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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors
null
《医学前沿(英文)》 2018年 第12卷 第2期 页码 229-235 doi: 10.1007/s11684-017-0581-0
On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.
关键词: molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H
MSI/LOH and extron expression of the FHIT gene in gastric carcinoma
XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan
《医学前沿(英文)》 2007年 第1卷 第1期 页码 99-103 doi: 10.1007/s11684-007-0019-1
Nonlinear dynamic analysis for elastic robotic arms
H. KORAYEM, H. N. RAHIMI
《机械工程前沿(英文)》 2011年 第6卷 第2期 页码 219-228 doi: 10.1007/s11465-011-0218-y
The aim of the paper is to analyze the nonlinear dynamics of robotic arms with elastic links and joints. The main contribution of the paper is the comparative assessment of assumed modes and finite element methods as more convenient approaches for computing the nonlinear dynamic of robotic systems. Numerical simulations comprising both methods are carried out and results are discussed. Hence, advantages and disadvantages of each method are illustrated. Then, adding the joint flexibility to the system is dealt with and the obtained model is demonstrated. Finally, a brief description of the optimal motion generation is presented and the simulation is carried out to investigate the role of robot dynamic modeling in the control of robots.
关键词: robotic arms elastic link elastic joint nonlinear dynamics optimal control
Jiao HU,Xiufan LIU
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 11-24 doi: 10.15302/J-FASE-2016092
关键词: avian influenza virus H9N2 H5N1 novel viruses public health
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 101-111 doi: 10.1007/s11684-019-0698-4
关键词: mismatch repair protein deficiency (MMR-D) microsatellite instability (MSI) short tandem repeats (STR) gastrointestinal tumor hypermutability
Development progress of China’s 600 km/h high-speed magnetic levitation train
《工程管理前沿(英文)》 2022年 第9卷 第3期 页码 509-515 doi: 10.1007/s42524-022-0199-z
关键词: 600 km/h high-speed magnetic levitation train development history technological innovation
growth of a-few-layered MoS on CdS nanorod for high efficient photocatalytic H production
《能源前沿(英文)》 2021年 第15卷 第3期 页码 752-759 doi: 10.1007/s11708-021-0779-3
关键词: photocatalytic H2 production CdS MoS2 cocatalyst charge separation
Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review
《化学科学与工程前沿(英文)》 2023年 第17卷 第2期 页码 123-138 doi: 10.1007/s11705-022-2194-7
关键词: NAD(P)H:quinone oxidoreductase 1 cancer therapy target probe nanosystem
Annett SCHROETER, Tanja ENGELBRECHT, Reinhard H. H. NEUBERT
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 29-36 doi: 10.1007/s11705-013-1302-0
关键词: nano-structure of the stratum corneum ceramide penetration enhancer model membrane neutron diffraction 2H NMR spectroscopy
A new technique for islanding operation of distribution network connected with mini hydro
LAGHARI,H. MOKHLIS,M. KARIMI,A. H. A. BAKAR,Hasmaini MOHAMAD
《信息与电子工程前沿(英文)》 2015年 第16卷 第5期 页码 418-427 doi: 10.1631/FITEE.1400309
关键词: Islanding operation Mini hydro Distributed generation (DG) Islanding detection Load shedding
Lei ZHAO,Wenbin ZHANG,Jingwei CHEN,Hongwei DIAO,Qi WANG,Wenjing WANG
《能源前沿(英文)》 2017年 第11卷 第1期 页码 85-91 doi: 10.1007/s11708-016-0437-3
关键词: PECVD high pressure and high power a-Si:H microstructure passivation heterojunction solar cell
Research progress on human infection with avian influenza H7N9
Xiaoxin Wu, Lanlan Xiao, Lanjuan Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 8-20 doi: 10.1007/s11684-020-0739-z
《能源前沿(英文)》 2021年 第15卷 第3期 页码 744-751 doi: 10.1007/s11708-021-0775-7
关键词: bismuth oxyiodide (BiOI)/ tungsten trioxide (WO3) nano-flake arrays (NFA) photoelectrocatalytic (PEC) H2S splitting H2 S
Anovel approach of noise statistics estimate using H∞ filter in target tracking
Xie WANG,Mei-qin LIU,Zhen FAN,Sen-lin ZHANG
《信息与电子工程前沿(英文)》 2016年 第17卷 第5期 页码 449-457 doi: 10.1631/FITEE.1500262
Haibin HUANG,Gangyu TIAN,Tao WANG,Chao GAO,Jiren YUAN,Zhihao YUE,Lang ZHOU
《能源前沿(英文)》 2017年 第11卷 第1期 页码 92-95 doi: 10.1007/s11708-016-0432-8
关键词: double-layer emitter α-Si:H/c-Si heterojunction solar cell short circuit current quantum efficiency current-voltage-temperature
标题 作者 时间 类型 操作
MSI/LOH and extron expression of the FHIT gene in gastric carcinoma
XIAO Yuping, MAO Lili, HAN Chengbo, LI Jinyi, XU Lei, XIN Yan
期刊论文
Endemicity of H9N2 and H5N1 avian influenza viruses in poultry in China poses a serious threat to poultry
Jiao HU,Xiufan LIU
期刊论文
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
期刊论文
Influence of short chain ceramides and lipophilic penetration enhancers on the nano-structure of stratum corneum model membranes studied using neutron diffraction
Annett SCHROETER, Tanja ENGELBRECHT, Reinhard H. H. NEUBERT
期刊论文
A new technique for islanding operation of distribution network connected with mini hydro
LAGHARI,H. MOKHLIS,M. KARIMI,A. H. A. BAKAR,Hasmaini MOHAMAD
期刊论文
Plasma enhanced chemical vapor deposition of excellent a-Si:H passivation layers for a-Si:H/c-Si heterojunction
Lei ZHAO,Wenbin ZHANG,Jingwei CHEN,Hongwei DIAO,Qi WANG,Wenjing WANG
期刊论文
Research progress on human infection with avian influenza H7N9
Xiaoxin Wu, Lanlan Xiao, Lanjuan Li
期刊论文
Photoelectrocatalytic generation of H and S from toxic HS by using a novel BiOI/WO nanoflake array photoanode
期刊论文
Anovel approach of noise statistics estimate using H∞ filter in target tracking
Xie WANG,Mei-qin LIU,Zhen FAN,Sen-lin ZHANG
期刊论文