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Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 2,   Pages 220-223 doi: 10.1007/s11705-008-0041-0

Abstract: L-4-Fluorophenylalanine (FPhe) was prepared from 4-fluorophenylpyruvate (FPPA) catalyzed by aspartateconditions: 37°C, pH value range of 5.0–8.0, 5.5 mass ratio of cell to FPPA, 0.6% (w/v) of Tween 80, 7.08 g/LFPPA, and 1.6 of molar ratio of L-Asp to FPPA.

Keywords： L-4-Fluorophenylalanine     Asp-AT     aspartate aminotransferase     4-fluorophenylpyruvate     FPPA    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4,PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1569-9

Abstract:

● Fe3O4 NPs increased the biomass and chlorophyll

Keywords： Fe3O4 nanoparticle     Hemp     Growth enhancement     THC     Metabolite    

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Initiation of Setaria as a model plant

Xianmin DIAO,James SCHNABLE,Jeffrey L. BENNETZEN,Jiayang LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 16-20 doi: 10.15302/J-FASE-2014011

Abstract: Model organisms such as Arabidopsis ( ) and rice ( ) have proven essential for efficient scientific discovery and development of new methods. With the diversity of plant lineages, some important processes such as C photosynthesis are not found in either Arabidopsis or rice, so new model species are needed. Due to their small diploid genomes, short life cycles, self-pollination, small adult statures and prolific seed production, domesticated foxtail millet ( ) and its wild ancestor, green foxtail ( ), have recently been proposed as novel model species for functional genomics of the Panicoideae, especially for study of C photosynthesis. This review outlines the development of these species as model organisms, and discusses current challenges and future potential of a Setaria model.

Keywords： Setaria     foxtail millet     C4 photosynthesis     model organism    

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Comments on the special issue on forestry of

John L. INNES

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 4,   Pages 502-503 doi: 10.15302/J-FASE-2017189

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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: Checkpoint blockades targeting the PD-1/PD-L1 axis have achieved effective clinical responses with acceptableIn this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway, including the expression patterns of PD-1/PD-L1 and potential PD-1/PD-L1-related therapeutic strategies

Keywords： PD-1     PD-L1     immune checkpoint blockade antibody     immunotherapy     cervical cancer    

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ZnFe2O4/BiVO4 Z-scheme heterojunction for efficient visible-light photocatalytic

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 11,   Pages 1728-1740 doi: 10.1007/s11705-023-2322-z

Abstract: A novel Z-scheme ZnFe2O4/BiVO4 heterojunction photocatalyst was successfullyCompared with the single-phase counterparts, ZnFe2O4/BiVO4 demonstratedConsequently, the 30% ZnFe2O4/BiVO4 catalyst afforded a degradationrate of up to 97% of 20 mg/L ciprofloxacin under 30 min of visible light irradiation with a total organicMoreover, the as-synthesized ZnFe2O4/BiVO4 heterojunctions were quite

Keywords： ZnFe2O4/BiVO4     Z-scheme heterojunction     photocatalytic degradation    

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In memory of Perry L. McCarty, seminal founder of Environmental Biotechnology

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 10, doi: 10.1007/s11783-023-1730-0

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Shear design of high strength concrete prestressed girders

Emad L. LABIB,Hemant B. DHONDE,Thomas T. C. HSU,Y. L. MO

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4,   Pages 373-387 doi: 10.1007/s11709-014-0087-7

Abstract: Normal strength prestressed concrete I-girders are commonly used as the primary superstructure components in highway bridges. However, shear design guidelines for high strength PC girders are not available in the current structural codes. Recently, ten 7.62 m (25 feet) long girders made with high strength concrete were designed, cast, and tested at the University of Houston (UH) to study the ultimate shear strength and the shear concrete contribution ( ) as a function of concrete strength ( ). A simple semi-empirical set of equations was developed based on the test results to predict the ultimate shear strength of prestressed concrete I-girders. The UH-developed set of equations is a function of concrete strength ( ), web area ( ), shear span to effective depth ratio ( / ), and percentage of transverse steel ( ). The proposed UH-Method was found to accurately predict the ultimate shear strength of PC girders with concrete strength up to 117 MPa (17000 psi) ensuring satisfactory ductility. The UH-Method was found to be not as overly conservative as the ACI-318 (2011) code provisions, and also not to overestimate the ultimate shear strength of high strength PC girders as the AASHTO LRFD (2010) code provisions. Moreover, the proposed UH-Method was found fairly accurate and not exceedingly conservative in predicting the concrete contribution to shear for concrete strength up to 117 MPa (17000 psi).

