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genotype 7

genotype variation 2

China 1

DNA damage 1

allele frequency 1

cadmium (Cd) accumulation 1

cadmium contamination 1

capacity 1

celery 1

chronic obstructive pulmonary disease 1

colistin-only-sensitive 1

crop breeding 1

cultivar regional test 1

cyclooxygenase-2 gene 1

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differentiation 1

disease burden 1

drug resistance 1

esophageal squamous cell carcinoma 1

food safety 1

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Genotype variations in accumulation of cadmium and lead in celery (

Kun ZHANG, Jianbing WANG, Zhongyi YANG, Guorong XIN, Jiangang YUAN, Junliang XIN, Charlie HUANG

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1,   Pages 85-96 doi: 10.1007/s11783-012-0399-3

Abstract: These genotype variations in Cd accumulation are sufficiently large to help reduce Cd contamination riskEvidence obtained proves that Cd and Pb accumulations in celery are stable and genotype-dependent at

Keywords： cadmium (Cd) accumulation     lead (Pb) accumulation     celery     genotype variation     food safety    

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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: In this study, we identified the correlation between p53 functional activation and its genotype in fivefollowing the DNA damages in YES 2 with wild-type , KYSE 70 with mutant , and EC9706 with unknown genotypeAll our data indicated that p53 function in certain cells is not closely correlated with its genotypecell line, it is important to examine the p53 functional activation, but not to simply rely on the genotype

Keywords： p53     esophageal squamous cell carcinoma     DNA damage    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract:

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality throughout the world and is mainly characterized by persistent airflow limitation. Given that multiple systems other than the lung can be impaired in COPD patients, the traditional FEV1/FVC ratio shows many limitations in COPD diagnosis and assessment. Certain heterogeneities are found in terms of clinical manifestations, physiology, imaging findings, and inflammatory reactions in COPD patients; thus, phenotyping can provide effective information for the prognosis and treatment. However, phenotypes are often based on symptoms or pathophysiological impairments in late-stage COPD, and the role of phenotypes in COPD prevention and early diagnosis remains unclear. This shortcoming may be overcome by the potential genotypes defined by the heterogeneities in certain genes. This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations between genotypes and phenotypes. The potential roles of these genotypes and phenotypes in the molecular mechanisms and management of COPD are also elucidated.

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Associations between

Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 92-97 doi: 10.1007/s11684-017-0610-z

Abstract: the genetic diversity of Mycobacterium tuberculosis in China have shown that Beijing genotypetuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosistuberculosis Beijing genotype and drug-resistance phenotype in China.Results confirmed that the Beijing genotype, the predominant M. tuberculosis genotype

Keywords： tuberculosis     drug resistance     genotype     molecular biology    

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The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 1-7 doi: 10.1007/s11684-019-0733-5

Abstract: NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being

Keywords： molecular epidemiology     norovirus     disease burden     genotype     China    

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Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 90-95 doi: 10.1007/s11684-010-0021-x

Abstract: This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infection. We conducted a population-based, case-control study enrolling 630 Han Chinese people in Hubei province. Subjects included primary HCC patients with HBV infection (=210), chronic hepatitis B cases (=210) and healthy Han Chinese (=210). -1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis. We found-1195A allele carriers had a higher risk of HCC with HBV infection (OR, 0.72; 95% CI, 0.548–0.946). The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.

Keywords： cyclooxygenase-2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma     hepatitis B virus infection    

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Advances in crop phenotyping and multi-environment trials

Zhe LIU,Fan ZHANG,Qin MA,Dong AN,Lin LI,Xiaodong ZHANG,Dehai ZHU,Shaoming LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 28-37 doi: 10.15302/J-FASE-2015051

Abstract: Efficient evaluation of crop phenotypes is a prerequisite for breeding, cultivar adoption, genomics and phenomics study. Plant genotyping is developing rapidly through the use of high-throughput sequencing techniques, while plant phenotyping has lagged far behind and it has become the rate-limiting factor in genetics, large-scale breeding and development of new cultivars. In this paper, we consider crop phenotyping technology under three categories. The first is high-throughput phenotyping techniques in controlled environments such as greenhouses or specifically designed platforms. The second is a phenotypic strengthening test in semi-controlled environments, especially for traits that are difficult to be tested in multi-environment trials (MET), such as lodging, drought and disease resistance. The third is MET in uncontrolled environments, in which crop plants are managed according to farmer’s cultural practices. Research and application of these phenotyping techniques are reviewed and methods for MET improvement proposed.

