资源类型

期刊论文 55

会议视频 6

年份

2024 1

2023 6

2022 11

2021 5

2020 2

2019 7

2018 3

2016 1

2015 2

2014 4

2013 2

2012 1

2010 1

2009 4

2007 5

2006 2

2005 1

2002 1

2000 1

展开 ︾

关键词

医学 2

无氢渗碳 2

钛合金 2

9 %~12 % Cr 钢 1

&prime 1

&gamma 1

GDM过滤技术 1

M23C6 碳化物 1

β-内酰胺/β-内酰胺酶抑制剂 1

三点弯曲梁 1

上部结构 1

个体抗缺氧能力 1

交错缠绕 1

亲水性 1

介孔二氧化硅 1

代谢与免疫 1

仿生 1

全双层结构 1

关键技术 1

展开 ︾

检索范围：

排序： 展示方式：

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

《医学前沿（英文）》 2021年 第15卷 第2期   页码 208-220 doi: 10.1007/s11684-020-0795-4

摘要： New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

关键词： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

HTML PDF 收藏

Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

《环境科学与工程前沿（英文）》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1525-8

摘要：

• Effect of gastric fluid on EDCs adsorption-desorption to microplastics was evaluated.

关键词： Microplastics     Gastric fluid     Endocrine-disrupting chemicals     Adsorption     Desorption    

HTML PDF 收藏

Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration

《环境科学与工程前沿（英文）》 2023年 第18卷 第4期 doi: 10.1007/s11783-024-1805-6

摘要：

● Urethane functionalities created on PES membranes via electron beam irradiation.

关键词： Surface functionalization     Electron beam irradiation     Microfiltration     Endocrine disrupting chemicals    

HTML PDF 收藏

Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products

Yong YU,Laosheng WU

《环境科学与工程前沿（英文）》 2015年 第9卷 第3期   页码 475-481 doi: 10.1007/s11783-014-0640-6

摘要： Endocrine disrupting compounds (EDCs), pharmaceuticals and personal care products (PPCPs) have attracted much attention due to widespread contamination in aquatic environment. In this study, we determined 13 EDCs and PPCPs in fish blood, bile and muscle by using gas chromatography-mass spectrometry (GC-MS). The limits of quantitation (LOQ) were in the ranges of 0.23–2.54, 0.22–2.36 ng·mL , and 0.24–2.57 ng·g dry weight (dw) for fish blood, bile and muscle, respectively. Recoveries of target compounds spiked into sample matrices and passed through the entire analytical procedure ranged from 65% to 95%, from 60% to 92% and from 62% to 91% for blood, bile and muscle, respectively. The methods were applied to the analysis of fish from a lake in California. Target compounds were relatively low in bile, and only bisphenol A (BPA) and diclofenac were measurable near the LOQ. Seven of 13 compounds were detected in blood, with total concentrations up to 39 ng·mL . Only BPA was frequently found in muscle, with mean concentration of 7.26 ng·g dw. The estimated daily intake of BPA through fish consumption for U.S. resident was significantly lower than the tolerable daily intake recommended by the European Food Safety Authority. This study showed that the exposure to the bisphenol A from fish diet is unlikely to pose a health risk.

关键词： endocrine disrupting compounds (EDCs)     pharmaceuticals and personal care products (PPCPs)     fish     bisphenol A (BPA)     risk assessment    

HTML PDF 收藏

nanochannels of MOF thin-film nanocomposite nanofiltration membranes for efficient removal of hydrophobic endocrine

《环境科学与工程前沿（英文）》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1474-7

摘要：

• PA layer properties tune the primary nanochannels in MIL-101(Cr) TFN NF membranes.