Keywords： shear design     high strength concrete     prestressed girders     full-scale tests    

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Li4SiO4-coated LiNi0.5Mn1.5O4 as the high performance

Shifeng YANG, Wenfeng REN, Jian CHEN

Frontiers in Energy 2017, Volume 11, Issue 3,   Pages 374-382 doi: 10.1007/s11708-017-0494-2

Abstract: The preparation of Li SiO -coated LiNi Mn O materials by sintering the SiO -coated nickel-manganese oxides with lithium salts using abundant and low-cost sodium silicate as the silicon source was reported. The samples were characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. It was found that a uniform and complete SiO coating layer could be obtained at a suitable pH value of 10, which transformed to a good Li SiO coating layer afterwards. When used as the cathode materials for lithium-ion batteries, the Li SiO -coated LiNi Mn O samples deliver a better electrochemical performance in terms of the discharge capacity, rate capability, and cycling stability than that of the pristine material. It can still deliver 111.1 mAh/g at 20 C after 300 cycles, with a retention ratio of 93.1% of the stable capacity, which is far beyond that of the pristine material (101.3 mAh/g, 85.6%).

Keywords： lithium-ion batteries     cathode material     LiNi0.5Mn1.5O4     lithium-ion conductor    

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Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic

Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1224-2

Abstract: zero-valent zinc coupled with ascorbic acid (ZVZ/AA) was developed and applied to debrominate the 2,2′,4,4The reaction conditions were optimized by the addition of 100 mg/L ZVZ particles and 3 mmol/L AA at originalsolution pH= 4.00 using the solvent of methanol/H2O (v:v= 4:6), which could convert approximately 94%of 5 mg/L BDE-47 into lower-brominated diphenyl ethers within a 90 min at the ZVZ/AA system.

Keywords： 2     2′     4     4′-tetrabromodiphenyl ether (BDE-47)     Ascorbic acid     Reductive debromination     Zero-valent zinc    

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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: In the present study, replication factor c subunit 4 (RFC4) is a key potential target involved in NPCFurthermore, the expression and mechanism of RFC4 in NPC were investigated in vitro and inOur results revealed that RFC4 was more elevated in NPC tumor tissues than in normal tissues.RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro andInterestingly, HOXA10 was confirmed as a downstream target of RFC4, and the overexpression of HOXA10

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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Deeply missing my career idol and role model ― Professor Perry L. McCarty

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1717-x

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Laws of 4D Printing Article

Farhang Momeni, Jun Ni

Engineering 2020, Volume 6, Issue 9,   Pages 1035-1055 doi: 10.1016/j.eng.2020.01.015

Abstract: Accordingly, four-dimensional (4D) printing is a manufacturing process that involves multiple researchfields. 4D printing conserves the general attributes of 3D printing (such as material waste reductionThe main difference between 3D- and 4D-printed structures is the presence of one additional dimensionshow that two types of time constants are needed to capture the correct time-dependent behavior of 4Dintroduce the concept of mismatch-driven stress at the interface of active and passive materials in 4D

Keywords： Manufacturing     Stimuli-responsive materials     Mechanics of materials     Time constant     4D printing    

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Urban watershed management under rapid urbanization

Pengfei DU, Haifeng JIA, Shaw L. YU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 5,   Pages 595-595 doi: 10.1007/s11783-012-0452-5

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Title Author Date Type Operation

Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)

Journal Article

Initiation of Setaria as a model plant

Xianmin DIAO,James SCHNABLE,Jeffrey L. BENNETZEN,Jiayang LI

Journal Article

Comments on the special issue on forestry of

John L. INNES

Journal Article

PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Journal Article

ZnFe2O4/BiVO4 Z-scheme heterojunction for efficient visible-light photocatalytic

Journal Article

In memory of Perry L. McCarty, seminal founder of Environmental Biotechnology

Journal Article

Shear design of high strength concrete prestressed girders

Emad L. LABIB,Hemant B. DHONDE,Thomas T. C. HSU,Y. L. MO

Journal Article

Li4SiO4-coated LiNi0.5Mn1.5O4 as the high performance

Shifeng YANG, Wenfeng REN, Jian CHEN

Journal Article

Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic

Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

Deeply missing my career idol and role model ― Professor Perry L. McCarty

Journal Article

Laws of 4D Printing

Farhang Momeni, Jun Ni

Journal Article

Urban watershed management under rapid urbanization

Pengfei DU, Haifeng JIA, Shaw L. YU

Journal Article