Resource Type

Journal Article 1989

Conference Videos 48

Year

2024 4

2023 155

2022 204

2021 191

2020 159

2019 157

2018 121

2017 128

2016 89

2015 105

2014 70

2013 65

2012 47

2011 64

2010 57

2009 69

2008 64

2007 80

2006 48

2005 36

open ︾

Keywords

optimization 18

Machine learning 13

fuel cell 13

multi-objective optimization 10

genetic algorithm 9

immunotherapy 8

neural network 8

Deep learning 7

Reinforcement learning 7

big data 7

COVID-19 6

control 6

different 5

fault diagnosis 5

hematopoietic stem cell transplantation 5

Adsorption 4

Artificial intelligence 4

Neural network 4

Optimization 4

open ︾

Search scope:

排序： Display mode:

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract:

Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryHowever, many critical issues associated mainly with incomplete understanding of stem cell biology andIn this review, we summarize some new achievements in stem cell studies, especially the preclinical andabreast of evolvement of stem cell sciences and technologies.

Keywords： stem cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines    

HTML PDF Collect

MAS-based production scheduling system for manufacturing cell-based workshop

CHU Hong-yan, CAO Quan-jun, FEI Ren-yuan

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 4,   Pages 375-380 doi: 10.1007/s11465-006-0043-x

Abstract: In this paper, the manufacturing cell-based workshop is described and its scheduling system structureis established based on MAS (multi-agent system) technology.The CORBA-based architecture of the communication is designed and some interfaces for the communication

Keywords： negotiation     selection     multi-agent     communication     abnormal    

HTML PDF Collect

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract: Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cellHowever, considering the safety, activities, and reliability of the cell products, researchers must developIn this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

HTML Collect

Static analysis of corrugated panels using homogenization models and a cell-based smoothed mindlin plate

Nhan NGUYEN-MINH, Nha TRAN-VAN, Thang BUI-XUAN, Trung NGUYEN-THOI

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 2,   Pages 251-272 doi: 10.1007/s11709-017-0456-0

Abstract: In addition, in the recent trend of development of smoothed finite element methods, the cell-based smoothedthree-node Mindlin plate element (CS-MIN3) based on the first-order shear deformation theory (FSDT)

Keywords： homogenization     corrugated panel     asymptotic analysis     smoothed finite element method (S-FEM)     cell-based    

HTML PDF Collect

An extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) for free vibration analysis

M. H. NGUYEN-THOI,L. Le-ANH,V. Ho-HUU,H. Dang-TRUNG,T. NGUYEN-THOI

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 341-358 doi: 10.1007/s11709-015-0302-1

Abstract: A cell-based smoothed discrete shear gap method (CS-FEM-DSG3) was recently proposed and proven to beThe method improves significantly the accuracy of the solution due to softening effect of the cell-basedsingular enrichment functions of the extended finite element method (XFEM) to give a so-called extended cell-based

Keywords： cracked Reissner-Mindlin shell     free vibration analysis     cell-based smoothed discrete shear gap method(CS-FEM-DSG3)     extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3)     smoothed finite element    

HTML PDF Collect

Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review

Yuan Hu, Zhigang Tian, Cai Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 106-114 doi: 10.1016/j.eng.2018.11.015

Abstract: transformed cells and malignancies in real time, tumors develop several strategies to escape from NK cellincluding autologous or allogeneic NK cells, umbilical cord blood (UCB) or induced pluripotent stem cell(iPSC)-derived NK cells, memory-like NK cells, and NK cell line NK-92 cells, for the treatment of differentIn this review, we summarize the mechanisms of tumor escape from NK cell recognition, the current statusand advanced progress of NK cell-based immunotherapy, ways of enhancing the antitumor capacity of NK

Keywords： Natural killer cell     Immunotherapy     Cancer     Clinical trial     Chimeric antigen receptor    

HTML PDF Collect

Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies

Jorge L. Escobar Ivirico, Maumita Bhattacharjee, Emmanuel Kuyinu, Lakshmi S. Nair, Cato T. Laurencin

Engineering 2017, Volume 3, Issue 1,   Pages 16-27 doi: 10.1016/J.ENG.2017.01.003

Abstract: Several biomaterial and cell-based therapies are currently in development and have shown early promise

Keywords： Knee osteoarthritis     Osteoarthritic pain     Mesenchymal stem cells     Biomaterials     Regenerative engineering    

HTML PDF Collect

White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 741-746 doi: 10.1007/s11684-017-0579-7

Abstract: The relationship between HUA and white blood cell (WBC) count remains unknown.

