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绿色化工 5

医学 4

9 %~12 % Cr 钢 1

&prime 1

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M23C6 碳化物 1

准入管理 1

应急处置 1

旅客列车事故 1

显微结构 1

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FGF23 associated bone diseases

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 65-80 doi: 10.1007/s11684-013-0254-6

摘要：

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease.

关键词： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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The FGF metabolic axis

Xiaokun Li

《医学前沿（英文）》 2019年 第13卷 第5期   页码 511-530 doi: 10.1007/s11684-019-0711-y

摘要： Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elements that enable functional divergence and specification. Heparan sulfate-binding FGFs, which play critical roles in embryonic development and adult tissue remodeling homeostasis, adapt to an autocrine/paracrine mode of action to promote cell proliferation and population growth. By contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparan sulfate while acquiring affinity for transmembrane α-Klotho (KL) or β-KL as a coreceptor, thereby adapting to an endocrine mode of action to drive interorgan crosstalk that regulates a broad spectrum of metabolic homeostasis. FGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis. FGF21 metabolic axes play multifaceted roles in controlling the homeostasis of lipid, glucose, and energy metabolism. FGF23 axes from the bone to kidney and parathyroid regulate metabolic homeostasis of phosphate, calcium, vitamin D, and parathyroid hormone that are important for bone health and systemic mineral balance. The significant divergence in structural elements and multiple functional specifications of FGF19, 21, and 23 in cellular and organismal metabolism instead of cell proliferation and growth sufficiently necessitate a new unified and specific term for these three endocrine FGFs. Thus, the term “FGF Metabolic Axis,” which distinguishes the unique pathways and functions of endocrine FGFs from other autocrine/paracrine mitogenic FGFs, is coined.

关键词： FGF19     FGF21     FGF23     FGFR     metabolism     endocrine     Klotho    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

《医学前沿（英文）》 2022年 第16卷 第6期   页码 896-908 doi: 10.1007/s11684-022-0944-z

摘要： Fibroblast growth factor 13 (FGF13) is aberrantly expressed in multiple cancer types, suggesting its essential role in tumorigenesis. Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize its associations with bone marrow niches. Results showed that FGF13 was lowly expressed in patients with AML and that its elevated expression was related to prolonged overall survival (OS). Univariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factor. A prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-, 3-, and 5-year OS. Gene mutation and functional analyses indicated that FGF13 was not associated with AML driver mutations but was related to bone marrow niches. As for immunity, FGF13 was remarkably associated with T cell count, immune checkpoint genes, and cytokines. In addition, FGF13 overexpression substantially inhibited the growth and significantly induced the early apoptosis of AML cells. The xenograft study indicated that FGF13 overexpression prolonged the survival of recipient mice. Overall, FGF13 could serve as an independent prognostic factor for AML, and it was closely related to the bone marrow microenvironment.

关键词： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

《医学前沿（英文）》 2009年 第3卷 第1期   页码 61-66 doi: 10.1007/s11684-009-0007-8

摘要： The aim of this study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 gene expression in myocardial cells. Ventricular cardiocytes were isolated from neonatal rats and cultured, and then treated with different concentrations of retinoic acid. The expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measured by using RT-PCR and Western blot technique, respectively. There was basal expression of Shh and Fgf8 in the control group. When treated with 3×10 mol/L RA, we observed that the expression of Shh mRNA and protein in neonatal rat myocardial cells were up-regulated by 1.51 ( <0.05) and 1.10 times ( <0.05), respectively. In comparison with the control group, under the concentration of 5×10 mol/L RA, they were up-regulated by 2.21 ( <0.05) and 2.38 times ( <0.05) individually. Meanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 times ( <0.05) and 80% ( <0.05) separately compared with the control group after stimulation of 3×10 mol/L RA, and they were up-regulated by 3.48 ( <0.05) and 2.04 times ( <0.05) individually after stimulation of 5×10 mol/L RA. The results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardial cells. At the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1 expression.

