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Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 880-888 doi: 10.1007/s11705-019-1864-6

Abstract: The conformation-dependent activity of azobenzene combretastatin A4 (Azo-CA4) provides a unique approach to reduce the side-effects of chemotherapy, due to the light-triggered conformation transition of its azobenzene moiety. Under hypoxic tumor microenvironment, however, the high expression of azoreductase can reduce azobenzene to aniline. It was postulated that the Azo-CA4 might be degraded under hypoxia, resulting in the decrease of its anti-tumor activity. The aim of this study was to verify such hypothesis in HeLa cells . The quantitative drug concentration analysis shows the ratiometric formation of degradation end-products, confirming the bioreduction of Azo-CA4. The tubulin staining study indicates that Azo-CA4 loses the potency of switching off microtubule dynamics under hypoxia. Furthermore, the cell cycle analysis shows that the ability of Azo-CA4 to induce mitotic arrest is lost at low oxygen content. Therefore, the cytotoxicity of Azo-CA4 is compromised under hypoxia. In contrast, combretastatin A4 as a positive control maintains the potency to inhibit tubulin polymerization and break down the nuclei irrespective of light irradiation and oxygen level. This work highlights the influence of hypoxic tumor microenvironment on the anti-tumor potency of Azo-CA4, which should be considered during the early stage of designing translational Azo-CA4 delivery systems.

Keywords： hypoxia     microtubule inhibitor     drug delivery     azo-combretastatin A4     photo-responsive    

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Experimental and computational assessment of 1,4-Dioxane degradation in a photo-Fenton reactive ceramic

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1341-y

Abstract:

• 1,4-Dioxane was degraded via the photo-Fenton reactive membrane filtration

Keywords： Photo-Fenton     Ceramic membrane     1     4-Dioxane     Goethite    

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Selective reduction of NO by photo-SCR with ammonia in an annular fixed-film photoreactor

YiangChen CHOU, Young KU

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 2,   Pages 149-155 doi: 10.1007/s11783-010-0296-9

Abstract: Gaseous NO was photocatalytically reduced at room temperature by photo-assisted selective catalytic reduction(photo-SCR) with ammonia over TiO in this study.The kinetic model proposed in this study can be used to reasonably describe the reaction mechanism of photo-SCR

Keywords： photo-SCR     photocatalysis     NO reduction     Eley-Rideal model    

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Visible light responsive photocatalysts developed by substitution with metal cations aiming at artificial

Frontiers in Energy 2021, Volume 15, Issue 3,   Pages 568-576 doi: 10.1007/s11708-021-0774-8

Abstract: , and formation of solid solution are often utilized as the useful methods to develop visible light responsive

Keywords： visible light responsive photocatalyst     water splitting     artificial photosynthesis: metal ion substitution    

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Lignin-based electrospun nanofiber membrane decorated with photo-Fenton Ag@MIF-100(Fe) heterojunctions

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 930-941 doi: 10.1007/s11705-023-2309-9

Abstract: /i> seeding method to fabricate a lignin-based electrospun nanofiber membrane (LENM) decorated with photo-Fentonwithin 30 min under illumination, which is attributed to a synergy of dye adsorption/enrichment and photo-FentonTherefore, the lignin-based photo-Fenton hybrid membrane can lay the foundation for the preparation and

Keywords： lignin     electrospinning     heterojunctions     photo-Fenton catalysis     wastewater remediation    

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Effect of adding a smart potassium ion-responsive copolymer into polysulfone support membrane on the

Meibo He, Zhuang Liu, Tong Li, Chen Chen, Baicang Liu, John C. Crittenden

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 400-414 doi: 10.1007/s11705-018-1757-0

Abstract: PIP) and 1,3,5-benzenetricarbonyl trichloride on polysulfone (PSf) support membranes blended with K -responsive

Keywords： nanofiltration     interfacial polymerization     support membrane     potassium ion-responsive     thin-film composite    

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Low temperature synthesis of visible light responsive rutile TiO

John TELLAM, Xu ZONG, Lianzhou WANG

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 1,   Pages 53-57 doi: 10.1007/s11705-011-1165-1

Abstract: a titanium carbide (TiC) nano-powder precursor at low temperature to produce a stable visible light responsiveThe rutile particles showed a faceted nano-rod structure, and were tested for absorption and photo-degradationParticles with shorter synthesis times showed higher visible light absorption and corresponding photo-degradation

Keywords： photocatalysis     rutile     TiO2     hydrothermal     visible     titanium carbide    