关键词： Porous metal organic framework     Thin-film nanocomposite membrane     Primary selective nanochannels     Nanofiltration     Endocrine disrupting compounds    

HTML PDF 收藏

Occurrence of estrogenic endocrine disrupting chemicals concern in sewage plant effluent

Yan SUN, Huang HUANG, Ying SUN, Chao WANG, Xiaolei SHI, Hongying HU, Takashi KAMEYA, Koichi FUJIE

《环境科学与工程前沿（英文）》 2014年 第8卷 第1期   页码 18-26 doi: 10.1007/s11783-013-0573-5

摘要： The purpose of this study was to give a worldwide overview of the concentrations of typical estrogenic endocrine disrupting chemicals (EDCs) in the effluent of sewage plants and then compare the concentration distribution of the estrogenic EDCs in ten countries based on the survey data of the estrogenic EDCs research. The concentrations of three main categories (totally eight kinds) of estrogenic EDCs including steroidal estrogens (estrone (E1), estradiol (E2), estriol (E3) and 17α-ethynylestradiol (EE2)), phenolic compounds (nonylphenol (NP) and bisphenol A (BPA)) and phthalate esters (dibutyl phthalate (DBP) and dibutyl phthalate (2-ethylhexyl) phthalate (DEHP)) in the effluents of sewage plants reported in major international journals over the past decade were collected. The statistics showed that the concentration distributions of eight kinds of EDCs were in the range of ng·L to μg·L . The concentrations of steroidal estrogens mainly ranged within 50.00 ng·L , and the median concentrations of E1, E2, E3 and EE2 were 11.00, 3.68, 4.90 and 1.00 ng·L , respectively. Phenolic compounds and phthalate esters were found at μg·L level (some individual values were at the high level of 40.00 μg·L ). The median concentrations of BPA, NP, DBP and DEHP were 0.06, 0.55, 0.07 and 0.88 μg·L , respectively. The concentrations of phenolic compounds and phthalate esters in the effluents were higher than that of steroids estrogens. The analysis of the concentration in various ten countries showed that steroids estrogens, phenolic compounds and phthalate esters in sewage plant effluents were detected with high concentration in Canada, Spain and China, respectively.

关键词： estrogenic endocrine disrupting chemicals     concentration distribution     sewage plant    

HTML PDF 收藏

Solvent-resistant porous membranes using poly(ether−ether ketone): preparation and application

《化学科学与工程前沿（英文）》 2023年 第17卷 第10期   页码 1536-1559 doi: 10.1007/s11705-022-2221-8

摘要： Poly(ether−ether ketone) (PEEK) is a linear aromatic macromolecule, which can form semi-crystalline aggregative status, allowing PEEK materials to have strong environment tolerance and excellent physicochemical properties. PEEK materials have become a promising alternative to fabricate particular membranes used in extreme conditions. In the past few decades, many researches and evolutions have emerged in membrane fabrication with PEEK materials and its applications for treating organic solvents and their mixtures; however, there are little systematic and comprehensive literature to summarize fabrication approaches, compile applications, and elaborate PEEK property-structure relationship. In this review, the main approaches to fabricate PEEK-based membranes are illustrated concretely, including conventional thermal-induced and non-solvent-induced phase separation, and novel chemical-induced crystallization; the representative applications in ultrafiltration, nanofiltration and membrane contactor containing organic solvents are demonstrated systematically. Meanwhile, the mechanism to tune PEEK solubility in solvents, which can be achieved by altering monomers in synthesis processes or changing membrane preparation routes, is deeply analyzed. Moreover, the existing problems and the future prospects are also discussed. This review provides positive guidance for designing and fabricating membranes using PEEK and its derivative materials for task-specific applications in harsh conditions.

关键词： PEEK     phase inversion     solvent-resistant membrane     nanofiltration     membrane contactor    