关键词： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin-23

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

《医学前沿（英文）》 2007年 第1卷 第1期   页码 41-45 doi: 10.1007/s11684-007-0008-4

摘要： The dendritic cell vaccine is a treatment vaccine with potent clinical applications. Functional cytokines can enhance dendritic cell anti-tumor immune responses. This experiment was conducted to study the effects of bone marrow-deriv

关键词： Functional     experiment     anti-tumor     dendritic     clinical    

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“7·23”旅客列车事故的重要启示

孙永福

《中国工程科学》 2012年 第14卷 第12期   页码 4-9

摘要：

阐述了“7·23”旅客列车事故发生经过并进行了原因分析，从工程管理视角研究提出了4点重要启示：强化铁路新产品研发管理

关键词： 旅客列车事故     研发管理     准入管理     应急处置     铁路建设管理    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 25-30 doi: 10.1007/s11684-013-0244-8

摘要：

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.

关键词： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Artificial intelligence and wireless communications

Wang, Yi-qun Ge, Qi-fan Zhang, Wu-xian Shi,justin.wangjun@huawei.com,lirongone.li@huawei.com,wangjian23

《信息与电子工程前沿（英文）》 2020年 第21卷 第10期   页码 1413-1534 doi: 10.1631/FITEE.1900527

摘要： The applications of (AI) and (ML) technologies in have drawn significant attention recently. AI has demonstrated real success in speech understanding, image identification, and natural language processing domains, thus exhibiting its great potential in solving problems that cannot be easily modeled. AI techniques have become an enabler in to fulfill the increasing and diverse requirements across a large range of application scenarios. In this paper, we elaborate on several typical wireless scenarios, such as channel modeling, channel decoding and signal detection, and channel coding design, in which AI plays an important role in . Then, AI and information theory are discussed from the viewpoint of the information bottleneck. Finally, we discuss some ideas about how AI techniques can be deeply integrated with wireless communication systems.
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High-quality industrial n-type silicon wafers with an efficiency of over 23% for Si heterojunction solar

Fanying MENG,Jinning LIU,Leilei SHEN,Jianhua SHI,Anjun HAN,Liping ZHANG,Yucheng LIU,Jian YU,Junkai ZHANG,Rui ZHOU,Zhengxin LIU

《能源前沿（英文）》 2017年 第11卷 第1期   页码 78-84 doi: 10.1007/s11708-016-0435-5

摘要： n-type CZ-Si wafers featuring longer minority carrier lifetime and higher tolerance of certain metal contamination can offer one of the best Si-based solar cells. In this study, Si heterojuction (SHJ) solar cells which was fabricated with different wafers in the top, middle and tail positions of the ingot, exhibited a stable high efficiency of>22% in spite of the various profiles of the resistivity and lifetime, which demonstrated the high material utilization of n-type ingot. In addition, for effectively converting the sunlight into electrical power, the pyramid size, pyramid density and roughness of surface of the Cz-Si wafer were investigated by scanning electron microscope (SEM) and transmission electron microscope (TEM). Furthermore, the dependence of SHJ solar cell open-circuit voltage on the surface topography was discussed, which indicated that the uniformity of surface pyramid helps to improve the open-circuit voltage and conversion efficiency. Moreover, the simulation revealed that the highest efficiency of the SHJ solar cell could be achieved by the wafer with a thickness of 100 µm. Fortunately, over 23% of the conversion efficiency of the SHJ solar cell with a wafer thickness of 100 µm was obtained based on the systematic optimization of cell fabrication process in the pilot production line. Evidently, the large availability of both n-type ingot and thinner wafer strongly supported the lower cost fabrication of high efficiency SHJ solar cell.

