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Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Frontiers of Medicine doi: 10.1007/s11684-023-1020-z

Abstract: Retroperitoneal liposarcoma (RLPS) is the main subtype of retroperitoneal soft sarcoma (RSTS) and has a poor prognosis and few treatment options, except for surgery. The proteomic and metabolic profiles of RLPS have remained unclear. The aim of our study was to reveal the metabolic profile of RLPS. Here, we performed proteomic analysis (n = 10), metabolomic analysis (n = 51), and lipidomic analysis (n = 50) of retroperitoneal dedifferentiated liposarcoma (RDDLPS) and retroperitoneal well-differentiated liposarcoma (RWDLPS) tissue and paired adjacent adipose tissue obtained during surgery. Data analysis mainly revealed that glycolysis, purine metabolism, pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue, whereas the tricarboxylic acid (TCA) cycle, lipid absorption and synthesis, fatty acid degradation and biosynthesis, as well as glycine, serine, and threonine metabolism were downregulated. Of particular importance, the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway (PPP) inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor abemaciclib. Our study not only describes the metabolic profiles of RDDLPS and RWDLPS, but also offers potential therapeutic targets and strategies for RLPS.

Keywords： RLPS     proteomics     metabolomics     lipidomics     metabolism    

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Technology and Equipment of Big Data on Crop Phenomics

Wen Weiliang , Guo Xinyu, Zhang Ying , Gu Shenghao, Zhao Chunjiang

Strategic Study of CAE 2023, Volume 25, Issue 4,   Pages 227-238 doi: 10.15302/J-SSCAE-2023.04.015

Abstract: "text-align: justify;">Automatic equipment and information technologies make it possible to acquire multi-scaleand multi-source heterogeneous data of crops under different growth conditions, forming big data

Keywords： crop phenomics     phenotyping big data     technology and equipment for phenotyping     multi-omics    

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The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery Review

Wei Chen,Chi Song,Liang Leng,Sanyin Zhang,Shilin Chen

Engineering 2024, Volume 32, Issue 1,   Pages 19-29 doi: 10.1016/j.eng.2023.09.011

Abstract: Furthermore, an AI-driven multi-omics integration strategy for GPCR ligand discovery that combines informationfrom various omics disciplines was proposed.

Keywords： G protein-coupled receptor     Ligand     Artificial intelligence     Multi-omics     Drug discovery    

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MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Tao Rui,Xueyou Zhang,Shi Feng,Haitao Huang,Shaowei Zhan,Haiyang Xie,Lin Zhou,Shusen Zheng,Qi Ling,

Engineering 2022, Volume 16, Issue 9,   Pages 162-175 doi: 10.1016/j.eng.2021.07.020

Abstract: The integrated multi-omics and co-enriched pathway analysis showed that miR-516a-3p regulates the metabolic

Keywords： Hepatocellular carcinoma     miRNA cluster     Exosome     Multi-omics    

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Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp. 1647: Pseudo-Tetrapeptides Article

Hongmin Sun, Xingxing Li, Minghua Chen, Ming Zhong, Yihua Li, Kun Wang, Yu Du, Xin Zhen, Rongmei Gao, Yexiang Wu, Yuanyuan Shi, Liyan Yu, Yongsheng Che, Yuhuan Li, Jian-Dong Jiang, Bin Hong, Shuyi Si

Engineering 2022, Volume 16, Issue 9,   Pages 176-186 doi: 10.1016/j.eng.2021.05.010

Abstract: We used an integrated multi-omics strategy to identify the antiviral agents from this streptomycete.By integrating multi-omics data, we discovered a number of novel antiviral pseudo-tetrapeptides produced

Keywords： Multi-omics     Anti-influenza A virus     Anti-coronavirus     Streptomyces sp. 1647     Pseudo-tetrapeptides    

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Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 58-67 doi: 10.1007/s11684-014-0318-2

Abstract: Omics technologies allow high-throughput screening of sepsis biomarkers.This review paper serves as a reference for future studies that employ an integrated, multi-omics approach

Keywords： sepsis     biomarker     genomics     transcriptomics     proteomics     metabolomics    

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Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut Article

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Engineering 2022, Volume 15, Issue 8,   Pages 115-125 doi: 10.1016/j.eng.2021.03.013

Abstract:

Due to the worldwide epidemic of allergic disease and a cure nowhere in sight, there is a crucial need to explore its pathophysiological mechanisms. As allergic disease has been associated with gut dysbiosis, we searched for a possible mechanism from the perspective of the molecular interface between host and microbiota with concurrent metabolomics and microbiome composition analysis. Sprague-Dawley rats were injected with Artemisia pollen extract to stimulate a hyper reaction to pollen. This hyper reaction decreased the circulation of valine, isoleucine, aspartate, glutamate, glutamine, indole-propionate (IPA), and myo-inositol, and reduced short-chain fatty acids (SCFAs) in feces. Several beneficial genera belonging to Ruminococcaceae, Lachnospiraceae, and Clostridiales declined in the model group, whereas Helicobacter and Akkermansia were only expressed in the model group. Furthermore, the expression of intestinal claudin-3 and liver fatty acid binding protein was downregulated in the model group and associated with metabolic changes and bacteria. Our results suggest that alterations in amino acids as well as their derivatives (especially valine, and IPA which is the reductive product of tryptophan) , SCFAs, and the gut microbiome (specifically Akkermansia and Helicobacter) may disrupt the intestinal barrier function by inhibiting the expression of claudin proteins and affecting the mucus layer, which further results in hay fever.