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Self-healing polyamide reverse osmosis membranes with temperature-responsive intelligent nanocontainers

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 9,   Pages 1183-1195 doi: 10.1007/s11705-022-2287-3

Abstract: Herein, temperature-responsive intelligent nanocontainers are designed and constructed to improve waterWith adding temperature-responsive intelligent nanocontainers, the NaCl rejection of thin film compositetreatment and outstanding chlorine resistance as well as satisfactory stability suggest that temperature-responsive

Keywords： reverse osmosis     nanocontainer     self-healing     chlorine resistance     water permeability    

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Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 24-31 doi: 10.1007/s11684-019-0679-7

Abstract: However, not all patients are responsive to immune checkpoint inhibitors.Atlas and Gene Expression Omnibus, provide large volumes of data, which allow researchers to explore responsive

Keywords： immune checkpoint blockade     sensitivity     resistance     data mining    

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Solar fuel from photo-thermal catalytic reactions with spectrum-selectivity: a review

Sanli TANG, Jie SUN, Hui HONG, Qibin LIU

Frontiers in Energy 2017, Volume 11, Issue 4,   Pages 437-451 doi: 10.1007/s11708-017-0509-z

Abstract: The synergy of photo and thermal effects leads to a new approach to higher solar fuel production underThis paper reviews different approaches for solar fuel production from spectrum-selective photo-thermalreview begins with the meaning of synergetic effects, and the mechanisms of spectrum-selectivity and photo-thermalA discussion is finally presented concerning future development of photo-thermal catalytic reactions

Keywords： photo-thermal catalysis     spectrum-selectivity     solar fuel     full-spectrum    

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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: Notch and Wnt signaling on the basis of the bidirectional regulation of Notch1 specifically in Wnt-responsiveWe concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependent

Keywords： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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Cold stress responsive microRNAs and their targets in

Jingyi WANG,Juhua LIU,Caihong JIA,Hongxia MIAO,Jianbin ZHANG,Zhuo WANG,Biyu XU,Zhiqiang JIN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4,   Pages 335-345 doi: 10.15302/J-FASE-2016121

Abstract: In addition, 393 target genes of 58 identified cold-responsive miRNAs were predicted and categorizedresults provide important information for further characterization and functional analysis of cold-responsive

Keywords： cold stress     microRNA     Musa balbisiana    

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Cyanobacterial photo-driven mixotrophic metabolism and its advantages for biosynthesis

Ni Wan,Mary Abernathy,Joseph Kuo-Hsiang Tang,Yinjie J. Tang,Le You

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 308-316 doi: 10.1007/s11705-015-1521-7

Abstract: The photo-fermentations show enhanced photosynthesis, while CO loss from organic substrate degradationThe use of cyanobacteria as “green ” could be a promising route to develop robust photo-biorefineries

Keywords： CO2 mass transfer     N2 fixation     photosystem     RuBisCO     the TCA cycle    

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Comparative proteomic analysis of cold responsive proteins in two wheat cultivars with different tolerance

Shujuan ZHANG,Guoqi SONG,Yulian LI,Jie GAO,Jiao WANG,Guiju CHEN,Haosheng LI,Genying LI,Zhendong ZHAO

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 37-45 doi: 10.15302/J-FASE-2014008

Abstract: Spring radiation frost (SRF) is a severe environmental stress which impairs wheat yield and productivity worldwide. To better understand the mechanism of wheat ( ) responding to SRF, a comparative proteomic analysis was performed to analyze the changes of the key proteins in two wheat cultivars Jimai22 and Luyuan301 with high and low tolerance to SRF respectively. A total of 43 differentially expressed proteins (DEPs) which mainly involved in carbohydrate metabolism, amino acid metabolism, resistance proteins and antioxidant enzymes, photosynthesis and cellular respiration proteins, cell-wall related proteins, protein translation/processing/degradation and signal transduction were isolated and identified by two-dimensional electrophoresis and MALDI-TOF-TOF MS. The results revealed that of the 21 DEPs in Jimai22 responding to the SRF, 13 DEPs were upregulated and 8 DEPs were downregulated, and that of the 22 DEPs in Luyuan301, 9 DEPs were upregulated and 13 DEPs were downregulated. These DEPs might be responsible for the stronger cold resistance of Jimai22 compared to Luyuan301. The expression pattern and function analysis of these DEPs were very significant to understanding the mechanism of the SRF responses in wheat.

