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促淤造陆 1

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大米草 1

改进萤火虫算法；雷达监视网络；部署优化；无人机入侵防御 1

海岸带 1

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Disabled homolog 2 is required for migration and invasion of prostate cancer cells

null

《医学前沿（英文）》 2015年 第9卷 第3期   页码 312-321 doi: 10.1007/s11684-015-0401-3

摘要：

Disabled homolog 2 (DAB2) is frequently deleted or epigenetically silenced in many human cancer cells. Therefore, DAB2 has always been regarded as a tumor suppressor gene. However, the role of DAB2 in tumor progression and metastasis remains unclear. In this study, DAB2 expression was upregulated along with human prostate cancer (PCa) progression. DAB2overexpression or knockdown effects in LNCaP and PC3 cell lines were verified to address the biological functions of DAB2 in PCa progression and metastasis. LNCaP and PC3 cell lines were generated from human PCa cells with low and high metastatic potentials, respectively. The results showed that DAB2 shRNA knockdown can inhibit the migratory and invasive abilities of PC3 cells, as well as the tumorigenicity, whereas DAB2 overexpression enhanced LNCaP cell migration and invasion. Further investigation showed that DAB2 regulated the cell migration associated genes in PC3 cells, and the differential DAB2 expression between LNCaP and PC3 cells was partly regulated by histone 4 acetylation. Therefore, DAB2 may play an important role in PCa progression and metastasis.

关键词： DAB2     prostate cancer     migration     invasion     acetylation    

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on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

《医学前沿（英文）》 2021年 第15卷 第5期   页码 649-656 doi: 10.1007/s11684-021-0830-0

摘要： Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is manifested by increased endogenous fat mobilization, hypertriglyceridemia, and increased fatty acid synthesis. Fatty acid synthase (FASN) is a key enzyme for the synthesis of fatty acids, and monoacylglycerol esterase (MGLL) is an important metabolic enzyme that converts triglycerides into free fatty acids. Both enzymes play an important role in lipid metabolism and are associated with tumor-related signaling pathways, the most common of which is the PI3K–AKT signaling pathway. They can also regulate the immune microenvironment, participate in epithelial–mesenchymal transition, and then regulate tumor invasion and metastasis. Current literature have shown that these two genes are abnormally expressed in many types of tumors and are highly correlated with tumor migration and invasion. This article introduces the structures and functions of FASN and MGLL, their relationship with abnormal lipid metabolism, and the mechanism of the regulation of tumor invasion and metastasis and reviews the research progress of the relationship of FASN and MGLL with tumor invasion and metastasis.

关键词： FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

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is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent fibrinolysis and matrix invasion

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 410-422 doi: 10.1007/s11684-017-0527-6

摘要：

Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion protein causes lethal hyperfibrinolysis in acute promyelocytic leukemia (APL), but the mechanism is unclear. To facilitate the investigation of regulatory association between ANXA2 and promyelocytic leukemia/retinoic acid receptor a (PML/RARα) fusion protein, this work was performed to determine the transcription start site of ANXA2 promoter with rapid amplification of 5′-cDNA ends analysis. Zinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2 transcripts and translational expressions of both ANXA2 and S100A10, while S100A10 transcripts remained constitutive. The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higher than that by control pSG5 vector or wild-type RARα. The overexpression of ANXA2 in U937 transfected with full-length ANXA2 cDNA was associated with increased S100A10 subunit, although S100A10 transcripts remained constitutive. The tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13-fold, and cell invasiveness increased by 27.6%. Antibodies against ANXA2, S100A10, or combination of both all remarkably inhibited the IRPG and invasiveness in U937/PR9 and NB4. Treatment of zinc-induced U937/PR9 or circulating APL blasts with all-trans retinoic acid (ATRA) significantly reduced cell surface ANXA2 and S100A10 and associated reductions in IRPG and invasiveness. Thus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate S100A10. Increased AIIt promoted IRPG and invasiveness, both of which were partly abolished by antibodies against ANXA2 and S100A10 or by ATRA.

