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Journal Article 7

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hydrogel 2

hydrogels 2

Aggregation-induced emission 1

Anticounterfeiting 1

Chitosan 1

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Freeze-tolerant hydrogels 1

Hydrogels 1

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MCF-7 cellular spheroids 1

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ammonia gas 1

bioprinting 1

concave wells 1

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dialdehyde cellulose 1

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Chemically triggered life control of “smart” hydrogels through click and declick reactions

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 9,   Pages 1399-1406 doi: 10.1007/s11705-022-2149-z

Abstract: ., hydrogels) through amine–thiol scrambling under mild conditions.glycol) (PEG-NH2) was reacted with the representative conjugate acceptors to synthesize hydrogelsIt is noteworthy that the mentioned hydrogels could be degraded efficiently in hours to release the originalThe recovered PEG-NH2 reagent could be employed again to regenerate hydrogels.

Keywords： hydrogels     degradation     synthesis     regeneration    

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Molecular tailoring to improve polypyrrole hydrogels’ stiffness and electrochemical energy storage capacity

Evelyn Chalmers, Yi Li, Xuqing Liu

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 4,   Pages 684-694 doi: 10.1007/s11705-019-1817-0

Abstract: This research looks at ways of tailoring and improving the stiffness of polypyrrole hydrogels for useThis is an increase of 140% compared to pristine polypyrrole hydrogels produced by this method.

Keywords： supercapacitor     polypyrrole     hydrogel     strengthening     electrochemical    

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Preparation of hydrogels with uniform and gradient chemical structures using dialdehyde cellulose and

Peiwen Liu, Carsten Mai, Kai Zhang

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 383-389 doi: 10.1007/s11705-018-1718-7

Abstract:

Hydrogels with precisely designed structures represent promising materials with a broad applicationHowever, with highly reactive compounds, the preparation of hydrogels still needs an efficient approachfor desired distribution of each component within hydrogels.In addition, a method for in situ preparation of gradient hydrogels is still lacking.Herein, we report the formation of hydrogels with either uniform or gradient internal structures via

Keywords： hydrogel     uniform     gradient     dialdehyde cellulose     ammonia gas     diamine    

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Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels

Jie Zhou, Xuewen Du, Jiaqing Wang, Natsuko Yamagata, Bing Xu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 509-515 doi: 10.1007/s11705-017-1613-7

Abstract: Enzyme-instructed self-assembly (EISA) offers a facile approach to explore the supramolecular assemblies of small molecules in cellular milieu for a variety of biomedical applications. One of the commonly used enzymes is phosphatase, but the study of the substrates of phosphatases mainly focuses on the phosphotyrosine containing peptides. In this work, we examine the EISA of phosphoserine containing small peptides for the first time by designing and synthesizing a series of precursors containing only phosphoserine or both phosphoserine and phosphotyrosine. Conjugating a phosphoserine to the -terminal of a well-established self-assembling peptide backbone, (naphthalene-2-ly)-acetyl-diphenylalanine (NapFF), affords a novel hydrogelation precursor for EISA. The incorporation of phosphotyrosine, another substrate of phosphatase, into the resulting precursor, provides one more enzymatic trigger on a single molecule, and meanwhile increases the precursors’ propensity to aggregate after being fully dephosphorylated. Exchanging the positions of phosphorylated serine and tyrosine in the peptide backbone provides insights on how the specific molecular structures influence self-assembling behaviors of small peptides and the subsequent cellular responses. Moreover, the utilization of D-amino acids largely enhances the biostability of the peptides, thus providing a unique soft material for potential biomedical applications.

Keywords： enzyme-instructed self-assembly     phosphoserine     phosphatase     supramolecular hydrogel    

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AIE-Active Freeze-Tolerant Hydrogels Enable Multistage Information Encryption and Decryption at Subzero Article

Xiaojie Sui, Xiaodong Wang, Chengcheng Cai, Junyi Ma, Jing Yang, Lei Zhang

Engineering 2023, Volume 23, Issue 4,   Pages 82-89 doi: 10.1016/j.eng.2022.03.021

Abstract:

Freeze-tolerant hydrogels can regulate the freezing behavior of the water inside them at subzero temperaturesHerein, a series of aggregation-induced emission (AIE)-active freeze-tolerant hydrogels are developedThe hydrogels possess varied freezing temperatures (Tf) depending on their betaineAbove/below Tf, the information in the hydrogels that is encoded by means of AIEFinally, because the decrypted information in the hydrogels is irreversibly sensitive to temperature

Keywords： Freeze-tolerant hydrogels     Aggregation-induced emission     Encryption     Decryption     Anticounterfeiting    

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A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Engineering doi: 10.1016/j.eng.2023.05.024

Abstract: Notably, DAA-mediated dynamic crosslinking not only maintains the overall integrity of the hydrogels

Keywords： Polysaccharides     Chitosan     Hydrogels     Oral delivery     Intestine-targeted    

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Bioprinting-Based High-Throughput Fabrication of Three-Dimensional MCF-7 Human Breast Cancer Cellular Spheroids Article

Kai Ling, Guoyou Huang, Juncong Liu, Xiaohui Zhang, Yufei Ma, Tianjian Lu, Feng Xu

Engineering 2015, Volume 1, Issue 2,   Pages 269-274 doi: 10.15302/J-ENG-2015062

Abstract:

Cellular spheroids serving as three-dimensional (3D) in vitro tissue models have attracted increasing interest for pathological study and drug-screening applications. Various methods, including microwells in particular, have been developed for engineering cellular spheroids. However, these methods usually suffer from either destructive molding operations or cell loss and non-uniform cell distribution among the wells due to two-step molding and cell seeding. We have developed a facile method that utilizes cell-embedded hydrogel arrays as templates for concave well fabrication and in situ MCF-7 cellular spheroid formation on a chip. A custom-built bioprinting system was applied for the fabrication of sacrificial gelatin arrays and sequentially concave wells in a high-throughput, flexible, and controlled manner. The ability to achieve in situ cell seeding for cellular spheroid construction was demonstrated with the advantage of uniform cell seeding and the potential for programmed fabrication of tissue models on chips. The developed method holds great potential for applications in tissue engineering, regenerative medicine, and drug screening.

Keywords： MCF-7 cellular spheroids     bioprinting     hydrogels     concave wells     tissue on a chip    

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Title Author Date Type Operation

Chemically triggered life control of “smart” hydrogels through click and declick reactions

Journal Article

Molecular tailoring to improve polypyrrole hydrogels’ stiffness and electrochemical energy storage capacity

Evelyn Chalmers, Yi Li, Xuqing Liu

Journal Article

Preparation of hydrogels with uniform and gradient chemical structures using dialdehyde cellulose and

Peiwen Liu, Carsten Mai, Kai Zhang

Journal Article

Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels

Jie Zhou, Xuewen Du, Jiaqing Wang, Natsuko Yamagata, Bing Xu

Journal Article

AIE-Active Freeze-Tolerant Hydrogels Enable Multistage Information Encryption and Decryption at Subzero

Xiaojie Sui, Xiaodong Wang, Chengcheng Cai, Junyi Ma, Jing Yang, Lei Zhang

Journal Article

A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Journal Article

Bioprinting-Based High-Throughput Fabrication of Three-Dimensional MCF-7 Human Breast Cancer Cellular Spheroids

Kai Ling, Guoyou Huang, Juncong Liu, Xiaohui Zhang, Yufei Ma, Tianjian Lu, Feng Xu

Journal Article

Qin Ling: Articular Cartilage Tissue Engineering based on Functional Hydrogels (2022-7-24)

27 Jul 2022

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