Keywords： common wheat     spring radiation frost     proteomic analysis     2-DE     MALDI-TOF-TOF MS    

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A Novel Light-Responsive Gene BcCfaS Regulates the Photomorphogenesis and Virulence of Botrytis cinerea

Guangjin Li,Zhanquan Zhang,Yong Chen,Tong Chen,Boqiang Li,Shiping Tian,

Engineering doi: 10.1016/j.eng.2023.08.015

Abstract: Light is a fundamental environmental factor for living organisms on earth—not only as a primary energy source but also as an informational signal. In fungi, light can be used as an indicator for both time and space to control important physiological and morphological responses. Botrytis cinerea (B. cinerea) is a devastating phytopathogenic fungus that exploits light cues to optimize virulence and the balance between conidiation and sclerotia development, thereby improving its dispersal and survival in ecosystems. However, the components and mechanisms underlying these processes remain obscure. Here, we identify a novel light-signaling component in B. cinerea, BcCfaS, which encodes a putative cyclopropane fatty-acyl-phospholipid synthase. BcCfaS is strongly induced by light at the transcriptional level and plays a crucial role in regulating photomorphogenesis. Deletion of BcCfaS results in reduced vegetative growth, altered colony morphology, impaired sclerotial development, and enhanced conidiation in a light-dependent manner. Moreover, the mutant exhibits serious defects in stress response and virulence on the host. Based on a lipidomics analysis, a number of previously unknown fungal lipids and many BcCfaS-regulated lipids are identified in B. cinerea, including several novel phospholipids and fatty acids. Importantly, we find that BcCfaS controls conidiation and sclerotial development by positively regulating methyl jasmonate (MeJA) synthesis to activate the transcription of light-signaling components, revealing for the first time the metabolic base of photomorphogenesis in fungi. Thus, we propose that BcCfaS serves as an integration node for light and lipid metabolism, thereby providing a regulatory mechanism by which fungi adapt their development to a changing light environment. These new findings provide an important target for antifungal design to prevent and control fungal disease.

Keywords： Light     Botrytis cinerea     Cyclopropane fatty-acyl-phospholipid synthase     Lipid metabolism     Photomorphogenesis     Virulence    

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Title Author Date Type Operation

Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang

Journal Article

Experimental and computational assessment of 1,4-Dioxane degradation in a photo-Fenton reactive ceramic

Journal Article

Selective reduction of NO by photo-SCR with ammonia in an annular fixed-film photoreactor

YiangChen CHOU, Young KU

Journal Article

Visible light responsive photocatalysts developed by substitution with metal cations aiming at artificial

Journal Article

Lignin-based electrospun nanofiber membrane decorated with photo-Fenton Ag@MIF-100(Fe) heterojunctions

Journal Article

Effect of adding a smart potassium ion-responsive copolymer into polysulfone support membrane on the

Meibo He, Zhuang Liu, Tong Li, Chen Chen, Baicang Liu, John C. Crittenden

Journal Article

Low temperature synthesis of visible light responsive rutile TiO

John TELLAM, Xu ZONG, Lianzhou WANG

Journal Article

Self-healing polyamide reverse osmosis membranes with temperature-responsive intelligent nanocontainers

Journal Article

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Journal Article

Solar fuel from photo-thermal catalytic reactions with spectrum-selectivity: a review

Sanli TANG, Jie SUN, Hui HONG, Qibin LIU

Journal Article

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Cold stress responsive microRNAs and their targets in

Jingyi WANG,Juhua LIU,Caihong JIA,Hongxia MIAO,Jianbin ZHANG,Zhuo WANG,Biyu XU,Zhiqiang JIN

Journal Article

Cyanobacterial photo-driven mixotrophic metabolism and its advantages for biosynthesis

Ni Wan,Mary Abernathy,Joseph Kuo-Hsiang Tang,Yinjie J. Tang,Le You

Journal Article

Comparative proteomic analysis of cold responsive proteins in two wheat cultivars with different tolerance

Shujuan ZHANG,Guoqi SONG,Yulian LI,Jie GAO,Jiao WANG,Guiju CHEN,Haosheng LI,Genying LI,Zhendong ZHAO

Journal Article

A Novel Light-Responsive Gene BcCfaS Regulates the Photomorphogenesis and Virulence of Botrytis cinerea

Guangjin Li,Zhanquan Zhang,Yong Chen,Tong Chen,Boqiang Li,Shiping Tian,

Journal Article