Keywords： crop breeding     genotyping     phenotyping     genotype-environment interaction     cultivar regional test    

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The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter baumannii

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 423-428 doi: 10.1007/s11684-007-0083-6

Abstract: The COS-AB from burn wards showed the identical PFGE pattern which was distinguished from the genotype

Keywords： identical     different     teaching hospital     genotype     colistin-only-sensitive    

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Construction of an immortalized neural progenitor cell strain and analysis of its immunogenicity

AN Ke, XU Ying, TIAN Xuebi, GAO Feng, TIAN Yuke, YANG Hui, ZHANG Chuanhan

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 63-69 doi: 10.1007/s11684-008-0012-3

Abstract: self-renewal and can proliferate infinitely, can produce a large number of NPCs with stable phenotype and genotype

Keywords： immortalized     long-term survival     differentiation     capacity     genotype    

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Identification of pakchoi cultivars with low cadmium accumulation and soil factors that affect their cadmium uptake and translocation

Lin WANG,Yingming XU,Yuebing SUN,Xuefeng LIANG,Dasong LIN

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6,   Pages 877-887 doi: 10.1007/s11783-014-0676-7

Abstract: The selection and use of low-Cd-accumulating cultivar (LCAC) has been proposed as one of the promising approaches in minimizing the entry of Cd in the human food chain. This study suggests a screening criterion of LCACs focusing on food safety. Pot culture and plot experiments were conducted to screen out LCACs from 35 pakchoi cultivars and to identify the crucial soil factors that affect Cd accumulation in LCACs. Results of the pot culture experiment showed that shoot Cd concentrations under the three Cd treatments significantly varied across cultivars. Two cultivars, Hualv 2 and Huajun 2, were identified as LCACs because their shoot Cd concentrations were lower than 0.2 mg·kg under low Cd treatment and high Cd exposure did not affect the biomass of their shoots. The plot experiment further confirmed the consistency and genotypic stability of the low-Cd-accumulating traits of the two LCACs under various soil conditions. Results also showed that soil phosphorus availability was the most important soil factor in the Cd accumulation of pakchoi, which related negatively not only to Cd uptake by root but also to Cd translocation from root to shoot. The total Cd accumulation and translocation rates were lower in the LCACs than in the high-Cd cultivar, suggesting that Cd accumulation in different cultivars is associated with the Cd uptake by root as well as translocation from root to shoot. This study proves the feasibility of the application of the LCAC strategy in pakchoi cultivation to cope with Cd contamination in agricultural soils.

Keywords： cadmium contamination     low-cadmium-accumulating cultivar (LCAC)     genotype variation     soil factor     translocation    

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Studies on Malate Dehydrogenase Ⅱ (MDH Ⅱ ) Isozymes in Different Races of Apis mellifera ligustica

Chen Shenglu,Bao Xiuliang,Su Songkun,Liu Yanhe

Strategic Study of CAE 2000, Volume 2, Issue 1,   Pages 57-61

Abstract: ), Italian Italian honey bee (Ee) and Australian Italian honey bee (Eo) have been used to study the genotype, genotype frequency, allele frequency, heterozygous and homzygous degrees of the malate dehydrogenasefound in Ea, Eb and Ee; four (a/b, a/c, b/c, c/c) are found in Eo; three (a/c, b/c, c/c) in Em.The genotypeThe results of test-independence show that there are significant differences in the distributions of genotype

Keywords： races of Apis mellifera malate dehydrogenase (MDH)     genotype     allele frequency     heterozygosity    

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Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 419-429 doi: 10.1007/s11684-010-0160-0

Abstract: C3060T, T3066A, T3069G, A3120T, and G3191C were significantly associated with increased risks of HCC in genotypeC, whereas these mutations were inversely associated with HCC in genotype B.Conclusively, the association of HBV mutations in the preS region with HCC depends on HBV genotype and

Keywords： hepatitis B virus     hepatocellular carcinoma     mutation     genotype     haplotype    

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Title Author Date Type Operation

Genotype variations in accumulation of cadmium and lead in celery (

Kun ZHANG, Jianbing WANG, Zhongyi YANG, Guorong XIN, Jiangang YUAN, Junliang XIN, Charlie HUANG

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Associations between

Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan

Journal Article

The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Journal Article

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Journal Article

Advances in crop phenotyping and multi-environment trials

Zhe LIU,Fan ZHANG,Qin MA,Dong AN,Lin LI,Xiaodong ZHANG,Dehai ZHU,Shaoming LI

Journal Article

The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter baumannii

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

Journal Article

Construction of an immortalized neural progenitor cell strain and analysis of its immunogenicity

AN Ke, XU Ying, TIAN Xuebi, GAO Feng, TIAN Yuke, YANG Hui, ZHANG Chuanhan

Journal Article

Identification of pakchoi cultivars with low cadmium accumulation and soil factors that affect their cadmium uptake and translocation

Lin WANG,Yingming XU,Yuebing SUN,Xuefeng LIANG,Dasong LIN

Journal Article

Studies on Malate Dehydrogenase Ⅱ (MDH Ⅱ ) Isozymes in Different Races of Apis mellifera ligustica

Chen Shenglu,Bao Xiuliang,Su Songkun,Liu Yanhe

Journal Article

Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma

Jia-Xin XIE, Jian-Hua YIN, Qi ZHANG, Rui PU, Wen-Ying LU, Hong-Wei ZHANG, Guang-Wen CAO, Jun ZHAO, Hong-Yang WANG,

Journal Article