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Damping Identification of Bridges Under Nonstationary Ambient Vibration

Sunjoong Kim, Ho-Kyung Kim

Engineering 2017, Volume 3, Issue 6,   Pages 839-844 doi: 10.1016/j.eng.2017.11.002

Abstract: To deal with nonstationarity, an amplitude-modulating function was calculated from measured responses

Keywords： Damping     Operational modal analysis     Traffic-induced vibration     Nonstationary     Signal stationarization     Amplitude-modulating    

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Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine   Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

Keywords： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 197-205 doi: 10.15302/J-FASE-2018245

Abstract:

The present study was designed to investigate the protective effects of leonurine, a compound purified from that is active on ischemic rat behavior and cortical neurons, and explore the underlying mechanism. The general rat activity, cortical neuron morphology, superoxide dismutase (SOD), malondialdehyde (MDA), -aminobutyric acid (GABA) and glutamate decarboxylase 67 (GAD67) levels were measured. We found leonurine significantly improve the general activity of rats in an open-field test, which was associated with attenuated neuronal damage induced by ischemia. Moreover, serum SOD activity was significantly greater, MDA level lower in the leonurine group as compared with ischemia group. In addition, GABA content in the cerebral cortex was significantly greater in high-dose leonurine group. Correspondingly, GAD67 protein level coincided with the GABA level. Taken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative and anti-excitotoxicity effects by targeting GABA and leonurine might become a useful adjuvant neuroprotective agent.

Keywords： cerebral ischemia     GABA     neuroprotection     leonurine     SOD    

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Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Engineering doi: 10.1016/j.eng.2022.10.010

Abstract: In conclusion, PTH protects against steatohepatitis development by modulating the gut microbiota and

Keywords： Pien Tze Huang     Non-alcoholic steatohepatitis     Gut barrier function     Gut microbiota    

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Research on direct digital process of inductance sensor

WANG Xuan-ze, YANG Lian-gen, ZHONG Yu-ning

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 3,   Pages 317-322 doi: 10.1007/s11465-006-0023-1

Abstract: Amplitude-displacement and phase-displacement equations are deduced for non-ideal carrier wave and inductancetraditional process method is an approximate one, a new method is presented to simultaneously obtain the amplitudeAccording to the characteristic of the amplitude-displacement and phase-displacement curves, we obtaindisplacement by phase and amplitude respectively when the sensor is close to the zero point position

Keywords： traditional     corresponding     phase-displacement     Amplitude-displacement     characteristic    

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Application of a Novel Fuzzy Clustering Method Based on Chaos Immune Evolutionary Algorithm for Edge Detection in Image Processing

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 1,   Pages 85-89 doi: 10.1007/s11465-005-0023-6

Abstract: a tiny disturbance is added to a filial generation group using a chaos variable and the disturbance amplitude

Keywords： disturbance amplitude     disturbance     diversity     generation     processing    

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Controlling nested wrinkle morphology through the boundary effect on narrow-band thin films

Hanyang XU, Tielin SHI, Guanglan LIAO, Qi XIA

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 2,   Pages 235-240 doi: 10.1007/s11465-017-0458-6

Abstract: The formation of nested wrinkles was explained through the amplitude and wavelength saturation of nano-scale

Keywords： nested and hierarchical wrinkles     morphology     amplitude saturation     boundary effect    

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Flow behavior of liquid-solid coupled system of piezoelectric micropump

LU Lijun, WU Jiankang

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 1,   Pages 50-54 doi: 10.1007/s11465-008-0003-8

Abstract: of the liquid-solid coupled system, the first-order natural frequency, diaphragm vibration shape and amplitude-frequency

Keywords： amplitude-frequency relationship     first-order     micropump     diaphragm vibration     electric    

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Air-bearing position optimization based on dynamic characteristics of ultra-precision linear stages

CHEN Xuedong, LI Zhixin

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 4,   Pages 400-407 doi: 10.1007/s11465-008-0060-z

Abstract: However, the dynamic characteristics including mode frequency, mode shape, and response amplitude are

Keywords： manufacture     different     interaction     air-bearings     response amplitude    

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Separation and extraction of bridge dynamic strain data

Baijian WU, Zhaoxia LI, Ying WANG, T. H. T. CHAN,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4,   Pages 395-400 doi: 10.1007/s11709-009-0049-7

Abstract: responsibility for the errors, and the main reason is that the random disturbance shifts the real strain/stress amplitude

Keywords： dynamic     valuable     separatrix     strain/stress amplitude     frequency    

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Fatigue Life Prediction of Fiber Reinforced Metal Laminates Under Variable Amplitude Loading

