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Effective Anti-Obesity Drugs Make Losing Weight a Big Deal

Sarah C. P. Williams

Engineering 2024, Volume 32, Issue 1,   Pages 4-6 doi: 10.1016/j.eng.2023.11.005

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Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia

Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 130-138 doi: 10.1007/s11684-017-0555-2

Abstract: know to exist only in mammals and the human neonate has received great attention for the treatment of obesityof evidence demonstrated that transplantation or activation of BAT or/and beige adipocytes reversed obesitythereby providing new promising strategies for future clinical application of BAT activation to treat obesity

Keywords： brown adipose tissue     beige adipocyte     anti-obesity     anti-diabetes     cancer cachexia     aging    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: mutation (NM_001301860: p.1835A>T/p.D612V) of Lipin3 in a large family with hypertriglyceridemia (HTG) and obesityWe found that Lipin3-heKO mice exhibited obvious obesity, HTG, and non-alcoholic fatty liver disorderOur study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 17-24 doi: 10.1007/s11684-021-0873-2

Abstract: Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threateningHowever, no perfect drug choice for obesity exists.This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishesexpectations on future clinical trials for obesity treatment.

Keywords： semaglutide     type 2 diabetes     obesity    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract:

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissueIn the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is requiredsupports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture

Frontiers of Medicine doi: 10.1007/s11684-023-1023-9

Abstract: the risk of osteoporosis, but the association of early-life undernutrition combined with adulthood obesityGeneral obesity was assessed using the body mass index (BMI), and abdominal obesity was evaluated withSignificant interactions were observed between fetal famine exposure and general obesity with fractureand WHR, the group of women who underwent fetal famine exposure and had both general and abdominal obesityThese results indicate that early-life famine exposure interacts with adulthood general obesity and significantly

Keywords： famine     obesity     body mass index     waist-to-hip ratio     low-energy fracture    

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Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 601-607 doi: 10.1007/s11684-018-0648-6

Abstract:

The incidence of obesity has been rapidly increasing, and this condition has become a major publicenvironmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesityLongitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesitymay interact with dietary factors in relation to the body mass index and risk of obesity.

Keywords： diet     genetic susceptibility     obesity     interaction    

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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract:

Obesity prevalence has increased in recent years.Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesityThe advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity researchin the mechanism of obesity remains unclear.on obesity are needed.

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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Mechanism of insulin resistance in obesity: a role of ATP

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 372-382 doi: 10.1007/s11684-021-0862-5

Abstract: Obesity increases the risk of type 2 diabetes through the induction of insulin resistance.

Keywords： type 2 diabetes     energy expenditure     mitochondria     hyperinsulinemia     hyperglucagonemia     AMPK    

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Epidemic obesity in children and adolescents: risk factors and prevention

Eun Young Lee, Kun-Ho Yoon

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 658-666 doi: 10.1007/s11684-018-0640-1

Abstract: The prevalence of obesity among children and adolescents (aged 2–18 years) has increased rapidly, withMoreover, the epidemic of obesity in this population has been an important public health problem in developedChildhood and adolescent obesity tracks adulthood obesity and has been implicated in many chronic diseasesFurthermore, childhood and adolescent obesity is linked to adulthood mortality and premature death.Many interventional trials for childhood and adolescent obesity have been proven ineffective.

Keywords： obesity     children     adolescents     epidemiology     risk factor     prevention    

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Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 129-133 doi: 10.1007/s11684-015-0387-x

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Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract:

In light of the rapid increase in the number of obesity incidences worldwide, obesity has become anObesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence ofThese mechanisms synergize with obesity to induce end-stage renal disease.

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

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Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: anovel model of obesity and puberty

Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 266-276 doi: 10.1007/s11684-017-0530-y

Abstract:

Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatalThe lack of a suitable animal model, however, remains a considerable challenge in obesity studies.We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity.Results showed that feeding with HFD induces fat deposition and obesity in pups.Our model suggests good construction validity of obesity and precocious puberty.

Keywords： postnatal HFD feeding     obesity     kisspeptin     HPG axis     precocious puberty    

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Analyzing the distinguishing factors that affect childhood obesity in South Korea

So Jung Yang, Hun-Sung Kim, Kun-Ho Yoon

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 707-716 doi: 10.1007/s11684-018-0660-x

Abstract:

Understanding obesity in children is crucial because it can lead to adulthood obesity and result inDistinctive factors associated with obesity in adults have been described, but distinctive factors relatedOur study revealed that the computing hours in elementary school students with overweight and obesityChildhood obesity can cause depression and reduce children’s quality of life because of their distortedIn conclusion, physical factors directly affecting childhood obesity and psychological and environmental

Keywords： screen time     quality of life     eating habits     childhood obesity     percentage of body mass index    

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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 306-332 doi: 10.15302/J-FASE-2023488

Abstract:

● Using visual analysis to predict the trend of natural product pest resistance.

Keywords： anti-pest activity     crop protection     insect pest     natural product     visual analysis    

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Title Author Date Type Operation

Effective Anti-Obesity Drugs Make Losing Weight a Big Deal

Sarah C. P. Williams

Journal Article

Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia

Meng Dong, Jun Lin, Wonchung Lim, Wanzhu Jin, Hyuek Jong Lee

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Journal Article

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture

Journal Article

Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Mechanism of insulin resistance in obesity: a role of ATP

Journal Article

Epidemic obesity in children and adolescents: risk factors and prevention

Eun Young Lee, Kun-Ho Yoon

Journal Article

Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article

Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: anovel model of obesity and puberty

Rahim Ullah, Yan Su, Yi Shen, Chunlu Li, Xiaoqin Xu, Jianwei Zhang, Ke Huang, Naveed Rauf, Yang He, Jingjing Cheng, Huaping Qin, Yu-Dong Zhou, Junfen Fu

Journal Article

Analyzing the distinguishing factors that affect childhood obesity in South Korea

So Jung Yang, Hun-Sung Kim, Kun-Ho Yoon

Journal Article

QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Journal Article