关键词： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

null

《医学前沿（英文）》 2014年 第8卷 第4期   页码 456-463 doi: 10.1007/s11684-014-0353-z

摘要：

microRNAs (miRNAs) have played a key role in human tumorigenesis, tumor progression, and metastasis. On the one hand, miRNAs are aberrantly expressed in many types of human cancer; on the other hand, miRNAs can function as tumor suppressors or oncogenes that target many cancer-related genes. This study aimed to investigate the effects of miRNA-200c (miR-200c) on the biological behavior and mechanism of proliferation, migration, and invasion in the prostate cancer cell line Du145. In this study, Du145 cells were transfected with miR-200c mimics or negative control miR-NC by using an X-tremeGENE siRNA transfection reagent. The relative expression of miR-200c was measured by RT-PCR. The proliferation, migration, and invasion abilities of Du145 cells were detected by CCK8 assays, migration assays and invasion assays, respectively. The expressions of ZEB1, E-cadherin, and vimentin were observed by western blot. Results showed that DU145 cells exhibited a high expression of miR-200c compared with immortalized normal prostate epithelial cell RWPE-1. Du145 cells were then transfected with miR-200c mimics and displayed lower abilities of proliferation, migration, and invasion than those transfected with the negative control. The protein levels of ZEB1 and vimentin were expressed at a low extent in Du145 cells, which were transfected with miR-200c mimics; by contrast, E-cadherin was highly expressed. Hence, miR-200c could significantly inhibit the proliferation of the prostate cancer cell line Du145; likewise, miR-200c could inhibit migration and invasion by epithelial-mesenchymal transition.

关键词： miR-200c     proliferation     migration     invasion     prostate cancer     Du145 cell     ZEB1    

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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 303-308 doi: 10.1007/s11684-009-0060-3

摘要： The effects of hypoxia on the invasion and the related protein expression of Hela cells and the role of hypoxia inducible factor-1α (HIF-1α) were investigated. The Hela cells were divided into three groups, namely, H (non-transfected Hela cells), H (pGenesil-1 empty plasmid-transfected Hela cells), and H (HIF-1α-shRNA plasmid-transfected Hela cells), and were cultured under hypoxia (1% O) and normoxia for 48h. The expression of HIF-1α, E-cadherin, β-catenin, and actin was detected using Western blot. The scratch test and the invasion assay were applied to examine the invasion in each group. The expression of HIF-1α, E-cadherin, and β-catenin in tumor grafts was assayed immunohistochemically. Western blot results revealed that the bands of HIF-1α, E-cadherin, β-catenin, and actin proteins were detected in the H and H groups under hypoxia for 48h. The expression of E-cadherin, β-catenin, and actin was detected in the H group under hypoxia for 48h, and normoxia. In the H, H, and H groups under normoxia, and the H group under hypoxia for 48h, no expression of HIF-1α was detectable. The scratch test showed that the invasive ability in the H group was significantly alleviated. Immunohistochemically, it was found that there was a significant difference in the expression of HIF-1α, E-cadherin, and β-catenin between the H and H groups (<0.05), but the difference was not significant between the H and H groups. It was concluded that the effects of hypoxia on the invasion of human cervical cancer Hela cells and the expression of related proteins (E-cadherin, β-catenin, and actin) depend on HIF-1α.

关键词： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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A global synthesis of the effectiveness and ecological impacts of management interventions for species

《环境科学与工程前沿（英文）》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1741-x

摘要：

● Spartina abundance decreases over time by chemical control.

关键词： Plant invasion     Biodiversity     Meta-analysis     Restoration     Salt marshes     Treatment timing    

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中国红树林湿地与生态工程的几个问题

林鹏

《中国工程科学》 2003年 第5卷 第6期   页码 33-38

摘要：

简述红树林湿地在滨海湿地中的地位，红树林的种类和分布，红树林类群的界定，湿地保护中的重要性，红树林的生态、社会和经济价值。着重讨论中国红树林生态工程中面临的四个问题：1.红树林生态恢复的关键是宜林地的选择标准；2.红树林区海堤修复工程的生态模式；3.防止引种时带进外来有害物种的生态入侵；4.要以最小的资源环境代价，谋求经济社会最大限度的发展，从而促进红树林湿地的保护与发展。

关键词： 红树林     湿地     生态恢复     生态入侵    

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论中国海岸带大米草生态工程效益与“生态入侵”

唐廷贵,张万钧

《中国工程科学》 2003年 第5卷 第3期   页码 15-20

摘要：

1963年以来，我国先后从国外引进3种大米草，分布在18000 km海岸带上，经过近40年的引种、驯化和栽培，种植面积已达到36000 hm2。实践证明大米草和互花米草适应于中国海岸带自然环境而正常生长发育，具有明显的促淤造陆、保滩护岸，环境保护等生态功能，并有显著的经济效益，是一种改造滩涂的优良植物，也是一种盐渍土裸地植物群落形成的先锋植物，已作为一个外来种被列入《中国植物志》、《中国高等植物图鉴》和各种地方植物志中。文章认为应客观地评估大米草的功与过。大米草和互花米草繁殖较快的原因是由于富营养化的结果，然而对环境、种群和人并未构成侵害行为，在北方海岸带区域尤未发现任何异常现象，不可认定大米草和互花米草是属于有害的生态入侵种。

