论文
Cracking evolution behaviors of lightweight materials based on
Y. Luo, S. C. Wu, Y. N. Hu, Y. N. Fu
期刊论文