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Function of Slit/Robo signaling in breast cancer

null

《医学前沿（英文）》 2015年第9卷第4期页码 431-436 doi: 10.1007/s11684-015-0416-9

摘要：

Slit and Robo are considered tumor suppressors because they are frequently inactivated in various tumor tissue. These genes are closely correlated with CpG hypermethylation in their promoters. The Slit/Robo signaling pathway is reportedly involved in breast cancer development and metastasis. Overexpression of Slit/Robo induces its tumor suppressive effects possibly by inactivating the β-catenin/LEF/TCF and PI3K/Akt signaling pathways or by altering β-catenin/E-cadherin-mediated cell-cell adhesion in breast cancer cells. Furthermore, loss of Slit proteins or their Robo receptors upregulates the CXCL12/CXCR4 signaling axis in human breast carcinoma. In addition, this pathway regulates the distant migration of breast cancer cells not only by mediating the phosphorylation of the downstream molecules of CXCL12/CXCR4 and srGAPs, such as PI3K/Src, RAFTK/ Pyk2, and CDC42, but also by regulating the activities of MAP kinases. This review includes recent studies on the functions of Slit/Robo signaling in breast cancer and its molecular mechanisms.

关键词： Slit/Robo hypermethylation β-catenin CXCL12/CXCR4 migration

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Facile controlled synthesis of hierarchically structured mesoporous Li4Ti5O12/C/rGO composites as high-performance

Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG

《能源前沿（英文）》 2022年第16卷第4期页码 607-612 doi: 10.1007/s11708-021-0798-0

摘要： In this paper, a facile strategy is proposed to controllably synthesize mesoporous Li₄Ti₅O₁₂/C nanocomposite embedded in graphene matrix as lithium-ion battery anode via the co-assembly of Li₄Ti₅O₁₂ (LTO) precursor, GO, and phenolic resin. The obtained composites, which consists of a LTO core, a phenolic-resin-based carbon shell, and a porous frame constructed by rGO, can be denoted as LTO/C/rGO and presents a hierarchical structure. Owing to the advantages of the hierarchical structure, including a high surface area and a high electric conductivity, the mesoporous LTO/C/rGO composite exhibits a greatly improved rate capability as the anode material in contrast to the conventional LTO electrode.

关键词： Li₄Ti₅O₁₂ phenolic-resin-based carbon mesoporous composite graphene

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Influence of the intensity and loading time of direct current electric field on the directional migration of rat bone marrow mesenchymal stem cells

null

《医学前沿（英文）》 2016年第10卷第3期页码 286-296 doi: 10.1007/s11684-016-0456-9

摘要：

Exogenic electric fields can effectively accelerate bone healing and remodeling through the enhanced migration of bone marrow mesenchymal stem cells (BMSCs) toward the injured area. This study aimed to determine the following: (1) the direction of rat BMSC (rBMSC) migration upon exposure to a direct current electric field (DCEF), (2) the optimal DCEF intensity and duration, and (3) the possible regulatory role of SDF-1/CXCR4 axis in rBMSC migration as induced by DCEF. Results showed that rBMSCs migrated to the positive electrode of the DCEF, and that the DCEF of 200 mV/mm for 4 h was found to be optimal in enhancing rBMSC migration. This DCEF strength and duration also upregulated the expression of osteoblastic genes, including ALP and OCN, and upregulated the expression of ALP and Runx2 proteins. Moreover, when CXCR4 was inhibited, rBMSC migration due to DCEF was partially blocked. These findings indicated that DCEF can effectively induce rBMSC migration. A DCEF of 200 mV/mm for 4 h was recommended because of its ability to promote rBMSC migration, proliferation, and osteogenic differentiation. The SDF-1/CXCR4 signaling pathway may play an important role in regulating the DCEF-induced migration of rBMSCs.

关键词： DCEF migration osteogenesis differentiation rBMSCs SDF-1/CXCR-4

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Advances of 12^th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

《化学科学与工程前沿（英文）》 2021年第15卷第3期页码 461-463 doi: 10.1007/s11705-020-2026-6

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Introduction to the special section on the 12

Zhen-Min CHENG

《化学科学与工程前沿（英文）》 2009年第3卷第1期页码 1-1 doi: 10.1007/s11705-009-0003-1

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ThMn₁₂型永磁合金 Review

G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

《工程（英文）》 2020年第6卷第2期页码 140-146 doi: 10.1016/j.eng.2018.12.011

摘要：

具有四方ThMn₁₂型结构的富铁化合物有潜力满足当下人们对于高磁能积、工作温度为150~200 ℃的贫稀土永磁体的需求。尽管磁体制备技术的发展滞后于相关磁性材料的研究是正常的，但对于ThMn₁₂型磁性材料而言，这种研究进展的差异非常显著。人们发现，引入镧（La）可以提高Sm(Fe,Ti)₁₂中少数低熔点相的稳定性，从而首次使得液相烧结成为可能。然而，La金属的高反应活性会明显地破坏材料的矫顽力（Hc）。,Sm)(Fe,Ti)₁₂合金中也可以实现。机械化学合成的(Sm,Zr)(Fe,Si)₁₂和(Sm,Zr)(Fe,Co,Ti)₁₂粉末可能适合烧结成具有高强度的全致密磁体，尽管在此之前，两者都已开发出较高的各向异性