关键词： 海岸带     大米草     生态工程     促淤造陆     保滩护岸    

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Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 336-340 doi: 10.1007/s11684-009-0053-2

摘要： Lanthanum salt is a prescription drug, but its underlying functions and mechanisms are not fully understood currently. To explore the potential therapeutic value of , cytotoxicity test was applied to investigate its effects on cell proliferation. Furthermore, we observed its influence on pro-oncogene by reverse transcription polymerase chain reaction (RT-PCR). In MCF-7 cell line, repressed cell proliferation at high concentration but had no significant inhibition effect on cell growth at low concentration. However, we observed that repressed transcription at a low concentration. This may suggest that is a potent drug to inhibit the high expression of in carcinoma cells and play a clue for inhibiting the growth and invasion of tumor.

关键词： proliferation     c-met     invasion     lanthanum chloride    

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Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver, gallbladder, and duodenum

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

《医学前沿（英文）》 2011年 第5卷 第4期   页码 434-437 doi: 10.1007/s11684-011-0157-3

摘要： Locally advanced colorectal cancer complicated with adjacent organic invasion may remain confined to the local area with minimal metastasis. In the present paper, we report on a patient with advanced right colon cancer, including liver, gallbladder, and duodenal invasion behind the scene of liver abscess. resection was performed on the patient, with right-hemicolectomy, cholecystectomy, partial duodental resection, and hepatectomy. Postoperative management was administered, including nutritional support in the early postoperative period, effective anti-infection treatment, and adjuvant chemotherapy (FOLFOX4). The patient survived for 16 months after the operation. Common clinical manifestations of colorectal cancer were digestive symptoms and changes in defecation. However, the clinical manifestation of locally advanced colon cancer was extremely complicated. Extended or multivisceral resection may offer patients a chance to survive an acute crisis and allow for treatment with adjuvant therapy.

关键词： liver abscess     locally advanced colon cancer     multiorganic invasion    

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基于改进萤火虫算法的雷达网络最优化部署 Regular Papers

Xue-jun ZHANG, Wei JIA, Xiang-min GUAN, Guo-qiang XU, Jun CHEN, Yan-bo ZHU

《信息与电子工程前沿（英文）》 2019年 第20卷 第3期   页码 425-437 doi: 10.1631/FITEE.1800749

摘要： 随着无人机行业快速发展，无人机入侵带来的威胁和挑战引起越来越多关注。雷达网络检测是无人机入侵防御的重要手段之一。为在有限雷达资源下形成紧密可靠的雷达监视网络，雷达网优化部署至关重要。然而，由于非线性且变量紧密耦合，雷达网部署优化问题难以解决。提出基于反馈机制的邻居学习策略和精英种群局部搜索策略的改进萤火虫算法，以平衡开发与探索能力，同时采用混沌序列初始化萤火虫位置，提高种群多样性。标准优化测试函数实验和典型雷达部署案例实验表明，该改进萤火虫算法比经典萤火虫算法和4个近期提出的改进算法有更好寻优性能，能有效解决雷达网部署优化问题。

关键词： 改进萤火虫算法；雷达监视网络；部署优化；无人机入侵防御    

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标题 作者 时间 类型 操作

Disabled homolog 2 is required for migration and invasion of prostate cancer cells

null

期刊论文

on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

期刊论文

is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent fibrinolysis and matrix invasion

null

期刊论文

Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

null

期刊论文

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

期刊论文

A global synthesis of the effectiveness and ecological impacts of management interventions for species

期刊论文

中国红树林湿地与生态工程的几个问题

林鹏

期刊论文

论中国海岸带大米草生态工程效益与“生态入侵”

唐廷贵,张万钧

期刊论文

Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

期刊论文

Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver, gallbladder, and duodenum

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

期刊论文

基于改进萤火虫算法的雷达网络最优化部署

Xue-jun ZHANG, Wei JIA, Xiang-min GUAN, Guo-qiang XU, Jun CHEN, Yan-bo ZHU

期刊论文