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Journal Article 7

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2023 1

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BPTF 1

Bacillus subtilis 1

CAR T cells 1

Genetic circuits 1

Isoprene pyrophosphate 1

Terpenoids 1

allograft vasculopathy 1

alveolus 1

arterial remodeling 1

chronic rejection 1

endogenous immune response 1

epigenetics 1

explosive loading 1

extraction 1

flexible material 1

immunology 1

immunoregulatory molecules 1

immunotherapy 1

load remodeling 1

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Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 248-253 doi: 10.1007/s11684-011-0149-3

Abstract: Arterial remodeling in allografts eventually causes ischemic graft failure.This review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including

Keywords： transplantation     chronic rejection     neointimal     immunology     arterial remodeling     allograft vasculopathy    

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 676-684 doi: 10.1007/s11705-017-1640-4

Abstract: Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitope-associated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems and , an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.

Keywords： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

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Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 408-414 doi: 10.1007/s11684-009-0069-7

Abstract: Bone remodeling in orthodontic treatment has been one of the most concerned issues.The purpose of this study was to characterize the changes in bone remodeling on both labial and lingual

Keywords： alveolus     remodeling     orthodontics     extraction    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma and have shown encouraging results in preclinical and clinical studies. However, CAR T cells have achieved minimal success against solid malignancies because of the additional obstacles of their insufficient migration into tumors and poor amplification and persistence, in addition to antigen-negative relapse and an immunosuppressive microenvironment. Various preclinical studies are exploring strategies to overcome the above challenges. Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeutic effect given the importance of the innate immune responses in the elimination of malignant tumors. In this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immune response in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulators to tumors to mobilize the endogenous immune response. We also explored the sensitizing effects of conventional treatment approaches, such as chemotherapy and radiotherapy, on CAR T cell therapy. Finally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance the anti-tumor outcomes of CAR T cell therapies in solid tumors.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 60-67 doi: 10.1007/s11684-019-0694-8

Abstract: Bromodomain PHD-finger transcription factor (BPTF) is the largest subunit of the nucleosome remodelingfactor and plays an important role in chromatin remodeling for gene activation through its association

Keywords： BPTF     small molecule     epigenetics     non-small-cell lung cancer    

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Research on the Buffering Effect of Flexible Materialon the Explosive Loading

Yu Shaojuan,Li Yongchi,Liu Haowen,Sun Yuxin, Hu Xiuzhang

Strategic Study of CAE 2007, Volume 9, Issue 4,   Pages 75-78

Abstract:

In this paper, on the basis of the constitutive relation theory which includes inner variables, with the general explicit description of incremental strain thermal-plastic constitutive relations and the specific incremental thermal-plastic constitutive relations, combining the simulation of X ray load and the tube responsing problem which is greatly important in practice, the self-contained equation group about the stress wave in the flexible material_steel composite shell problem is developed. Numerical simulations are carried out with the presented constitutive relations for explosive-filled sphere fracture problem and the results are analyzed.  The thickness of explosive and flexible material that influences the load of the interface is discussed emphatically.

Keywords： flexible material     explosive loading     load remodeling     numerical simulation    

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Remodeling Isoprene Pyrophosphate Metabolism for Promoting Terpenoids Bioproduction Article

Xianhao Xu, Xueqin Lv, Shixiu Cui, Yanfeng Liu, Hongzhi Xia, Jianghua Li, Guocheng Du, Zhaofeng Li, Rodrigo Ledesma-Amaro, Jian Chen, Long Liu

Engineering 2023, Volume 28, Issue 9,   Pages 166-178 doi: 10.1016/j.eng.2023.03.019

Abstract: As a proof-of-concept validation, we design an IPP metabolism remodeling strategy to improve the productionThus, we propose a TIMO genetic circuits-assisted IPP metabolism remodeling framework that can be generally

Keywords： Terpenoids     Genetic circuits     Bacillus subtilis     Isoprene pyrophosphate    

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Title Author Date Type Operation

Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

Journal Article

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

Journal Article

Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

Journal Article

Research on the Buffering Effect of Flexible Materialon the Explosive Loading

Yu Shaojuan,Li Yongchi,Liu Haowen,Sun Yuxin, Hu Xiuzhang

Journal Article

Remodeling Isoprene Pyrophosphate Metabolism for Promoting Terpenoids Bioproduction

Xianhao Xu, Xueqin Lv, Shixiu Cui, Yanfeng Liu, Hongzhi Xia, Jianghua Li, Guocheng Du, Zhaofeng Li, Rodrigo Ledesma-Amaro, Jian Chen, Long Liu

Journal Article