关键词：永磁体，稀土永磁体，ThMn ₁₂结构

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行星表面动力着陆自主制导方法综述 Review

宋征宇1,5,王聪2,Stephan THEIL3,David SEELBINDER3,Marco SAGLIANO3,刘新福4,邵之江5

《信息与电子工程前沿（英文）》 2020年第21卷第5期页码 649-808 doi: 10.1631/FITEE.1900458

摘要：本文总结了天体表面精确软着陆的自主制导方法。首先回顾了动力下降制导方法的发展，重点介绍了其在约束处理和提升计算效率方面的贡献。随着对可重复使用运载器需求的不断增加，以及太空探索带来更多的科学回报，定点软着陆成为一项基本要求。不同于过去任务中公里级的着陆精度，未来行星着陆器在满足全部速度和姿态约束条件下，着陆位置精度要达到10米级，这项任务的困难引起学者对自主制导方法的兴趣。本文讨论了动力下降阶段一般性的3自由度和6自由度优化问题，并对比月球、火星和地球3种典型着陆场景的特点。在此基础上，通过比较解析制导方法、数值优化算法和基于学习的方法，详细阐述自主制导方法的特点和适应性，并讨论非凸问题的凸化处理和求解策略。随后提出自主制导方法工程应用的3个关键问题：物理可行性、模型精度和实时性。最后，简要介绍各国航天组织（包括美国、中国、法国、德国和日本）研发的垂直起降验证飞行器，以及目前在验证飞行器上开展的制导方法试验工作。

关键词：自主制导方法；定点软着陆；动力下降；非线性规划

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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

《医学前沿（英文）》 2019年第13卷第1期页码 83-93 doi: 10.1007/s11684-019-0682-z

摘要：

Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%–85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC have been demonstrated to cause an S492R mutation in EGFR. However, little is known about the biological function of S492R EGFR. Therefore, we attempted to elucidate its biological function in CRC cells and explore new treatment strategies for this mutant form. Our study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12, which specifically recognizes an EGFR tumor-specific epitope, can bind efficiently to S492R EGFR. Furthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a more potent antibody-dependent cellular cytotoxicity effect on CRC cells bearing S492R EGFR than mAb C225. mAb CH12 obviously suppressed the growth of CRC xenografts with S492R EGFR mutations in vivo. Thus, mAb CH12 may be a promising therapeutic agent in treating patients with CRC bearing an S492R EGFR mutation.

关键词： S492R EGFR ectodomain mutation colorectal cancer mAb CH12 immunnotherapy

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我国半导体硅片发展现状与展望

张果虎,肖清华,马飞

《中国工程科学》 2023年第25卷第1期页码 68-78 doi: 10.15302/J-SSCAE-2023.01.002

摘要：本文重点围绕市场主流的8 in、12 in硅片，分析了全球半导体硅片的技术和产业发展现状，研判了全球半导体硅片产业未来的发展趋势，重点分析了我国半导体硅片的发展现状，指出我国半导体硅片在当前市场需求、宏观政策

关键词：半导体硅片；8 in；12 in；产业协同；先进制程

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Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

null

《医学前沿（英文）》 2017年第11卷第1期页码 53-61 doi: 10.1007/s11684-017-0502-2

摘要：

Low adherence to secondary prevention medications (ATM) of patients after acute coronary syndrome (ACS) is associated with poor clinical outcomes. However, literature provides limited data on assessment of ATM and risks associated with poor in Chinese patients with ACS. In the current work, ATM was assessed in consecutively recruited patients with ACS in Tongji Hospital from November 5, 2013 to December 31, 2014. A total of 2126 patients were classified under low adherence (proportion of days covered (PDC)<50%) and high adherence (PDC>50%) groups based on their performance after discharge. All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and major adverse cardiac events (MACE). Bivariate logistic regression was used to identify the factors associated with ATM. Cox regression was used to analyze the association between ATM and MACE within one year after discharge. Results showed that coronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12 antagonists (83.0% vs. 90.7%, P<0.01) than patients treated with percutaneous coronary intervention (PCI) only. Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACE (hazard ratio=0.172, 95% confidence interval: 0.039–0.763; P=0.021). In conclusion, PCI-treated patients are more prone to remaining adherent to medications than CABG-treated patients. High adherence to P2Y12 antagonists was associated with lower risk of MACE.

