Resource Type

Journal Article 479

Conference Videos 9

Year

2023 6

2022 41

2021 47

2020 41

2019 32

2018 32

2017 25

2016 20

2015 30

2014 33

2013 20

2012 27

2011 17

2010 20

2009 17

2008 13

2007 22

2006 4

2005 7

2004 7

open ︾

Keywords

evaluation 16

COVID-19 13

performance evaluation 11

traditional Chinese medicine 7

diagnosis 5

evaluation system 4

fuzzy comprehensive evaluation 4

index system 4

quality evaluation 4

Clinical trial 3

Clinical trials 3

Efficacy 3

comprehensive evaluation 3

Bayesian belief network 2

Cartilage tissue engineering 2

Clinical characteristics 2

Clinical translation 2

Coronavirus disease 2

SARS-CoV-2 2

open ︾

Search scope:

排序： Display mode:

Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guidelinedevelopment for clinical practice with acupuncture and moxibustion

Hong Zhao, Fengxia Liang, Yigong Fang, Baoyan Liu

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 590-594 doi: 10.1007/s11684-017-0537-4

Abstract:

Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approachto guideline development for clinical practice.For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed inoverall progression to develop recommendations, and strength of recommendations providing specific clinicalIn the guideline development for clinical practice with acupuncture and moxibustion, we suggest that

Keywords： guideline     acupuncture     GRADE    

HTML PDF Collect
Share

Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 321-327 doi: 10.1007/s11684-014-0370-y

Abstract: and genomic data have been accumulated dramatically, which generates big data in medical field for clinicalevaluation based on sampling.” This not only facilitates the evaluation of individualized treatment, disease prediction, preventiondifferentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluationTo conduct clinical studies involved in big data in TCM domain, top level design is needed and should

Keywords： big data     traditional Chinese medicine     clinical evaluation     evidence based medicine    

HTML PDF Collect
Share

Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical

Liyun He, Tiancai Wen, Shiyan Yan, Runjin Li, Zufa Liu, Hui Ren, Jinmin Liu, Fengshan Zhang, Jianzhong Wu, Jian Liu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 229-234 doi: 10.1007/s11684-011-0139-5

Abstract: Based on a multicenter, prospective, randomized, and controlled clinical trial design, we used the seizure

Keywords： Dianxianning     epilepsy seizure     evaluation    

HTML PDF Collect
Share

Next Steps for Efficacy Evaluation in Clinical Trials of COVID-19 Vaccines

Hu-Dachuan Jiang, Li Zhang, Jing-Xin Li, Feng-Cai Zhu

Engineering 2021, Volume 7, Issue 7,   Pages 903-907 doi: 10.1016/j.eng.2021.04.013

HTML PDF Collect
Share

Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Strategic Study of Chinese Academy of Engineering 2021, Volume 23, Issue 1,   Pages 185-192 doi: 10.15302/J-SSCAE-2021.01.022

Abstract: span style="color:#231f20">drug research and development, innovation of traditional Chinese medicine, clinicalTo integrate modern and traditional pharmacy, we suggest that clinical practice guidelines for integrativedevelopment based on integrative pharmacy, the design idea of integrative drugs should be innovated, a drug evaluationTo promote the clinical application of integrative pharmacy, patient-centered clinical medication guidancebe further improved, individualized treatment should be encouraged, the clinical

Keywords： integrative pharmacy     integrative drugs     new drug development     drug evaluation     clinical medication guidance    

HTML PDF Collect
Share

Clinical evaluation of recombinant human growth hormone injection in children with growth hormone deficiency

Ling HOU, Xiaoping LUO, Minlian DU, Huamei MA, Chunxiu GONG, Yuchuan LI, Shuixian SHEN, Zhuhui ZHAO, Li LIANG, Guanping DONG, Chaoying YAN, Hongwei DU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 171-176 doi: 10.1007/s11684-009-0027-4

Abstract: Recombinant human growth hormone (rhGH) has been widely used in the clinical treatment of growth hormone

Keywords： recombinant human growth hormone     injection     growth hormone deficiency    

HTML PDF Collect
Share

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation

Keywords： ontology     traditional Chinese medicine     clinical terminology    

HTML PDF Collect
Share

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract: A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

HTML PDF Collect
Share

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life quality and a dismal prognosis. However, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades. To date, no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM. Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention. The risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists. We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions. We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities. Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms, as well as the development of novel effective therapies for HCC patients with BM.