HTML PDF 收藏

In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water

Kaifeng RAO, Na LI, Mei MA, Zijian WANG

《环境科学与工程前沿（英文）》 2014年 第8卷 第1期   页码 69-78 doi: 10.1007/s11783-013-0502-7

摘要： Effluents from wastewater treatment plant (WWTP) have been reported to have a broad spectrum of endocrine disrupting compounds (EDCs). The majority of studies have focused on the occurrence of estrogenic activity, while ignoring nuclear hormone receptors (NRs) pathways. In the present study, a battery of in vitro yeast bioassays and a cell bioassay, including antagonistic and agonistic effects on estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), estrogen-related receptor (ERR) and aryl hydrocarbon receptor (AHR), were conducted to evaluate the removal efficiencies of EDCs by different treatment processes of a WWTP located in Beijing. Estrogenic, anti-estrogenic, anti- androgenic, anti-progesteronic, anti-ERR and the activation of AHR activities were detected in samples from all treatment processes and the receiving water. The concentration of estrogenic contaminants with estradiol (E ) equivalent concentrations ranged from 0.82 × 10 to 3.54 × 10 g E -EQ·L . The concentration of anti-estrogenic contaminants with 4-hydroxytamoxifen (4-OHT) equivalent concentrations ranged from 1.24 × 10 to 2.36 × 10 g 4-OHT-EQ·L . The concentration of anti-androgenic contaminants ranged from 2.21 × 10 to 3.52 × 10 g flutamide-EQ·L . The concentration of anti-progesteronic contaminants ranged from 3.15 × 10 to 2.71 × 10 g RU486-EQ·L . The concentration of anti-ERR contaminants ranged from 7.09 × 10 to 6.50 × 10 g 4-OHT-EQ·L . The concentration of AHR activators ranged from 1.7 × 10 to 3.4 × 10 g TCDD-EQ·L . These processes including secondary clarifier, coagulation, as well as coal and sand filtration could eliminated 67.2% of estrogenic contaminants, 47.0% of anti-estrogenic contaminants, 98.3% of anti-androgenic contaminants, 88.4% of anti-progesteronic contaminants, 65.4% of anti-ERR contaminants and 46.9% of AHR activators. WWTP effluents contain multiple receptor disruptors may have very complex adverse effects on exposed organisms.

关键词： waste water     in vitro     recombinant yeast assay     ethoxyresorufin-O-deethylase (EROD)     receptor     endocrine    

HTML PDF 收藏

Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation

XU Bin, GAO Naiyun, RUI Min, WANG Hong, WU Haihui

《环境科学与工程前沿（英文）》 2007年 第1卷 第3期   页码 350-356 doi: 10.1007/s11783-007-0060-y

摘要： The ozone oxidation of endocrine disruptor bisphenol A in drinking water was investigated. A stainless completely mixed reactor was employed to carry out the degradation experiments by means of a batch model. With an initial concentration of 11.0 mg/L, the removal efficiencies of BPA (bisphenol A) could be measured up to 70%, 82%, and 90% when the dosages of ozone were 1, 1.5, and 2 mg/L, respectively. The impacts on BPA degradation under the conditions of different ozone dosages, water background values, BPA initial concentrations, and ozone adding time were analyzed. The results showed that ozone dosage plays a dominant role during the process of BPA degradation, while the impact of the contact time could be ignored. UV wavelength scanning was used to confirm that the by-products were produced, which could be absorbed at UV254. The value of UV254 was observed to have changed during the ozonation process. Based on the change of UV254, it could be concluded that BPA is not completely degraded at low ozone dosage, while shorter adding time of total ozone dosage, high ozone dosage, and improvement of dissolved ozone concentration greatly contribute to the extent of BPA degradation. The effects of applied HO dose in ozone oxidation of BPA were also examined in this study. The O-HO processes proved to have similar effects on the degradation of BPA by ozone oxidation.

关键词： BPA     scanning     reactor     process     O-HO    

HTML PDF 收藏

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

《环境科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 433-440 doi: 10.1007/s11783-013-0594-0