Keywords： Metabolome     Gut microbiota     Hay fever     Allergic diseases     Intestinal barrier dysfunction    

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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis using omics

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 564-574 doi: 10.1007/s11684-018-0676-2

Abstract: Thus, this study establishes a new omics analytical method integrated with bioinformatics analysis forelucidating the multi-pathway mechanisms of TCM.

Keywords： arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced arthritis     omics    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits the activation of immune cells through the interaction with its ligand CD24 on tumor cells. Here, by analyzing public databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10 was altered in 18 types of cancers and was associated with the clinical outcomes of 11 cancer types. In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRC) and was inversely associated with the prognosis of the patients. In 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patients compared with that in their counterpart normal kidney tissues. Moreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse prognosis. Silencing of CD24 in KIRC cells significantly increased the number of Siglec10-expressing macrophages phagocytosing KIRC cells. In addition, luciferase activity assays suggested that Siglec10 was a potential target of the transcription factors c-FOS and GATA1, which were identified by data mining. These results demonstrate that Siglec10 may have important oncogenic functions in KIRC, and represents a novel target for the development of immunotherapies.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Applying TCM Constitution Theory to Infertility via Omics

Qi Wang

Engineering 2023, Volume 30, Issue 11,   Pages 30-31 doi: 10.1016/j.eng.2023.05.005

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction networks

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: Recently, the rapid development of omics techniques (e.g., genomics, proteomics and transcriptomics)

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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Multi-objective optimization for the multi-mode finance-based project scheduling problem

Sameh Al-SHIHABI, Mohammad AlDURGAM

Frontiers of Engineering Management 2020, Volume 7, Issue 2,   Pages 223-237 doi: 10.1007/s42524-020-0097-1

Abstract: The FBSP is extended to consider different execution modes that result in the multi-mode FBSP (MMFBSPNo exact models are available for contractors who look for optimal solutions to the multi-objective MMFBSPMoreover, its current version, CPLEX 12.9, solves multi-objective optimization problems.This study presents a mixed-integer linear programming model for the multi-objective MMFBSP.Using CPLEX 12.9, we discuss several techniques that researchers can use to optimize a multi-objective

Keywords： multi-objective optimization     finance-based scheduling     multi-mode project scheduling     mixed-integer linear    

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Build orientation determination of multi-feature mechanical parts in selective laser melting via multi-objective

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-022-0737-8

Abstract: This study proposes a method to determine the build orientation of multi-feature mechanical parts (MFMPsLastly, a multi-objective decision making method integrated by the technique for order of preference

Keywords： selective laser melting (SLM)     build orientation determination     multi-feature mechanical part (MFMP)     fuzzy analytical hierarchy process     multi-objective decision making (MODM)    

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Expanding the Scope of Multivariate Regression Approaches in Cross-Omics Research Article

Xiaoxi Hu, Yue Ma, Yakun Xu, Peiyao Zhao, Jun Wang

Engineering 2021, Volume 7, Issue 12,   Pages 1725-1731 doi: 10.1016/j.eng.2020.05.028

Abstract: Our method extensions provide valuable guidelines for future omics research, especially with respect

Keywords： Multivariate regression methods     Reduced rank regression     Sparsity     Dimensionality reduction     Variable selection    

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A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 877-894 doi: 10.1007/s11709-021-0756-2

Abstract: Many bridge design specifications consider multi-lane factors (MLFs) a critical component of the trafficMeasured multi-lane traffic data generally exhibit significant lane disparities in traffic loads overTo address this drawback, a multi-coefficient MLF model was developed based on an improved probabilistic

Keywords： bridges     multi-lane factor     traffic load     lane load disparity     multi-truck presence     weigh-in-motion    

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Title Author Date Type Operation

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Journal Article

Technology and Equipment of Big Data on Crop Phenomics

Wen Weiliang , Guo Xinyu, Zhang Ying , Gu Shenghao, Zhao Chunjiang

Journal Article

The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery

Wei Chen,Chi Song,Liang Leng,Sanyin Zhang,Shilin Chen

Journal Article

MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism

Tao Rui,Xueyou Zhang,Shi Feng,Haitao Huang,Shaowei Zhan,Haiyang Xie,Lin Zhou,Shusen Zheng,Qi Ling,

Journal Article

Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp. 1647: Pseudo-Tetrapeptides

Hongmin Sun, Xingxing Li, Minghua Chen, Ming Zhong, Yihua Li, Kun Wang, Yu Du, Xin Zhen, Rongmei Gao, Yexiang Wu, Yuanyuan Shi, Liyan Yu, Yongsheng Che, Yuhuan Li, Jian-Dong Jiang, Bin Hong, Shuyi Si

Journal Article

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Journal Article

Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Journal Article

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis using omics

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Applying TCM Constitution Theory to Infertility via Omics

Qi Wang

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction networks

Hong LI,Ziding ZHANG

Journal Article

Multi-objective optimization for the multi-mode finance-based project scheduling problem

Sameh Al-SHIHABI, Mohammad AlDURGAM

Journal Article

Build orientation determination of multi-feature mechanical parts in selective laser melting via multi-objective

Journal Article

Expanding the Scope of Multivariate Regression Approaches in Cross-Omics Research

Xiaoxi Hu, Yue Ma, Yakun Xu, Peiyao Zhao, Jun Wang

Journal Article

A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Journal Article