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

HTML PDF Collect
Share

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical

Keywords： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

HTML PDF Collect
Share

Hypertension in patients with CKD in China: clinical characteristics and management

Guangyan Cai, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 307-309 doi: 10.1007/s11684-017-0578-8

HTML PDF Collect
Share

Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 564-582 doi: 10.1007/s11684-019-0724-6

Abstract: Berberine, an isoquinoline alkaloid isolated from the Chinese herb and other plants, has a wide range of pharmacological properties. Berberine can be used to treat many diseases, such as cancer and digestive, metabolic, cardiovascular, and neurological diseases. Berberine has protective capacities in digestive diseases. It can inhibit toxins and bacteria, including , protect the intestinal epithelial barrier from injury, and ameliorate liver injury. Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis. Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies. In addition, berberine regulates glycometabolism and lipid metabolism, improves energy expenditure, reduces body weight, and alleviates nonalcoholic fatty liver disease. Berberine also improves cardiovascular hemodynamics, suppresses ischemic arrhythmias, attenuates the development of atherosclerosis, and reduces hypertension. Berberine shows potent neuroprotective effects, including antioxidative, antiapoptotic, and anti-ischemic. Furthermore, berberine exerts protective effects against other diseases. The mechanisms of its functions have been extensively explored, but much remains to be clarified. This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive, metabolic, cardiovascular, and neurological diseases.

Keywords： berberine     Coptis chinensis     pharmacological properties     mechanism     clinical applications    

HTML PDF Collect
Share

Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis

Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 411-419 doi: 10.1007/s11684-018-0659-3

Abstract: These predictors include but are certainly not limited to genetic variations, clinical factors, and demographicHowever, no clinical application is currently available.

Keywords： rheumatoid arthritis     gene     clinical markers     therapy    

HTML PDF Collect
Share

Anatomy and embryology of umbilicus in newborns: a review and clinical correlations

Abdelmonem A. Hegazy

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 271-277 doi: 10.1007/s11684-016-0457-8

Abstract: This article aimed to address the basic knowledge of the umbilicus in relation to clinical disordersThus, the umbilicus is prone to various clinical disorders.

Keywords： anatomy     embryology     newborns     umbilicus    

HTML PDF Collect
Share

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 389-402 doi: 10.1007/s11684-021-0856-3

Abstract: The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-α-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinicalThe families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.

Keywords： severe community-acquired pneumonia     lung microbiota     clinical improvements     7-category ordinal scale    

HTML PDF Collect
Share

Title Author Date Type Operation

Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guidelinedevelopment for clinical practice with acupuncture and moxibustion

Hong Zhao, Fengxia Liang, Yigong Fang, Baoyan Liu

Journal Article

Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Journal Article

Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical

Liyun He, Tiancai Wen, Shiyan Yan, Runjin Li, Zufa Liu, Hui Ren, Jinmin Liu, Fengshan Zhang, Jianzhong Wu, Jian Liu

Journal Article

Next Steps for Efficacy Evaluation in Clinical Trials of COVID-19 Vaccines

Hu-Dachuan Jiang, Li Zhang, Jing-Xin Li, Feng-Cai Zhu

Journal Article

Development Strategy of Integrative Pharmacy

Zhang Yong, Zhao Yixiu, Yang Baofeng

Journal Article

Clinical evaluation of recombinant human growth hormone injection in children with growth hormone deficiency

Ling HOU, Xiaoping LUO, Minlian DU, Huamei MA, Chunxiu GONG, Yuchuan LI, Shuixian SHEN, Zhuhui ZHAO, Li LIANG, Guanping DONG, Chaoying YAN, Hongwei DU

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Journal Article

Hypertension in patients with CKD in China: clinical characteristics and management

Guangyan Cai, Xiangmei Chen

Journal Article

Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Journal Article

Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis

Xin Wu, Xiaobao Sheng, Rong Sheng, Hongjuan Lu, Huji Xu

Journal Article

Anatomy and embryology of umbilicus in newborns: a review and clinical correlations

Abdelmonem A. Hegazy

Journal Article

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical

Journal Article