Wu Xueren,Guo Yajun

Strategic Study of CAE 1999, Volume 1, Issue 3,   Pages 35-40

Abstract: mechanism-based fatigue model was developed for the prediction of the fatigue lives of FRMLs under constant amplitudeof glass fiber reinforced laminates (GLARE), including crack growth and delamination, under constant amplitudeAn equivalent crack closure model for predicting crack growth in FRMLs under variable amplitude loadingAll the models in this paper were verified by applying to GLARE under constant amplitude loading and

Keywords： fiber reinforced metal laminates     fatigue     bridging stress     delamination     life prediction    

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Development of electrorheological chip and conducting polymer-based sensor

Xianzhou ZHANG, Weihua LI, Weijia WEN, Yanzhe WU, Gordon WALLACE,

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 4,   Pages 393-396 doi: 10.1007/s11465-009-0043-8

Abstract: Experimental results show that the amplitude decreases monotonically when the frequency increases, owing

Keywords： electrorheological (ER) fluids     conducting polymer (CP)     polydimethylsioxane (PDMS)     driving frequency     amplitude    

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Impact drive rotary precision actuator with piezoelectric bimorphs

ZHANG Hongzhuang, ZENG Ping, HUA Shunming, CHENG Guangming, YANG Zhigang

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 1,   Pages 71-75 doi: 10.1007/s11465-008-0008-3

Abstract: characteristics of end-loaded piezoelectric cantilever bimorphs, a specific fixed-frequency and adjustable-amplitudeThe results show that an actuator excited by fixed-frequency and the adjustable-amplitude ramp voltage

Keywords： specific fixed-frequency     waveform     piezoelectric cantilever     mechanisms     adjustable-amplitude    

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Reverse-Time Migration from Rugged Topography to Image Ground-Penetrating Radar Data in Complex Environments Article

John H. Bradford,Janna Privette,David Wilkins,Richard Ford

Engineering 2018, Volume 4, Issue 5,   Pages 661-666 doi: 10.1016/j.eng.2018.09.004

Abstract:

In ground-penetrating radar (GPR) imaging, it is common for the depth of investigation to be on the same order as the variability in surface topography. In such cases, migration fails when it is carried out from a datum after the application of elevation statics. We introduce a reverse-time migration (RTM) algorithm based on the second-order decoupled form of Maxwell’s equations, which requires computation of only the electric field. The wavefield extrapolation is computed directly from the acquisition surface without the need for datuming. In a synthetic case study, the algorithm significantly improves image accuracy over a processing sequence in which migration is performed after elevation statics. In addition, we acquired a field dataset at the Coral Pink Sand Dunes (CPSD) in Utah, USA. The data were acquired over rugged topography and have the complex internal stratigraphy of multiply eroded, modern, and ancient eolian deposits. The RTM algorithm significantly improves radar depth images in this challenging environment.

Keywords： Ground-penetrating radar     Reverse-time migration     Sand dune     Amplitude analysis    

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Title Author Date Type Operation

Damping Identification of Bridges Under Nonstationary Ambient Vibration

Sunjoong Kim, Ho-Kyung Kim

Journal Article

Discovery of small molecule degraders for modulating cell cycle

Journal Article

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Journal Article

Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Journal Article

Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Journal Article

Research on direct digital process of inductance sensor

WANG Xuan-ze, YANG Lian-gen, ZHONG Yu-ning

Journal Article

Application of a Novel Fuzzy Clustering Method Based on Chaos Immune Evolutionary Algorithm for Edge Detection in Image Processing

Journal Article

Controlling nested wrinkle morphology through the boundary effect on narrow-band thin films

Hanyang XU, Tielin SHI, Guanglan LIAO, Qi XIA

Journal Article

Flow behavior of liquid-solid coupled system of piezoelectric micropump

LU Lijun, WU Jiankang

Journal Article

Air-bearing position optimization based on dynamic characteristics of ultra-precision linear stages

CHEN Xuedong, LI Zhixin

Journal Article

Separation and extraction of bridge dynamic strain data

Baijian WU, Zhaoxia LI, Ying WANG, T. H. T. CHAN,

Journal Article

Fatigue Life Prediction of Fiber Reinforced Metal Laminates Under Variable Amplitude Loading

Wu Xueren,Guo Yajun

Journal Article

Development of electrorheological chip and conducting polymer-based sensor

Xianzhou ZHANG, Weihua LI, Weijia WEN, Yanzhe WU, Gordon WALLACE,

Journal Article

Impact drive rotary precision actuator with piezoelectric bimorphs

ZHANG Hongzhuang, ZENG Ping, HUA Shunming, CHENG Guangming, YANG Zhigang

Journal Article

Reverse-Time Migration from Rugged Topography to Image Ground-Penetrating Radar Data in Complex Environments

John H. Bradford,Janna Privette,David Wilkins,Richard Ford

Journal Article