摘要： Study on effective disposal and utilization of sewage sludge has recently been the target of growing interest in China. However, potential risks are associated with the use of sludge due to its contamination with toxic organics, heavy metals and pathogenic microorganisms. In this study, a screening assessment was conducted on sewage sludge samples collected from 17 different sewage treatment plants in Beijing, based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrine disruption, and an ethoxy resorufin-O-deethylase (EROD) assay using H4IIE cells for aryl hydrocarbon receptor (Ah-R) agonistic activities. Our results suggested that moderate levels of estrogen receptor agonistic activities (0.9 ng E2·g to 6.8 ng E2·g , dw), but relative higher androgen receptor antagonistic activities (nd to 45%), progestin receptor antagonistic activities (nd to 80%) and Ah-R agonistic activities (1390 to 6740 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)·g , dw) were found in sewage sludge samples. However, there were no significant correlations between the toxic effects of sewage sludge and the sewage treatment processes. In addition, the 17β-estradiol (E2) equivalent quantity (EEQ) level of the sewage sludge was increased after the composting treatment, whereas the 2,3,7,8-tetrachlorodibenzo- -dioxin toxic equivalent quantity (TEQ) level of sewage sludge composted was much lower than that of sewage sludge.

关键词： sewage sludge     in vitro bioassay     endocrine disruption     dioxin-like effect    

HTML PDF 收藏

Identification of resistant pharmaceuticals in ozonation using QSAR modeling and their fate in electro-peroxone

《环境科学与工程前沿（英文）》 2021年 第15卷 第5期 doi: 10.1007/s11783-021-1394-6

摘要：

• Effect of converting ozonation to E-peroxone was studied on pharmaceutical removal.

关键词： Ozone     Electro-peroxone     Wastewater     Quantitative structure activity relationship     Advanced oxidation processes    

HTML PDF 收藏

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

《医学前沿（英文）》 2022年 第16卷 第3期   页码 467-482 doi: 10.1007/s11684-021-0869-y

摘要： Cabozantinib, mainly targeting cMet and vascular endothelial growth factor receptor 2, is the second-line treatment for patients with advanced hepatocellular carcinoma (HCC). However, the lower response rate and resistance limit its enduring clinical benefit. In this study, we found that cMet-low HCC cells showed primary resistance to cMet inhibitors, and the combination of cabozantinib and mammalian target of rapamycin (mTOR) inhibitor, rapamycin, exhibited a synergistic inhibitory effect on the in vitro cell proliferation and in vivo tumor growth of these cells. Mechanically, the combination of rapamycin with cabozantinib resulted in the remarkable inhibition of AKT, extracellular signal-regulated protein kinases, mTOR, and common downstream signal molecules of receptor tyrosine kinases; decreased cyclin D1 expression; and induced cell cycle arrest. Meanwhile, rapamycin enhanced the inhibitory effects of cabozantinib on the migration and tubule formation of human umbilical vascular endothelial cells and human growth factor-induced invasion of cMet inhibitor-resistant HCC cells under hypoxia condition. These effects were further validated in xenograft models. In conclusion, our findings uncover a potential combination therapy of cabozantinib and rapamycin to combat cabozantinib-resistant HCC.

关键词： hepatocellular carcinoma     cabozantinib     primary resistance     rapamycin    

HTML PDF 收藏

Effect of a promoter on the methanation activity of a Mo-based sulfur-resistant catalyst

Can LIN, Haiyang WANG, Zhenhua LI, Baowei WANG, Xinbin MA, Shaodong QIN, Qi SUN

《化学科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 88-94 doi: 10.1007/s11705-013-1301-1

摘要： The effect of adding Co, Ni or La on the methanation activity of a Mo-based sulfur-resistant catalyst was investigated. As promoters, Co, Ni and La all improved the methanation activity of a 15% MoO /Al O catalyst but to different extents. Similar improvements were also found when Co, Ni or La was added to a 15% MoO /25%-CeO -Al O catalyst. The promotion effects of Co and Ni were better than that of La. However, the catalytic methanation activity deteriorated the most with time for the Ni-promoted catalyst. The used catalysts were analyzed by nitrogen adsorption measurement, X-ray diffraction and X-ray photoelectron spectroscopy.