关键词： n-type Cz-Si     thinner wafer     surface texture     high efficiency     SHJ solar cell    

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700 °C 及以上蒸汽温度下先进USC发电厂用耐热材料的研究和开发 Review

Fujio Abe

《工程（英文）》 2015年 第1卷 第2期   页码 211-224 doi: 10.15302/J-ENG-2015031

摘要：

欧洲、美国、日本已开展蒸汽温度为700 °C 及以上的先进超超临界(A-USC) 发电厂用材料开发项目，以实现更高能效和低二氧化碳排放量。近年来中国、印度等也开展了上述项目的开发和研究。这些项目涉及采用镍基合金更换马氏体9%~12%Cr 钢以用于最高温度的锅炉和涡轮部件，从而在700 °C 及以上温度下提供充足的蠕变强度。为尽量减少对昂贵的镍基合金的需求，马氏体9%~12%Cr 钢可用于A-USC 电厂中的次高温部件(最高温度不超过650 °C)。本文综述了A-USC 电厂厚型材锅炉和涡轮部件用镍基合金和马氏体9%~12%Cr 钢的研究和开发，主要关注高温下基底金属和焊缝的长期蠕变断裂强度、焊缝强度损失、蠕变疲劳性质和显微结构演化。

关键词： 镍基合金     9 %~12 % Cr 钢     蠕变强度     蠕变疲劳性质     焊缝     晶界     显微结构     &gamma     &prime     M23C6 碳化物    

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Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

《医学前沿（英文）》 2020年 第14卷 第3期   页码 262-272 doi: 10.1007/s11684-019-0717-5

摘要： Regeneration carries the idea of regrowing partially or completely a missing organ. Repair, on the other hand, allows restoring the function of an existing but failing organ. The recognition that human lungs can both repair and regenerate is quite novel, the concept has not been widely used to treat patients. We present evidence that the human adult lung does repair and regenerate and introduce different ways to harness this power. Various types of lung stem cells are capable of proliferating and differentiating upon injury driving the repair/regeneration process. Injury models, primarily in mice, combined with lineage tracing studies, have allowed the identification of these important cells. Some of these cells, such as basal cells, broncho-alveolar stem cells, and alveolar type 2 cells, rely on fibroblast growth factor (FGF) signaling for their survival, proliferation and/or differentiation. While pre-clinical studies have shown the therapeutic benefits of FGFs, a recent clinical trial for acute respiratory distress syndrome (ARDS) using intravenous injection of FGF7 did not report the expected beneficial effects. We discuss the potential reasons for these negative results and propose the rationale for new approaches for future clinical trials, such as delivery of FGFs to the damaged lungs through efficient inhalation systems, which may be more promising than systemic exposure to FGFs. While this change in the administration route presents a challenge, the therapeutic promises displayed by FGFs are worth the effort.

关键词： FGF     human lung     repair     regeneration     stem cells    

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谭天伟：绿色生物制造（2019年5月23日）

谭天伟(院士)

2021年04月22日

关键词： 绿色化工    

标题 作者 时间 类型 操作

FGF23 associated bone diseases

null

期刊论文

The FGF metabolic axis

Xiaokun Li

期刊论文

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

期刊论文

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

期刊论文

pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin-23

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

期刊论文

“7·23”旅客列车事故的重要启示

孙永福

期刊论文

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

期刊论文

Artificial intelligence and wireless communications

Wang, Yi-qun Ge, Qi-fan Zhang, Wu-xian Shi,justin.wangjun@huawei.com,lirongone.li@huawei.com,wangjian23

期刊论文

High-quality industrial n-type silicon wafers with an efficiency of over 23% for Si heterojunction solar

Fanying MENG,Jinning LIU,Leilei SHEN,Jianhua SHI,Anjun HAN,Liping ZHANG,Yucheng LIU,Jian YU,Junkai ZHANG,Rui ZHOU,Zhengxin LIU

期刊论文

700 °C 及以上蒸汽温度下先进USC发电厂用耐热材料的研究和开发

Fujio Abe

期刊论文

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

期刊论文

王保红：人体微生态与疾病的研究进展（2021年7月23日）

2021年10月23日

会议视频

谭天伟：绿色生物制造（2019年5月23日）

谭天伟(院士)

2021年04月22日

会议视频

钟武：小分子抗新冠病毒药物的研究（2021年7月23日）

2021年10月23日

会议视频

褚良银：智能人造膜（2019年5月23日）

2021年04月22日

会议视频