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Journal Article 5

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Aphanomyces euteiches 1

Accessory protein 1

Field pea 1

Fusarium head blight 1

Gene knockout 1

HaNPV 1

MERS-CoV 1

Nascent polypeptide-associated complex 1

Nonstructural protein 1

Pathogenicity 1

Pathogenicity variability 1

Quantitative trait loci 1

Root rot 1

Shigella flexneri 2a 301 strain 1

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acute intravenous injection 1

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Safety evaluation of microbial pesticide (HaNPV) based on PCR method

Miao Zhao, Shufei Li, Qinghong Zhou, Dianming Zhou, Ning He, Zhiyong Qian

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 377-384 doi: 10.1007/s11705-018-1777-9

Abstract: In this paper, we have investigated the infectivity and pathogenicity of a representative of viral microbialspecificity and repeatability, and could provide an important reference for establishment of infectivity and pathogenicity

Keywords： microbial pesticides     HaNPV     acute intravenous injection     infectivity     pathogenicity    

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Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins Review

Yan-Hua Li, Chen-Yu Hu, Nan-Ping Wu, Hang-Ping Yao, Lan-Juan Li

Engineering 2019, Volume 5, Issue 5,   Pages 940-947 doi: 10.1016/j.eng.2018.11.035

Abstract:

Middle East respiratory syndrome (MERS) is a viral respiratory disease caused by a de novo coronavirus—Middle East respiratory syndrome coronavirus (MERS-CoV)—that is associated with high mortality. However, the mechanism by which MERS-CoV infects humans remains unclear. To date, there is no effective vaccine or antibody for human immunity and treatment, other than the safety and tolerability of the fully human polyclonal Immunoglobulin G (IgG) antibody (SAB-301) as a putative therapeutic agent specific for MERS. Although rapid diagnostic and public health measures are currently being implemented, new cases of MERS-CoV infection are still being reported. Therefore, various effective measures should be taken to prevent the serious impact of similar epidemics in the future. Further investigation of the epidemiology and pathogenesis of the virus, as well as the development of effective therapeutic and prophylactic anti-MERS-CoV infections, is necessary. For this purpose, detailed information on MERS-CoV proteins is needed. In this review, we describe the major structural and nonstructural proteins of MERS-CoV and summarize different potential strategies for limiting the outbreak of MERS-CoV. The combination
of computational biology and virology can accelerate the advanced design and development of effective peptide therapeutics against MERS-CoV. In summary, this review provides important information about the progress of the elimination of MERS, from prevention to treatment.

Keywords： MERS-CoV     Spike protein     Structural protein     Accessory protein     Nonstructural protein    

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Aphanomyces euteiches: A Threat to Canadian Field Pea Production Review

Longfei Wu,Kan-Fa Chang,Robert L. Conner,Stephen Strelkov,Rudolph Fredua-Agyeman,Sheau-Fang Hwang,David Feindel

Engineering 2018, Volume 4, Issue 4,   Pages 542-551 doi: 10.1016/j.eng.2018.07.006

Abstract:

Field pea (Pisum sativum var. arvense L.) is an important legume crop around the world. It produces grains with high protein content and can improve the amount of available nitrogen in the soil. Aphanomyces root rot (ARR), caused by the soil-borne oomycete Aphanomyces euteiches Drechs. (A. euteiches), is a major threat to pea production in many pea-growing regions including Canada; it can cause severe root damage, wilting, and considerable yield losses under wet soil conditions. Traditional disease management strategies, such as crop rotations and seed treatments, cannot fully prevent ARR under conditions conducive for the disease, due to the longevity of the pathogen oospores, which can infect field pea plants at any growth stage. The development of pea cultivars with partial resistance or tolerance to ARR may be a promising approach to analyze the variability and physiologic specialization of A. euteiches in field pea and to improve the management of this disease. As such, the detection of quantitative trait loci (QTL) for resistance is essential to field pea-breeding programs. In this paper, the pathogenic characteristics of A. euteiches are reviewed along with various ARR management strategies and the QTL associated with partial resistance to ARR.

Keywords： Field pea     Aphanomyces euteiches     Root rot     Pathogenicity variability     Quantitative trait loci    

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Nascent Polypeptide-Associated Complex Involved in the Development and Pathogenesis of Fusarium graminearum on Wheat Article

Xuli Wang, Xin Xie, Jin Liu, Guo-Liang Wang, Dewen Qiu

Engineering 2020, Volume 6, Issue 5,   Pages 546-552 doi: 10.1016/j.eng.2019.07.025

Abstract:

Reliable knowledge on pathogenic agents contributes to effective plant protection. For most plant pathogens, maintaining protein homeostasis (proteostasis) is essential for unfolding the cellular functions to survive and thrive. However, the fungal proteins involved in proteostasis remain poorly characterized in the process of pathogenesis. In this study, we characterized the function of the nascent polypeptide-associated complex (NAC) in Fusarium graminearum (F. graminearum, FgNAC), one of the top 10 fungal pathogens with predominant scientific/economic importance. We found that FgNACα, a subunit of FgNAC, manifests high structural and functional similarity to its homologous counterparts in yeast and other species. The mutants of F. graminearum lacking NACα are viable but suffer significant defects in vegetative growth, conidial production, and pathogenesis. In addition, we show here that FgNACα can interact with another subunit of NAC (FgNACβ) in a yeast-two-hybrid assay. The subcellular localization results show that FgNACα and FgNACβ are predominantly localized in the cytoplasm. Future studies should focus on deciphering the mechanism by which NAC orchestrates protein biogenesis and consequentially modulates development and pathogenesis.

Keywords： Fusarium head blight     Nascent polypeptide-associated complex     Gene knockout     Pathogenicity     Subcellular    

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Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Strategic Study of CAE 2002, Volume 4, Issue 10,   Pages 40-47

Abstract: Among them, the authors identified 7 putative Sis with typical structure of pathogenicity islands (PAI

Keywords： Shigella flexneri 2a 301 strain     genome sequence     genomic island     pathogenicity island    

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Title Author Date Type Operation

Safety evaluation of microbial pesticide (HaNPV) based on PCR method

Miao Zhao, Shufei Li, Qinghong Zhou, Dianming Zhou, Ning He, Zhiyong Qian

Journal Article

Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins

Yan-Hua Li, Chen-Yu Hu, Nan-Ping Wu, Hang-Ping Yao, Lan-Juan Li

Journal Article

Aphanomyces euteiches: A Threat to Canadian Field Pea Production

Longfei Wu,Kan-Fa Chang,Robert L. Conner,Stephen Strelkov,Rudolph Fredua-Agyeman,Sheau-Fang Hwang,David Feindel

Journal Article

Nascent Polypeptide-Associated Complex Involved in the Development and Pathogenesis of Fusarium graminearum on Wheat

Xuli Wang, Xin Xie, Jin Liu, Guo-Liang Wang, Dewen Qiu

Journal Article

Complete Genome Sequence of Shigella flexneri 2a 301 Strain and Analysis of “Shigella-islands”

Liu Hong,Yang Fan,Zhang Xiaobing,Zhang Jiyu,Yang Guowei,Dong Jie,Xue Ying,Hou Yunde,Yuan Zhenghong,Wen Yumei,Xu Jianguo,Cheng Hongsong,Ma Dalong,Wang Yu,Yang Jian,Shen Yan,Qiang Boqin,Wu Hongtao,Lü Weichuan,Jin Qi

Journal Article