关键词： sulfur-resistant     methanation     promoter    

HTML PDF 收藏

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

《医学前沿（英文）》 2019年 第13卷 第1期   页码 24-31 doi: 10.1007/s11684-019-0679-7

摘要： Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advanced types. However, not all patients are responsive to immune checkpoint inhibitors. The response rate depends on the immune microenvironment, tumor mutational burden (TMB), expression level of immune checkpoint proteins, and molecular subtypes of cancers. Along with the Cancer Genome Project, various open access databases, including The Cancer Genome Atlas and Gene Expression Omnibus, provide large volumes of data, which allow researchers to explore responsive or resistant biomarkers of immune checkpoint inhibitors. In this review, we introduced some methodologies on database selection, biomarker screening, current progress of immune checkpoint blockade in solid tumor treatment, possible mechanisms of drug resistance, strategies of overcoming resistance, and indications for immune checkpoint inhibitor therapy.

关键词： immune checkpoint blockade     sensitivity     resistance     data mining    

HTML PDF 收藏

Effect of ultraviolet irradiation and chlorination on ampicillin-resistant

Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU

《环境科学与工程前沿（英文）》 2016年 第10卷 第3期   页码 522-530 doi: 10.1007/s11783-015-0779-9

摘要： Antibiotic resistance is a serious public health risk that may spread via potable and reclaimed water. Effective disinfection is important for inactivation of antibiotic-resistant bacteria and disruption of antibiotic resistance genes. Ampicillin is a widely prescribed antibiotic but its effectiveness is increasingly undermined by resistance. In this study, changes in ampicillin resistance for ( ) CGMCC 1.1595 were analyzed after exposure to different doses of ultraviolet (UV) or chlorine, and damage incurred by the plasmid encoding ampicillin resistance gene was assessed. We reported a greater stability in ampicillin-resistant CGMCC 1.1595 after UV irradiation or chlorination when compared with previously published data for other strains. UV irradiation and chlorination led to a shift in the mortality frequency distributions of ampicillin-resistant when subsequently exposed to ampicillin. The ampicillin hemi-inhibitory concentration (IC ) without disinfection was 3800 mg·L , and an increment was observed after UV irradiation or chlorination. The IC of ampicillin-resistant was 1.5-fold higher at a UV dose of 40 mJ·cm , and was 1.4-fold higher when exposed to 2.0 mg·L chlorine. These results indicate that UV irradiation and chlorination can potentially increase the risk of selection for strains with high ampicillin resistance. There was no evident damage to after 1–10 mg Cl ·L chlorination, while a UV dose of 80 mJ·cm yielded a damage ratio for of approximately 1.2-log. Therefore, high UV doses are required for effective disruption of antibiotic resistance genes in bacteria.

关键词： antibiotic resistance     Escherichia coli     ampicillin resistance gene     ultraviolet irradiation     chlorination    

HTML PDF 收藏

标题 作者 时间 类型 操作

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

期刊论文

Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

期刊论文

Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration

期刊论文

Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products

Yong YU,Laosheng WU

期刊论文

nanochannels of MOF thin-film nanocomposite nanofiltration membranes for efficient removal of hydrophobic endocrine

期刊论文

Occurrence of estrogenic endocrine disrupting chemicals concern in sewage plant effluent

Yan SUN, Huang HUANG, Ying SUN, Chao WANG, Xiaolei SHI, Hongying HU, Takashi KAMEYA, Koichi FUJIE

期刊论文

Solvent-resistant porous membranes using poly(ether−ether ketone): preparation and application

期刊论文

In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water

Kaifeng RAO, Na LI, Mei MA, Zijian WANG

期刊论文

Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation

XU Bin, GAO Naiyun, RUI Min, WANG Hong, WU Haihui

期刊论文

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

期刊论文

Identification of resistant pharmaceuticals in ozonation using QSAR modeling and their fate in electro-peroxone

期刊论文

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

期刊论文

Effect of a promoter on the methanation activity of a Mo-based sulfur-resistant catalyst

Can LIN, Haiyang WANG, Zhenhua LI, Baowei WANG, Xinbin MA, Shaodong QIN, Qi SUN

期刊论文

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

期刊论文

Effect of ultraviolet irradiation and chlorination on ampicillin-resistant

Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU

期刊论文