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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 973-984 doi: 10.1007/s11705-021-2123-1

Abstract: To increase antibody secretion and dose sparing, squalene-in-water aluminium hydrogel (alum)-stabilised emulsions (ASEs) have been developed, which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses. Nevertheless, the squalene (oil) in previous attempts suffered from limited oxidation resistance, thus, safety and stability were compromised. From a clinical translational perspective, it is imperative to screen the optimal oils for enhanced emulsion adjuvants. Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions, which were then screened for their stability and immunogenicity. Additionally, the underlying mechanisms of oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets. As a result, compared with squalene-in-water ASEs, soybean-in-water ASEs exhibited comparable immune responses and enhanced stability. By optimising the oil phase of the emulsion adjuvants, this work may offer an alternative strategy for safe, stable, and effective emulsion adjuvants.

Keywords： pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: After subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredAnother group was treated with the vaccine after tumor implantation.It was found that human SART3 DNA vaccine can elicit a specific CTL reaction from the mouse splenocytesThe vaccine also shows activity in tumor treatment.We conclude that the human SART3 DNA vaccine can induce antitumor ability against tumor cells expressing

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: However, vaccine development has remained challenging.in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccineOur review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and

Keywords： HIV-1     broadly neutralizing antibodies     Env conformational states     vaccine design     SOSIP    

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Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of Chinese Academy of Engineering 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: the urgent needs of coronavirus disease 2019 (COVID-19) epidemic prevention and control, nucleic acid vaccinehas attracted great attention in the vaccine research and development (R&D) field owing to its highParticularly, the R&D process of messenger RNA (mRNA) vaccine has significantly accelerated, andthe mRNA vaccine was approved for the first time to be marketed and used in humans.Subsequently, it analyzes the impact of COVID-19 outbreak on the mRNA vaccine research, summarizes the

Keywords： nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messengerRNA (mRNA) vaccine     coronavirus disease 2019 (COVID-19)     cancer    

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virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract: Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanif superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract: and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccineA total of 15 young mice aged 3 weeks to 5 weeks were immunized with the conjugate vaccine, and another15 young mice of the same age were immunized with the licensed Hib-tetanus toxoid (TT) vaccine.This new Hib-PsaA conjugate vaccine can induce both anti-PsaA and anti-Hib immune responses in young

Keywords： conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

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Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China Review

Zhiming Huang, Zhihao Fu, Junzhi Wang

Engineering 2022, Volume 10, Issue 3,   Pages 127-132 doi: 10.1016/j.eng.2022.01.001

Abstract: This review summarizes the overall state of the vaccine industry, research and development (R&D)Ultimately, this review provides a reference for the formulation of a vaccine development strategy inresponse to the current pandemic and the field of vaccine development in the post-pandemic era, as well

Keywords： Regulatory science     COVID-19 vaccine     Vaccine industry    

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Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract:

Chronic hepatitis B is a major health burden worldwide. In addition to the recent progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitis B. On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis B patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based therapeutic vaccines, which have undergone clinical trials. The advantages, disadvantages, and future perspectives for these therapeutic vaccines are discussed.

Keywords： chronic hepatitis B     therapeutic     antigen-antibody complexes     DNA     vaccine    

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SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 185-195 doi: 10.1007/s11684-021-0913-y

Abstract: challenges are both great and multidimensional due to the rapid emergence of virus variants and waning of vaccineadapt to these challenges to keep population immunity above the herd immunity threshold, by increasing vaccinefor older adults and young people, and providing timely booster doses with homologous or heterologous vaccinedevelop more effective vaccines against SARS-CoV-2 variants and to understand the best prime-boost vaccine

Keywords： COVID-19     pandemics     SARS-CoV-2     vaccination    

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immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 66-72 doi: 10.15302/J-FASE-2015047

Abstract: was identified as a membrane protein, and a previous study indicated that NcIMP1 could be a promising vaccineThese data suggest that IMP1 is a promising vaccine candidate against neosporosis.

Keywords： Neospora caninum     immune mapped protein 1 (IMP1)     vaccine candidate     BALB/c mice    

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Research and development of a novel subunit vaccine for the currently circulating pseudorabies virus

Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 216-222 doi: 10.15302/J-FASE-2015072

Abstract: Commercial gE-deleted live pseudorabies virus (PRV) vaccine has been widely used to control this diseaseSeveral killed and live vaccine candidates based on current PRV variants have been reported to be effectiveA subunit vaccine based on gB protein, one major PRV glycoprotein which elicits strong humoral and cellularin baculovirus/insect cells in the soluble format and was tested on 3-week-old piglets as a subunit vaccineHence, this novel gB-based vaccine could be applied as an effective subunit vaccine to control PRV variant

Keywords： pseudorabies virus     glycoprotein B protein     subunit vaccine    

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The preparation and application of inactivated vaccine and its antiserum from eight common pathogens

Gan Lingling,Wang Weifang,Gao Chunren,Lei Jilin

Strategic Study of Chinese Academy of Engineering 2014, Volume 16, Issue 9,   Pages 21-25

Abstract: , Edwardsiella ictaluri, Aeromonas hydrophila, in order to preparethe inactivated vaccineThen vaccine was used to immune turbot by intramuscular injection.immune, and the level of antibody is research highest in the tenth week which is inoculated inactivated vaccine

Keywords： Flatfish     Vaccine     Antiserum     pathogen    

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Challenges in the Development of a Vaccine Against COVID-19

Wei Chen, Feng-Cai Zhu

Engineering 2020, Volume 6, Issue 10,   Pages 1067-1069 doi: 10.1016/j.eng.2020.08.012

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/i> and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies virus vaccine

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: genes based on a / / triple gene-deleted pseudorabies virus and tested its efficacy in pigs as a vaccine

Keywords： pseudorabies virus     RR1 and RR2     ribonucleotide reductase     vaccine candidate    

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Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 390-395 doi: 10.1007/s11684-009-0087-5

Abstract: It was employed to evaluate immune response of the mice inoculated doubly with the DNA vaccine.The serum titer of IgG antibody against LMP2 epitope in the mice immunized with the DNA vaccine encodingIn conclusion, the EBV DNA vaccine can induce a strong humoral immune response in mice.

Keywords： Epstein-Barr virus     latent membrane protein 2     nasopharyngeal carcinoma     humoral immunity    

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Title Author Date Type Operation

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article

Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China

Zhiming Huang, Zhihao Fu, Junzhi Wang

Journal Article

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Journal Article

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Journal Article

immune mapped protein 1 (NcIMP1) is a novel vaccine candidate against neosporosis

Xia CUI,Daoyu YANG,Tao LEI,Hui WANG,Pan HAO,Qun LIU

Journal Article

Research and development of a novel subunit vaccine for the currently circulating pseudorabies virus

Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN

Journal Article

The preparation and application of inactivated vaccine and its antiserum from eight common pathogens

Gan Lingling,Wang Weifang,Gao Chunren,Lei Jilin

Journal Article

Challenges in the Development of a Vaccine Against COVID-19

Wei Chen, Feng-Cai Zhu

Journal Article

/i> and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies virus vaccine

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine

Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,

Journal Article