Keywords： white blood cell count     hyperuricemia     chronic kidney disease     inflammation    

HTML PDF Collect

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: In this review of our group’s research, an innovative silica-based, mucoadhesive oral insulin formulationwith encapsulated-insulin/cell penetrating peptide (CPP) to overcome both enzyme and mucosal barriersIt was also confirmed that low molecular weight protamine (LMWP) behaves like a CPP peptide, with a cell

Keywords： insulin     cell penetrating peptide     mucoadhesive composites     oral delivery    

HTML PDF Collect

Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 160-188 doi: 10.1007/s11684-018-0629-9

Abstract: We describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions

Keywords： bone tissue engineering     stem cell     bone scaffold     growth factor     bone regeneration    

HTML PDF Collect

Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 90-98 doi: 10.1007/s11705-015-1550-2

Abstract: The well-designed microscale intermediary is also ideal for the study of cell biology.Particularly, microfluidic chip is helpful for better understanding cell-cell interactions.

Keywords： microfluidic chip     co-culture     cell-cell interactions     review    

HTML PDF Collect

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine   Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cellMNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cellThese MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting

Keywords： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing    

HTML PDF Collect

Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 451-462 doi: 10.1007/s11684-018-0651-y

Abstract: Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential

Keywords： deubiquitinase     ubiquitination     T cell activation     T cell differentiation     T cell tolerance    

HTML PDF Collect

Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 46-57 doi: 10.1007/s11705-017-1609-3

Abstract: Cell surface protein engineering facilitated by accumulation of information on genome and protein structureinvolves heterologous production and modification of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts.In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a carrier protein.

Keywords： cell surface engineering     surface display     whole-cell catalysts     bioprocess    

HTML PDF Collect

Prospect of carbon-based solid oxide fuel cells

Han Minfang,Peng Suping

Strategic Study of CAE 2013, Volume 15, Issue 2,   Pages 4-6

Abstract: The fuel cell which could turn chemical energy directly into electrical energy is a kind of high efficiencyIn all kinds of fuel cells, solid oxide fuel cell (SOFC) could use many kinds of carbon-based fuelssystem and excellent long term stability is observed during operation when using this kind of fuel cellstructure and the superiority of rare earth resource in China, it is necessary to develop carbon-basedfuels, cell structure, theoretical modeling and the problems of foundation science and technique

Keywords： solid oxide fuel cell     carbon-based fuels     power generation system    

HTML PDF Collect

Title Author Date Type Operation

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

MAS-based production scheduling system for manufacturing cell-based workshop

CHU Hong-yan, CAO Quan-jun, FEI Ren-yuan

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Static analysis of corrugated panels using homogenization models and a cell-based smoothed mindlin plate

Nhan NGUYEN-MINH, Nha TRAN-VAN, Thang BUI-XUAN, Trung NGUYEN-THOI

Journal Article

An extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) for free vibration analysis

M. H. NGUYEN-THOI,L. Le-ANH,V. Ho-HUU,H. Dang-TRUNG,T. NGUYEN-THOI

Journal Article

Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects

Yuan Hu, Zhigang Tian, Cai Zhang

Journal Article

Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies

Jorge L. Escobar Ivirico, Maumita Bhattacharjee, Emmanuel Kuyinu, Lakshmi S. Nair, Cato T. Laurencin

Journal Article

White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

Journal Article

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Journal Article

Current advances for bone regeneration based on tissue engineering strategies

Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian

Journal Article

Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Journal Article

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Journal Article

Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Journal Article

Prospect of carbon-based solid oxide fuel cells

Han Minfang,Peng Suping

Journal Article