关键词： acute coronary syndromes adherence to secondary prevention medications clinical outcome

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三塔悬索桥人字型钢中塔选型及关键构造设计

华新,韩大章,周彦锋,徐瑞丰

《中国工程科学》 2010年第12卷第4期页码 37-42

摘要：

三塔悬索桥整体刚度低，中塔选择对整个结构的受力有非常显著的影响。中塔的设计需要解决主缆在塔顶抗滑移安全系数问题和主梁跨中挠跨比问题这一对矛盾。文章介绍了泰州大桥中塔的受力特点和结构行为，在此基础上对其进行了结构选型，最终采用了纵向人字型的全钢索塔。介绍了钢塔的结构设计和对主要关键构造的处理和设计细节，包括厚板的焊缝设计、分叉点的结构处理、塔底钢塔柱与混凝土承台的连接方式及构造，以及根据起吊能力而进行的塔柱纵向分块设计。

关键词：三塔悬索桥钢中塔选型关键构造设计

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交直流电力集成技术

马伟明

《中国工程科学》 2002年第4卷第12期页码 53-59

摘要：在此基础上，将定子3相绕组、12相绕组、整流装置、励磁系统、励磁调节器等集于一体，功研制出性能优良的交直流发电机，能同时提供高品质交直流电源，为独立电力系统的集成化奠定了基础。

关键词：电力集成双绕组交直流发电机 12相整流交直流同时供电独立电力系统

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利用基因组特异性引物和Cas12a介导技术快速检测稻瘟菌小麦致病型 Article

康厚祥, 彭烨, Kangyu Hua, 邓雨飞, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, 周益林, 周雪平, Md Tofazzal Islam, 王国梁

《工程（英文）》 2021年第7卷第9期页码 1326-1335 doi: 10.1016/j.eng.2020.07.016

摘要：随后，我们使用Cas12a 蛋白及导向RNA（gRNA）靶向MoT-6098 和MoT-6099 序列，两个靶标被识别后，均能激活Cas12a 非特异切割单链脱氧核糖核酸酶（ssDNAase）的活性，我们将依赖靶向Cas12a 激活ssDNase 活性，同时将重组酶聚合酶扩增（RPA）和核酸侧流免疫分析法（NALFIA）相结合，开发出一种准确、灵敏且经济高效地检测受感染小麦植株中

关键词：麦瘟病稻瘟菌小麦致病型 Cas12a 核酸侧流免疫分析田间检测

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ZnFe₂O₄/BiVO₄ Z-scheme heterojunction for efficient visible-light photocatalytic

《化学科学与工程前沿（英文）》 2023年第17卷第11期页码 1728-1740 doi: 10.1007/s11705-023-2322-z

摘要： A novel Z-scheme ZnFe₂O₄/BiVO₄ heterojunction photocatalyst was successfully synthesized using a convenient solvothermal method and applied in the visible light photocatalytic degradation of ciprofloxacin, which is a typical antibiotic contaminant in wastewater. The heterostructure of as-synthesized catalysts was confirmed using X-ray diffraction, scanning electron microscopy, transmission electron microscopy and X-ray photoelectron spectroscopy characterizations. Compared with the single-phase counterparts, ZnFe₂O₄/BiVO₄ demonstrated considerably enhanced photogenerated charge separation efficiencies because of the Z-scheme transfer mechanism of electrons between the composite photocatalysts. Consequently, the 30% ZnFe₂O₄/BiVO₄ catalyst afforded a degradation rate of up to 97% of 20 mg/L ciprofloxacin under 30 min of visible light irradiation with a total organic carbon removal rate of 50%, which is an excellent activity compared with ever reported BiVO₄-based catalysts. In addition, the liquid chromatography-mass spectrometry and quantitative structure-activity relationships model analyses demonstrated that the toxicity of the intermediates was lower than that of the parent ciprofloxacin. Moreover, the as-synthesized ZnFe₂O₄/BiVO₄ heterojunctions were quite stable and could be reused at least four times. This study thus provides a promising Z-scheme heterojunction photocatalyst for the efficient removal and detoxication of antibiotic pollutants from wastewater.

关键词： ZnFe₂O₄/BiVO₄ Z-scheme heterojunction photocatalytic degradation ciprofloxacin

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Li₄SiO₄-coated LiNi_0.5Mn_1.5O₄ as the high performance

Shifeng YANG, Wenfeng REN, Jian CHEN

《能源前沿（英文）》 2017年第11卷第3期页码 374-382 doi: 10.1007/s11708-017-0494-2

摘要： The preparation of Li SiO -coated LiNi Mn O materials by sintering the SiO -coated nickel-manganese oxides with lithium salts using abundant and low-cost sodium silicate as the silicon source was reported. The samples were characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. It was found that a uniform and complete SiO coating layer could be obtained at a suitable pH value of 10, which transformed to a good Li SiO coating layer afterwards. When used as the cathode materials for lithium-ion batteries, the Li SiO -coated LiNi Mn O samples deliver a better electrochemical performance in terms of the discharge capacity, rate capability, and cycling stability than that of the pristine material. It can still deliver 111.1 mAh/g at 20 C after 300 cycles, with a retention ratio of 93.1% of the stable capacity, which is far beyond that of the pristine material (101.3 mAh/g, 85.6%).

关键词： lithium-ion batteries cathode material LiNi_0.5Mn_1.5O₄ lithium-ion conductor coating