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Advances in airborne microorganisms detection using biosensors: A critical review

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 3, doi: 10.1007/s11783-021-1420-8

Abstract:

Humanity has been facing the threat of a variety of infectious diseases. Airborne microorganisms can cause airborne infectious diseases, which spread rapidly and extensively, causing huge losses to human society on a global scale. In recent years, the detection technology for airborne microorganisms has developed rapidly; it can be roughly divided into biochemical, immune, and molecular technologies.

Keywords： Biosensor Airborne microorganisms Microbiological detection technology

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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12, Pages 1866-1878 doi: 10.1007/s11705-023-2340-x

Abstract: This review, therefore, provides researchers working on implantable biosensors for CGM systems with vital

Keywords： implantable glucose biosensor anti-biofouling continuous glucose monitoring immune responses

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Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 15-26 doi: 10.1007/s11705-017-1629-z

Abstract: For this purpose, many genetic components have been adapted into biosensors of small molecules, whichSuch biosensors allow a high-throughput screening of the small-molecule products, and can be roughlyclassified as protein-based and RNA-based biosensors.This review summarizes the recent developments in the design and applications of biosensors for small-molecule

Keywords： biosensor small molecule product transcription factor riboswitch high-throughput screening

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An Outlook on Implantable Biosensors for Personalized Medicine

Rita Rebelo,Ana Isabel Barbosa,Vitor M. Correlo,Rui L. Reis

Engineering 2021, Volume 7, Issue 12, Pages 1696-1699 doi: 10.1016/j.eng.2021.08.010

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oocyst directed assembly of gold nanoparticles and graphene oxide

Sona Jain, Zhicheng Huang, Brent R. Dixon, Syed Sattar, Juewen Liu

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3, Pages 608-615 doi: 10.1007/s11705-019-1813-4

Abstract: Understanding the interactions between inorganic nanomaterials and biological species is an important topic for surface and environmental chemistry. In this work, we systematically studied the oocysts of as a model protozoan parasite and its interaction with gold nanoparticles (AuNPs) and graphene oxide (GO). The as-prepared citrate-capped AuNPs adsorb strongly on the oocysts leading to a vivid color change. The adsorption of the AuNPs was confirmed by transmission electron microscopy. Heat treatment fully inhibited the color change, indicating a large change of surface chemistry of the oocysts that can be probed by the AuNPs. Adding proteases such as trypsin and proteinase K partially inhibited the color change. DNA-capped AuNPs, on the other hand, could not be adsorbed by the oocysts. GO was found to wrap around the oocysts forming a conformal shell reflecting the shape of the oocysts. Both citrate-capped AuNPs and GO compromised the membrane integrity of the oocysts as indicated by the propidium iodide staining experiment, and they may be potentially used for inactivating the oocysts. This is the first example of using nanomaterials to probe the surface of the oocysts, and it suggests the possibility of using such organisms to template the assembly of nanomaterials.

Keywords： nanomaterials toxicology water biosensors

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Big Data for Precision Medicine

Daniel Richard Leff, Guang-Zhong Yang

Engineering 2015, Volume 1, Issue 3, Pages 277-279 doi: 10.15302/J-ENG-2015075

Abstract:

This article focuses on the potential impact of big data analysis to improve health, prevent and detect disease at an earlier stage, and personalize interventions. The role that big data analytics may have in interrogating the patient electronic health record toward improved clinical decision support is discussed. We examine developments in pharmacogenetics that have increased our appreciation of the reasons why patients respond differently to chemotherapy. We also assess the expansion of online health communications and the way in which this data may be capitalized on in order to detect public health threats and control or contain epidemics. Finally, we describe how a new generation of wearable and implantable body sensors may improve wellbeing, streamline management of chronic diseases, and improve the quality of surgical implants.

Keywords： big data biosensors body-sensing networks implantable sensors clinical decision support systems pharmacogenetics

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An Additive Manufacturing Approach that Enables the Field Deployment of Synthetic Biosensors Article

Daniel Wolozny, John R. Lake, Paul G. Movizzo, Zhicheng Long, Warren C. Ruder

Engineering 2019, Volume 5, Issue 1, Pages 173-180 doi: 10.1016/j.eng.2018.12.001

Abstract:

The tools of synthetic biology can be used to engineer living biosensors that report the presenceAlthough these engineered cellular biosensors have many potential applications for deployment outsideMany biosensors lack the versatility required for deployment in the field, where many diseases can go3D printing to create a portable, modular, and inexpensive device for the field deployment of living biosensors

Keywords： Synthetic biology Additive manufacturing Biosensors

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Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer Article

Ana Montero-Calle, Itziar Aranguren-Abeigon, María Garranzo-Asensio, Carmen Poves, María Jesús Fernández-Aceñero, Javier Martínez-Useros, Rodrigo Sanz, Jana Dziaková, Javier Rodriguez-Cobos, Guillermo Solís-Fernández, Eloy Povedano, Maria Gamella, Rebeca Magnolia Torrente-Rodríguez, Miren Alonso-Navarro, Vivian de los Ríos, J. Ignacio Casal, Gemma Domínguez, Ana Guzman-Aranguez, Alberto Peláez-García, José Manuel Pingarrón, Susana Campuzano, Rodrigo Barderas

Engineering 2021, Volume 7, Issue 10, Pages 1393-1412 doi: 10.1016/j.eng.2021.04.026

Abstract:

Colorectal cancer (CRC) is the second leading cause of cancer related death worldwide. The 5-year survival rate of CRC patients depends on the stage at diagnosis, being higher than 80% when CRC is diagnosed in the early stages but lower than 10% when CRC is diagnosed in advanced stages. Autoantibodies against specific CRC autoantigens (tumor-associated antigens (TAAs)) in the sera of patients have been widely demonstrated to aid in early diagnosis. Thus, we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy. To that end, we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis. A total of 103 proteins were identified as potential autoantigens specific to CRC. After bioinformatics and meta-analysis, we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot (WB) and immunohistochemistry (IHC). We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients, along with an association of nine of these proteins with CRC prognosis. After validation, all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals, either by luminescence Halotag-based beads, or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection. Taken together, our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases; they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care (POC) device for CRC detection with high diagnostic ability.

Keywords： Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care Biosensors